Scholars@Duke
Shelby Derene Reed

Shelby Derene Reed

Professor in Population Health Sciences
Population Health Sciences
Duke Box 17969, #6044 North Pavilion, Durham, NC 27715
300 N Mangum Street, Durham, NC 27701

Featured Works

Tools for Economic Analysis of Patient Management Interventions in Heart Failure Cost-Effectiveness Model: A Web-based program designed to evaluate the cost-effectiveness of disease management programs in heart failure.

Journal article Am Heart J · November 2015 Featured Publication BACKGROUND: Heart failure disease management programs can influence medical resource use and quality-adjusted survival. Because projecting long-term costs and survival is challenging, a consistent and valid approach to extrapolating short-term outcomes wou ... Full text Link to item Cite

Resource use, costs, and utility estimates for patients with cystic fibrosis with mild impairment in lung function: analysis of data collected alongside a 48-week multicenter clinical trial.

Journal article Value Health · 2012 Featured Publication OBJECTIVES: Transport of ions to generate epithelial rehydration (TIGER)-1 was a randomized trial conducted to evaluate the safety and efficacy of denufosol versus placebo in patients with cystic fibrosis with mild impairment in lung function. The trial me ... Full text Link to item Cite

Introduction of the Tools for Economic Analysis of Patient Management Interventions in Heart Failure Costing Tool: a user-friendly spreadsheet program to estimate costs of providing patient-centered interventions.

Journal article Circ Cardiovasc Qual Outcomes · January 2012 Featured Publication BACKGROUND: Patient-centered health care interventions, such as heart failure disease management programs, are under increasing pressure to demonstrate good value. Variability in costing methods and assumptions in economic evaluations of such interventions ... Full text Link to item Cite

End point selection in acute decompensated heart failure clinical trials: economic end points.

Journal article Heart Fail Clin · October 2011 Featured Publication The selection of economic end points in acute decompensated heart failure (ADHF) clinical trials requires prospectively planned evaluations that are developed in tandem with clinical end points. Integrating economic end points with concrete clinical outcom ... Full text Link to item Cite

Effects of family history and genetic polymorphism on the cost-effectiveness of chemoprevention with finasteride for prostate cancer.

Journal article J Urol · March 2011 Featured Publication PURPOSE: Improvement in the cost-effectiveness of chemoprevention for prostate cancer could be realized through the identification of patients at higher risk. We estimated the cost-effectiveness of prostate cancer chemoprevention across risk groups defined ... Full text Link to item Cite

What do international pharmacoeconomic guidelines say about economic data transferability?

Journal article Value Health · December 2010 Featured Publication OBJECTIVES: The objectives of this article were to assess the positions of the various national pharmacoeconomic guidelines on the transferability (or lack of transferability) of clinical and economic data and to review the methods suggested in the guideli ... Full text Link to item Cite

Costs of vasospasm in patients with aneurysmal subarachnoid hemorrhage.

Journal article Neurosurgery · August 2010 Featured Publication OBJECTIVE: To assess the impact of vasospasm on costs, length of stay, and mortality among inpatients with aneurysmal subarachnoid hemorrhage. METHODS: We combined hospital accounting and physician billing data for a consecutive cohort of 198 patients who ... Full text Link to item Cite

Economic evaluation of the HF-ACTION (Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training) randomized controlled trial: an exercise training study of patients with chronic heart failure.

Journal article Circ Cardiovasc Qual Outcomes · July 2010 Featured Publication BACKGROUND: Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION) assigned 2331 outpatients with medically stable heart failure to exercise training or usual care. We compared medical resource use and costs incurred by t ... Full text Link to item Cite

Comparison of costs, length of stay, and mortality associated with Candida glabrata and Candida albicans bloodstream infections.

Journal article Am J Infect Control · February 2010 Featured Publication We compared costs, length of stay, and mortality between adults with Candida albicans and Candida glabrata bloodstream infections. Early evidence of C glabrata, as defined by a positive culture within 2 days of admission, was associated with higher costs ( ... Full text Link to item Cite

Economic evaluation of home blood pressure monitoring with or without telephonic behavioral self-management in patients with hypertension.

Journal article Am J Hypertens · February 2010 Featured Publication BACKGROUND: The Take Control of Your Blood Pressure trial evaluated the effect of a multicomponent telephonic behavioral lifestyle intervention, patient self-monitoring, and both interventions combined compared with usual care on reducing systolic blood pr ... Full text Link to item Cite

Costs and length of stay for patients with and without sickle cell disease after hysterectomy, appendectomy, or knee replacement.

