Simon Wilton Davis | Scholars@Duke

Simon Wilton Davis
Assistant Professor - Track V in Neurology

My research centers around the use of structural and functional imaging measures to study the shifts in network architecture in the aging brain. I am specifically interested in changes in how changes in structural and functional connectivity associated with aging impact the semantic retrieval of word or fact knowledge. Currently this involves asking why older adults have particular difficulty in certain kinds of semantic retrieval, despite the fact that vocabularies and knowledge stores typically improve with age.

A second line of research involves asking questions about how this semantic system is organized in young adults, understanding which helps form a basis for asking questions about older adults. To what degree are these semantic retrieval processes lateralized? What cognitive factors affect this laterality? How are brain structures like the corpus callosum involved in mediating distributed activation patterns associated with semantic retrieval?

Current Appointments & Affiliations

Assistant Professor in Neurology, Neurology, Behavioral Neurology, Neurology 2016
Assistant Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Brain Stimulation and Neurophysiology, Psychiatry & Behavioral Sciences 2017
Member of the Center for Cognitive Neuroscience, Center for Cognitive Neuroscience, Duke Institute for Brain Sciences 2016

Contact Information

B243Q LSRC, Durham, NC 27708
DUMC Box 2900, Bryan Research Building, Rm 227E, Durham, NC 27708
simon.davis@duke.edu (919) 668-2299

Background
Education, Training, & Certifications
- Ph.D., Duke University 2011
Recognition
In the News
- SEP 20, 2017 Duke Neurology
  
