Shiao-Wen David Hsu | Scholars@Duke

Shiao-Wen David Hsu
Assistant Professor of Medicine

Current Appointments & Affiliations

Assistant Professor of Medicine, Medicine, Medical Oncology, Medicine 2010
William Dalton Family Assistant Professor of Medical Oncology, in the School of Medicine, Medicine, Medical Oncology, Medicine 2011
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2004

Contact Information

Dept of Medicine, Box 3233, Durham, NC 27710
Duke Box 3233, Durham, NC 27710
shiaowen.hsu@duke.edu (919) 681-3480

Background
Education, Training, & Certifications
- Fellow in Hematology-Oncology, Medicine, Duke University 2004 - 2007
- Medical Resident, Medicine, University of Texas at Dallas 2001 - 2004
- M.D., University of North Carolina at Chapel Hill 2001
Duke Appointment History
- Medical Instructor in the Department of Medicine, Medicine, Medical Oncology, Medicine 2007 - 2010
- Instructor, Temporary in the Department of Medicine, Medicine, Medical Oncology, Medicine 2007
Research
Selected Grants
- Epigenomic Reprogramming in Patient Derived Models of Colorectal Cancer awarded by National Institutes of Health 2018 - 2023
- Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
- Race-Related Alternative Splicing: Novel Targets in Prostate Cancer awarded by National Institutes of Health 2017 - 2022
- Targeting the p38/Snail/PD-L1 axis in hormone-therapy resistance and metastasis awarded by Department of Defense 2018 - 2021
- Selectively targeting apoptosis in PIK3CA mutant colorectal cancers awarded by National Institutes of Health 2016 - 2021
- Identifying gene-environment interactions that confer metabolic vulnerabilities in cancer awarded by National Institutes of Health 2018 - 2021
- Targeting KRAS (G12C) Mutant in Colorectal Cancer awarded by Amgen, Inc. 2018 - 2019
- Determining the Efficacy of Liposomal Gemcitabine in Patient Derived Xenografts (PDXs) awarded by FUJIFILM Pharmaceuticals U.S.A. 2017 - 2019
- Targeting differential apoptosis regulation in triple negative breast cancer awarded by Department of Defense 2016 - 2019
- Targeting the TK1 receptor in colorectal and lung PDX using CarT cell and Motorcar cell awarded by Thunder Biotech 2017 - 2019
- Role of the Stroma in Fibrolamellar Hepatocellular Carcinoma awarded by Fibrolamellar Cancer Foundation 2016 - 2019
- Using bacterial CRISPR/Cas endonucleases to selectively eliminate HPV-transformed cells in vivo awarded by National Institutes of Health 2015 - 2017
- Targeting Calreticulin in Colorectal Cancer Liver Metastasis awarded by National Institutes of Health 2015 - 2017
- Development and Validation of Novel Therapeutic Targets in Anal Cancer awarded by The Farrah Fawcett Foundation 2015 - 2016
- Aptamer Targeted Drug and Toxin Delivery to Prostate Cancer awarded by Department of Defense 2014 - 2016
- A Platform for Real-time Drug Profiling of Patient-Derived Melanomas awarded by National Institutes of Health 2014 - 2016
- In Vivo Selection of Tumor-Specific RNA Binding Motifs awarded by National Institutes of Health 2011 - 2015
- Administrative Supplement for Recruitment of New Faculty awarded by National Cancer Institute 2009 - 2011
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Wang, Jiangbo, Robert A. Mook, Xiu-Rong Ren, Qingfu Zhang, Genevieve Jing, Min Lu, Ivan Spasojevic, H Kim Lyerly, David Hsu, and Wei Chen. “Identification of DK419, a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth..” Bioorganic & Medicinal Chemistry 26, no. 20 (November 2018): 5435–42. https://doi.org/10.1016/j.bmc.2018.09.016.
    Full Text
  - Bu, Pengcheng, Kai-Yuan Chen, Kun Xiang, Christelle Johnson, Scott B. Crown, Nikolai Rakhilin, Yiwei Ai, et al. “Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis..” Cell Metabolism 27, no. 6 (June 2018): 1249-1262.e4. https://doi.org/10.1016/j.cmet.2018.04.003.
    Full Text
  - Lu, Min, Amelia S. Zessin, Wayne Glover, and David S. Hsu. “Activation of the mTOR Pathway by Oxaliplatin in the Treatment of Colorectal Cancer Liver Metastasis..” Plos One 12, no. 1 (January 6, 2017). https://doi.org/10.1371/journal.pone.0169439.
