Current Appointments & Affiliations
Medical Instructor in the Department of Surgery
·
2023 - Present
Surgery, Abdominal Transplant Surgery,
Surgery
Recent Publications
Immunomodulation of T cell-mediated alloimmunity by proximity to endothelial cells under the mammalian target of rapamycin blockade.
Journal Article Am J Transplant · February 2025 Endothelial cells (ECs) are an initial barrier between vascularized organ allografts and the host immune system and are thus well positioned to initiate and influence alloimmune rejection. The mammalian target of rapamycin inhibitor rapamycin is known to i ... Full text Link to item CiteRapamycin Prevents Expansion of Costimulation Blockade-resistant CD8+ Alloreactive Memory Cells following Depletional Induction in Renal Transplant Recipients.
Journal Article J Immunol · November 1, 2024 Alemtuzumab induction with belatacept/rapamycin-based maintenance immunotherapy (ABR) prevents kidney allograft rejection and specifically limits early costimulation blockade-resistant rejection (CoBRR). To evaluate the mechanisms by which this regimen alt ... Full text Open Access Link to item CiteXenorecognition and costimulation of porcine endothelium-derived extracellular vesicles in initiating human porcine-specific T cell immune responses.
Journal Article Am J Transplant · July 2023 Porcine vascular endothelial cells (PECs) form a mechanistic centerpiece of xenograft rejection. Here, we determined that resting PECs release swine leukocyte antigen class I (SLA-I) but not swine leukocyte antigen class-II DR (SLA-DR) expressing extracell ... Full text Open Access Link to item CiteRecent Grants
Surgical Critical Care Initiative (SC2I): Civilian application of military decision support tools for critically injured patients.
ResearchLab Research Analyst I · Awarded by Henry M. Jackson Foundation · 2021 - 2026Neonatal porcine islet xenografts for the treatment of type 1 diabetes
ResearchLab Research Analyst I · Awarded by National Institute of Allergy and Infectious Diseases · 2014 - 2025Sc2i
ResearchLab Research Analyst I · Awarded by Henry M. Jackson Foundation · 2020 - 2021View All Grants
Education, Training & Certifications
Wuhan University (China) ·
2007
Ph.D.