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Sina Farsiu

Anderson-Rupp Professor of Biomedical Engineering
Biomedical Engineering
Box 3802 Med Ctr, Durham, NC 27710
CIEMAS 2575, Durham, NC 27708

Scholarly Works - Conferences


Large-scale data harmonization of radiology studies via multigranular vision-language alignment

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · April 2, 2026 Current radiology study harmonization methods rely heavily on textual metadata from DICOM headers, creating significant vulnerabilities when descriptions are incomplete, corrupted, or missing. This research introduces a Multi-Granular Vision-Language Align ... Full text Cite

RETI-DIFF: ILLUMINATION DEGRADATION IMAGE RESTORATION WITH RETINEX-BASED LATENT DIFFUSION MODEL

Conference 13th International Conference on Learning Representations Iclr 2025 · January 1, 2025 Illumination degradation image restoration (IDIR) techniques aim to improve the visibility of degraded images and mitigate the adverse effects of deteriorated illumination. Among these algorithms, diffusion-based models (DM) have shown promising performanc ... Cite

RUN: Reversible Unfolding Network for Concealed Object Segmentation

Conference Proceedings of Machine Learning Research · January 1, 2025 Existing concealed object segmentation (COS) methods frequently utilize reversible strategies, e.g., background reversible attention and foreground-background reversible calibration, to address uncertain regions. However, these approaches are typically res ... Cite

Dual modality handheld adaptive optics optical coherence tomography probe for in vivo 3-D photoreceptor imaging

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2023 Adaptive optics optical coherence tomography (AO-OCT) has allowed for the reliable 3-D imaging of individual retinal cells. The current AO-OCT systems are limited to tabletop implementation due to their size and complexity. This work describes the design a ... Full text Cite

Modeling Extremes with d-max-decreasing Neural Networks

Conference Proceedings of the 38th Conference on Uncertainty in Artificial Intelligence Uai 2022 · January 1, 2022 We propose a neural network architecture that enables non-parametric calibration and generation of multivariate extreme value distributions (MEVs). MEVs arise from Extreme Value Theory (EVT) as the necessary class of models when extrapolating a distributio ... Cite

Modeling Extremes with d-max-decreasing Neural Networks

Conference Proceedings of Machine Learning Research · January 1, 2022 We propose a neural network architecture that enables non-parametric calibration and generation of multivariate extreme value distributions (MEVs). MEVs arise from Extreme Value Theory (EVT) as the necessary class of models when extrapolating a distributio ... Cite

The RUSH2A study: Baseline microperimetry and SD-OCT measures

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 2021 Link to item Cite

Fisher Auto-Encoders

Conference Proceedings of Machine Learning Research · January 1, 2021 It has been conjectured that the Fisher divergence is more robust to model uncertainty than the conventional Kullback-Leibler (KL) divergence. This motivates the design of a new class of robust generative auto-encoders (AE) referred to as Fisher auto-encod ... Cite

Incoherent 3D k-space synthesis with volumetric optical coherence refraction tomography

Conference Optics Infobase Conference Papers · January 1, 2021 We present 3D optical coherence refraction tomography (OCRT), which incoherently synthesizes an extended 3D transfer function using multi-view OCT volumes spanning two angular dimensions. Our setup features a novel use of parabolic mirrors, achieving milli ... Cite

Mesoscopic photogrammetry with an unstabilized phone camera

Conference Proceedings of the IEEE Computer Society Conference on Computer Vision and Pattern Recognition · January 1, 2021 We present a feature-free photogrammetric technique that enables quantitative 3D mesoscopic (mm-scale height variation) imaging with tens-of-micron accuracy from sequences of images acquired by a smartphone at close range (several cm) under freehand motion ... Full text Cite

Beyond Performance Metrics: Automatic Deep Learning Retinal OCT Analysis Reproduces Clinical Trial Outcome.

