Scholarly Works - Book sections
Book section
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January 1, 2021
Controlled clinical trials often randomly assign individuals to treatment arms and follow them to collect measurements at intervals across a treatment period of fixed duration. This type of data are called longitudinal data. In such studies, one of popular ...
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January 1, 2018
Phase II trials have been very widely conducted and published every year for cancer clinical research. Because of their small sample sizes, statistical methods based on large sample approximation are not appropriate for design and analysis of phase II tria ...
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January 1, 2018
In clustered data, each cluster consists of multiple subjects, called subunits, and observations are collected from the subjects of each cluster. Since the subjects in each cluster share some common frailties, their outcome data are usually positively corr ...
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Book section
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January 1, 2018
Cancer clinical trials often use a repeated measurement design in which individuals are randomly assigned to treatment arms and followed for measurements at intervals across a treatment period of fixed duration. In such studies, one of popular primary inte ...
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Book section
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January 1, 2018
This entry compares the change rate of repeated measurements over time between two treatment groups. It proposes a closed-form, sample size formula for between-group comparison that can be used when designing a randomized longitudinal study with either con ...
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Book section
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January 1, 2018
In a cluster randomization trial, clusters consisting of multiple subjects are randomized to two or more treatment arms, and observations are collected from the subjects of each cluster while receiving the same intervention. In such a trial, inferences are ...
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