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Sheng-Yang He

Benjamin E. Powell Distinguished Professor of Biology
Biology
Office hours 9 am - 5 pm daily  

Overview


Interested in the fascinating world of plants, microbes or inter-organismal communication and co-evolution? Please contact Prof. Sheng-Yang He (shengyang.he@duke.edu; hes@msu.edu).

Millions of years of co-evolution between plants and microbes have resulted in an intricate web of attack, counter-attack, decoy, and hijacking mechanisms in biology. Moreover, co-evolution between plants and microbes is greatly impacted by ongoing climate change. In our lab, we probe “host-microbe-climate” interactions to answer the following fundamental questions: (1) How do microbial pathogens infect a susceptible host? (2) How do plants select beneficial microbiomes to ensure health? (3) How do climate conditions impact disease and immunity?      

We use contemporary methods to address these questions, including those commonly used in molecular genetics, genomics, biochemistry, cell biology, bioinformatics, microbiology, plant biology, co-evolution and infectious disease biology.    

Current Appointments & Affiliations


Benjamin E. Powell Distinguished Professor of Biology · 2021 - Present Biology, Trinity College of Arts & Sciences
Professor of Biology · 2020 - Present Biology, Trinity College of Arts & Sciences
Professor of Cell Biology · 2022 - Present Cell Biology, Basic Science Departments

In the News


Published September 13, 2024
Crop Diseases, Spoilage Can Hurt the Food Supply. Could Plant Prebiotics Help?
Published November 16, 2023
Which Duke Scholars Made the Most Cited List?
Published September 13, 2023
Mysterious Family of Microbial Proteins Hijack Crops’ Cellular Plumbing

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Recent Publications


A natural defense against plant disease

Journal Article Science · April 11, 2025 Wild citrus plants contain a natural defense against a devastating bacterial disease ... Full text Cite

The conserved AvrE family of bacterial effectors: functions and targets during pathogenesis.

Journal Article Trends in microbiology · February 2025 The AvrE family of type III secreted effectors are highly conserved among many agriculturally important phytopathogenic bacteria. Despite their critical roles in the pathogenesis of phytopathogenic bacteria, the molecular functions and virulence mechanisms ... Full text Cite

Rapid intracellular acidification is a plant defense response countered by the brown planthopper.

Journal Article Current biology : CB · November 2024 The brown planthopper (BPH) is the most destructive insect pest in rice. Through a stylet, BPH secretes a plethora of salivary proteins into rice phloem cells as a crucial step of infestation. However, how various salivary proteins function in rice cells t ... Full text Cite
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Recent Grants


Tri-Institutional Molecular Mycology and Pathogenesis Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2024 - 2029

Cell and Molecular Biology Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2021 - 2026

Establishment of an aqueous environment as a novel mechanism of bacterial pathogenesis

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2020 - 2025

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Education, Training & Certifications


Cornell University · 1991 Ph.D.

External Links


He Lab Web Page