Siqing Shan | Scholars@Duke

Siqing Shan
Assistant Professor Emeritus of Radiation Oncology

My researches focus on tumor microenvironment physiology and biology (tumor microcirculation, oxygenation and liposomal drug pharmacokenetics in microvascular level), especially the molecular and cellular mechanisms of tumor angiogenesis. In addition to in vitro and ex vivo assays, we apply different animal models to quantitatively investigate the effects of novel biological and chemical agents on tumor cellular behaviors and initiation of early angiogenesis in vivo.

Current Appointments & Affiliations

Assistant Professor Emeritus of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2012

Contact Information

4238 Bluffs Ln, Durham, NC 27712
Box 3455 Med Ctr, Durham, NC 27710
siqing.shan@duke.edu (919) 389-0559

Background
Education, Training, & Certifications
- M.D., Shandong Medical University (China) 1965
Duke Appointment History
- Assistant Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2007 - 2012
- Assistant Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2006 - 2007
- Assistant Research Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2002 - 2006
Research
Selected Grants
- Harnessing the power of light to see and treat breast cancer awarded by United States Army Medical Research and Materiel Command 2009 - 2015
- TGFbeta-PTEN Interactions in Glioma Biology & Therapy awarded by National Institutes of Health 2006 - 2008
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Telen, MJ, Batchvarova, M, Shan, S, Bovee-Geurts, PH, Zennadi, R, Leitgeb, A, Brock, R, and Lindgren, M. "Sevuparin binds to multiple adhesive ligands and reduces sickle red blood cell-induced vaso-occlusion." British Journal of Haematology 175, no. 5 (December 2016): 935-948. Full Text
  - Hanna, G, Fontanella, A, Palmer, G, Shan, S, Radiloff, DR, Zhao, Y, Irwin, D, Hamilton, K, Boico, A, Piantadosi, CA, Blueschke, G, Dewhirst, M, McMahon, T, and Schroeder, T. "Automated measurement of blood flow velocity and direction and hemoglobin oxygen saturation in the rat lung using intravital microscopy." American Journal of Physiology. Lung Cellular and Molecular Physiology 304, no. 2 (January 2013): L86-L91. Full Text
  - Radiloff, DR, Zhao, Y, Boico, A, Wu, C, Shan, S, Palmer, G, Hamilton, K, Irwin, D, Hanna, G, Piantadosi, CA, and Schroeder, T. "The combination of theophylline and endothelin receptor antagonism improves exercise performance of rats under simulated high altitude." Journal of Applied Physiology (Bethesda, Md. : 1985) 113, no. 8 (October 2012): 1243-1252. Full Text
  - Palmer, GM, Fontanella, AN, Shan, S, and Dewhirst, MW. "High-resolution in vivo imaging of fluorescent proteins using window chamber models." Methods Mol Biol 872 (2012): 31-50. Full Text Link to Item
  - Palmer, GM, Fontanella, AN, Shan, S, Hanna, G, Zhang, G, Fraser, CL, and Dewhirst, MW. "In vivo optical molecular imaging and analysis in mice using dorsal window chamber models applied to hypoxia, vasculature and fluorescent reporters." Nature Protocols 6, no. 9 (August 18, 2011): 1355-1366. Full Text
  - Schroeder, T, Hanna, G, Irwin, D, Hamilton, K, Shan, S, Zhao, Y, and Radiloff, D. "Blood pressure stabilization as a therapeutic approach to reverse high altitude induced loss of physical capacity." FASEB JOURNAL 24 (April 2010). Link to Item
  - Cárdenas-Navia, LI, Mace, D, Richardson, RA, Wilson, DF, Shan, S, and Dewhirst, MW. "The pervasive presence of fluctuating oxygenation in tumors." Cancer Research 68, no. 14 (July 2008): 5812-5819. Full Text
  - Fitzhugh, DJ, Shan, S, Dewhirst, MW, and Hale, LP. "Bromelain treatment decreases neutrophil migration to sites of inflammation." Clinical Immunology (Orlando, Fla.) 128, no. 1 (July 2008): 66-74. Full Text
  - Zennadi, R, Moeller, BJ, Whalen, EJ, Batchvarova, M, Xu, K, Shan, S, Delahunty, M, Dewhirst, MW, and Telen, MJ. "Epinephrine-induced activation of LW-mediated sickle cell adhesion and vaso-occlusion in vivo." Blood 110, no. 7 (October 2007): 2708-2717. Full Text
  - Shan, S, and Dewhirst, MW. "Corneal Angiogenesis Assay." (September 27, 2007): 203-228. (Chapter) Full Text
