Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • M.D., Shandong Medical University (China) 1965
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  Previous Appointments & Affiliations

  • Assistant Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2007 - 2012
  • Assistant Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2006 - 2007
  • Assistant Research Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2002 - 2006
• Research
• 

  Selected Grants

  • Harnessing the power of light to see and treat breast cancer awarded by United States Army Medical Research and Materiel Command 2009 - 2015
  • TGFbeta-PTEN Interactions in Glioma Biology & Therapy awarded by National Institutes of Health 2006 - 2008
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • McMahon, Timothy J., Siqing Shan, Daniel A. Riccio, Milena Batchvarova, Hongmei Zhu, Marilyn J. Telen, and Rahima Zennadi. “Nitric oxide loading reduces sickle red cell adhesion and vaso-occlusion in vivo.” Blood Adv 3, no. 17 (September 10, 2019): 2586–97. https://doi.org/10.1182/bloodadvances.2019031633.
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    • Telen, Marilyn J., Milena Batchvarova, Siqing Shan, Petra H. Bovee-Geurts, Rahima Zennadi, Anna Leitgeb, Roland Brock, and Maria Lindgren. “Sevuparin binds to multiple adhesive ligands and reduces sickle red blood cell-induced vaso-occlusion.” Br J Haematol 175, no. 5 (December 2016): 935–48. https://doi.org/10.1111/bjh.14303.
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    • Hanna, Gabi, Andrew Fontanella, Gregory Palmer, Siqing Shan, Daniel R. Radiloff, Yulin Zhao, David Irwin, et al. “Automated measurement of blood flow velocity and direction and hemoglobin oxygen saturation in the rat lung using intravital microscopy.” Am J Physiol Lung Cell Mol Physiol 304, no. 2 (January 15, 2013): L86–91. https://doi.org/10.1152/ajplung.00178.2012.
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    • Radiloff, Daniel R., Yulin Zhao, Alina Boico, Chan Wu, Siqing Shan, Gregory Palmer, Karyn Hamilton, et al. “The combination of theophylline and endothelin receptor antagonism improves exercise performance of rats under simulated high altitude.” J Appl Physiol (1985) 113, no. 8 (October 15, 2012): 1243–52. https://doi.org/10.1152/japplphysiol.01622.2011.
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    • Schroeder, Thies, Gabi Hanna, David Irwin, Karyn Hamilton, Siqing Shan, Yulin Zhao, and Daniel Radiloff. “Blood pressure stabilization as a therapeutic approach to reverse high altitude induced loss of physical capacity.” Faseb Journal 26 (April 1, 2012).
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    • Palmer, Gregory M., Andrew N. Fontanella, Siqing Shan, and Mark W. Dewhirst. “High-resolution in vivo imaging of fluorescent proteins using window chamber models.” Methods Mol Biol 872 (2012): 31–50. https://doi.org/10.1007/978-1-61779-797-2_3.
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    • Palmer, Gregory M., Andrew N. Fontanella, Siqing Shan, Gabi Hanna, Guoqing Zhang, Cassandra L. Fraser, and Mark W. Dewhirst. “In vivo optical molecular imaging and analysis in mice using dorsal window chamber models applied to hypoxia, vasculature and fluorescent reporters.” Nat Protoc 6, no. 9 (August 18, 2011): 1355–66. https://doi.org/10.1038/nprot.2011.349.
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    • Cárdenas-Navia, Laura I., Daniel Mace, Rachel A. Richardson, David F. Wilson, Siqing Shan, and Mark W. Dewhirst. “The pervasive presence of fluctuating oxygenation in tumors.” Cancer Res 68, no. 14 (July 15, 2008): 5812–19. https://doi.org/10.1158/0008-5472.CAN-07-6387.
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    • Fitzhugh, David J., Siqing Shan, Mark W. Dewhirst, and Laura P. Hale. “Bromelain treatment decreases neutrophil migration to sites of inflammation.” Clin Immunol 128, no. 1 (July 2008): 66–74. https://doi.org/10.1016/j.clim.2008.02.015.
