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Shruti Agashe

Assistant Professor of Neurology
Neurology, Epilepsy and Sleep
Box 90361, Durham, NC 27708-0361
Law School Library, Durham, NC 27708

Overview


My patients have motivated me to be involved in clinical research. My interests spans areas such as identification of biomarkers in epilepsy, pre-surgical evaluation in epilepsy including stereoEEG and drugs/ device trials in epilepsy. Given my background in biomedical engineering, I have a special interest in Neuromodulation including deep brain stimulation, responsive neurostimulation, use of Artificial intelligence/machine learning on EEGs as well as developing novel device therapies for use in epilepsy care.

Current Appointments & Affiliations


Assistant Professor of Neurology · 2023 - Present Neurology, Epilepsy and Sleep, Neurology
Assistant Professor of Neurosurgery · 2025 - Present Neurosurgery, Neurosurgery
Assistant Professor of Biomedical Engineering · 2025 - Present Biomedical Engineering, Pratt School of Engineering

Recent Publications


Responsive neurostimulation detections: "Recognizing the unseen".

Journal Article Epileptic Disord · October 2025 BACKGROUND: Closed-loop responsive neurostimulation (RNS) is an established non-resective neuromodulatory therapy for individuals with drug-resistant epilepsy (DRE). RNS systems are typically programmed to detect and respond to predefined seizure onset pat ... Full text Open Access Link to item Cite

Leveraging Functional and Structural Connectomics to Guide Neuromodulation in Epilepsy.

Journal Article J Clin Neurophysiol · July 25, 2025 Epilepsy is not solely a disorder of abnormal brain structure; it is fundamentally a disorder of disrupted brain networks and impaired communication across brain regions. Thalamic neuromodulation, once conceptualized as a fixed, anatomically guided interve ... Full text Link to item Cite

Individualizing Programming of Responsive Neurostimulation and Deep Brain Stimulation Therapies in Epilepsy.

Journal Article J Clin Neurophysiol · July 25, 2025 Responsive neurostimulation and deep brain stimulation have emerged as effective intracranial neuromodulation therapies for drug-resistant epilepsy when surgical resection is not an option. However, programming these devices presents unique challenges in e ... Full text Link to item Cite
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Recent Grants


Developing a Neuromodulation System to Improve Sleep Quality in Epilepsy with a Vision for Broader Neuropsychiatric Applications

ResearchPrincipal Investigator · Awarded by North Carolina Biotechnology Center · 2025 - 2026

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Education, Training & Certifications


University of Texas, Medical Branch at Galveston · 2017 M.D.