    Full Text
  - Zhang, Tian, Rengasamy Boominathan, Brad Foulk, Chandra Rao, Gabor Kemeny, John H. Strickler, James L. Abbruzzese, et al. “Development of a Novel c-MET-Based CTC Detection Platform..” Mol Cancer Res 14, no. 6 (June 2016): 539–47. https://doi.org/10.1158/1541-7786.MCR-16-0011.
    Full Text Open Access Copy Link to Item
  - Mi, Jing, Partha Ray, Jenny Liu, Chien-Tsun Kuan, Jennifer Xu, David Hsu, Bruce A. Sullenger, Rebekah R. White, and Bryan M. Clary. “In Vivo Selection Against Human Colorectal Cancer Xenografts Identifies an Aptamer That Targets RNA Helicase Protein DHX9..” Molecular Therapy. Nucleic Acids 5 (April 26, 2016). https://doi.org/10.1038/mtna.2016.27.
    Full Text
  - Tang, Xiaohu, Jianli Wu, Chien-Kuang Ding, Min Lu, Melissa M. Keenan, Chao-Chieh Lin, Chih-An Lin, et al. “Cystine Deprivation Triggers Programmed Necrosis in VHL-Deficient Renal Cell Carcinomas..” Cancer Research 76, no. 7 (April 2016): 1892–1903. https://doi.org/10.1158/0008-5472.CAN-15-2328.
    Full Text
  - Bu, Pengcheng, Lihua Wang, Kai-Yuan Chen, Nikolai Rakhilin, Jian Sun, Adria Closa, Kuei-Ling Tung, et al. “miR-1269 promotes metastasis and forms a positive feedback loop with TGF-β..” Nature Communications 6 (April 15, 2015). https://doi.org/10.1038/ncomms7879.
    Full Text
  - Zhang, Tian, Elizabeth L. Boswell, Shannon J. McCall, and David S. Hsu. “Mismatch repair gone awry: Management of Lynch syndrome..” Critical Reviews in Oncology/Hematology 93, no. 3 (March 2015): 170–79. https://doi.org/10.1016/j.critrevonc.2014.10.005.
    Full Text
  - Ganapathi, Asvin M., Paul J. Speicher, Brian R. Englum, Anthony W. Castleberry, John Migaly, David S. Hsu, and Christopher R. Mantyh. “Adjuvant chemotherapy for t1 node-positive colon cancers provides significant survival benefit..” Diseases of the Colon and Rectum 57, no. 12 (December 2014): 1341–48. https://doi.org/10.1097/DCR.0000000000000245.
    Full Text
  - Zhang, Jenny, Dereje Jima, Andrea B. Moffitt, Qingquan Liu, Magdalena Czader, Eric D. Hsi, Yuri Fedoriw, et al. “The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cells..” Blood 123, no. 19 (May 8, 2014): 2988–96. https://doi.org/10.1182/blood-2013-07-517177.
    Full Text Link to Item
  - Rangwala, F., J. C. Bendell, M. F. Kozloff, C. C. Arrowood, A. Dellinger, J. Meadows, S. Tourt-Uhlig, et al. “Phase I study of capecitabine, oxaliplatin, bevacizumab, and everolimus in advanced solid tumors.” Investigational New Drugs 32, no. 4 (January 1, 2014): 700–709. https://doi.org/10.1007/s10637-014-0089-2.
    Full Text
  - Strickler, J. H., S. McCall, A. B. Nixon, J. C. Brady, H. Pang, C. Rushing, A. Cohn, et al. “Phase i study of dasatinib in combination with capecitabine, oxaliplatin and bevacizumab followed by an expanded cohort in previously untreated metastatic colorectal cancer.” Investigational New Drugs 32, no. 2 (January 1, 2014): 330–39. https://doi.org/10.1007/s10637-013-0042-9.
    Full Text
  - Morse, M. A., D. Niedzwiecki, J. L. Marshall, C. Garrett, D. Z. Chang, M. Aklilu, T. S. Crocenzi, et al. “A randomized phase II study of immunization with dendritic cells modified with poxvectors encoding CEA and MUC1 compared with the same poxvectors plus GM-CSF for resected metastatic colorectal cancer.” Annals of Surgery 258, no. 6 (December 1, 2013): 879–86. https://doi.org/10.1097/SLA.0b013e318292919e.
