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Shiao-Wen David Hsu

Professor of Medicine
Medicine, Medical Oncology
Duke Box 3233, Durham, NC 27710
Dept of Medicine, Box 3233, Durham, NC 27710

Current Appointments & Affiliations


Professor of Medicine · 2024 - Present Medicine, Medical Oncology, Medicine
Member of the Duke Cancer Institute · 2004 - Present Duke Cancer Institute, Institutes and Centers

Recent Publications


Trends in Receipt of Adjuvant Chemotherapy and its Impact on Survival in Resected Biliary Tract Cancers.

Journal Article Ann Surg Oncol · August 2023 BACKGROUND: Resection remains the cornerstone of curative-intent treatment for biliary tract cancers (BTCs). However, recent randomized data also support a role for adjuvant chemotherapy (AC). This study aimed to characterize trends in the use of AC and su ... Full text Link to item Cite

Identification of DK419, a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth.

Journal Article Bioorg Med Chem · November 1, 2018 The Wnt signaling pathway is critical for normal tissue development and is an underlying mechanism of disease when dysregulated. Previously, we reported that the drug Niclosamide inhibits Wnt/β-catenin signaling by decreasing the cytosolic levels of Dishev ... Full text Link to item Cite

Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis.

Journal Article Cell Metab · June 5, 2018 Cancer metastasis accounts for the majority of cancer-related deaths and remains a clinical challenge. Metastatic cancer cells generally resemble cells of the primary cancer, but they may be influenced by the milieu of the organs they colonize. Here, we sh ... Full text Link to item Cite
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Recent Grants


Role of the NLRP3-NLRC5 Signaling Pathway in Melanoma Immune Evasion and Dormancy

ResearchCollaborator · Awarded by Department of Defense · 2024 - 2027

Precision Medicine Trial Using MicroOrganoSpheres to Guide Care in Colorectal Cancer

Clinical TrialPrincipal Investigator · Awarded by Mario Family Foundation · 2022 - 2025

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Education, Training & Certifications


University of North Carolina, Chapel Hill · 2001 M.D.