  Brain Halves Increase Communication to Compensate for Aging, Study Finds
Expertise
Subject Headings
- Research
Research
Selected Grants
- Impact of Timing, Targeting, and Brain State on rTMS of Human and Non-Human Primates awarded by National Institutes of Health 2017 - 2021
- Bilateral Brain Dynamics Supporting Cognition in Normal Aging and Dementia awarded by National Institutes of Health 2017 - 2021
- Using fMRI-guided TMS to increase central executive function in older adults awarded by National Institutes of Health 2015 - 2020
- Role of white-matter connectivity on age-related reorganization of brain networks awarded by National Institutes of Health 2008 - 2011
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Fuhrmann, D, Nesbitt, D, Shafto, M, Rowe, JB, Price, D, Gadie, A, Kievit, RA, Tyler, LK, Brayne, C, Bullmore, ET, Calder, AC, Cusack, R, Dalgleish, T, Duncan, J, Henson, RN, Matthews, FE, Marslen-Wilson, WD, Shafto, MA, Campbell, K, Cheung, T, Davis, S, Geerligs, L, Kievit, R, McCarrey, A, Mustafa, A, Samu, D, Taylor, JR, Treder, M, Tsvetanov, K, van Belle, J, Williams, N, Bates, L, Emery, T, Erzinlioglu, S, Gerbase, S, Georgieva, S, Hanley, C, Parkin, B, Troy, D, Auer, T, Correia, M, Gao, L, Green, E, Henriques, R, Allen, J, Amery, G, Amunts, L, Barcroft, A, Castle, A, Dias, C, Dowrick, J, Fair, M, Fisher, H, Goulding, A, Grewal, A, Hale, G, Hilton, A, Johnson, F, Johnston, P, Kavanagh-Williamson, T, Kwasniewska, M, McMinn, A, Norman, K, Penrose, J, Roby, F, Rowland, D, Sargeant, J, Squire, M, Stevens, B, Stoddart, A, Stone, C, Thompson, T, Yazlik, O, Barnes, D, Dixon, M, Hillman, J, Mitchell, J, and Villis, L. "Strong and specific associations between cardiovascular risk factors and white matter micro- and macrostructure in healthy aging(Accepted)." Neurobiology of Aging 74 (February 2019): 46-55. Full Text
  - Davis, SW, Crowell, CA, Beynel, L, Deng, L, Lakhlani, D, Hilbig, SA, Lim, W, Nguyen, D, Peterchev, AV, Luber, BM, Lisanby, SH, Appelbaum, LG, and Cabeza, R. "Complementary topology of maintenance and manipulation brain networks in working memory." Scientific Reports 8, no. 1 (December 13, 2018): 17827-null. Full Text
  - Green, E, Bennett, H, Brayne, C, and Matthews, FE. "Exploring patterns of response across the lifespan: the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) study." Bmc Public Health 18, no. 1 (December 2018). Full Text
  - Neacsiu, AD, Luber, BM, Davis, SW, Bernhardt, E, Strauman, TJ, and Lisanby, SH. "On the Concurrent Use of Self-System Therapy and Functional Magnetic Resonance Imaging-Guided Transcranial Magnetic Stimulation as Treatment for Depression." The Journal of Ect 34, no. 4 (December 2018): 266-273. Full Text
  - Monge, ZA, Stanley, ML, Geib, BR, Davis, SW, and Cabeza, R. "Functional networks underlying item and source memory: shared and distinct network components and age-related differences." Neurobiology of Aging 69 (September 2018): 140-150. Full Text
  - Wang, W-C, Wing, EA, Murphy, DLK, Luber, BM, Lisanby, SH, Cabeza, R, and Davis, SW. "Excitatory TMS modulates memory representations." Cognitive Neuroscience 9, no. 3-4 (July 2018): 151-166. Full Text
  - Wang, W-C, Wing, E, Murphy, DLK, Luber, B, Lisanby, S, Cabeza, R, and Davis, S. "Excitatory TMS Boosts Memory Representations." (March 10, 2018). Full Text
  - Davis, SW, Wing, EA, and Cabeza, R. "Contributions of the ventral parietal cortex to declarative memory." Handbook of Clinical Neurology 151 (January 2018): 525-553. (Review) Full Text
  - Davis, SW, Luber, B, Murphy, DLK, Lisanby, SH, and Cabeza, R. "Frequency-specific neuromodulation of local and distant connectivity in aging and episodic memory function." Human brain mapping 38, no. 12 (December 2017): 5987-6004. Full Text
