Shiao-Wen David Hsu | Scholars@Duke

Shiao-Wen David Hsu
Assistant Professor of Medicine

Current Appointments & Affiliations

Assistant Professor of Medicine, Medicine, Medical Oncology, Medicine 2010
William Dalton Family Assistant Professor of Medical Oncology, in the School of Medicine, Medicine, Medical Oncology, Medicine 2011
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2004

Contact Information

Dept of Medicine, Box 3233, Durham, NC 27710
Duke Box 3233, Durham, NC 27710
shiaowen.hsu@duke.edu (919) 681-3480

Background
Education, Training, & Certifications
- Fellow In Hematology Oncology, Medicine, Duke University 2004 - 2007
- Medical Resident, Medicine, University of Texas at Dallas 2001 - 2004
- M.D., University of North Carolina at Chapel Hill 2001
Duke Appointment History
- Medical Instructor in the Department of Medicine, Medicine, Medical Oncology, Medicine 2007 - 2010
- Instructor, Temporary in the Department of Medicine, Medicine, Medical Oncology, Medicine 2007
Research
Selected Grants
- Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
- Race-related alternative splicing: novel targets in prostate cancer awarded by National Institutes of Health 2017 - 2022
- Targeting differential apoptosis regulation in triple negative breast cancer awarded by Department of Defense 2016 - 2019
- Using bacterial CRISPR/Cas endonucleases to selectively eliminate HPV-transformed cells in vivo awarded by National Institutes of Health 2015 - 2017
- Targeting Calreticulin in Colorectal Cancer Liver Metastasis awarded by National Institutes of Health 2015 - 2017
- Development and Validation of Novel Therapeutic Targets in Anal Cancer awarded by The Farrah Fawcett Foundation 2015 - 2016
- Aptamer Targeted Drug and Toxin Delivery to Prostate Cancer awarded by Department of Defense 2014 - 2016
- In Vivo Selection of Tumor-Specific RNA Binding Motifs awarded by National Institutes of Health 2011 - 2015
- Administrative Supplement for Recruitment of New Faculty awarded by National Cancer Institute 2009 - 2011
Publications & Artistic Works
Selected Publications
- Book Sections
  - Hsu, DS, Morse, M, Clay, T, Devi, G, and Lyerly, HK. "Immune Cells and the Tumor Microenvironment." 818-829. 2009. Full Text
- Journal Articles
  - Zhang, T, Boominathan, R, Foulk, B, Rao, C, Kemeny, G, Strickler, JH, Abbruzzese, JL, Harrison, MR, Hsu, DS, Healy, P, Li, J, Pi, C, Prendergast, KM, Hobbs, C, Gemberling, S, George, DJ, Hurwitz, HI, Connelly, M, Garcia-Blanco, MA, and Armstrong, AJ. "Development of a Novel c-MET-Based CTC Detection Platform." Molecular cancer research : MCR 14, no. 6 (June 2016): 539-547. Full Text Open Access Copy
  - Mi, J, Ray, P, Liu, J, Kuan, C-T, Xu, J, Hsu, D, Sullenger, BA, White, RR, and Clary, BM. "In Vivo Selection Against Human Colorectal Cancer Xenografts Identifies an Aptamer That Targets RNA Helicase Protein DHX9." Molecular therapy. Nucleic acids 5 (April 26, 2016): e315-. Full Text
  - Tang, X, Wu, J, Ding, C-K, Lu, M, Keenan, MM, Lin, C-C, Lin, C-A, Wang, CC, George, D, Hsu, DS, and Chi, J-T. "Cystine Deprivation Triggers Programmed Necrosis in VHL-Deficient Renal Cell Carcinomas." Cancer research 76, no. 7 (April 2016): 1892-1903. Full Text
