Scholars@Duke
Scott Streater Kelley

Scott Streater Kelley

Professor of Orthopaedic Surgery
Orthopaedic Surgery
3609 Southwest Durham Drive, Durham, NC 27707

Selected Publications

Tips and Tricks to Overcome the Learning Curve of the ABMS Approach to the Hip

Chapter · September 19, 2022 This text serves as a compendium of information for those surgeons interested in utilizing this surgical approach as an all-inclusive reference. ... Link to item Cite

Femoral Revision via the ABMS Approach

Chapter · September 19, 2022 This text serves as a compendium of information for those surgeons interested in utilizing this surgical approach as an all-inclusive reference. ... Cite

What can be learned from minimum 20-year followup studies of knee arthroplasty?

Journal Article Clin Orthop Relat Res · January 2015 BACKGROUND: Long-term evaluation of knee arthroplasty should provide relevant information concerning the durability and performance of the implant and the procedure. Because most arthroplasties are performed in older patients, most long-term followup studi ... Full text Link to item Cite

Custom intramedullary intercalating device for treatment of supracondylar fracture between constrained total knee arthroplasty and well-fixed total hip arthroplasty.

Journal Article Knee · March 2014 Management of periprosthetic fractures between ipsilateral total knee arthroplasty (TKA) and total hip arthroplasty (THA) is difficult, and is further complicated in the setting of poor femoral bone stock. We present a case of supracondylar fracture betwee ... Full text Link to item Cite

Total hip arthroplasty surgical approach does not alter postoperative gait mechanics one year after surgery.

Journal Article PM R · March 2014 OBJECTIVE: To investigate the differences in gait biomechanics on the basis of surgical approach 1 year after surgery. DESIGN: This was a descriptive laboratory study to investigate the side-to-side differences in walking mechanics at a self-selected walki ... Full text Open Access Link to item Cite

Does surgical approach during total hip arthroplasty alter gait recovery during the first year following surgery?

Journal Article J Arthroplasty · October 2013 Multiple surgical approaches exist for total hip arthroplasty (THA). Each approach has risks and benefits in regard to complications and changes in postoperative gait. This study examined the effect of three surgical approaches on postoperative gait mechan ... Full text Link to item Cite

Durability of a cruciate-retaining TKA with modular tibial trays at 20 years.

Journal Article Clin Orthop Relat Res · January 2013 BACKGROUND: Modular tibial trays have been utilized in TKA for more than 20 years. However, concerns have been raised about modular implants and it is unclear whether these devices are durable in the long term. QUESTIONS/PURPOSES: We determined (1) surviva ... Full text Link to item Cite

Response of Chondrocytes to Local Mechanical Injury in an Ex Vivo Model.

Journal Article Cartilage · January 2012 BACKGROUND: Our goal was to set up an ex vivo culture system to assess whether cartilage wounding (partial-thickness defects) can induce morphological changes in neighboring chondrocytes and whether these cells can translocate to the surface of the defect. ... Full text Link to item Cite

The effect of total hip arthroplasty surgical approach on postoperative gait mechanics.

Journal Article J Arthroplasty · September 2011 Surgical approach for total hip arthroplasty (THA) is determined by clinician preference from limited prospective data. This study aimed to examine the effect of surgical approach (direct lateral, posterior, and anterolateral) on 6-week postoperative gait ... Full text Link to item Cite

The Rottinger approach for total hip arthroplasty: technique and review of the literature.

Journal Article Curr Rev Musculoskelet Med · September 2011 The surgical approach utilized in total hip arthroplasty has been identified as a factor that may affect surgical outcomes. There have been many different approaches and modifications used since the procedure was popularized by Sir John Charnley. The popul ... Full text Link to item Cite

Routine surveillance of modular PFC TKA shows increasing failures after 10 years.

Journal Article Clin Orthop Relat Res · September 2010 BACKGROUND/RATIONALE: A 10-year survivorship of 100% was reported for patients with PFC cruciate-retaining prostheses. Beyond 10 years, we observed additional polyethylene wear likely related to thin liners gamma-irradiated in air and were concerned this w ... Full text Link to item Cite

Activity scale for arthroplasty patients after total hip arthroplasty.