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    • Zennadi, Rahima, Benjamin J. Moeller, Erin J. Whalen, Milena Batchvarova, Ke Xu, Siqing Shan, Martha Delahunty, Mark W. Dewhirst, and Marilyn J. Telen. “Epinephrine-induced activation of LW-mediated sickle cell adhesion and vaso-occlusion in vivo.” Blood 110, no. 7 (October 1, 2007): 2708–17. https://doi.org/10.1182/blood-2006-11-056101.
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    • Shan, S., and M. W. Dewhirst. “Corneal Angiogenesis Assay,” September 27, 2007, 203–28. https://doi.org/10.1002/9780470029350.ch11.
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    • Chi, Sulene L., Miriam L. Wahl, Yvonne M. Mowery, Siqing Shan, Somnath Mukhopadhyay, Susana C. Hilderbrand, Daniel J. Kenan, et al. “Angiostatin-like activity of a monoclonal antibody to the catalytic subunit of F1F0 ATP synthase.” Cancer Res 67, no. 10 (May 15, 2007): 4716–24. https://doi.org/10.1158/0008-5472.CAN-06-1094.
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    • Shan, Siqing, Clay Flowers, Cathy D. Peltz, Heather Sweet, Norbert Maurer, Eun-Joo Gina Kwon, Ave Krol, Fan Yuan, and Mark W. Dewhirst. “Preferential extravasation and accumulation of liposomal vincristine in tumor comparing to normal tissue enhances antitumor activity.” Cancer Chemother Pharmacol 58, no. 2 (August 2006): 245–55. https://doi.org/10.1007/s00280-005-0145-x.
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    • Grichnik, James M., James A. Burch, Ryan D. Schulteis, Siqing Shan, Jie Liu, Timothy L. Darrow, Carol E. Vervaert, and Hilliard F. Seigler. “Melanoma, a tumor based on a mutant stem cell?” J Invest Dermatol 126, no. 1 (January 2006): 142–53. https://doi.org/10.1038/sj.jid.5700017.
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    • Tong, Sheng, Qing Chen, Si-Qing Shan, Mark W. Dewhirst, and Fan Yuan. “Quantitative comparison of the inhibitory effects of GW5638 and tamoxifen on angiogenesis in the cornea pocket assay.” Angiogenesis 9, no. 2 (2006): 53–58. https://doi.org/10.1007/s10456-006-9029-x.
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    • Hardee, M. E., J. P. Kirkpatrick, S. Shan, S. A. Snyder, Z. Vujaskovic, Z. N. Rabbani, M. W. Dewhirst, and K. L. Blackwell. “Human recombinant erythropoietin (rEpo) has no effect on tumour growth or angiogenesis.” Br J Cancer 93, no. 12 (December 12, 2005): 1350–55. https://doi.org/10.1038/sj.bjc.6602846.
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    • Cao, Yiting, Chuan-Yuan Li, Benjamin J. Moeller, Daohai Yu, Yulin Zhao, Matthew R. Dreher, Siqing Shan, and Mark W. Dewhirst. “Observation of incipient tumor angiogenesis that is independent of hypoxia and hypoxia inducible factor-1 activation.” Cancer Res 65, no. 13 (July 1, 2005): 5498–5505. https://doi.org/10.1158/0008-5472.CAN-04-4553.
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    • Shan, Siqing, Nicole D. Robson, Yiting Cao, Tong Qiao, Chuan Y. Li, Christopher D. Kontos, Mariano Garcia-Blanco, and Mark W. Dewhirst. “Responses of vascular endothelial cells to angiogenic signaling are important for tumor cell survival.” Faseb J 18, no. 2 (February 2004): 326–28. https://doi.org/10.1096/fj.03-0765fje.
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    • White, Rebekah R., Siqing Shan, Christopher P. Rusconi, Geetha Shetty, Mark W. Dewhirst, Christopher D. Kontos, and Bruce A. Sullenger. “Inhibition of rat corneal angiogenesis by a nuclease-resistant RNA aptamer specific for angiopoietin-2.” Proc Natl Acad Sci U S A 100, no. 9 (April 29, 2003): 5028–33. https://doi.org/10.1073/pnas.0831159100.
