Scholars@Duke
Shengli Song

Scholarly Works - Preprints

Apoptotic Quality Control of Cellular Competence Limits Cryptic Germinal Center B Cell States.

Preprint · September 16, 2026 Germinal center (GC) B cells undergo extensive apoptosis, but how this process shapes evolving GC populations remains unclear. Using mice lacking intrinsic apoptotic effectors BAK and BAX in B cells, we found that mitochondrial apoptosis was dispensable fo ... Full text Link to item Cite

Functional Convergence of Genetically Diverse B-Cell Receptors in Simian-HIV Infected Rhesus Macaques

Preprint · August 10, 2026 Germline-targeting or lineage-design vaccine strategies are being used to induce HIV broadly neutralizing antibody (bnAb) responses. These strategies assume that genetically diverse individuals respond similarly to the same immunogen by mobilizing ... Full text Cite

Functional Convergence of Genetically Diverse B-Cell Receptors in Simian-HIV Infected Rhesus Macaques

Preprint · August 10, 2026 Germline-targeting or lineage-design vaccine strategies are being used to induce HIV broadly neutralizing antibody (bnAb) responses. These strategies assume that genetically diverse individuals respond similarly to the same immunogen by mobilizing ... Full text Cite

Profiling Allogeneic HLA-specific B-cell Responses Utilizing a 64-plex Single-HLA Reporter Cell Panel.

Preprint · January 20, 2026 Identifying allogeneic HLA-specific B cells in sensitized individuals is essential for defining the cellular basis of allogeneic humoral immunity but remains technically challenging due to their low frequency. To overcome this barrier, we generated a 64-pl ... Full text Link to item Cite

Functional Convergence of Genetically Diverse B-Cell Receptors in Simian-HIV Infected Rhesus Macaques.

Preprint · January 12, 2026 Germline-targeting or lineage-design vaccine strategies are being used to induce HIV broadly neutralizing antibody (bnAb) responses. These strategies assume that genetically diverse individuals respond similarly to the same immunogen by mobilizing comparab ... Full text Link to item Cite

Fluorescence-barcoded cell lines stably expressing membrane-anchored influenza neuraminidases.

Preprint · April 15, 2025 The discovery of broadly protective antibodies to the influenza virus neuraminidase (NA) has raised interest in NA as a vaccine target. However, recombinant, solubilized tetrameric NA ectodomains are often challenging to express and isolate, hindering the ... Full text Link to item Cite