Journal Article J Arthroplasty · January 2010 The purpose of the Activity Scale for Arthroplasty Patients (ASAP) is to develop and validate a self-report questionnaire that demonstrated discrimination of functional gains, low burden, appropriate concurrent validity, and was not limited by ceiling effe ... Full text Link to item Cite

Survival of polished compared with precoated roughened cemented femoral components. A prospective, randomized study.

Journal Article J Bone Joint Surg Am · July 2008 BACKGROUND: The optimal surface finish for cemented femoral components remains controversial. The purpose of this randomized clinical trial was to compare the survival of two femoral components with similar geometry but substantially different surface fini ... Full text Link to item Cite

Characterization of a consistent radiographic finding in chronic anterior cruciate ligament deficiency: the posteromedial osteophyte.

Journal Article Am J Orthop (Belle Mead NJ) · September 2007 Often found in patients undergoing total knee arthroplasty (TKA) is an osteophyte, at the posterior lateral corner of the medial tibial plateau, that prevents anterior translation. This osteophyte does not occur in the presence of an entirely normal anteri ... Link to item Cite

Antimicrobial prophylaxis to prevent surgical site infection: Commentary

Journal Article Journal of Bone and Joint Surgery · January 1, 2006 Full text Cite

Two mechanical devices for prophylaxis of thromboembolism after total knee arthroplasty. A prospective, randomised study.

Journal Article J Bone Joint Surg Br · November 2004 The optimal characteristics of pneumatic compression for mechanical prophylaxis of thromboembolism after total knee arthroplasty (TKA) are not known. Our study compared two methods of calf compression, with the hypothesis that the device which provided a l ... Full text Link to item Cite

Hip arthroplasty after extracapsular hip fracture: a matched pair cohort analysis.

Journal Article J Surg Orthop Adv · 2004 Eighteen patients with a prior intertrochanteric or basicervical hip fracture had a total or bipolar hip arthroplasty. The clinical and radiographic results of these patients were compared to a control group of patients (matched for age, gender, associated ... Link to item Cite

Dependence of endoplasmic reticulum-associated degradation on the peptide binding domain and concentration of BiP.

Journal Article Molecular biology of the cell · August 2003 ER-associated degradation (ERAD) removes defective and mis-folded proteins from the eukaryotic secretory pathway, but mutations in the ER lumenal Hsp70, BiP/Kar2p, compromise ERAD efficiency in yeast. Because attenuation of ERAD activates the UPR, we scree ... Cite

Cementation for femoral head osteonecrosis: a preliminary clinic study.

Journal Article Clin Orthop Relat Res · July 2003 Treatment for femoral head osteonecrosis has been less successful in late stages of the disease, after progression to collapse. The current authors treated 21 patients (22 hips) with Stage III osteonecrosis by a technique of open reduction and fixation wit ... Full text Link to item Cite

Role of pericellular matrix in development of a mechanically functional neocartilage.

Journal Article Biotechnol Bioeng · May 20, 2003 The role of the chondrocyte pericellular matrix (PCM) was examined in a three-dimensional chondrocyte culture system to determine whether retention of the native pericellular matrix could stimulate collagen and proteoglycan accumulation and also promote th ... Full text Link to item Cite

The role of sequential and concurrent sexual relationships in the risk of sexually transmitted diseases among adolescents.

Journal Article The Journal of adolescent health : official publication of the Society for Adolescent Medicine · April 2003 PURPOSE: To explore whether patterns of sexual relationships, such as sequential (nonoverlapping in time) or concurrent (overlapping in time), are more important indicators of sexually transmitted disease (STD) risk among adolescents than number of sexual ... Cite

Cement supplementation as a treatment for osteonecrosis

Journal Article Current Opinion in Orthopaedics · February 1, 2003 Treatment for femoral head osteonecrosis has been less successful in late stages of the disease, after progression to collapse. Several treatment techniques have been reported, however, no single approach has been convincingly successful. Ideally, the goal ... Full text Cite

Posterior cruciate-retaining modular total knee arthroplasty: a 9- to 12-year follow-up investigation.

Journal Article J Arthroplasty · December 2002 Between November 1988 and January 1991, 101 press-fit condylar (PFC; Johnson & Johnson, Raynham, MA) posterior cruciate-retaining total knee arthroplasties were performed in 75 patients. All tibial components were modular metal-backed, and all patellar com ... Full text Link to item Cite

Development of selective tolerance to interleukin-1beta by human chondrocytes in vitro.