  - Bu, P, Wang, L, Chen, K-Y, Rakhilin, N, Sun, J, Closa, A, Tung, K-L, King, S, Kristine Varanko, A, Xu, Y, Huan Chen, J, Zessin, AS, Shealy, J, Cummings, B, Hsu, D, Lipkin, SM, Moreno, V, Gümüş, ZH, and Shen, X. "miR-1269 promotes metastasis and forms a positive feedback loop with TGF-β." Nature communications 6 (April 15, 2015): 6879-. Full Text
  - Zhang, T, Boswell, EL, McCall, SJ, and Hsu, DS. "Mismatch repair gone awry: Management of Lynch syndrome." Critical reviews in oncology/hematology 93, no. 3 (March 2015): 170-179. (Review) Full Text
  - Ganapathi, AM, Speicher, PJ, Englum, BR, Castleberry, AW, Migaly, J, Hsu, DS, and Mantyh, CR. "Adjuvant chemotherapy for t1 node-positive colon cancers provides significant survival benefit." Diseases of the colon and rectum 57, no. 12 (December 2014): 1341-1348. Full Text
  - Zhang, J, Jima, D, Moffitt, AB, Liu, Q, Czader, M, Hsi, ED, Fedoriw, Y, Dunphy, CH, Richards, KL, Gill, JI, Sun, Z, Love, C, Scotland, P, Lock, E, Levy, S, Hsu, DS, Dunson, D, and Dave, SS. "The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cells." Blood 123, no. 19 (May 2014): 2988-2996. Full Text
  - Rangwala, F, Bendell, JC, Kozloff, MF, Arrowood, CC, Dellinger, A, Meadows, J, Tourt-Uhlig, S, Murphy, J, Meadows, KL, Starr, A, Broderick, S, Brady, JC, Cushman, SM, Morse, MA, Uronis, HE, Hsu, SD, Zafar, SY, Wallace, J, Starodub, AN, Strickler, JH, Pang, H, Nixon, AB, and Hurwitz, HI. "Phase I study of capecitabine, oxaliplatin, bevacizumab, and everolimus in advanced solid tumors." Investigational New Drugs 32, no. 4 (January 1, 2014): 700-709. Full Text
  - Strickler, JH, McCall, S, Nixon, AB, Brady, JC, Pang, H, Rushing, C, Cohn, A, Starodub, A, Arrowood, C, Haley, S, Meadows, KL, Morse, MA, Uronis, HE, Blobe, GC, Hsu, SD, Zafar, SY, and Hurwitz, HI. "Phase i study of dasatinib in combination with capecitabine, oxaliplatin and bevacizumab followed by an expanded cohort in previously untreated metastatic colorectal cancer." Investigational New Drugs 32, no. 2 (January 1, 2014): 330-339. Full Text
  - Morse, MA, Niedzwiecki, D, Marshall, JL, Garrett, C, Chang, DZ, Aklilu, M, Crocenzi, TS, Cole, DJ, Dessureault, S, Hobeika, AC, Osada, T, Onaitis, M, Clary, BM, Hsu, D, Devi, GR, Bulusu, A, Annechiarico, RP, Chadaram, V, Clay, TM, and Lyerly, HK. "A randomized phase II study of immunization with dendritic cells modified with poxvectors encoding CEA and MUC1 compared with the same poxvectors plus GM-CSF for resected metastatic colorectal cancer." Annals of Surgery 258, no. 6 (December 1, 2013): 879-886. Full Text
  - Morse, MA, Chaudhry, A, Gabitzsch, ES, Hobeika, AC, Osada, T, Clay, TM, Amalfitano, A, Burnett, BK, Devi, GR, Hsu, DS, Xu, Y, Balcaitis, S, Dua, R, Nguyen, S, Balint, JP, Jones, FR, and Lyerly, HK. "Novel adenoviral vector induces T-cell responses despite anti-adenoviral neutralizing antibodies in colorectal cancer patients." Cancer Immunol Immunother 62, no. 8 (August 2013): 1293-1301. Full Text Link to Item
  - Zani, S, Papalezova, K, Stinnett, S, Tyler, D, Hsu, D, and Blazer, DG. "Modest advances in survival for patients with colorectal-associated peritoneal carcinomatosis in the era of modern chemotherapy." J Surg Oncol 107, no. 4 (March 2013): 307-311. Full Text Link to Item
  - Mettu, NB, Hurwitz, H, and Hsu, DS. "Use of molecular biomarkers to inform adjuvant therapy for colon cancer." ONCOLOGY (United States) 27, no. 8 (2013).