    Full Text
  - Morse, Michael A., Arvind Chaudhry, Elizabeth S. Gabitzsch, Amy C. Hobeika, Takuya Osada, Timothy M. Clay, Andrea Amalfitano, et al. “Novel adenoviral vector induces T-cell responses despite anti-adenoviral neutralizing antibodies in colorectal cancer patients..” Cancer Immunology, Immunotherapy : Cii 62, no. 8 (August 2013): 1293–1301. https://doi.org/10.1007/s00262-013-1400-3.
    Full Text
  - Zani, Sabino, Katia Papalezova, Sandra Stinnett, Douglas Tyler, David Hsu, and Dan G. Blazer. “Modest advances in survival for patients with colorectal-associated peritoneal carcinomatosis in the era of modern chemotherapy..” Journal of Surgical Oncology 107, no. 4 (March 2013): 307–11. https://doi.org/10.1002/jso.23222.
    Full Text
  - Mettu, N. B., H. Hurwitz, and D. S. Hsu. “Use of molecular biomarkers to inform adjuvant therapy for colon cancer.” Oncology (United States) 27, no. 8 (January 1, 2013).
  - Morse, M. A., A. Chaudhry, E. S. Gabitzsch, A. C. Hobeika, T. Osada, T. M. Clay, A. Amalfitano, et al. “Novel adenoviral vector induces T-cell responses despite anti-adenoviral neutralizing antibodies in colorectal cancer patients.” Cancer Immunology, Immunotherapy 62, no. 8 (2013): 1293–1301. https://doi.org/10.1007/s00262-013-1400-3.
    Full Text
  - Uronis, Hope E., Johanna C. Bendell, Ivy Altomare, Gerard C. Blobe, S David Hsu, Michael A. Morse, Herbert Pang, et al. “A phase II study of capecitabine, oxaliplatin, and bevacizumab in the treatment of metastatic esophagogastric adenocarcinomas..” The Oncologist 18, no. 3 (January 2013): 271–72. https://doi.org/10.1634/theoncologist.2012-0404.
    Full Text
  - Zani, S., K. Papalezova, S. Stinnett, D. Tyler, D. Hsu, and D. G. B. III. “Modest advances in survival for patients with colorectal-associated peritoneal carcinomatosis in the era of modern chemotherapy.” Journal of Surgical Oncology 107, no. 4 (2013): 307–11. https://doi.org/10.1002/jso.23222.
    Full Text
  - Kim, Mickey K., Takuya Osada, William T. Barry, Xiao Yi Yang, Jennifer A. Freedman, Katherine A. Tsamis, Michael Datto, et al. “Characterization of an oxaliplatin sensitivity predictor in a preclinical murine model of colorectal cancer..” Molecular Cancer Therapeutics 11, no. 7 (July 2012): 1500–1509. https://doi.org/10.1158/1535-7163.MCT-11-0937.
    Full Text
  - Riedel, Richard F., Alessandro Porrello, Emily Pontzer, Emily J. Chenette, David S. Hsu, Bala Balakumaran, Anil Potti, Joseph Nevins, and Phillip C. Febbo. “Retraction in part: A genomic approach to identify molecular pathways associated with chemotherapy resistance..” Molecular Cancer Therapeutics 11, no. 5 (May 2012): 1214–15. https://doi.org/10.1158/1535-7163.mct-12-0210.
    Full Text
  - Levine, Edward A., Dan G. Blazer, Mickey K. Kim, Perry Shen, John H. Stewart, Cynthia Guy, and David S. Hsu. “Gene expression profiling of peritoneal metastases from appendiceal and colon cancer demonstrates unique biologic signatures and predicts patient outcomes..” Journal of the American College of Surgeons 214, no. 4 (April 2012): 599–606. https://doi.org/10.1016/j.jamcollsurg.2011.12.028.
    Full Text
  - Acharya, Chaitanya R., David S. Hsu, Carey K. Anders, Ariel Anguiano, Kelly H. Salter, Kelli S. Walters, Richard C. Redman, et al. “Retraction: Acharya CR, et al. Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer. JAMA. 2008;299(13):1574-1587..” Jama 307, no. 5 (February 2012). https://doi.org/10.1001/jama.2012.2.
    Full Text
  - Uronis, Joshua M., Takuya Osada, Shannon McCall, Xiao Yi Yang, Christopher Mantyh, Michael A. Morse, H Kim Lyerly, Bryan M. Clary, and David S. Hsu. “Histological and molecular evaluation of patient-derived colorectal cancer explants..” Plos One 7, no. 6 (January 2012). https://doi.org/10.1371/journal.pone.0038422.
