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Simon Wilton Davis

Adjunct Associate Professor in the Department of Neurology
Neurology, Translational Brain Sciences
DUMC Box 2900, Bryan Research Building, Rm 227E, Durham, NC 27708
B243Q LSRC, Durham, NC 27708

Overview


My research centers around the use of structural and functional imaging measures to study the shifts in network architecture in the aging brain. I am specifically interested in changes in how changes in structural and functional connectivity associated with aging impact the semantic retrieval of word or fact knowledge. Currently this involves asking why older adults have particular difficulty in certain kinds of semantic retrieval, despite the fact that vocabularies and knowledge stores typically improve with age.

A second line of research involves asking questions about how this semantic system is organized in young adults, understanding which helps form a basis for asking questions about older adults. To what degree are these semantic retrieval processes lateralized? What cognitive factors affect this laterality? How are brain structures like the corpus callosum involved in mediating distributed activation patterns associated with semantic retrieval? 

Current Appointments & Affiliations


Adjunct Associate Professor in the Department of Neurology · 2025 - Present Neurology, Translational Brain Sciences, Neurology
Member of the Center for Cognitive Neuroscience · 2016 - Present Center for Cognitive Neuroscience, Duke Institute for Brain Sciences

In the News


Published September 20, 2017
Brain Halves Increase Communication to Compensate for Aging, Study Finds

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Recent Publications


Perceptual and conceptual influences on memory judgments.

Journal Article Commun Psychol · March 26, 2026 Memory representations contain a rich array of features, including perceptual and conceptual features of encoded stimuli. While prior research demonstrates that both feature types are independently represented in memory, available evidence suggests that re ... Full text Link to item Cite

Mapping concept and relational semantic representation in the brain using large language models.

Journal Article Curr Biol · March 9, 2026 How the brain organizes semantic information is one of the most challenging and expansive questions in cognitive neuroscience. Prior studies have shed light on how the brain represents concepts, but where relations are represented, independently of concept ... Full text Link to item Cite
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Recent Grants


Neural Mechanisms Underlying Attentional Resilience in the Aging Brain

ResearchCo Investigator · Awarded by National Institute on Aging · 2024 - 2029

Understanding language production after right hemisphere stroke using lesion symptom mapping.

ResearchAdvisor · Awarded by National Institute on Deafness and Other Communication Disorders · 2022 - 2027

Effects of Healthy Aging and Mild Cognitive Impairment on Memory Representations

ResearchCo Investigator · Awarded by National Institutes of Health · 2021 - 2027

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Education


Duke University · 2011 Ph.D.