  - Davis, S, Allen, AJ, O'Leary, R, Power, M, Price, DA, Simpson, AJ, Tunbridge, A, Vale, L, Whiteside, M, Evans, C, and Raza, M. "Diagnostic accuracy and cost analysis of the Alere™ i Influenza A&B near-patient test using throat swabs." The Journal of Hospital Infection 97, no. 3 (November 2017): 301-309. Full Text
  - Kievit, RA, Davis, SW, Griffiths, J, Correia, MM, Cam-Can, , and Henson, RN. "Erratum to "A watershed model of individual differences in fluid intelligence" [Neuropsychologia 91 (2016) 186-198]." Neuropsychologia 106 (November 2017): 417-null. Full Text
  - Samu, D, Campbell, KL, Tsvetanov, KA, Shafto, MA, Cam-CAN consortium, , and Tyler, LK. "Preserved cognitive functions with age are determined by domain-dependent shifts in network responsivity." Nature Communications 8 (May 8, 2017): 14743-null. Full Text
  - Luber, BM, Davis, S, Bernhardt, E, Neacsiu, A, Kwapil, L, Lisanby, SH, and Strauman, TJ. "Reprint of ''Using neuroimaging to individualize TMS treatment for depression: Toward a new paradigm for imaging-guided intervention''." NeuroImage 151 (May 2017): 65-71. Full Text
  - Luber, BM, Davis, S, Bernhardt, E, Neacsiu, A, Kwapil, L, Lisanby, SH, and Strauman, TJ. "Using neuroimaging to individualize TMS treatment for depression: Toward a new paradigm for imaging-guided intervention." Neuroimage 148 (March 2017): 1-7. (Review) Full Text Open Access Copy
  - Davis, SW, Stanley, ML, Moscovitch, M, and Cabeza, R. "Resting-state networks do not determine cognitive function networks: a commentary on Campbell and Schacter (2016)." Language, Cognition and Neuroscience 32, no. 6 (January 2017): 669-673. Full Text Open Access Copy
  - Kievit, RA, Davis, SW, Griffiths, J, Correia, MM, Cam-CAN, , and Henson, RN. "A watershed model of individual differences in fluid intelligence." Neuropsychologia 91 (October 2016): 186-198. Full Text Open Access Copy
  - Henson, RN, Campbell, KL, Davis, SW, Taylor, JR, Emery, T, Erzinclioglu, S, Cam-CAN, , and Kievit, RA. "Multiple determinants of lifespan memory differences." Scientific Reports 6 (September 7, 2016): 32527-null. Full Text Open Access Copy
  - Campbell, KL, Samu, D, Davis, SW, Geerligs, L, Mustafa, A, Tyler, LK, and for Cambridge Centre for Aging and Neuroscience, . "Robust Resilience of the Frontotemporal Syntax System to Aging." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 36, no. 19 (May 2016): 5214-5227. Full Text Open Access Copy
  - Campbell, KL, Shafto, MA, Wright, P, Tsvetanov, KA, Geerligs, L, Cusack, R, Cam-CAN, , and Tyler, LK. "Idiosyncratic responding during movie-watching predicted by age differences in attentional control." Neurobiology of Aging 36, no. 11 (November 2015): 3045-3055. Full Text
  - Geerligs, L, Rubinov, M, Cam-Can, , and Henson, RN. "State and Trait Components of Functional Connectivity: Individual Differences Vary with Mental State." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 35, no. 41 (October 2015): 13949-13961. Full Text
  - Tsvetanov, KA, Henson, RNA, Tyler, LK, Davis, SW, Shafto, MA, Taylor, JR, Williams, N, Cam-Can, , and Rowe, JB. "The effect of ageing on fMRI: Correction for the confounding effects of vascular reactivity evaluated by joint fMRI and MEG in 335 adults." Human Brain Mapping 36, no. 6 (June 2015): 2248-2269. Full Text Open Access Copy
  - Davis, SW, and Cabeza, R. "Cross-hemispheric collaboration and segregation associated with task difficulty as revealed by structural and functional connectivity." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 35, no. 21 (May 2015): 8191-8200. Full Text Open Access Copy