    Full Text
  - Deusen, J. van, and D. S. Hsu. “Predictive and prognostic biomarkers in colorectal cancer.” Frontiers in Biology 6, no. 6 (December 1, 2011): 482–89. https://doi.org/10.1007/s11515-011-1158-y.
    Full Text
  - Garman, Katherine S., Chaitanya R. Acharya, Elena Edelman, Marian Grade, Jochen Gaedcke, Shivani Sud, William Barry, et al. “Retraction for Garman et al: A genomic approach to colon cancer risk stratification yields biologic insights into therapeutic opportunities..” Proceedings of the National Academy of Sciences of the United States of America 108, no. 42 (October 3, 2011). https://doi.org/10.1073/pnas.1115170108.
    Full Text
  - Hsu, D. S., C. R. Acharya, B. S. Balakumaran, R. F. Riedel, M. K. Kim, M. Stevenson, S. Tuchman, et al. “Erratum: Characterizing the developmental pathways TTF-1, NKX2-8, and PAX9 in lung cancer (Proceedings of the National Academy of Sciences of the United States of America (2009) 106, 13 (5312-5317) DOI: 10.1073/pnas.0900827106).” Proceedings of the National Academy of Sciences of the United States of America 108, no. 35 (August 30, 2011). https://doi.org/10.1073/pnas.1111196108.
    Full Text
  - Freedman, Jennifer A., Christina K. Augustine, Angelica M. Selim, Kirsten C. Holshausen, Zhengzheng Wei, Katherine A. Tsamis, David S. Hsu, et al. “A methodology for utilization of predictive genomic signatures in FFPE samples..” Bmc Medical Genomics 4 (July 11, 2011). https://doi.org/10.1186/1755-8794-4-58.
    Full Text
  - Osada, Takuya, Minyong Chen, Xiao Yi Yang, Ivan Spasojevic, Jeffrey B. Vandeusen, David Hsu, Bryan M. Clary, et al. “Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations..” Cancer Res 71, no. 12 (June 15, 2011): 4172–82. https://doi.org/10.1158/0008-5472.CAN-10-3978.
    Full Text Link to Item
  - Altomare, Ivy, Johanna C. Bendell, Karen E. Bullock, Hope E. Uronis, Michael A. Morse, S David Hsu, S Yousuf Zafar, et al. “A phase II trial of bevacizumab plus everolimus for patients with refractory metastatic colorectal cancer..” The Oncologist 16, no. 8 (January 2011): 1131–37. https://doi.org/10.1634/theoncologist.2011-0078.
    Full Text
  - Garman, K. S., C. R. Acharya, E. Edelman, M. Grade, J. Gaedcke, S. Sud, W. Barry, et al. “A genomic approach to colon cancer risk stratification yields biologic insights into therapeutic opportunities (Proceedings of the National Academy of Sciences of the United States of America (2008) 105, 49, (19432-19437) DOI: 10.1073/pnas.0806674105).” Proceedings of the National Academy of Sciences of the United States of America 108, no. 42 (2011). https://doi.org/10.1073/pnas.1115170108.
    Full Text
  - Wang, Xinhui, Takuya Osada, Yangyang Wang, Ling Yu, Koichi Sakakura, Akihiro Katayama, James B. McCarthy, et al. “CSPG4 protein as a new target for the antibody-based immunotherapy of triple-negative breast cancer..” Journal of the National Cancer Institute 102, no. 19 (October 2010): 1496–1512. https://doi.org/10.1093/jnci/djq343.
    Full Text
  - Hsu, David S., Mickey K. Kim, Bala S. Balakumaran, Chaitanya R. Acharya, Carey K. Anders, Tim Clay, H Kim Lyerly, Charles G. Drake, Michael A. Morse, and Phillip G. Febbo. “Immune signatures predict prognosis in localized cancer..” Cancer Investigation 28, no. 7 (August 2010): 765–73. https://doi.org/10.3109/07357900903095755.
    Full Text
  - Osada, T., D. Hsu, S. Hammond, A. Hobeika, G. Devi, T. M. Clay, H. K. Lyerly, and M. A. Morse. “Metastatic colorectal cancer cells from patients previously treated with chemotherapy are sensitive to T-cell killing mediated by CEA/CD3-bispecific T-cell-engaging BiTE antibody..” British Journal of Cancer 102, no. 1 (January 2010): 124–33. https://doi.org/10.1038/sj.bjc.6605364.
