Current Appointments & Affiliations
Professor of Medicine
·
2024 - Present
Medicine, Medical Oncology,
Medicine
Member of the Duke Cancer Institute
·
2004 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Trends in Receipt of Adjuvant Chemotherapy and its Impact on Survival in Resected Biliary Tract Cancers.
Journal Article Ann Surg Oncol · August 2023 BACKGROUND: Resection remains the cornerstone of curative-intent treatment for biliary tract cancers (BTCs). However, recent randomized data also support a role for adjuvant chemotherapy (AC). This study aimed to characterize trends in the use of AC and su ... Full text Link to item CiteIdentification of DK419, a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth.
Journal Article Bioorg Med Chem · November 1, 2018 The Wnt signaling pathway is critical for normal tissue development and is an underlying mechanism of disease when dysregulated. Previously, we reported that the drug Niclosamide inhibits Wnt/β-catenin signaling by decreasing the cytosolic levels of Dishev ... Full text Link to item CiteAldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis.
Journal Article Cell Metab · June 5, 2018 Cancer metastasis accounts for the majority of cancer-related deaths and remains a clinical challenge. Metastatic cancer cells generally resemble cells of the primary cancer, but they may be influenced by the milieu of the organs they colonize. Here, we sh ... Full text Link to item CiteRecent Grants
Harnessing treatment-induced tumor evolution and collateral sensitivities using a human rectal cancer co-clinical platform
ResearchAdvisor · Awarded by National Cancer Institute · 2022 - 2027Role of the NLRP3-NLRC5 Signaling Pathway in Melanoma Immune Evasion and Dormancy
ResearchCollaborator · Awarded by Department of Defense · 2024 - 2027Precision Medicine Trial Using MicroOrganoSpheres to Guide Care in Colorectal Cancer
Clinical TrialPrincipal Investigator · Awarded by Mario Family Foundation · 2022 - 2025View All Grants
Education, Training & Certifications
University of North Carolina, Chapel Hill ·
2001
M.D.