Journal Article J Cell Physiol · July 2002 Interleukin-1 induces release of NO and PGE(2) and production of matrix degrading enzymes in chondrocytes. In osteoarthritis (OA), IL-1 continually, or episodically, acts on chondrocytes in a paracrine and autocrine manner. Human chondrocytes in chondron p ... Full text Link to item Cite

Retention of the native chondrocyte pericellular matrix results in significantly improved matrix production.

Journal Article Matrix Biol · June 2002 The interaction of the cell with its surrounding extracellular matrix (ECM) has a major effect on cell metabolism. We have previously shown that chondrons, chondrocytes with their in vivo-formed pericellular matrix, can be enzymatically isolated from artic ... Full text Link to item Cite

Collar versus collarless cemented HD-II femoral prostheses.

Journal Article Clin Orthop Relat Res · May 2002 A randomized prospective study was done in 1982 to evaluate the effect of a collar on the cemented femoral component. During a 2-year period, 84 patients were enrolled to receive a collared (44 hips) or a collarless (40 hips) HD-II femoral component at the ... Full text Link to item Cite

Use of NIR and pyrolysis-MBMS coupled with multivariate analysis for detecting the chemical changes associated with brown-rot biodegradation of spruce wood.

Journal Article FEMS microbiology letters · March 2002 Near infrared (NIR) spectroscopy and pyrolysis-molecular beam mass spectrometry (py-MBMS) analysis can be used in conjunction with multivariate regression and principal components analysis to differentiate brown-rot-degraded wood from non-degraded spruce a ... Cite

The use of constrained components in total hip arthroplasty.

Journal Article J Am Acad Orthop Surg · 2002 The use of a constrained component may be appropriate for the surgical treatment of recurrent dislocation due to soft-tissue insufficiency following a total hip arthroplasty. Constrained components usually include a locking mechanism incorporated into the ... Full text Link to item Cite

Infected joint replacements in HIV-positive patients with haemophilia.

Journal Article J Bone Joint Surg Br · September 2001 Joint replacement in HIV-positive patients remains uncommon, with most experience gained in patients with haemophilia. We analysed retrospectively the outcome of 102 replacement arthroplasties in 73 HIV-positive patients from eight specialist haemophilia c ... Full text Link to item Cite

ATP induces Ca(2+) signaling in human chondrons cultured in three-dimensional agarose films.

Journal Article Osteoarthritis Cartilage · August 2001 OBJECTIVE: In vivo, chondrocytes are surrounded by an extracellular matrix, preventing direct cell-to-cell contact. Consequently, intercellular communication through gap junctions is unlikely. However, signaling at a distance is possible through extracellu ... Full text Link to item Cite

Cementless fixation of the femoral stem

Journal Article Current Opinion in Orthopaedics · March 3, 2001 Uncemented fixation of the femur has become widely accepted as an excellent option for select groups of patients requiring total hip arthroplasty. This article reviews recent clinical series, animal studies, and basic science research on cementless femoral ... Full text Cite

Early failure of revision total hip arthroplasty with cemented precoated femoral components: comparison with uncemented components at 2 to 8 years.

Journal Article J Arthroplasty · September 2000 This is a retrospective analysis of 2 methods of fixation of the femoral component in 86 consecutive revision arthroplasties, for which all clinical and radiographic data were recorded prospectively. There were 56 cemented revisions using precoated femoral ... Full text Link to item Cite

Open reduction and cementation for femoral head fracture secondary to avascular necrosis: preliminary report.

Journal Article Iowa Orthop J · 2000 Current treatment for femoral head avascular necrosis has shown good results in early stages of disease, but are not as impressive after progression to collapse. We treated 19 patients (20 hips) with Stage III avascular necrosis (AVN) by open reduction aug ... Link to item Cite

The incidence of enlarged chondrons in normal and osteoarthritic human cartilage and their relative matrix density.

Journal Article Osteoarthritis Cartilage · January 2000 OBJECTIVE: To quantitate changes in the pericellular matrix in osteoarthritic (OA) articular cartilage. DESIGN: Chondrons were enzymatically isolated from normal and OA human cartilage. The cross-sectional area of the chondrons were measured. After immunol ... Full text Link to item Cite

Efficacy of prophylaxis against thromboembolism with intermittent pneumatic compression after primary and revision total hip arthroplasty.

Journal Article J Bone Joint Surg Am · May 1999 BACKGROUND: Thromboembolism is a common and important complication after total hip arthroplasty. A variety of pharmacological and mechanical measures have been proposed for prophylaxis. The purpose of the present study was to evaluate the efficacy of inter ... Full text Link to item Cite

Knee arthroplasty in hemophilic arthropathy.

Journal Article Clin Orthop Relat Res · March 1999 Twenty-three total knee arthroplasties in 15 patients with severe hemophilia were performed between February 1974 and September 1988. Thirteen patients had Factor VIII deficiency and two had Factor IX deficiency. The mean followup period was 7.5 years, wit ... Full text Link to item Cite

Alterations in the Young's modulus and volumetric properties of chondrocytes isolated from normal and osteoarthritic human cartilage.

Journal Article J Biomech · February 1999 The mechanical environment of the chondrocyte is an important factor that influences the maintenance of the articular cartilage extracellular matrix. Previous studies have utilized theoretical models of chondrocytes within articular cartilage to predict th ... Full text Link to item Cite

Cortical strut allografts for the treatment of femoral fractures and deficiencies in revision total hip arthroplasty.

Journal Article J South Orthop Assoc · 1999 Thirty-three hips had revision total hip arthroplasty, using an average of three cortical strut allografts fixed to the femur with cables and followed-up for a mean of 4 years. The indications for strut allografts were ectatic femurs or segmental defects o ... Link to item Cite

Periprosthetic fractures of the femur

Journal Article Techniques in Orthopaedics · January 1, 1999 Periprosthetic fractures of the femur after total hip arthroplasty are challenging to the orthopaedic surgeon. Location of the fracture and stability of the implant are the keys to their treatment. Fractures proximal to the tip of the stem, around a loose ... Full text Cite

Mechanical load stimulates expression of novel genes in vivo and in vitro in avian flexor tendon cells.

Journal Article Osteoarthritis Cartilage · January 1999 OBJECTIVE: Our experiments were designed to test the hypothesis that tendon cells might respond differently to applied strain in vitro than in vivo. DESIGN: We tested cells in whole tendons from exercised chickens and from isolated surface (TSC) and intern ... Full text Link to item Cite

Relationship of femoral head and acetabular size to the prevalence of dislocation.

Journal Article Clin Orthop Relat Res · October 1998 Two clinical studies, one prospective randomized and one retrospective, were performed to evaluate the relationship of femoral head size and acetabular component outer diameter to the prevalence of dislocation of the modular total hip replacement. Between ... Full text Link to item Cite

The value of serial postoperative radiographs of total knee arthroplasties.

Journal Article J South Orthop Assoc · 1998 In a prospective study of 35 cemented press fit condylar knees, we studied the prevalence of radiolucent lines 1 mm wide or wider using two methods of detection: conventional (plain) and fluoroscopically-guided radiographs. All films were evaluated in acco ... Link to item Cite

The influence of patient-related factors and the position of the acetabular component on the rate of dislocation after total hip replacement.

Journal Article J Bone Joint Surg Am · August 1997 The senior one of us performed 438 primary and 181 revision total hip arthroplasties with use of so-called modern prostheses between July 1983 and January 1994. Fifty-three patients, who had had forty-seven primary procedures and twelve revisions, either d ... Full text Link to item Cite

Isolated chondrons: a viable alternative for studies of chondrocyte metabolism in vitro.

Journal Article Osteoarthritis Cartilage · July 1997 OBJECTIVE: To develop and test a simple enzymatic procedure for isolating chondrons, which consist of the chondrocytes and their surrounding pericellular microenvironment. DESIGN: Chondrons were obtained by digesting adult human articular cartilage with a ... Full text Link to item Cite

Aspiration of the knee joint before revision arthroplasty.

Journal Article Clin Orthop Relat Res · October 1996 Sixty-four operative procedures were performed on 55 patients with knee arthroplasties for pain, loosening, instability, or suspicion of infection. Forty-three knees had a preoperative aspiration. In 19 knees, the aspiration showed growth on solid media, a ... Full text Link to item Cite

Total hip replacement for coxarthrosis secondary to congenital dysplasia and dislocation of the hip. Long-term results.