Conference Ophthalmology · June 2020 PurposeTo validate the efficacy of a fully automatic, deep learning-based segmentation algorithm beyond conventional performance metrics by measuring the primary outcome of a clinical trial for macular telangiectasia type 2 (MacTel2).Design Full text Cite

Effects of aging on conventional outflow anatomy and physiology in C57BL/6 mice

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 2020 Link to item Cite

Effects of aging on conventional outflow anatomy and physiology in C57BL/6 mice

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 2020 Link to item Cite

Mouse corneal transplant evaluation with topography and pachymetry using OCT

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 2020 Link to item Cite

Meta-learning approach to automatically register multivendor retinal images

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 2020 Link to item Cite

Deep learning-based automatic segmentation of retinal cavitations on OCT images of MacTel2

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 2020 Link to item Cite

Resolution enhancement and speckle reduction in coherence imaging: A k-space model of optical coherence refraction tomography (OCRT)

Conference Optics Infobase Conference Papers · January 1, 2020 We present a preliminary k-space-based analysis of OCT and our recently proposed extension, optical coherence refraction tomography (OCRT). Our theory provides insight into how angular compounding enhances resolution and reduces speckle in coherence imagin ... Cite

Fully automatic quantification of individual ganglion cells from AO-OCT volumes via weakly supervised learning

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2020 Quantitative features of individual ganglion cells (GCs) are potential paradigm changing biomarkers for improved diagnosis and treatment monitoring of GC loss in neurodegenerative diseases like glaucoma and Alzheimer's disease. The recent incorporation of ... Full text Cite

Wavefront sensorless multimodal handheld adaptive optics scanning laser ophthalmoscope for in vivo imaging of human retinal cones

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2020 Adaptive optics scanning laser ophthalmoscopy (AOSLO) has advanced the study of retinal structure and function by enabling in vivo imaging of individual photoreceptors. Most implementations of AOSLOs are large, complex tabletop systems, thereby preventing ... Full text Cite

MimickNet, Matching Clinical Post-Processing under Realistic Black-Box Constraints

Conference IEEE International Ultrasonics Symposium Ius · October 1, 2019 Image post-processing is used in clinical-grade ultrasound scanners to improve image quality (e.g., reduce speckle noise and enhance contrast). These post-processing techniques vary across manufacturers and are generally kept proprietary, which presents a ... Full text Cite

In vivo measurement of TM stiffness: proof-of-principle in mice

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2019 Link to item Cite

Choroidal Thickness in Myopic Children in the BLINK Study

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2019 Link to item Cite

Reliability of physicians' measurements when manually annotating images of microbial keratitis

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2019 Link to item Cite

Real- time Corneal Segmentation and 3D Needle Tracking in Intrasurgical OCT

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2018 Link to item Cite

Semi-Automated Segmentation of Hyperreflective Foci on Optical Coherence Tomography

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2018 Link to item Cite

Phase 2 Trial of Ciliary Neurotrophic Factor for Macular Telangiectasia Type 2

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2018 Link to item Cite

Assessing ganglion cell layer topography in human albinism using optical coherence tomography

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2018 Link to item Cite

Pentablock Copolymer Dexamethasone Nanoformulations Induced Ocular Hypertension in Mice

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2018 Link to item Cite

Integrating optical imaging of mummy mask cartonnage

Conference Is and T Archiving Conference Archiving 2018 · January 1, 2018 This rapid development and testing project captured data from multiple digital imaging techniques to try to see texts in papyrus mâché mummy mask cartonnage layers. Prior studies by other scholars destroyed the masks to access the papyri, denying future re ... Cite

Optical Coherence Tomography Predictors of Risk for Progression to Non-Neovascular Atrophic Age-Related Macular Degeneration.