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    • Shan, Siqing, Brian Sorg, and Mark W. Dewhirst. “A novel rodent mammary window of orthotopic breast cancer for intravital microscopy.” Microvasc Res 65, no. 2 (March 2003): 109–17. https://doi.org/10.1016/s0026-2862(02)00017-1.
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    • Dewhirst, Mark W., S. Shan, Yiting Cao, Benjamin Moeller, Fan Yuan, and Chuan-Yuan Li. “Intravital fluorescence facilitates measurement of multiple physiologic functions and gene expression in tumors of live animals.” Dis Markers 18, no. 5–6 (2002): 293–311. https://doi.org/10.1155/2002/820102.
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    • Tozer, G. M., V. E. Prise, J. Wilson, M. Cemazar, S. Shan, M. W. Dewhirst, P. R. Barber, B. Vojnovic, and D. J. Chaplin. “Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: intravital microscopy and measurement of vascular permeability.” Cancer Res 61, no. 17 (September 1, 2001): 6413–22.
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    • Shan, S., A. C. Lockhart, W. Y. Saito, A. M. Knapp, K. R. Laderoute, and M. W. Dewhirst. “The novel tubulin-binding drug BTO-956 inhibits R3230AC mammary carcinoma growth and angiogenesis in Fischer 344 rats.” Clin Cancer Res 7, no. 8 (August 2001): 2590–96.
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    • Blackwell, K. L., Z. A. Haroon, S. Shan, W. Saito, G. Broadwater, C. S. Greenberg, and M. W. Dewhirst. “Tamoxifen inhibits angiogenesis in estrogen receptor-negative animal models.” Clin Cancer Res 6, no. 11 (November 2000): 4359–64.
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    • Hoffman, R. M. “Re: initial stages of tumor cell-induced angiogenesis: evaluation via skin window chambers in rodent models.” J Natl Cancer Inst 92, no. 17 (September 6, 2000): 1445–46. https://doi.org/10.1093/jnci/92.17.1445.
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    • Li, C. Y., S. Shan, Q. Huang, and M. W. Dewhirst. “RESPONSE: re: initial stages of tumor cell-induced angiogenesis: evaluation via skin window chambers in rodent models.” J Natl Cancer Inst 92, no. 17 (September 6, 2000): 1445–46. https://doi.org/10.1093/jnci/92.17.1445-a.
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    • Li, C. Y., S. Shan, Q. Huang, R. D. Braun, J. Lanzen, K. Hu, P. Lin, and M. W. Dewhirst. “Initial stages of tumor cell-induced angiogenesis: evaluation via skin window chambers in rodent models.” J Natl Cancer Inst 92, no. 2 (January 19, 2000): 143–47. https://doi.org/10.1093/jnci/92.2.143.
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    • Li, C. Y., S. Shan, Y. Cao, and M. W. Dewhirst. “Role of incipient angiogenesis in cancer metastasis.” Cancer Metastasis Rev 19, no. 1–2 (2000): 7–11. https://doi.org/10.1023/a:1026538601947.
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    • Huang, Q., S. Shan, R. D. Braun, J. Lanzen, G. Anyrhambatla, G. Kong, M. Borelli, P. Corry, M. W. Dewhirst, and C. Y. Li. “Noninvasive visualization of tumors in rodent dorsal skin window chambers.” Nat Biotechnol 17, no. 10 (October 1999): 1033–35. https://doi.org/10.1038/13736.
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    • Lin, P., S. Sankar, S. Shan, M. W. Dewhirst, P. J. Polverini, T. Q. Quinn, and K. G. Peters. “Inhibition of tumor growth by targeting tumor endothelium using a soluble vascular endothelial growth factor receptor.” Cell Growth Differ 9, no. 1 (January 1998): 49–58.
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    • Lin, P., P. Polverini, M. Dewhirst, S. Shan, P. S. Rao, and K. Peters. “Inhibition of tumor angiogenesis using a soluble receptor establishes a role for Tie2 in pathologic vascular growth.” J Clin Invest 100, no. 8 (October 15, 1997): 2072–78. https://doi.org/10.1172/JCI119740.