  - Morse, MA, Chaudhry, A, Gabitzsch, ES, Hobeika, AC, Osada, T, Clay, TM, Amalfitano, A, Burnett, BK, Devi, GR, Hsu, DS, Xu, Y, Balcaitis, S, Dua, R, Nguyen, S, Jr, JPB, Jones, FR, and Lyerly, HK. "Novel adenoviral vector induces T-cell responses despite anti-adenoviral neutralizing antibodies in colorectal cancer patients." Cancer Immunology, Immunotherapy 62, no. 8 (2013): 1293-1301. Full Text
  - Uronis, HE, Bendell, JC, Altomare, I, Blobe, GC, Hsu, SD, Morse, MA, Pang, H, Zafar, SY, Conkling, P, Favaro, J, Arrowood, CC, Cushman, SM, Meadows, KL, Brady, JC, Nixon, AB, and Hurwitz, HI. "A phase II study of capecitabine, oxaliplatin, and bevacizumab in the treatment of metastatic esophagogastric adenocarcinomas." Oncologist 18, no. 3 (2013): 271-272. Full Text Link to Item
  - Zani, S, Papalezova, K, Stinnett, S, Tyler, D, Hsu, D, and III, DGB. "Modest advances in survival for patients with colorectal-associated peritoneal carcinomatosis in the era of modern chemotherapy." Journal of Surgical Oncology 107, no. 4 (2013): 307-311. Full Text
  - Kim, MK, Osada, T, Barry, WT, Yang, XY, Freedman, JA, Tsamis, KA, Datto, M, Clary, BM, Clay, T, Morse, MA, Febbo, PG, Lyerly, HK, and Hsu, DS. "Characterization of an oxaliplatin sensitivity predictor in a preclinical murine model of colorectal cancer." Mol Cancer Ther 11, no. 7 (July 2012): 1500-1509. Full Text Link to Item
  - Riedel, RF, Porrello, A, Pontzer, E, Chenette, EJ, Hsu, DS, Balakumaran, B, Potti, A, Nevins, J, and Febbo, PC. "Retraction in part: A genomic approach to identify molecular pathways associated with chemotherapy resistance." Mol Cancer Ther 11, no. 5 (May 2012): 1214-1215. Full Text Link to Item
  - Acharya, CR, Hsu, DS, Anders, CK, Anguiano, A, Salter, KH, Walters, KS, Redman, RC, Tuchman, SA, Moylan, CA, Mukherjee, S, Barry, WT, Dressman, HK, Ginsburg, GS, Marcom, KP, Garman, KS, Lyman, GH, Nevins, JR, and Potti, A. "Retraction: Acharya CR, et al. Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer. JAMA. 2008;299(13):1574-1587." JAMA 307, no. 5 (February 1, 2012): 453-. Full Text Link to Item
  - Levine, EA, III, DGB, Kim, MK, Shen, P, IV, JHS, Guy, C, and Hsu, DS. "Gene expression profiling of peritoneal metastases from appendiceal and colon cancer demonstrates unique biologic signatures and predicts patient outcomes." Journal of the American College of Surgeons 214, no. 4 (2012): 599-606. Full Text
  - Uronis, JM, Osada, T, McCall, S, Yang, XY, Mantyh, C, Morse, MA, Lyerly, HK, Clary, BM, and Hsu, DS. "Histological and molecular evaluation of patient-derived colorectal cancer explants." PLoS One 7, no. 6 (2012): e38422-. Full Text Link to Item
  - Garman, KS, Acharya, CR, Edelman, E, Grade, M, Gaedcke, J, Sud, S, Barry, W, Diehl, AM, Provenzale, D, Ginsburg, GS, Ghadimi, BM, Ried, T, Nevins, JR, Mukherjee, S, Hsu, D, and Potti, A. "Retraction for Garman et al: A genomic approach to colon cancer risk stratification yields biologic insights into therapeutic opportunities." Proc Natl Acad Sci U S A 108, no. 42 (October 18, 2011): 17569-. Full Text Link to Item
  - Freedman, JA, Augustine, CK, Selim, AM, Holshausen, KC, Wei, Z, Tsamis, KA, Hsu, DS, Dressman, HK, Barry, WT, Tyler, DS, and Nevins, JR. "A methodology for utilization of predictive genomic signatures in FFPE samples. (Published online)" BMC Med Genomics 4 (July 11, 2011): 58-. Full Text Link to Item
