Scholars@Duke
Peter Kent Smith

Peter Kent Smith

Mary and Deryl Hart Distinguished Professor of Surgery, in the School of Medicine
Surgery, Cardiovascular and Thoracic Surgery
smith058@mc.duke.edu
Box 3442 Med Ctr, Durham, NC 27710
127 Baker House, Durham, NC 27710

Featured Works

Postcardiac surgery complications: association of acute renal dysfunction and atrial fibrillation.

Journal article Anesth Analg · March 2003 Featured Publication UNLABELLED: Postoperative creatinine increase is associated with adverse outcome after cardiac surgery. Although postoperative stroke and renal dysfunction are associated after cardiac surgery, suggesting a common systemic insult, a similar assessment of a ... Full text Link to item Cite

Risk of anaphylaxis from aprotinin re-exposure during LVAD removal and heart transplantation.

Journal article J Heart Lung Transplant · October 2002 Featured Publication Aprotinin has been shown to reduce transfusion requirements in re-operative cardiac surgery and in implantation of long-term left ventricular assist devices (LVAD). However, it is an antigenic polypeptide and re-exposure is associated with a small incidenc ... Full text Link to item Cite

Basic fibroblast growth factor is upregulated in hibernating myocardium.

Journal article J Surg Res · September 2002 Featured Publication BACKGROUND: Ischemia is known to be a potent stimulus for the upregulation of angiogenic growth factors, such as basic fibroblast growth factor (bFGF). While previous investigations have shown that many angiogenic growth factors are upregulated in animal m ... Full text Link to item Cite

Comparison of coronary artery bypass grafting versus medical therapy on long-term outcome in patients with ischemic cardiomyopathy (a 25-year experience from the Duke Cardiovascular Disease Databank).

Journal article Am J Cardiol · July 15, 2002 Featured Publication In this observational treatment comparison in a single center over 25 years, we sought to assess long-term outcomes of coronary artery bypass surgery (CABG) or medical therapy in patients with heart failure, coronary artery disease, and left ventricular sy ... Full text Link to item Cite

Serum creatinine patterns in coronary bypass surgery patients with and without postoperative cognitive dysfunction.

Other Anesth Analg · July 2002 Featured Publication UNLABELLED: Renal dysfunction is common after coronary artery bypass graft (CABG) surgery. We have previously shown that CABG procedures complicated by stroke have a threefold greater peak serum creatinine level relative to uncomplicated surgery. However, ... Full text Link to item Cite

Neuroprotection is associated with beta-adrenergic receptor antagonists during cardiac surgery: evidence from 2,575 patients.

Journal article J Cardiothorac Vasc Anesth · June 2002 Featured Publication OBJECTIVE: To determine the impact of perioperative beta-adrenergic receptor (betaAR) antagonist administration on neurologic complications. DESIGN: Observational database analysis. SETTING: A clinical investigation at a single tertiary academic medical ce ... Full text Link to item Cite

The association of complication type with mortality and prolonged stay after cardiac surgery with cardiopulmonary bypass.

Journal article Anesth Analg · May 2002 Featured Publication UNLABELLED: Outcome after cardiac surgery varies depending on complication type. We therefore sought to determine the association between complication type, mortality, and length of stay in a large series of patients undergoing cardiac surgery with cardiop ... Full text Link to item Cite

Postoperative hyperthermia is associated with cognitive dysfunction after coronary artery bypass graft surgery.

Journal article Stroke · February 2002 Featured Publication BACKGROUND AND PURPOSE: Temperature is a well-known modulator of experimental cerebral injury. We hypothesized that hyperthermia would be associated with a worsened cognitive outcome after coronary artery bypass graft surgery (CABG). METHODS: Three hundred ... Full text Link to item Cite

Association of leukocyte-depleted blood transfusions with infectious complications after cardiac surgery.

Journal article Surg Infect (Larchmt) · 2002 Featured Publication BACKGROUND: To test the hypothesis that leukocyte-mediated immunosuppression may contribute to postoperative infections after blood transfusions, we compared the incidence of postoperative infections in patients undergoing elective coronary artery bypass g ... Full text Link to item Cite

Report of a substudy on warm versus cold cardiopulmonary bypass: changes in creatinine clearance.

Journal article Ann Thorac Surg · November 2001 Featured Publication BACKGROUND: Renal dysfunction remains a major complication of cardiac operations. There is concern regarding the possibility of increased renal injury during warm cardiopulmonary bypass (CPB). Therefore, we tested the hypothesis that warm CPB is associated ... Full text Link to item Cite

Prospective randomized trial of normothermic versus hypothermic cardiopulmonary bypass on cognitive function after coronary artery bypass graft surgery.

Journal article Anesthesiology · November 2001 Featured Publication BACKGROUND: Despite significant advances in cardiopulmonary bypass (CPB) technology, surgical techniques, and anesthetic management, central nervous system complications occur in a large percentage of patients undergoing surgery requiring CPB. Many centers ... Full text Link to item Cite

The "ideal" replacement heart valve.

Journal article Am Heart J · May 2001 Featured Publication Full text Link to item Cite

Depressive symptoms and outcome of coronary artery bypass grafting.

Journal article Am J Crit Care · January 2001 Featured Publication BACKGROUND: Depressive symptoms are an independent risk factor for outcome in patients with cardiac disease, but their effect on outcome among patients undergoing coronary artery bypass grafting is not well understood. OBJECTIVES: To determine whether or n ... Link to item Cite