  - Daselaar, SM, Iyengar, V, Davis, SW, Eklund, K, Hayes, SM, and Cabeza, RE. "Less wiring, more firing: low-performing older adults compensate for impaired white matter with greater neural activity." Cerebral Cortex (New York, N.Y. : 1991) 25, no. 4 (April 2015): 983-990. Full Text Open Access Copy
  - Kievit, RA, Davis, SW, Mitchell, DJ, Taylor, JR, Duncan, J, Cam-CAN Research Team, , Henson, RNA, and Cam-CAN Research Team, . "Distinct aspects of frontal lobe structure mediate age-related differences in fluid intelligence and multitasking." Nature Communications 5 (December 18, 2014): 5658-null. Full Text Open Access Copy
  - Madden, DJ, Parks, EL, Davis, SW, Diaz, MT, Potter, GG, Chou, Y-H, Chen, N-K, and Cabeza, R. "Age mediation of frontoparietal activation during visual feature search." NeuroImage 102 Pt 2 (November 2014): 262-274. Full Text Open Access Copy
  - Shafto, MA, Tyler, LK, Dixon, M, Taylor, JR, Rowe, JB, Cusack, R, Calder, AJ, Marslen-Wilson, WD, Duncan, J, Dalgleish, T, Henson, RN, Brayne, C, Matthews, FE, and Cam-CAN, . "The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) study protocol: a cross-sectional, lifespan, multidisciplinary examination of healthy cognitive ageing." Bmc Neurology 14 (October 14, 2014): 204-null. Full Text
  - Davis, SW, Zhuang, J, Wright, P, and Tyler, LK. "Age-related sensitivity to task-related modulation of language-processing networks." Neuropsychologia 63 (October 2014): 107-115. Full Text Open Access Copy
  - Hall, SA, Rubin, DC, Miles, A, Davis, SW, Wing, EA, Cabeza, R, and Berntsen, D. "The neural basis of involuntary episodic memories." Journal of cognitive neuroscience 26, no. 10 (October 2014): 2385-2399. Full Text Open Access Copy
  - Whalley, MG, Kroes, MCW, Huntley, Z, Rugg, MD, Davis, SW, and Brewin, CR. "An fMRI investigation of posttraumatic flashbacks." Brain and Cognition 81, no. 1 (February 2013): 151-159. Full Text Open Access Copy
  - Davis, SW, Kragel, JE, Madden, DJ, and Cabeza, R. "The architecture of cross-hemispheric communication in the aging brain: linking behavior to functional and structural connectivity." Cerebral cortex (New York, N.Y. : 1991) 22, no. 1 (January 2012): 232-242. Full Text Open Access Copy
  - Cantlon, JF, Davis, SW, Libertus, ME, Kahane, J, Brannon, EM, and Pelphrey, KA. "Inter-Parietal White Matter Development Predicts Numerical Performance in Young Children." Learning and Individual Differences 21, no. 6 (December 2011): 672-680. Full Text Open Access Copy
  - Madden, DJ, Costello, MC, Dennis, NA, Davis, SW, Shepler, AM, Spaniol, J, Bucur, B, and Cabeza, R. "Adult age differences in functional connectivity during executive control." Neuroimage 52, no. 2 (August 2010): 643-657. Full Text
  - Davis, SW, Dennis, NA, Buchler, NG, White, LE, Madden, DJ, and Cabeza, R. "Assessing the effects of age on long white matter tracts using diffusion tensor tractography." Neuroimage 46, no. 2 (June 2009): 530-541. Full Text
  - Madden, DJ, Spaniol, J, Costello, MC, Bucur, B, White, LE, Cabeza, R, Davis, SW, Dennis, NA, Provenzale, JM, and Huettel, SA. "Cerebral white matter integrity mediates adult age differences in cognitive performance." J Cogn Neurosci 21, no. 2 (February 2009): 289-302. Full Text Link to Item
  - Davis, SW, Dennis, NA, Daselaar, SM, Fleck, MS, and Cabeza, R. "Que PASA? The posterior-anterior shift in aging." Cerebral Cortex (New York, N.Y. : 1991) 18, no. 5 (May 2008): 1201-1209. Full Text
  - Davis, SW, Dennis, NA, Daselaar, SM, Fleck, MS, and Cabeza, R. "Que PASA? The Posterior-Anterior Shift in Aging." Cerebral Cortex 18, no. 5 (May 1, 2008): 1201-1209. Full Text
  - Leow, AD, Yanovsky, I, Chiang, M-C, Lee, AD, Klunder, AD, Lu, A, Becker, JT, Davis, SW, Toga, AW, and Thompson, PM. "Statistical properties of Jacobian maps and the realization of unbiased large-deformation nonlinear image registration." Ieee Transactions on Medical Imaging 26, no. 6 (June 2007): 822-832. Full Text