  - Chi, SL, Wahl, ML, Mowery, YM, Shan, S, Mukhopadhyay, S, Hilderbrand, SC, Kenan, DJ, Lipes, BD, Johnson, CE, Marusich, MF, Capaldi, RA, Dewhirst, MW, and Pizzo, SV. "Angiostatin-like activity of a monoclonal antibody to the catalytic subunit of F1F0 ATP synthase." Cancer Research 67, no. 10 (May 2007): 4716-4724. Full Text
  - Shan, S, Flowers, C, Peltz, CD, Sweet, H, Maurer, N, Kwon, E-JG, Krol, A, Yuan, F, and Dewhirst, MW. "Preferential extravasation and accumulation of liposomal vincristine in tumor comparing to normal tissue enhances antitumor activity." Cancer Chemother Pharmacol 58, no. 2 (August 2006): 245-255. Full Text Link to Item
  - Grichnik, JM, Burch, JA, Schulteis, RD, Shan, S, Liu, J, Darrow, TL, Vervaert, CE, and Seigler, HF. "Melanoma, a tumor based on a mutant stem cell?." J Invest Dermatol 126, no. 1 (January 2006): 142-153. Full Text Link to Item
  - Tong, S, Chen, Q, Shan, S-Q, Dewhirst, MW, and Yuan, F. "Quantitative comparison of the inhibitory effects of GW5638 and tamoxifen on angiogenesis in the cornea pocket assay." Angiogenesis 9, no. 2 (2006): 53-58. Full Text Link to Item
  - Hardee, ME, Kirkpatrick, JP, Shan, S, Snyder, SA, Vujaskovic, Z, Rabbani, ZN, Dewhirst, MW, and Blackwell, KL. "Human recombinant erythropoietin (rEpo) has no effect on tumour growth or angiogenesis." Br J Cancer 93, no. 12 (December 12, 2005): 1350-1355. Full Text Link to Item
  - Cao, Y, Li, C-Y, Moeller, BJ, Yu, D, Zhao, Y, Dreher, MR, Shan, S, and Dewhirst, MW. "Observation of incipient tumor angiogenesis that is independent of hypoxia and hypoxia inducible factor-1 activation." Cancer Res 65, no. 13 (July 1, 2005): 5498-5505. Full Text Link to Item
  - Shan, S, Robson, ND, Cao, Y, Qiao, T, Li, CY, Kontos, CD, Garcia-Blanco, M, and Dewhirst, MW. "Responses of vascular endothelial cells to angiogenic signaling are important for tumor cell survival." FASEB JOURNAL 18, no. 2 (February 2004): 326-328. Full Text Link to Item
  - Shan, S, Robson, ND, Cao, Y, Qiao, T, Li, CY, Kontos, CD, Garcia-Blanco, M, and Dewhirst, MW. "Responses of vascular endothelial cells to angiogenic signaling are important for tumor cell survival." Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology 18, no. 2 (February 2004): 326-328. Full Text
  - White, RR, Shan, S, Rusconi, CP, Shetty, G, Dewhirst, MW, Kontos, CD, and Sullenger, BA. "Inhibition of rat corneal angiogenesis by a nuclease-resistant RNA aptamer specific for angiopoietin-2." Proceedings of the National Academy of Sciences of the United States of America 100, no. 9 (April 11, 2003): 5028-5033. Full Text
  - Shan, S, Sorg, B, and Dewhirst, MW. "A novel rodent mammary window of orthotopic breast cancer for intravital microscopy." Microvasc Res 65, no. 2 (March 2003): 109-117. Link to Item
  - Dewhirst, MW, Shan, S, Cao, Y, Moeller, B, Yuan, F, and Li, C-Y. "Intravital fluorescence facilitates measurement of multiple physiologic functions and gene expression in tumors of live animals." Dis Markers 18, no. 5-6 (2002): 293-311. (Review) Link to Item
  - Tozer, GM, Prise, VE, Wilson, J, Cemazar, M, Shan, S, Dewhirst, MW, Barber, PR, Vojnovic, B, and Chaplin, DJ. "Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: intravital microscopy and measurement of vascular permeability." Cancer Research 61, no. 17 (September 2001): 6413-6422.
  - Shan, S, Lockhart, AC, Saito, WY, Knapp, AM, Laderoute, KR, and Dewhirst, MW. "The novel tubulin-binding drug BTO-956 inhibits R3230AC mammary carcinoma growth and angiogenesis in Fischer 344 rats." Clin Cancer Res 7, no. 8 (August 2001): 2590-2596. Link to Item
  - Blackwell, KL, Haroon, ZA, Shan, S, Saito, W, Broadwater, G, Greenberg, CS, and Dewhirst, MW. "Tamoxifen inhibits angiogenesis in estrogen receptor-negative animal models." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 6, no. 11 (November 2000): 4359-4364.
  - Hoffman, RM. "Re: initial stages of tumor cell-induced angiogenesis: evaluation via skin window chambers in rodent models." Journal of the National Cancer Institute 92, no. 17 (September 2000): 1445-1446. (Letter) Full Text
  - Li, CY, Shan, S, Huang, Q, and Dewhirst, MW. "RESPONSE: re: initial stages of tumor cell-induced angiogenesis: evaluation via skin window chambers in rodent models." Journal of the National Cancer Institute 92, no. 17 (September 2000): 1445-1446. Full Text