Conference Ophthalmology · December 2017 PurposeAppearance of geographic atrophy (GA) on color photography (CP) is preceded by specific features on spectral-domain optical coherence tomography (SD OCT). We aimed to build SD OCT-based risk assessment models for 5-year new onset of GA and ... Full text Cite

Effect of Sildenafil Citrate on Choroidal Thickness in Age-Related Macular Degeneration

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2017 Link to item Cite

Multimodal Imaging of Drusenoid Lesions in Rhesus Macaques

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2017 Link to item Cite

Optical photon reassignment super-resolution scanning laser ophthalmoscopy

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2017 Link to item Cite

Retinal Biomarkers of Alzheimer's Disease

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · September 1, 2016 Link to item Cite

IOP-induced Changes in Schlemm's Canal Dimensions and the Relation to Shear Stress

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · September 1, 2016 Link to item Cite

Topography of the Vitreoretinal Interface in Vitreomacular Traction Syndrome

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · September 1, 2016 Link to item Cite

Segmentation and analysis software for mapping aqueous humor outflow pattern in living mice

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · September 1, 2016 Link to item Cite

Real-time Visualization of AR-13324 Effects on Schlemm's Canal and Scleral Vessels in Living Mice

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · September 1, 2016 Link to item Cite

Optical coherence tomography noise modeling and fundamental bounds on human retinal layer segmentation accuracy (Conference Presentation)

Conference Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XX · April 26, 2016 Full text Cite

Label-free vascular imaging in a spontaneous hamster cheek pouch carcinogen model for pre-cancer detection (Conference Presentation)

Conference Optical Biopsy XIV: Toward Real-Time Spectroscopic Imaging and Diagnosis · April 26, 2016 Full text Cite

Novel real-time volumetric tool segmentation algorithm for intraoperative microscope integrated OCT (Conference Presentation)

Conference Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XX · April 26, 2016 Full text Cite

Retinal imaging biomarkers for early diagnosis of Alzheimer's disease

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2015 Link to item Cite

Relationship of Central Choroidal Thickness with Age-Related Macular Degeneration Status

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2015 Link to item Cite

Retinal Macrophages in Stages of Age-related Macular Degeneration

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2015 Link to item Cite

Retinal Structural Changes in Amyotrophic Lateral Sclerosis (ALS)

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2015 Link to item Cite

Comparing retinal sensitivity and SDOCT volumes in the AMD Phenotype and Genotype study

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2015 Link to item Cite

Ultra-compact switchable SLO/OCT handheld probe design

Conference SPIE Proceedings · March 4, 2015 Full text Cite

Dynamic alterations in conventional outflow function in Bmp2-induced ocular hypertensive mice

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · April 1, 2014 Link to item Cite

Compressed Wavefront Aberrometry of the Human Eye

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · April 1, 2014 Link to item Cite

Patient-specific modeling of retinal oxygen as a predictor of AMD progression

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · April 1, 2014 Link to item Cite

Handheld Simultaneous True Color SLO-OCT System

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · April 1, 2014 Link to item Cite

Retinal Photoreceptor Development and Maturation in Preterm and Term Infants

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2013 Link to item Cite

Handheld Combined SLO/OCT System

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2013 Link to item Cite

Structural changes in the retina and cornea during diabetic neuropathy

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2013 Link to item Cite

Distributed scan SDOCT improves post refractive surgery corneal biometry

Conference Digital Holography and Three Dimensional Imaging Dh 2012 · December 1, 2012 We report on a preliminary study comparing corneal refractive power acquired using distributed scanning OCT (DSOCT) to corneal topography and Scheimpflug photography in normal subjects both before and after refractive surgery. ... Cite

SDOCT Measurement of Corneal Power and Comparision With Standard Techniques

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · April 1, 2010 Link to item Cite

Automated Segmentation of Seven Retinal Layers in SDOCT Congruent With Expert Manual Segmentation

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · April 1, 2010 Link to item Cite

Efficient Restoration and Enhancement of Super-resolved X-ray Images

Conference 2008 IEEE INTERNATIONAL CONFERENCE ON IMAGE PROCESSING, PROCEEDINGS · January 1, 2008 Link to item Cite

Multi-scale statistical detection and ballistic imaging through turbid media

Conference 2007 IEEE INTERNATIONAL CONFERENCE ON IMAGE PROCESSING, VOLS 1-7 · January 1, 2007 Link to item Cite