Journal article Am J Hematol · January 2010 Featured Publication Patients with sickle cell disease (SCD) who undergo surgical procedures experience greater risk for preoperative and postoperative complications than patients without SCD; however, the impact of SCD on inpatient resource use and costs had not been reported ... Full text Link to item Cite

Resource use and costs of treatment with anticoagulation and antiplatelet agents: results of the WATCH trial economic evaluation.

Journal article J Card Fail · December 2009 Featured Publication BACKGROUND: The Warfarin and Antiplatelet Therapy in Chronic Heart Failure (WATCH) trial revealed no significant differences among 1587 symptomatic heart failure patients randomized to warfarin, clopidogrel, or aspirin in time to all-cause death, nonfatal ... Full text Link to item Cite

Outcomes of inpatients with and without sickle cell disease after high-volume surgical procedures.

Journal article Am J Hematol · November 2009 Featured Publication In this study, we examined differences in inpatient costs, length of stay, and in-hospital mortality between hospitalizations for patients with and without sickle cell disease (SCD) undergoing high-volume surgical procedures. We used Clinical Classificatio ... Full text Link to item Cite

Pattern and predictors of the initiation of biologic agents for the treatment of rheumatoid arthritis in the United States: an analysis using a large observational data bank.

Journal article Clin Ther · August 2009 Featured Publication OBJECTIVE: The aim of this study was to identify factors associated with the initiation of biologic agents for the treatment of rheumatoid arthritis (RA) in a large US observational cohort. METHODS: Semiannual patient-reported data in the ARAMIS (Arthritis ... Full text Link to item Cite

Transferability of economic evaluations across jurisdictions: ISPOR Good Research Practices Task Force report.

Journal article Value Health · June 2009 Featured Publication ABSTRACT A growing number of jurisdictions now request economic data in support of their decision-making procedures for the pricing and/or reimbursement of health technologies. Because more jurisdictions request economic data, the burden on study sponsors ... Full text Link to item Cite

Candida albicans and non-albicans bloodstream infections in adult and pediatric patients: comparison of mortality and costs.

Journal article Pediatr Infect Dis J · May 2009 Featured Publication We compared length of stay, inpatient costs, and mortality associated with Candida albicans and non-albicans bloodstream infections in adults and children. Compared with adults, children with Candida bloodstream infections had longer lengths of stay (36.7 ... Full text Link to item Cite

Cost effectiveness of ixabepilone plus capecitabine for metastatic breast cancer progressing after anthracycline and taxane treatment.

Journal article J Clin Oncol · May 1, 2009 Featured Publication PURPOSE: Using data from a recent randomized trial, we evaluated the cost effectiveness of ixabepilone plus capecitabine versus capecitabine alone in patients with predominantly metastatic breast cancer considered to be taxane-resistant and previously trea ... Full text Link to item Cite

Outcomes of Staphylococcus aureus infection in hemodialysis-dependent patients.

Journal article Clin J Am Soc Nephrol · February 2009 Featured Publication BACKGROUND AND OBJECTIVES: Staphylococcus aureus is a leading cause of infection in patients with ESRD. Clinical and economic outcomes associated with S. aureus bacteremia and other S. aureus infections in patients with ESRD were examined. DESIGN, SETTING, ... Full text Link to item Cite

Economic implications of potential changes to regulatory and reimbursement policies for medical devices.

Journal article J Gen Intern Med · January 2008 Featured Publication OBJECTIVE: To evaluate the impact of regulatory scenarios on the financial viability of medical device companies. DESIGN: We developed a model to calculate the expected net present value of a hypothetical product throughout preclinical development, clinica ... Full text Link to item Cite

Updated estimates of survival and cost effectiveness for imatinib versus interferon-alpha plus low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukaemia.

Journal article Pharmacoeconomics · 2008 Featured Publication BACKGROUND: For trials in which participants are followed beyond the main study period to assess long-term outcomes, economic evaluations conducted using short-term data should be systematically updated to reflect new information. METHODS: We used 60-month ... Full text Link to item Cite

Use of larger versus smaller drug-safety databases before regulatory approval: the trade-offs.

Journal article Health Aff (Millwood) · 2008 Featured Publication Although efforts to revamp the drug-safety system have been directed at strengthening postmarketing surveillance, strategies for the preapproval stage may be useful. One strategy would be to require larger sample sizes in preapproval safety databases. To e ... Full text Link to item Cite

Geographic variation in the treatment of acute myocardial infarction in the VALsartan In Acute myocardial iNfarcTion (VALIANT) trial.

Journal article Am Heart J · September 2006 Featured Publication BACKGROUND: The VALIANT trial compared the efficacy and safety of captopril, valsartan, and their combination in patients with left ventricular systolic dysfunction, heart failure, or both after acute myocardial infarction (MI). By examining this internati ... Full text Link to item Cite

Analytic considerations in economic evaluations of multinational cardiovascular clinical trials.

