Sudha Kaup Shenoy

Journal article Oncogene · January 19, 2012 Featured Publication β-Arrestins 1 and 2 are multifunctional adaptor proteins originally discovered for their role in desensitizing seven-transmembrane receptor signaling via the heterotrimeric guanine nucleotide-binding proteins. Recently identified roles of β-arrestins inclu ... Full text Link to item Cite

Beta2-adrenergic receptor lysosomal trafficking is regulated by ubiquitination of lysyl residues in two distinct receptor domains.

Journal article J Biol Chem · April 8, 2011 Featured Publication Agonist stimulation of the β2-adrenergic receptors (β2ARs) leads to their ubiquitination and lysosomal degradation. Inhibition of lysosomal proteases results in the stabilization and retention of internalized full-length β2ARs in the lysosomes, whereas inh ... Full text Link to item Cite

β-arrestin-biased signaling by the β-adrenergic receptors.

Journal article Curr Top Membr · 2011 Featured Publication Full text Link to item Cite

The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization.

Journal article EMBO J · June 17, 2009 Featured Publication Agonist-induced ubiquitination of the beta(2) adrenergic receptor (beta(2)AR) functions as an important post-translational modification to sort internalized receptors to the lysosomes for degradation. We now show that this ubiquitination is reversed by two ... Full text Link to item Cite

Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2.

Journal article Proc Natl Acad Sci U S A · April 21, 2009 Featured Publication Beta-arrestins are multifunctional adaptors that mediate the desensitization, internalization, and some signaling functions of seven-transmembrane receptors (7TMRs). Agonist-stimulated ubiquitination of beta-arrestin2 mediated by the E3 ubiquitin ligase Md ... Full text Link to item Cite

Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor.

Journal article J Biol Chem · August 8, 2008 Featured Publication Agonist-stimulated beta(2)-adrenergic receptor (beta(2)AR) ubiquitination is a major factor that governs both lysosomal trafficking and degradation of internalized receptors, but the identity of the E3 ubiquitin ligase regulating this process was unknown. ... Full text Link to item Cite

Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation.

Journal article J Biol Chem · October 5, 2007 Featured Publication Beta-arrestin2 and its ubiquitination play crucial roles in both internalization and signaling of seven-transmembrane receptors (7TMRs). To understand the connection between ubiquitination and the endocytic and signaling functions of beta-arrestin, we gene ... Full text Link to item Cite

Seven-transmembrane receptors and ubiquitination.

Journal article Circ Res · April 27, 2007 Featured Publication Regulation of protein function by posttranslational modification plays an important role in many biological pathways. The most well known among such modifications is protein phosphorylation performed by highly specific protein kinases. In the past decade, ... Full text Link to item Cite

Beta-arrestin and Mdm2 mediate IGF-1 receptor-stimulated ERK activation and cell cycle progression.

Journal article J Biol Chem · April 13, 2007 Featured Publication Beta-arrestin1, which regulates many aspects of seven transmembrane receptor (7TMR) biology, has also been shown to serve as an adaptor, which brings Mdm2, an E3 ubiquitin ligase to the insulin-like growth factor-1 receptor (IGF-1R), leading to its proteas ... Full text Link to item Cite

Beta-arrestins and cell signaling.

Journal article Annu Rev Physiol · 2007 Featured Publication Upon their discovery, beta-arrestins 1 and 2 were named for their capacity to sterically hinder the G protein coupling of agonist-activated seven-transmembrane receptors, ultimately resulting in receptor desensitization. Surprisingly, recent evidence shows ... Full text Link to item Cite

beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor.

Journal article J Biol Chem · January 13, 2006 Featured Publication Physiological effects of beta adrenergic receptor (beta2AR) stimulation have been classically shown to result from G(s)-dependent adenylyl cyclase activation. Here we demonstrate a novel signaling mechanism wherein beta-arrestins mediate beta2AR signaling ... Full text Link to item Cite

Receptor regulation: beta-arrestin moves up a notch.

Journal article Nat Cell Biol · December 2005 Featured Publication Full text Link to item Cite

Angiotensin II-stimulated signaling through G proteins and beta-arrestin.

Journal article Sci STKE · November 22, 2005 Featured Publication Beta-arrestin, originally identified as a protein that inhibits heterotrimeric guanine nucleotide-binding protein (G protein) coupling to cognate seven-transmembrane receptors [(7TMRs), also known as G protein-coupled receptors (GPCRs)], is currently being ... Full text Link to item Cite

Seven-transmembrane receptor signaling through beta-arrestin.

Journal article Sci STKE · November 1, 2005 Featured Publication Cell surface receptors are important communicators of external stimuli to the cell interior where they lead to initiation of various signaling pathways and cellular responses. The largest receptor family is the seven-transmembrane receptor (7TMR) family, w ... Full text Link to item Cite

Transduction of receptor signals by beta-arrestins.

Journal article Science · April 22, 2005 Featured Publication The transmission of extracellular signals to the interior of the cell is a function of plasma membrane receptors, of which the seven transmembrane receptor family is by far the largest and most versatile. Classically, these receptors stimulate heterotrimer ... Full text Link to item Cite

Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes.

Journal article J Biol Chem · April 15, 2005 Featured Publication Angiotensin II type 1a (AT1a), vasopressin V2, and neurokinin 1 (NK1) receptors are seven-transmembrane receptors (7TMRs) that bind and co-internalize with the multifunctional adaptor protein, beta-arrestin. These receptors also lead to robust and persiste ... Full text Link to item Cite

Constitutive protease-activated receptor-2-mediated migration of MDA MB-231 breast cancer cells requires both beta-arrestin-1 and -2.

Journal article J Biol Chem · December 31, 2004 Featured Publication Protease-activated receptor-2 (PAR-2) is activated by trypsin-like serine proteases and can promote cell migration through an ERK1/2-dependent pathway, involving formation of a scaffolding complex at the leading edge of the cell. Previous studies also show ... Full text Link to item Cite

Resonating to the music of ubiquitination.

Journal article Nat Methods · December 2004 Featured Publication Full text Link to item Cite

Regulation of V2 vasopressin receptor degradation by agonist-promoted ubiquitination.

Journal article J Biol Chem · November 14, 2003 Featured Publication The seven-transmembrane-spanning vasopressin V2 receptor (V2R) is a Gs-coupled receptor that is rapidly phosphorylated and internalized following stimulation with the agonist, arginine-vasopressin. Herein, we show that the V2R is ubiquitinated following ag ... Full text Link to item Cite

Multifaceted roles of beta-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling.

Journal article Biochem J · November 1, 2003 Featured Publication Beta-arrestins are cytosolic proteins that bind to activated and phosphorylated G-protein-coupled receptors [7MSRs (seven-membrane-spanning receptors)] and uncouple them from G-protein-mediated second messenger signalling pathways. The binding of beta-arre ... Full text Link to item Cite

Trafficking patterns of beta-arrestin and G protein-coupled receptors determined by the kinetics of beta-arrestin deubiquitination.

Journal article J Biol Chem · April 18, 2003 Featured Publication Agonist-dependent internalization of G protein-coupled receptors via clathrin-coated pits is dependent on the adaptor protein beta-arrestin, which interacts with elements of the endocytic machinery such as AP2 and clathrin. For the beta(2)-adrenergic recep ... Full text Link to item Cite

Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin.

Journal article Science · November 9, 2001 Featured Publication Although trafficking and degradation of several membrane proteins are regulated by ubiquitination catalyzed by E3 ubiquitin ligases, there has been little evidence connecting ubiquitination with regulation of mammalian G protein (heterotrimeric guanine nuc ... Full text Link to item Cite