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Simon Wilton Davis

Associate Professor in Neurology
Neurology, Translational Brain Sciences
DUMC Box 2900, Bryan Research Building, Rm 227E, Durham, NC 27708
B243Q LSRC, Durham, NC 27708

Overview


My research centers around the use of structural and functional imaging measures to study the shifts in network architecture in the aging brain. I am specifically interested in changes in how changes in structural and functional connectivity associated with aging impact the semantic retrieval of word or fact knowledge. Currently this involves asking why older adults have particular difficulty in certain kinds of semantic retrieval, despite the fact that vocabularies and knowledge stores typically improve with age.

A second line of research involves asking questions about how this semantic system is organized in young adults, understanding which helps form a basis for asking questions about older adults. To what degree are these semantic retrieval processes lateralized? What cognitive factors affect this laterality? How are brain structures like the corpus callosum involved in mediating distributed activation patterns associated with semantic retrieval? 

Current Appointments & Affiliations


Associate Professor in Neurology · 2025 - Present Neurology, Translational Brain Sciences, Neurology
Associate Professor in Psychiatry and Behavioral Sciences · 2024 - Present Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences, Psychiatry & Behavioral Sciences
Associate Professor in Pathology · 2024 - Present Pathology, Clinical Science Departments
Associate Professor in Psychology and Neuroscience · 2024 - Present Psychology & Neuroscience, Trinity College of Arts & Sciences
Member of the Center for Cognitive Neuroscience · 2016 - Present Center for Cognitive Neuroscience, Duke Institute for Brain Sciences

In the News


Published September 20, 2017
Brain Halves Increase Communication to Compensate for Aging, Study Finds

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Recent Publications


Motor network reorganization associated with rTMS-induced writing improvement in writer's cramp dystonia.

Journal Article Brain Stimul · February 7, 2025 BACKGROUND: Writer's cramp (WC) dystonia is an involuntary movement disorder with distributed abnormalities in the brain's motor network. Prior studies established the potential for repetitive transcranial magnetic stimulation (rTMS) to either premotor cor ... Full text Link to item Cite

Subsequent Memory Effects in Cortical Pattern Similarity Differ by Semantic Class.

Journal Article J Cogn Neurosci · January 2, 2025 Although living and nonliving stimuli are known to rely on distinct brain regions during perception, it is largely unknown if their episodic memory encoding mechanisms differ as well. To investigate this issue, we asked participants to encode object pictur ... Full text Link to item Cite
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Recent Grants


Neural Mechanisms Underlying Attentional Resilience in the Aging Brain

ResearchCo Investigator · Awarded by National Institutes of Health · 2024 - 2029

Understanding language production after right hemisphere stroke using lesion symptom mapping.

ResearchAdvisor · Awarded by National Institute on Deafness and Other Communication Disorders · 2022 - 2027

Adaptive Neuromodulation of Working Memory Networks in Aging and Dementia

ResearchPrincipal Investigator · Awarded by National Institute on Aging · 2022 - 2027

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Education, Training & Certifications


Duke University · 2011 Ph.D.