  - Osada, T, Chen, M, Yang, XY, Spasojevic, I, Vandeusen, JB, Hsu, D, Clary, BM, Clay, TM, Chen, W, Morse, MA, and Lyerly, HK. "Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations." Cancer Res 71, no. 12 (June 15, 2011): 4172-4182. Full Text Link to Item
  - Altomare, I, Bendell, JC, Bullock, KE, Uronis, HE, Morse, MA, Hsu, SD, Zafar, SY, Blobe, GC, Pang, H, Honeycutt, W, Sutton, L, and Hurwitz, HI. "A phase II trial of bevacizumab plus everolimus for patients with refractory metastatic colorectal cancer." Oncologist 16, no. 8 (2011): 1131-1137. Full Text Link to Item
  - Deusen, JV, and Hsu, DS. "Predictive and prognostic biomarkers in colorectal cancer." Frontiers in Biology 6, no. 6 (2011): 482-489. Full Text
  - Garman, KS, Acharya, CR, Edelman, E, Grade, M, Gaedcke, J, Sud, S, Barry, W, Diehl, AM, Provenzale, D, Ginsburg, GS, Ghadimi, BM, Ried, T, Nevins, JR, Mukherjee, S, Hsu, D, and Potti, A. "A genomic approach to colon cancer risk stratification yields biologic insights into therapeutic opportunities (Proceedings of the National Academy of Sciences of the United States of America (2008) 105, 49, (19432-19437) DOI: 10.1073/pnas.0806674105)." Proceedings of the National Academy of Sciences of the United States of America 108, no. 42 (2011): 17569--. Full Text
  - Hsu, DS, Acharya, CR, Balakumaran, BS, Riedel, RF, Kim, MK, Stevenson, M, Tuchman, S, Mukherjee, S, Barry, W, Dressman, HK, and al, E. "Characterizing the developmental pathways TTF-1, NKX2-8, and PAX9 in lung cancer (Proceedings of the National Academy of Sciences of the United States of America (2009) 106, 13 (5312-5317) DOI: 10.1073/pnas.0900827106)." Proceedings of the National Academy of Sciences of the United States of America 108, no. 35 (2011): 14705--. Full Text
  - Wang, X, Osada, T, Wang, Y, Yu, L, Sakakura, K, Katayama, A, McCarthy, JB, Brufsky, A, Chivukula, M, Khoury, T, Hsu, DS, Barry, WT, Lyerly, HK, Clay, TM, and Ferrone, S. "CSPG4 protein as a new target for the antibody-based immunotherapy of triple-negative breast cancer." J Natl Cancer Inst 102, no. 19 (October 6, 2010): 1496-1512. Full Text Link to Item
  - Hsu, DS, Kim, MK, Balakumaran, BS, Acharya, CR, Anders, CK, Clay, T, Lyerly, HK, Drake, CG, Morse, MA, and Febbo, PG. "Immune signatures predict prognosis in localized cancer." Cancer Invest 28, no. 7 (August 2010): 765-773. Full Text Link to Item
  - Osada, T, Hsu, D, Hammond, S, Hobeika, A, Devi, G, Clay, TM, Lyerly, HK, and Morse, MA. "Metastatic colorectal cancer cells from patients previously treated with chemotherapy are sensitive to T-cell killing mediated by CEA/CD3-bispecific T-cell-engaging BiTE antibody." Br J Cancer 102, no. 1 (January 5, 2010): 124-133. Full Text Link to Item
  - Balakumaran, BS, Porrello, A, Hsu, DS, Glover, W, Foye, A, Leung, JY, Sullivan, BA, Hahn, WC, Loda, M, and Febbo, PG. "MYC activity mitigates response to rapamycin in prostate cancer through eukaryotic initiation factor 4E-binding protein 1-mediated inhibition of autophagy." Cancer Res 69, no. 19 (October 1, 2009): 7803-7810. Full Text Open Access Copy Link to Item
  - Balakumaran, BS, Porrello, A, Hsu, DS, Glover, W, Foye, A, Leung, JY, Sullivan, BA, Hahn, WC, Loda, M, and Febbo, PG. "MYC activity mitigates response to rapamycin in prostate cancer through eukaryotic initiation factor 4E-binding protein 1-mediated inhibition of autophagy." Cancer Research 69, no. 19 (October 1, 2009): 7803-7810. Full Text