  - Simons, JS, Davis, SW, Gilbert, SJ, Frith, CD, and Burgess, PW. "Discriminating imagined from perceived information engages brain areas implicated in schizophrenia." Neuroimage 32, no. 2 (August 2006): 696-703. Full Text
  - Becker, JT, Davis, SW, Hayashi, KM, Meltzer, CC, Toga, AW, Lopez, OL, Thompson, PM, and Imaging Methods and Analysis in Geriatrics Research Group, . "Three-dimensional patterns of hippocampal atrophy in mild cognitive impairment." Archives of Neurology 63, no. 1 (January 2006): 97-101. Full Text
  - Carmichael, OT, Aizenstein, HA, Davis, SW, Becker, JT, Thompson, PM, Meltzer, CC, and Liu, Y. "Atlas-based hippocampus segmentation in Alzheimer's disease and mild cognitive impairment." Neuroimage 27, no. 4 (October 2005): 979-990. Full Text
  - Leow, A, Huang, S-C, Geng, A, Becker, J, Davis, S, Toga, A, and Thompson, P. "Inverse consistent mapping in 3D deformable image registration: its construction and statistical properties." Information Processing in Medical Imaging : Proceedings of the ... Conference 19 (January 2005): 493-503.
- Conference Papers
  - Davis, S, Salgado, E, Elsayed, NM, and Williamson, DE. "F113. Hippocampal Connectivity Insulates High-Risk Adolescents From the Relationship Between Stress and Depressive Symptoms." May 2018. Full Text
  - Deng, Z-D, Davis, S, Szymanski, A, Liston, C, and Dubin, M. "T176. Controllability of Structural Brain Networks in Depressed Patients Receiving Repetitive Transcranial Magnetic Stimulation." May 2018. Full Text
  - Brooks, J, Davis, S, Komes, J, and Cabeza, R. "NEURAL CORRELATES OF THE OWN-AGE BIAS IN YOUNGER AND OLDER ADULTS." 20th Annual Meeting of the Cognitive-Neuroscience-Society. San Francisco, CA. April 13, 2013 - April 16, 2013.: MIT PRESS, January 1, 2013. Link to Item
  - Hall, S, Miles, A, Davis, S, Berntsen, D, Cabeza, R, and Rubin, D. "AN FMRI INVESTIGATION OF THE NEURAL BASIS OF INVOLUNTARY MEMORY: HOW DO THEY DIFFER FROM ESTABLISHED VOLUNTARY MEMORY NETWORKS?." 20th Annual Meeting of the Cognitive-Neuroscience-Society. San Francisco, CA. April 13, 2013 - April 16, 2013.: MIT PRESS, January 1, 2013. Link to Item
  - Madden, D, Davis, S, and Cabeza, R. "AGE-RELATED DIFFERENCES IN THE FUNCTIONAL NEUROANATOMY OF TOP-DOWN ATTENTIONAL CONTROL DURING VISUAL SEARCH." 20th Annual Meeting of the Cognitive-Neuroscience-Society. San Francisco, CA. April 13, 2013 - April 16, 2013.: MIT PRESS, January 1, 2013. Link to Item
  - Yanovsky, I, Chiang, M-C, Thompson, P, Klunder, A, Becker, J, Davis, S, Toga, A, and Leow, A. "QUANTIFYING DEFORMATION USING INFORMATION THEORY: THE LOG-UNBIASED NONLINEAR REGISTRATION." 2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro. April 12, 2007 - April 15, 2007.: IEEE, 2007. Full Text
  - "Inverse consistent mapping in 3D deformable image registration: Its construction and statistical properties." October 17, 2005.
  - "Discriminative MR image feature analysis for automatic schizophrenia and Alzheimer's disease classification." December 1, 2004.
  - Price, JC, Ziolko, SK, Weissfeld, LA, Klunk, WE, Lu, X, Hoge, JA, Meltzer, CC, Davis, SW, Lopresti, BJ, Holt, DP, DeKosky, ST, and Mathis, CA. "Quantitative and statistical analyses of PET imaging studies of amyloid deposition in humans." December 1, 2004.
Teaching & Mentoring
Recent Courses
Advising & Mentoring
Available to mentor:
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- PhD
- Post-Doc
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Education, Training, & Certifications

In the News

Subject Headings

Selected Grants

Selected Publications

Academic Articles

Conference Papers

Recent Courses

Advising & Mentoring

Available to mentor: