Scholars@Duke
Shelby Addison Neal

Shelby Addison Neal

Assistant Professor of Obstetrics and Gynecology
Obstetrics and Gynecology, Reproductive Endocrinology & Infertility
5601 Arringdon Park Drive, Suite 210, Morrisville, NC 27560
5601 Arringdon Park Drive, Suite 210, Morrisville, NC 27560

Scholarly Works - Journal articles

Sonographic characteristics associated with early pregnancy loss in pregnancies conceived via in vitro fertilization.

Journal article Eur J Obstet Gynecol Reprod Biol · December 2025 RESEARCH QUESTION: Can gestational age-based sonographic criteria with near 100% positive predictive value (PPV) for early pregnancy loss (EPL) be established in pregnancies conceived via in vitro fertilization (IVF)? DESIGN: A retrospective cohort study w ... Full text Link to item Cite

Success rates with preimplantation genetic testing for aneuploidy in good prognosis patients are dependent on age.

Journal article Fertil Steril · March 2025 OBJECTIVE: To evaluate cumulative live birth after preimplantation genetic testing for aneuploidy (PGT-A) with next generation sequencing (NGS) compared with morphology alone among patients aged 21-40 years undergoing single blastocyst transfer. DESIGN: Re ... Full text Link to item Cite

Survey assessing policies regarding patient age and provision of fertility treatment in the United States.

Journal article J Assist Reprod Genet · September 2023 PURPOSE: To determine what policies exist regarding age and provision of fertility treatment in United States fertility clinics. METHODS: Medical directors of the Society for Assisted Reproductive Technology (SART) member clinics were surveyed regarding cl ... Full text Link to item Cite

The Appraisal of Body Content (ABC) trial: Increased male or female adiposity does not significantly impact in vitro fertilization laboratory or clinical outcomes.

Journal article Fertil Steril · August 2021 OBJECTIVE: To investigate the impact of obesity as determined by bioelectric impedance analysis (BIA) and body mass index (BMI) on in vitro fertilization (IVF) laboratory and clinical outcomes. DESIGN: Prospective cohort study. SETTING: Academic-affiliated ... Full text Link to item Cite

The appraisal of body content (ABC) trial: obesity does not significantly impact gamete production in infertile men and women.

Journal article J Assist Reprod Genet · November 2020 PURPOSE: As obesity becomes increasingly prevalent, its impact on fertility has been a subject of great debate. Nearly all prior research is retrospective and evaluates obesity utilizing body mass index (BMI), which may overestimate adiposity in individual ... Full text Link to item Cite

Interpretation of noninvasive prenatal testing results following in vitro fertilization and preimplantation genetic testing for aneuploidy.

Journal article Am J Obstet Gynecol MFM · November 2020 BACKGROUND: The positive predictive value of noninvasive prenatal testing is approximately 69% in the general population. However, positive predictive value is dependent on the prevalence of the disease in the population being tested. Patients who undergo ... Full text Link to item Cite

Three-dimensional ultrasound diagnosis of adenomyosis is not associated with adverse pregnancy outcome following single thawed euploid blastocyst transfer: prospective cohort study.

Journal article Ultrasound Obstet Gynecol · October 2020 OBJECTIVES: The objectives of this study were (1) to assess the prevalence of ultrasound (US) features of adenomyosis in an infertile population undergoing in-vitro fertilization (IVF), (2) to define the inter- and intrarater agreement of three-dimensional ... Full text Link to item Cite

Prognostic value of blastocyst grade after frozen euploid embryo transfer in patients with recurrent pregnancy loss

Journal article F and S Reports · September 1, 2020 Objective: To determine whether trophectoderm (TE) grade or inner cell mass (ICM) grade have predictive value after euploid frozen embryo transfer (euFET) among recurrent pregnancy loss (RPL) patients. Design: Retrospective cohort study. Setting: Single fe ... Full text Cite

Consistency in rates of diagnosis of embryonic mosaicism, segmental abnormalities, and “no call” results among experienced embryologists performing preimplantation genetic testing for aneuploidy

Journal article F and S Reports · September 1, 2020 Objective: To determine whether differences exist in rates of subchromosomal abnormalities, mosaicism, and “no call” results among embryologists performing and loading trophectoderm biopsies for preimplantation genetic testing for aneuploidy (PGT-A). Desig ... Full text Cite

A comparison of the relative efficiency of ICSI and extended culture with epididymal sperm versus testicular sperm in patients with obstructive azoospermia.

Journal article Asian J Androl · 2020 This is a retrospective cohort study comparing blastocyst transfer outcomes following intracytoplasmic sperm injection utilizing epididymal versus testicular sperm for men with obstructive azoospermia. All cases at a single center between 2012 and 2016 wer ... Full text Link to item Cite

Three-dimensional ultrasound diagnosis of T-shaped uterus is associated with adverse pregnancy outcomes after embryo transfer.

Journal article Reprod Biomed Online · November 2019 RESEARCH QUESTION: Is T-shaped uterine cavity morphology associated with adverse pregnancy outcomes after transfer of a single thawed euploid blastocyst? DESIGN: In this secondary analysis of a prospective cohort study, 648 patients with three-dimensional ... Full text Link to item Cite

When next-generation sequencing-based preimplantation genetic testing for aneuploidy (PGT-A) yields an inconclusive report: diagnostic results and clinical outcomes after re biopsy.