Journal Article J Bone Joint Surg Am · January 1996 Between 1970 and 1982, sixty-six total hip replacements were performed with cement, without bone-grafting, in fifty-three patients who had congenital dysplasia and dislocation of the hip. Preoperatively, the patients had had Crowe type-II, III, or IV sublu ... Full text Link to item Cite

Pneumatic compression or aspirin prophylaxis against thromboembolism in total hip arthroplasty.

Journal Article J South Orthop Assoc · 1996 We prospectively studied the use of either aspirin or intermittent pneumatic compression (IPC) as prophylaxis against thromboembolism after 330 consecutive total hip arthroplasties. Duplex ultrasonography of the veins of both lower extremities and ventilat ... Link to item Cite

Results of knee arthroplasty using the cemented press-fit condylar prosthesis. Based on a preliminary report.

Journal Article Am J Orthop (Belle Mead NJ) · November 1995 Although retention of the posterior cruciate ligament in total knee arthroplasty remains controversial, several prostheses exist for this purpose and have been reported to have varying results. This study examines the short-term follow-up results of 107 to ... Link to item Cite

Custom-made molds that prevent cement extrusion through bone defects.

Journal Article Clin Orthop Relat Res · August 1995 The success of a hip arthroplasty using a cemented femoral component relies in part on the quality of the cement technique, and is enhanced by obtaining a uniform, well-pressurized cement mantle around the prosthesis. For that reason, cortical bone defects ... Link to item Cite

Hip arthroplasty in hemophilic arthropathy.

Journal Article J Bone Joint Surg Am · June 1995 As hemophilic arthropathy infrequently affects the hip joint, we performed a multicenter retrospective study to determine the results of hip arthroplasty in hemophilic patients. Thirty-four hip arthroplasties were performed in twenty-seven male patients at ... Full text Link to item Cite

A simple technique for insertion of distal screws into interlocking nails.

Journal Article J Orthop Trauma · June 1995 Placement of distal interlocking screws into femoral and tibial nails is an exacting technique. Many techniques are described, each with their advantages and disadvantages. We describe an alternative technique using the "third point in space." This method ... Full text Link to item Cite

Techniques for the removal of broken small-diameter tibial nails: a report of two cases.

Journal Article J Orthop Trauma · 1995 The availability of small-diameter interlocking nails for unreamed applications has expanded the indications for intramedullary nailing of open tibial shaft fractures. Smaller diameter nails that are inserted without reaming are mechanically weaker than th ... Full text Link to item Cite

High hip center in revision arthroplasty.

Journal Article J Arthroplasty · October 1994 What is the effect of superior placement of the acetabulum in complex hip reconstruction? Twenty-two patients (23 cases) had revision hip arthroplasty with superiorly placed porous-coated components without bone-grafts. Cemented femoral components were use ... Full text Link to item Cite

Periprosthetic Femoral Fractures.

Journal Article J Am Acad Orthop Surg · May 1994 Fracture of the femoral shaft around a hip prosthesis presents the simultaneous problems of prosthetic stability and femoral- fracture management. Treatment options include nonoperative stabilization (traction) and operative stabilization by means of intra ... Cite

A prospective randomized study of a collar versus a collarless femoral prosthesis.

Journal Article Clin Orthop Relat Res · September 1993 A prospective, randomized study of 44 collared versus 40 collarless cemented HD-2 total hip arthroplasties (THAs) was performed in 84 patients. Seventy patients were examined at an average of 4.6 years after surgery. Five hips have required, or are schedul ... Link to item Cite

The outcome of Charnley total hip arthroplasty with cement after a minimum twenty-year follow-up. The results of one surgeon.

Journal Article J Bone Joint Surg Am · July 1993 We evaluated the results of 330 total hip arthroplasties that were performed with use of the Charnley prosthesis and cement in 262 patients by the senior one of us between July 1970 and April 1972. All hips had been thoroughly assessed preoperatively to do ... Full text Link to item Cite

Debris from cobalt-chrome cable may cause acetabular loosening.

Journal Article Clin Orthop Relat Res · December 1992 To address the issue of nonunion with trochanteric osteotomy, surgeons have experimented with various modes of fixation, wire and cable being the two most popular. From a group of 643 primary cemented total hip arthroplasties performed by a single surgeon ... Link to item Cite

Current concepts in hip joint replacement.

Journal Article Iowa Med · October 1990 The authors present an overview of the 'state of the art' in hip joint replacement. Short and long-term success rates are discussed. ... Link to item Cite