    Full Text
  - Balakumaran, B. S., A. Porrello, D. S. Hsu, W. Glover, A. Foye, J. Y. Leung, B. A. Sullivan, W. C. Hahn, M. Loda, and P. G. Febbo. “MYC activity mitigates response to rapamycin in prostate cancer through eukaryotic initiation factor 4E-binding protein 1-mediated inhibition of autophagy.” Cancer Research 69, no. 19 (October 1, 2009): 7803–10. https://doi.org/10.1158/0008-5472.CAN-09-0910.
    Full Text
  - Balakumaran, Bala S., Alessandro Porrello, David S. Hsu, Wayne Glover, Adam Foye, Janet Y. Leung, Beth A. Sullivan, William C. Hahn, Massimo Loda, and Phillip G. Febbo. “MYC activity mitigates response to rapamycin in prostate cancer through eukaryotic initiation factor 4E-binding protein 1-mediated inhibition of autophagy..” Cancer Research 69, no. 19 (October 2009): 7803–10. https://doi.org/10.1158/0008-5472.CAN-09-0910.
    Full Text Open Access Copy
  - Garman, K. S., C. R. Acharya, E. Edelman, M. Grade, J. Gaedcke, S. Sud, W. Barry, et al. “Erratum: A genomic approach to colon cancer risk stratification yields biologic insights into therapeutic opportunities (Proceedings of the National Academy of Sciences of the United States of America (2008) 105:49 (19432-19437) Doi: 10.1073/pnas.0806674105).” Proceedings of the National Academy of Sciences of the United States of America 106, no. 16 (April 21, 2009). https://doi.org/10.1073/pnas.0902004106.
    Full Text
  - Hsu, David S., Chaitanya R. Acharya, Bala S. Balakumaran, Richard F. Riedel, Mickey K. Kim, Marvaretta Stevenson, Sascha Tuchman, et al. “Characterizing the developmental pathways TTF-1, NKX2-8, and PAX9 in lung cancer..” Proceedings of the National Academy of Sciences of the United States of America 106, no. 13 (March 11, 2009): 5312–17. https://doi.org/10.1073/pnas.0900827106.
    Full Text
  - Garman, Katherine S., Chaitanya R. Acharya, Elena Edelman, Marian Grade, Jochen Gaedcke, Shivani Sud, William Barry, et al. “A genomic approach to colon cancer risk stratification yields biologic insights into therapeutic opportunities..” Proceedings of the National Academy of Sciences of the United States of America 105, no. 49 (December 2, 2008): 19432–37. https://doi.org/10.1073/pnas.0806674105.
    Full Text
  - Riedel, Richard F., Alessandro Porrello, Emily Pontzer, Emily J. Chenette, David S. Hsu, Bala Balakumaran, Anil Potti, Joseph Nevins, and Phillip G. Febbo. “A genomic approach to identify molecular pathways associated with chemotherapy resistance..” Molecular Cancer Therapeutics 7, no. 10 (October 2008): 3141–49. https://doi.org/10.1158/1535-7163.mct-08-0642.
    Full Text
  - Anders, Carey K., David S. Hsu, Gloria Broadwater, Chaitanya R. Acharya, John A. Foekens, Yi Zhang, Yixin Wang, et al. “Young age at diagnosis correlates with worse prognosis and defines a subset of breast cancers with shared patterns of gene expression..” Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology 26, no. 20 (July 2008): 3324–30. https://doi.org/10.1200/jco.2007.14.2471.
    Full Text
  - Acharya, Chaitanya R., David S. Hsu, Carey K. Anders, Ariel Anguiano, Kelly H. Salter, Kelli S. Walters, Richard C. Redman, et al. “Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer..” Jama 299, no. 13 (April 2008): 1574–87. https://doi.org/10.1001/jama.299.13.1574.
    Full Text
  - Anders, Carey K., Chaitanya R. Acharya, David S. Hsu, Gloria Broadwater, Katherine Garman, John A. Foekens, Yi Zhang, et al. “Age-specific differences in oncogenic pathway deregulation seen in human breast tumors..” Plos One 3, no. 1 (January 2, 2008). https://doi.org/10.1371/journal.pone.0001373.
    Full Text Open Access Copy Link to Item
  - Hsu, David S., Bala S. Balakumaran, Chaitanya R. Acharya, Vanja Vlahovic, Kelli S. Walters, Katherine Garman, Carey Anders, et al. “Pharmacogenomic strategies provide a rational approach to the treatment of cisplatin-resistant patients with advanced cancer..” Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology 25, no. 28 (October 2007): 4350–57. https://doi.org/10.1200/jco.2007.11.0593.
    Full Text
  - Thresher, R. J., M. H. Vitaterna, Y. Miyamoto, A. Kazantsev, D. S. Hsu, C. Petit, C. P. Selby, et al. “Role of mouse cryptochrome blue-light photoreceptor in circadian photoresponses..” Science (New York, N.Y.) 282, no. 5393 (November 1998): 1490–94. https://doi.org/10.1126/science.282.5393.1490.
    Full Text
  - Zhao, X., J. Liu, D. S. Hsu, S. Zhao, J. S. Taylor, and A. Sancar. “Reaction mechanism of (6-4) photolyase..” J Biol Chem 272, no. 51 (December 19, 1997): 32580–90. https://doi.org/10.1074/jbc.272.51.32580.
    Full Text Link to Item
  - Mu, D., M. Wakasugi, D. S. Hsu, and A. Sancar. “Characterization of reaction intermediates of human excision repair nuclease..” J Biol Chem 272, no. 46 (November 14, 1997): 28971–79. https://doi.org/10.1074/jbc.272.46.28971.
    Full Text Link to Item
  - Hsu, D. S., X. Zhao, S. Zhao, A. Kazantsev, R. P. Wang, T. Todo, Y. F. Wei, and A. Sancar. “Putative human blue-light photoreceptors hCRY1 and hCRY2 are flavoproteins..” Biochemistry 35, no. 44 (November 1996): 13871–77. https://doi.org/10.1021/bi962209o.
    Full Text
  - Mu, D., D. S. Hsu, and A. Sancar. “Reaction mechanism of human DNA repair excision nuclease..” J Biol Chem 271, no. 14 (April 5, 1996): 8285–94. https://doi.org/10.1074/jbc.271.14.8285.
    Full Text Link to Item
  - Ozer, Z., J. T. Reardon, D. S. Hsu, K. Malhotra, and A. Sancar. “The other function of DNA photolyase: stimulation of excision repair of chemical damage to DNA..” Biochemistry 34, no. 49 (December 1995): 15886–89. https://doi.org/10.1021/bi00049a002.
    Full Text
  - Mu, D., C. H. Park, T. Matsunaga, D. S. Hsu, J. T. Reardon, and A. Sancar. “Reconstitution of human DNA repair excision nuclease in a highly defined system..” J Biol Chem 270, no. 6 (February 10, 1995): 2415–18. https://doi.org/10.1074/jbc.270.6.2415.
    Full Text Link to Item
  - Huang, J. C., D. S. Hsu, A. Kazantsev, and A. Sancar. “Substrate spectrum of human excinuclease: repair of abasic sites, methylated bases, mismatches, and bulky adducts..” Proceedings of the National Academy of Sciences of the United States of America 91, no. 25 (December 1994): 12213–17. https://doi.org/10.1073/pnas.91.25.12213.
    Full Text
  - Hsu, D. S., M. Takahashi, E. Delagoutte, E. Bertrand-Burggraf, Y. H. Wang, B. Norden, R. P. Fuchs, J. Griffith, and A. Sancar. “Flow linear dichroism and electron microscopic analysis of protein-DNA complexes of a mutant UvrB protein that binds to but cannot kink DNA..” Journal of Molecular Biology 241, no. 5 (September 1994): 645–50. https://doi.org/10.1006/jmbi.1994.1541.
    Full Text
  - Hsu, D. S., S. T. Kim, Q. Sun, and A. Sancar. “Structure and function of the UvrB protein..” J Biol Chem 270, no. 14 (April 7, 1995): 8319–27. https://doi.org/10.1074/jbc.270.14.8319.
    Full Text Link to Item
- Book Sections
  - Hsu, D. S., M. Morse, T. Clay, G. Devi, and H. Kim Lyerly. “Immune Cells and the Tumor Microenvironment.” In Genomic and Personalized Medicine, Two-Vol Set, 818–29, 2009. https://doi.org/10.1016/B978-0-12-369420-1.00068-8.
    Full Text
- Other Articles
  - “Retraction. Pharmacogenomic strategies provide a rational approach to the treatment of cisplatin-resistant patients with advanced cancer. J Clin Oncol 25:4350–7, 2007..” Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, December 2010. https://doi.org/10.1200/jco.2010.33.7311.
    Full Text
Teaching & Mentoring
Recent Courses

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Academic Articles

Book Sections

Other Articles

Recent Courses