  - Hsu, DS, Acharya, CR, Balakumaran, BS, Riedel, RF, Kim, MK, Stevenson, M, Tuchman, S, Mukherjee, S, Barry, W, Dressman, HK, Nevins, JR, Powers, S, Mu, D, and Potti, A. "Characterizing the developmental pathways TTF-1, NKX2-8, and PAX9 in lung cancer." Proc Natl Acad Sci U S A 106, no. 13 (March 31, 2009): 5312-5317. Full Text Link to Item
  - Garman, KS, Acharya, CR, Edelman, E, Grade, M, Gaedcke, J, Sud, S, Barry, W, Diehl, AM, Provenzale, D, Ginsburg, GS, Ghadimi, BM, Ried, T, Nevins, JR, Mukherjee, S, Hsu, D, and Potti, A. "Erratum: A genomic approach to colon cancer risk stratification yields biologic insights into therapeutic opportunities (Proceedings of the National Academy of Sciences of the United States of America (2008) 105:49 (19432-19437) Doi: 10.1073/pnas.0806674105)." Proceedings of the National Academy of Sciences of the United States of America 106, no. 16 (2009): 6878--. Full Text
  - Garman, KS, Acharya, CR, Edelman, E, Grade, M, Gaedcke, J, Sud, S, Barry, W, Diehl, AM, Provenzale, D, Ginsburg, GS, Ghadimi, BM, Ried, T, Nevins, JR, Mukherjee, S, Hsu, D, and Potti, A. "A genomic approach to colon cancer risk stratification yields biologic insights into therapeutic opportunities." Proc Natl Acad Sci U S A 105, no. 49 (December 9, 2008): 19432-19437. Full Text Link to Item
  - Riedel, RF, Porrello, A, Pontzer, E, Chenette, EJ, Hsu, DS, Balakumaran, B, Potti, A, Nevins, J, and Febbo, PG. "A genomic approach to identify molecular pathways associated with chemotherapy resistance." Mol Cancer Ther 7, no. 10 (October 2008): 3141-3149. Full Text Link to Item
  - Anders, CK, Hsu, DS, Broadwater, G, Acharya, CR, Foekens, JA, Zhang, Y, Wang, Y, Marcom, PK, Marks, JR, Febbo, PG, Nevins, JR, Potti, A, and Blackwell, KL. "Young age at diagnosis correlates with worse prognosis and defines a subset of breast cancers with shared patterns of gene expression." J Clin Oncol 26, no. 20 (July 10, 2008): 3324-3330. Full Text Link to Item
  - Acharya, CR, Hsu, DS, Anders, CK, Anguiano, A, Salter, KH, Walters, KS, Redman, RC, Tuchman, SA, Moylan, CA, Mukherjee, S, Barry, WT, Dressman, HK, Ginsburg, GS, Marcom, KP, Garman, KS, Lyman, GH, Nevins, JR, and Potti, A. "Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer." JAMA 299, no. 13 (April 2, 2008): 1574-1587. Full Text Link to Item
  - Anders, CK, Acharya, CR, Hsu, DS, Broadwater, G, Garman, K, Foekens, JA, Zhang, Y, Wang, Y, Marcom, K, Marks, JR, Mukherjee, S, Nevins, JR, Blackwell, KL, and Potti, A. "Age-specific differences in oncogenic pathway deregulation seen in human breast tumors. (Published online)" PLoS One 3, no. 1 (January 2, 2008): e1373-. Full Text Open Access Copy Link to Item
  - Hsu, DS, Balakumaran, BS, Acharya, CR, Vlahovic, V, Walters, KS, Garman, K, Anders, C, Riedel, RF, Lancaster, J, Harpole, D, Dressman, HK, Nevins, JR, Febbo, PG, and Potti, A. "Pharmacogenomic strategies provide a rational approach to the treatment of cisplatin-resistant patients with advanced cancer." J Clin Oncol 25, no. 28 (October 1, 2007): 4350-4357. Full Text Link to Item
  - Thresher, RJ, Vitaterna, MH, Miyamoto, Y, Kazantsev, A, Hsu, DS, Petit, C, Selby, CP, Dawut, L, Smithies, O, Takahashi, JS, and Sancar, A. "Role of mouse cryptochrome blue-light photoreceptor in circadian photoresponses." Science 282, no. 5393 (1998): 1490-1494.