Journal article Value Health · 2006 Featured Publication OBJECTIVES: The growing number of economic evaluations that use data collected in multinational clinical trials raises numerous questions regarding their execution and interpretation. Although recommendations for conducting economic evaluations have been w ... Full text Link to item Cite

How changes in drug-safety regulations affect the way drug and biotech companies invest in innovation.

Journal article Health Aff (Millwood) · 2006 Featured Publication Changes in the economics of product development resulting from heightened safety regulations could have a sizable negative impact on drug and biotechnology companies' decisions about investing in innovation. We developed a model to compare the potential ec ... Full text Link to item Cite

Economic evaluation of weekly epoetin alfa versus biweekly darbepoetin alfa for chemotherapy-induced anaemia: evidence from a 16-week randomised trial.

Journal article Pharmacoeconomics · 2006 Featured Publication INTRODUCTION: A 16-week, open-label, multicentre, randomised trial of weekly epoetin alfa 40 000 units versus biweekly darbepoetin alfa 200microg among 358 patients with solid-tumour cancers and chemotherapy-induced anaemia demonstrated superior haematolog ... Full text Link to item Cite

Early hemoglobin response and alternative metrics of efficacy with erythropoietic agents for chemotherapy-related anemia.

Journal article Curr Med Res Opin · October 2005 Featured Publication OBJECTIVE: To examine associations between early hemoglobin response and alternative measures of efficacy following treatment with an erythropoietic agent for chemotherapy-related anemia. RESEARCH DESIGN AND METHODS: Preliminary data from an ongoing random ... Full text Link to item Cite

Resource use, costs, and quality of life among patients in the multinational Valsartan in Acute Myocardial Infarction Trial (VALIANT).

Journal article Am Heart J · August 2005 Featured Publication BACKGROUND: In a multinational clinical trial, valsartan was statistically not inferior to captopril in reducing mortality and cardiovascular morbidity after myocardial infarction (MI) in patients with signs of heart failure and/or left ventricular dysfunc ... Full text Link to item Cite

Conducting economic evaluations alongside multinational clinical trials: toward a research consensus.

Journal article Am Heart J · March 2005 Featured Publication Demand for economic evaluations in multinational clinical trials is increasing, but there is little consensus about how such studies should be conducted and reported. At a workshop in Durham, North Carolina, we sought to identify areas of agreement about h ... Full text Link to item Cite

Costs and outcomes among hemodialysis-dependent patients with methicillin-resistant or methicillin-susceptible Staphylococcus aureus bacteremia.

Journal article Infect Control Hosp Epidemiol · February 2005 Featured Publication OBJECTIVE: Comorbid conditions have complicated previous analyses of the consequences of methicillin resistance for costs and outcomes of Staphylococcus aureus bacteremia. We compared costs and outcomes of methicillin resistance in patients with S. aureus ... Full text Link to item Cite

Cost-effectiveness of imatinib versus interferon-alpha plus low-dose cytarabine for patients with newly diagnosed chronic-phase chronic myeloid leukemia.

Journal article Cancer · December 1, 2004 Featured Publication BACKGROUND: Despite a lack of long-term data, imatinib has become standard therapy for patients with newly diagnosed chronic-phase chronic myeloid leukemia (CML) who are not candidates for allogeneic stem cell transplantation. In the current study, the aut ... Full text Link to item Cite

Long-term survival estimates for imatinib versus interferon-alpha plus low-dose cytarabine for patients with newly diagnosed chronic-phase chronic myeloid leukemia.

Journal article Cancer · December 1, 2004 Featured Publication BACKGROUND: The authors estimated survival among patients with chronic myeloid leukemia for a cost-effectiveness analysis of imatinib versus interferon-alpha plus low-dose cytarabine (IFN+LDAC). METHODS: Two-year survival and cytogenetic response were dete ... Full text Link to item Cite

A Bayesian approach to aid in formulary decision making: incorporating institution-specific cost-effectiveness data with clinical trial results.

Journal article Med Decis Making · 2003 Featured Publication Pharmacy and therapeutics committees commonly cite a lack of generalizability as a reason for not incorporating cost-effectiveness information into decision making. To address this concern, many committees undertake site-specific economic evaluations, whic ... Full text Link to item Cite

Comparison of hospital costing methods in an economic evaluation of a multinational clinical trial.

Journal article Int J Technol Assess Health Care · 2003 Featured Publication OBJECTIVES: To develop and evaluate strategies for estimating hospitalization costs in multinational clinical trials. METHODS: Hospital cost estimates for eleven diagnoses were collected from twelve countries participating in a trial of therapies for conge ... Full text Link to item Cite