Overview
Interested in the fascinating world of plants, microbes or inter-organismal communication and co-evolution? Please contact Prof. Sheng-Yang He (shengyang.he@duke.edu; hes@msu.edu).
Millions of years of co-evolution between plants and microbes have resulted in an intricate web of attack, counter-attack, decoy, and hijacking mechanisms in biology. Moreover, co-evolution between plants and microbes is greatly impacted by ongoing climate change. In our lab, we probe “host-microbe-climate” interactions to answer the following fundamental questions: (1) How do microbial pathogens infect a susceptible host? (2) How do plants select beneficial microbiomes to ensure health? (3) How do climate conditions impact disease and immunity?
We use contemporary methods to address these questions, including those commonly used in molecular genetics, genomics, biochemistry, cell biology, bioinformatics, microbiology, plant biology, co-evolution and infectious disease biology.
Current Appointments & Affiliations
Recent Publications
A natural defense against plant disease
Journal Article Science · April 11, 2025 Wild citrus plants contain a natural defense against a devastating bacterial disease ... Full text CiteThe conserved AvrE family of bacterial effectors: functions and targets during pathogenesis.
Journal Article Trends in microbiology · February 2025 The AvrE family of type III secreted effectors are highly conserved among many agriculturally important phytopathogenic bacteria. Despite their critical roles in the pathogenesis of phytopathogenic bacteria, the molecular functions and virulence mechanisms ... Full text CiteRapid intracellular acidification is a plant defense response countered by the brown planthopper.
Journal Article Current biology : CB · November 2024 The brown planthopper (BPH) is the most destructive insect pest in rice. Through a stylet, BPH secretes a plethora of salivary proteins into rice phloem cells as a crucial step of infestation. However, how various salivary proteins function in rice cells t ... Full text CiteRecent Grants
Tri-Institutional Molecular Mycology and Pathogenesis Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2024 - 2029Cell and Molecular Biology Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2021 - 2026Establishment of an aqueous environment as a novel mechanism of bacterial pathogenesis
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2020 - 2025View All Grants