  - Mu, D, Wakasugi, M, Hsu, DS, and Sancar, A. "Characterization of reaction intermediates of human excision repair nuclease." Journal of Biological Chemistry 272, no. 46 (1997): 28971-28979. Full Text
  - Zhao, X, Liu, J, Hsu, DS, Zhao, S, Taylor, J-S, and Sancar, A. "Reaction mechanism of (6-4) photolyase." Journal of Biological Chemistry 272, no. 51 (1997): 32580-32590. Full Text
  - Hsu, DS, Zhao, X, Zhao, S, Kazantsev, A, Wang, R-P, Todo, T, Wei, Y-F, and Sancar, A. "Putative human blue-light photoreceptors hCRY1 and hCRY2 are flavoproteins." Biochemistry 35, no. 44 (1996): 13871-13877. Full Text
  - Mu, D, Hsu, DS, and Sancar, A. "Reaction mechanism of human DNA repair excision nuclease." Journal of Biological Chemistry 271, no. 14 (1996): 8285-8294. Full Text
  - Hsu, DS, Kim, S-T, Sun, Q, and Sancar, A. "Structure and function of the UvrB protein." Journal of Biological Chemistry 270, no. 14 (1995): 8319-8327. Full Text
  - Mu, D, Park, C-H, Matsunaga, T, Hsu, DS, Reardon, JT, and Sancar, A. "Reconstitution of human DNA repair excision nuclease in a highly defined system." Journal of Biological Chemistry 270, no. 6 (1995): 2415-2418. Full Text
  - Ozer, Z, Reardon, JT, Hsu, DS, Malhotra, K, and Sancar, A. "The other function of DNA photolyase: Stimulation of excision repair of chemical damage to DNA." Biochemistry 34, no. 49 (1995): 15886-15889. Full Text
  - Hsu, DS, Takahashi, M, Delagoutte, E, Bertrand-Burggraf, E, Wang, Y-H, Norden, B, Fuchs, RPP, Griffith, J, and Sancar, A. "Flow linear dichroism and electron microscopic analysis of protein-DNA complexes of a mutant UvrB protein that binds to but cannot kink DNA." Journal of Molecular Biology 241, no. 5 (1994): 645-650. Full Text
  - Huang, J-C, Hsu, DS, Kazantsev, A, and Sancar, A. "Substrate spectrum of human excinuclease: Repair of abasic sites, methylated bases, mismatches, and bulky adducts." Proceedings of the National Academy of Sciences of the United States of America 91, no. 25 (1994): 12213-12217. Full Text
- Other Articles
  - Hsu, DS, Balakumaran, BS, Acharya, CR, Vlahovic, V, Walters, KS, Garman, K, Anders, C, Riedel, RF, Lancaster, J, Harpole, D, and al, E. "Pharmacogenomic strategies provide a rational approach to the treatment of cisplatin-resistant patients with advanced cancer (Journal of Clinical Oncology (2007) 25, (4350-4357))." Journal of Clinical Oncology 28, no. 35 (2010): 5229--. Full Text
Teaching & Mentoring
Recent Courses

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Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Book Sections

Journal Articles

Other Articles

Recent Courses