Journal article J Assist Reprod Genet · October 2019 PURPOSE: To describe diagnostic results following re-biopsy of blastocysts with inconclusive results on preimplantation genetic screening for aneuploidy (PGT-A) and to evaluate the reproductive potential of re-biopsied blastocysts. METHODS: This retrospect ... Full text Link to item Cite

Preimplantation genetic testing for aneuploidy is cost-effective, shortens treatment time, and reduces the risk of failed embryo transfer and clinical miscarriage.

Journal article Fertil Steril · October 2018 OBJECTIVE: To determine if preimplantation genetic testing for aneuploidy (PGT-A) is cost-effective for patients undergoing in vitro fertilization (IVF). DESIGN: Decision analytic model comparing costs and clinical outcomes of two strategies: IVF with and ... Full text Link to item Cite

Celiac disease is not more prevalent in patients undergoing in vitro fertilization and does not affect reproductive outcomes with or without treatment: a large prospective cohort study.

Journal article Fertil Steril · August 2018 OBJECTIVE: To study the prevalence of celiac disease in the infertile population undergoing in vitro fertilization (IVF) and assess outcomes. DESIGN: Prospective cohort study. SETTING: A single infertility center from January 2016 to March 2017. PATIENT(S) ... Full text Link to item Cite

Diminished ovarian reserve and poor response to stimulation in patients <38 years old: a quantitative but not qualitative reduction in performance.

Journal article Hum Reprod · August 1, 2018 STUDY QUESTION: Do infertile women aged <38 years with quantitative evidence of diminished ovarian reserve and/or poor response to stimulation also exhibit poor oocyte quality as measured by blastulation rates, aneuploidy rates, and live birth rates? SUMMA ... Full text Link to item Cite

The impact of contemporary preimplantation genetic screening and diagnosis on the detection of aneuploidy and inherited genetic diseases.

Journal article Birth Defects Res · May 1, 2018 Pre-implantation genetic screening and diagnosis represent important tools for embryo selection in patients undergoing in vitro fertilization. Methods have evolved in recent years and it can be challenging to remain up to date on the current technology. Th ... Full text Link to item Cite

CD8, FoxP3, and CD45RO+ Lymphocytic Infiltrates in Type I and Type II Endometrial Cancers in African American and European American Females.

Journal article Int J Gynecol Pathol · November 2017 African American (AA) females with endometrial carcinoma have a significantly worse prognosis with regard to disease-free survival and overall survival than their European American (EA) counterparts and this finding is true across all stages and grades. Th ... Full text Link to item Cite

High relative deoxyribonucleic acid content of trophectoderm biopsy adversely affects pregnancy outcomes.

Journal article Fertil Steril · March 2017 OBJECTIVE: To evaluate the association between relative DNA content of the trophectoderm biopsy and pregnancy outcomes. DESIGN: Retrospective cohort study. SETTING: Academic-affiliated private practice. PATIENT(S): This study included patients undergoing t ... Full text Link to item Cite

Characterization of reproductive endocrinology and infertility (REI) fellowship applicants: guiding our mentees toward success.

Journal article Fertil Res Pract · 2017 BACKGROUND: Advanced subspecialty training in reproductive endocrinology and infertility (REI) entails a competitive application process with many data points considered. It is not known what components weigh more heavily for applicants. Thus, we sought to ... Full text Link to item Cite

Lymphovascular space invasion in uterine corpus cancer: What is its prognostic significance in the absence of lymph node metastases?

Journal article Gynecol Oncol · August 2016 OBJECTIVE: Lymphovascular space invasion (LVSI) is a poor prognostic indicator in uterine cancer, primarily due to its association with lymph node metastases. We sought to determine if LVSI provides any prognostic information for uterine cancer subjects in ... Full text Link to item Cite

SNP array-based analyses of unbalanced embryos as a reference to distinguish between balanced translocation carrier and normal blastocysts.

Journal article J Assist Reprod Genet · August 2016 PURPOSE: The purpose of the study is to validate a method that provides the opportunity to distinguish a balanced translocation carrier embryo from a truly normal embryo in parallel with comprehensive chromosome screening (CCS). METHODS: A series of transl ... Full text Link to item Cite

Whole-body bone scintigraphy provides a measure of the total-body burden of osteoarthritis for the purpose of systemic biomarker validation.

Journal article Arthritis Rheum · November 2009 OBJECTIVE: To evaluate the association of serum and synovial fluid cartilage oligomeric matrix protein (COMP) with systemic and local measures of osteoarthritis (OA) activity by bone scintigraphy. METHODS: Samples of serum and knee joint synovial fluid (27 ... Full text Link to item Cite

Type II collagen markers in osteoarthritis: what do they indicate?

Journal article Curr Opin Rheumatol · September 2007 PURPOSE OF REVIEW: We provide a critical review of recent in-vitro, animal and human clinical studies on type II collagen biomarkers. In describing the human studies, we have applied the BIPED (burden of disease, investigative, prognostic, efficacy of inte ... Full text Link to item Cite