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    • Wu, N. Z., R. D. Braun, M. H. Gaber, G. M. Lin, E. T. Ong, S. Shan, D. Papahadjopoulos, and M. W. Dewhirst. “Simultaneous measurement of liposome extravasation and content release in tumors.” Microcirculation 4, no. 1 (March 1997): 83–101. https://doi.org/10.3109/10739689709148320.
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    • Hahn, J. S., R. D. Braun, M. W. Dewhirst, S. Shan, S. A. Snyder, J. M. Taube, E. T. Ong, et al. “Stroma-free human hemoglobin A decreases R3230Ac rat mammary adenocarcinoma blood flow and oxygen partial pressure.” Radiat Res 147, no. 2 (February 1997): 185–94.
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    • Shan, S. Q., G. L. Rosner, R. D. Braun, J. Hahn, C. Pearce, and M. W. Dewhirst. “Effects of diethylamine/nitric oxide on blood perfusion and oxygenation in the R3230Ac mammary carcinoma.” Br J Cancer 76, no. 4 (1997): 429–37. https://doi.org/10.1038/bjc.1997.406.
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    • Dewhirst, M. W., E. T. Ong, G. L. Rosner, S. W. Rehmus, S. Shan, R. D. Braun, D. M. Brizel, and T. W. Secomb. “Arteriolar oxygenation in tumour and subcutaneous arterioles: effects of inspired air oxygen content.” Br J Cancer Suppl 27 (July 1996): S241–46.
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    • Dewhirst, M. W., E. T. Ong, G. L. Rosner, S. W. Rehmus, S. Shan, R. D. Braun, D. M. Brizel, and T. W. Secomb. “Arteriolar oxygenation in tumour and subcutaneous arterioles: Effects of inspired air oxygen content.” British Journal of Cancer 74, no. SUPPL. XXVII (January 1, 1996).
    • Meyer, R. E., S. Shan, J. DeAngelo, R. K. Dodge, J. Bonaventura, E. T. Ong, and M. W. Dewhirst. “Nitric oxide synthase inhibition irreversibly decreases perfusion in the R3230Ac rat mammary adenocarcinoma.” Br J Cancer 71, no. 6 (June 1995): 1169–74. https://doi.org/10.1038/bjc.1995.228.
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    • Meyer, R. E., S. Shan, J. DeAngelo, R. K. Dodge, J. Bonaventura, E. T. Ong, and M. W. Dewhirst. “Nitric oxide synthase inhibition irreversibly decreases perfusion in the R3230Ac rat mammary adenocarcinoma.” British Journal of Cancer 71, no. 6 (January 1, 1995): 1169–74. https://doi.org/10.1038/bjc.1995.228.
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    • Belfi, C. A., C. R. Paul, S. Shan, and F. Q. Ngo. “Comparison of the effects of hydralazine on tumor and normal tissue blood perfusion by MRI.” Int J Radiat Oncol Biol Phys 29, no. 3 (June 15, 1994): 473–79. https://doi.org/10.1016/0360-3016(94)90441-3.
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  • Conference Papers

    • Batchvarova, Milena, Siqing Shan, Rahima Zennadi, Maria Lindgren, Anna Leitgeb, Pirkko Sulila Tamsen, and Marilyn J. Telen. “Sevuparin Reduces Adhesion Of Both Sickle Red Cells and Leukocytes To Endothelial Cells In Vitro and Inhibits Vaso-Occlusion In Vivo.” In Blood, 122:182–182. American Society of Hematology, 2013. https://doi.org/10.1182/blood.v122.21.182.182.
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    • Schroeder, Thies, Gabi Hanna, David Irwin, Karyn Hamilton, Siqing Shan, Yulin Zhao, and Daniel Radiloff. “Blood pressure stabilization as a therapeutic approach to reverse high altitude induced loss of physical capacity.” In Faseb Journal, Vol. 26, 2012.
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