Overview
Current Appointments & Affiliations
Assistant Professor Emeritus of Radiation Oncology
·
2012 - Present
Radiation Oncology,
Clinical Science Departments
Recent Publications
Nitric oxide loading reduces sickle red cell adhesion and vaso-occlusion in vivo.
Journal Article Blood Adv · September 10, 2019 Sickle red blood cells (SSRBCs) are adherent to the endothelium, activate leukocyte adhesion, and are deficient in bioactive nitric oxide (NO) adducts such as S-nitrosothiols (SNOs), with reduced ability to induce vasodilation in response to hypoxia. All t ... Full text Open Access Link to item CiteSevuparin binds to multiple adhesive ligands and reduces sickle red blood cell-induced vaso-occlusion.
Journal Article Br J Haematol · December 2016 Sevuparin is a novel drug candidate in phase II development as a treatment for vaso-occlusive crises (VOC) in patients with sickle cell disease (SCD). As a heparin-derived polysaccharide, sevuparin has been designed to retain anti-adhesive properties, whil ... Full text Link to item CiteSevuparin Reduces Adhesion Of Both Sickle Red Cells and Leukocytes To Endothelial Cells In Vitro and Inhibits Vaso-Occlusion In Vivo
Conference Blood · November 15, 2013 AbstractIntroductionSevuparin is a new chemically modified heparin with low anticoagulant activity currently being studied as an adjuv ... Full text CiteRecent Grants
Harnessing the power of light to see and treat breast cancer
ResearchInvestigator · Awarded by United States Army Medical Research and Materiel Command · 2009 - 2015TGFbeta-PTEN Interactions in Glioma Biology & Therapy
ResearchInvestigator · Awarded by National Institutes of Health · 2006 - 2008View All Grants
Education, Training & Certifications
Fudan University, Shanghai Medical College (China) ·
1965
M.D.