Huaxin Sheng

Professor in Anesthesiology

sheng001@mc.duke.edu

Box 3094 Med Ctr, Durham, NC 27710

138 Sands Bldg, Durham, NC 27710

More About This Person

At a Glance

Credentials
1. Education

Academic Experience

Global Scholarship

Keywords

Research
1. Selected Grants
2. External Relationships

Scholarly Works

Teaching & Mentoring

Recognition

Professional Activities

Embed Profile Data

Embed Profile Data

Scholarly Works - Conferences

Sirtuin-3 Deletion in the Distal Nephron Protects Against Ischemic AKI

Conference JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY · October 2025 Link to item Cite

The Role of Glucocorticoid Signaling in Lymphopenia After Cardiac Arrest in Mice

Conference CIRCULATION · December 17, 2024 Link to item Cite

The Immune Landscape in Young and Aged Mouse Brains After Cardiac Arrest and Resuscitation

Conference CIRCULATION · December 17, 2024 Link to item Cite

Redox-active Mn porphyrin-based clinical candidate, MnTnBuOE-2-PyP5+ (BMX-001) reduces paclitaxel-induced neuropathy, while suppressing ovarian cancer growth

Conference Free Radical Biology and Medicine · November 2024 Full text Cite

MnTnBuOE-2-PyP5+ Ascorbate in the Treatment of Ovarian Cancer

Conference Free Radical Biology and Medicine · November 2020 Full text Cite

Aging-Related Impairment in Post-Ischemic O-GlcNAcylation Activation Critically Contributes to Stroke Outcome

Conference STROKE · February 2020 Link to item Cite

The PERK branch of the unfolded protein response confers neuroprotection in ischemic stroke through modulation of protein synthesis and autophagy

Conference JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM · July 1, 2019 Link to item Cite

24 HOUR POST-TREATMENT WITH THE NOBLE GAS ARGON PROVIDES ROBUST NEUROPROTECTION AND IMPROVEMENT IN NEUROLOGIC OUTCOME AFTER FOCAL CEREBRAL ISCHEMIA IN RATS

Conference ANESTHESIA AND ANALGESIA · April 1, 2018 Link to item Cite

Protection of rat prostate and erectile function from radiation-induced damage by novel Mn(III) N- substituted pyridylporphyrin and ascorbate

Conference Free Radical Biology and Medicine · November 2017 Full text Cite

GW28-e0140 Knockout of Small Ubiquitin-Like Modifier 1 Protects the Mice from Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction

Conference Journal of the American College of Cardiology · October 2017 Full text Cite

Boosting O-GlcNAcylation, a pro-survival pathway downstream of the unfolded protein response, improves ischemic stroke outcome in mice

Conference JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM · April 1, 2017 Link to item Cite

Xenon as a therapy in experimental intracerebral hemorrhage

Conference JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM · April 1, 2017 Link to item Cite

Loss of Small Ubiquitin-Like Modifier 1 Protects the Heart From Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction in Mice

Conference CIRCULATION · November 11, 2016 Link to item Cite

Loss of Small Ubiquitin- Like Modifier 1 Protects the Heart From Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction in Mice

Conference CIRCULATION · November 11, 2016 Link to item Cite

IDENTIFICATION OF DYSFUNCTIONAL STRESS RESPONSE PATHWAYS IN POST-ISCHEMIC BRAINS OF OLD MICE: IMPLICATIONS FOR IMPAIRED FUNCTIONAL RECOVERY FROM ISCHEMIC STRESS

Conference JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM · June 1, 2016 Link to item Cite

Novel approaches to neuroprotection

Conference JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM · June 1, 2016 Link to item Cite

CHARACTERIZATION OF A MODIFIED LONG TERM SURVIVAL MOUSE MODEL OF CEREBRAL ISCHEMIA

Conference JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM · June 1, 2016 Link to item Cite

Progesterone Improves Neurobehavioral Outcome in Models of Intracerebral Hemorrhage.

Conference Neuroendocrinology · 2016 In models of acute brain injury, progesterone improves recovery through several mechanisms including modulation of neuroinflammation. Secondary injury from neuroinflammation is a potential therapeutic target after intracerebral hemorrhage (ICH). For potent ... Full text Link to item Cite

Comprehensive Pharmacokinetic Studies and Biodistribution of Two Cationic Mn Porphyrin-Based Catalysts, MnTE-2-PyP5+ and MnTnHex-2-PyP5+: Plasma and Organ Oral Availability, Mitochondrial, Cytosolic, Whole Brain, Hippocampus and Cortex Distribution

Conference Free Radical Biology and Medicine · November 2012 Full text Cite

Quantification of Tetrahydrobiopterin (BH4), Dihydrobiopterin (BH2) and Biopterin (BP) in Mouse Brain and Intestines After Ischemic Injury by Liquid Chromatography-Electrospray Tandem Mass Spectrometry (LC-ESI-MS/MS)

Conference Free Radical Biology and Medicine · November 2012 Full text Cite

A Breakthrough in the Development of SOD Mimics/Cellular Redox Modulators: a Superior Mn porphyrin, MnTnBuOE-2-PyP5+ With Finely Tuned Properties

Conference Free Radical Biology and Medicine · November 2011 Full text Cite

Structural Modification Diminishes Toxicity of Lipophilic Longer Mn(III) N-alkylpyridyl porphyrin-based Powerful SOD Mimics: Synthesis, Characterization and SOD-deficient E. coli and S. cerevisiae studies

Conference Free Radical Biology and Medicine · 2010 Full text Cite

Oral Availability of Mnte-2-Pyp(5+), a Potent Antioxidant and Cellular Redox Modulator

Conference FREE RADICAL BIOLOGY AND MEDICINE · January 1, 2008 Link to item Cite

Ec-SOD overexpression reduces blood-spinal cord barrier permeability and inflammatory cell infiltration, but does not improve outcome from spinal cord compression injury in the mouse

Conference FREE RADICAL BIOLOGY AND MEDICINE · January 1, 2004 Link to item Cite

Mn(III) meso tetrakis(N,N '-diethylimidazolium-2-yl)porphyrin (AEOL-10150) offers protection in mouse model of spinal cord injury

Conference FREE RADICAL BIOLOGY AND MEDICINE · January 1, 2003 Link to item Cite

Mn(III) meso-tetrakis(ortho N-ethyl-pyridyl)porphyrin, MnTE-2-PyP (AEOL-10113) offers protection in mouse spinal cord injury model

Conference FREE RADICAL BIOLOGY AND MEDICINE · January 1, 2002 Link to item Cite