  - Li, CY, Shan, S, Cao, Y, and Dewhirst, MW. "Role of incipient angiogenesis in cancer metastasis." Cancer Metastasis Rev 19, no. 1-2 (2000): 7-11. (Review) Link to Item
  - Li, CY, Shan, S, Huang, Q, Braun, RD, Lanzen, J, Hu, K, Lin, P, and Dewhirst, MW. "Initial stages of tumor cell-induced angiogenesis: evaluation via skin window chambers in rodent models." Journal of the National Cancer Institute 92, no. 2 (January 2000): 143-147. Full Text
  - Huang, Q, Shan, S, Braun, RD, Lanzen, J, Anyrhambatla, G, Kong, G, Borelli, M, Corry, P, Dewhirst, MW, and Li, CY. "Noninvasive visualization of tumors in rodent dorsal skin window chambers." Nature Biotechnology 17, no. 10 (October 1999): 1033-1035. Full Text
  - Lin, P, Sankar, S, Shan, S, Dewhirst, MW, Polverini, PJ, Quinn, TQ, and Peters, KG. "Inhibition of tumor growth by targeting tumor endothelium using a soluble vascular endothelial growth factor receptor." Cell Growth Differ 9, no. 1 (January 1998): 49-58. Link to Item
  - Lin, P, Polverini, P, Dewhirst, M, Shan, S, Rao, PS, and Peters, K. "Inhibition of tumor angiogenesis using a soluble receptor establishes a role for Tie2 in pathologic vascular growth." The Journal of Clinical Investigation 100, no. 8 (October 1997): 2072-2078. Full Text
  - Wu, NZ, Braun, RD, Gaber, MH, Lin, GM, Ong, ET, Shan, S, Papahadjopoulos, D, and Dewhirst, MW. "Simultaneous measurement of liposome extravasation and content release in tumors." Microcirculation (New York, N.Y. : 1994) 4, no. 1 (March 1997): 83-101. Full Text
  - Hahn, JS, Braun, RD, Dewhirst, MW, Shan, S, Snyder, SA, Taube, JM, Ong, ET, Rosner, GL, Dodge, RK, Bonaventura, J, Bonaventura, C, DeAngelo, J, and Meyer, RE. "Stroma-free human hemoglobin A decreases R3230Ac rat mammary adenocarcinoma blood flow and oxygen partial pressure." Radiat Res 147, no. 2 (February 1997): 185-194. Link to Item
  - Shan, SQ, Rosner, GL, Braun, RD, Hahn, J, Pearce, C, and Dewhirst, MW. "Effects of diethylamine/nitric oxide on blood perfusion and oxygenation in the R3230Ac mammary carcinoma." British Journal of Cancer 76, no. 4 (January 1997): 429-437. Full Text
  - Dewhirst, MW, Ong, ET, Rosner, GL, Rehmus, SW, Shan, S, Braun, RD, Brizel, DM, and Secomb, TW. "Arteriolar oxygenation in tumour and subcutaneous arterioles: effects of inspired air oxygen content." The British Journal of Cancer. Supplement 27 (July 1996): S241-S246.
  - Dewhirst, MW, Ong, ET, Rosner, GL, Rehmus, SW, Shan, S, Braun, RD, Brizel, DM, and Secomb, TW. "Arteriolar oxygenation in tumour and subcutaneous arterioles: Effects of inspired air oxygen content." British Journal of Cancer 74, no. SUPPL. XXVII (January 1, 1996).
  - Meyer, RE, Shan, S, DeAngelo, J, Dodge, RK, Bonaventura, J, Ong, ET, and Dewhirst, MW. "Nitric oxide synthase inhibition irreversibly decreases perfusion in the R3230Ac rat mammary adenocarcinoma." Br J Cancer 71, no. 6 (June 1995): 1169-1174. Link to Item
  - Meyer, RE, Shan, S, DeAngelo, J, Dodge, RK, Bonaventura, J, Ong, ET, and Dewhirst, MW. "Nitric oxide synthase inhibition irreversibly decreases perfusion in the R3230Ac rat mammary adenocarcinoma." British Journal of Cancer 71, no. 6 (January 1, 1995): 1169-1174. Full Text
  - Belfi, CA, Paul, CR, Shan, S, and Ngo, FQ. "Comparison of the effects of hydralazine on tumor and normal tissue blood perfusion by MRI." International Journal of Radiation Oncology, Biology, Physics 29, no. 3 (June 1994): 473-479. Full Text
- Conference Papers
  - Batchvarova, M, Shan, S, Zennadi, R, Lindgren, M, Leitgeb, A, Tamsen, PS, and Telen, MJ. "Sevuparin Reduces Adhesion Of Both Sickle Red Cells and Leukocytes To Endothelial Cells In Vitro and Inhibits Vaso-Occlusion In Vivo." November 15, 2013. Link to Item
  - Schroeder, T, Hanna, G, Irwin, D, Hamilton, K, Shan, S, Zhao, Y, and Radiloff, D. "Blood pressure stabilization as a therapeutic approach to reverse high altitude induced loss of physical capacity." April 2012. Link to Item

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Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Academic Articles

Conference Papers