Sonali Advani | Scholars@Duke

Sonali Advani
Assistant Professor of Medicine

Dr. Advani is an Assistant Professor of Medicine at Duke University School of Medicine and serves as the Co-Medical Director of Duke Infection Control Outreach Network (DICON). In her role, she assists member hospitals in further development and strengthening of their existing infection prevention programs. She also participates as a physician investigator in the research activities of the Duke Center for Antimicrobial Stewardship and Infection Prevention. She is currently a Fellow in Implementation Science at HIGH IRI (HIV, Infectious Disease and Global Health Implementation Research) Institute at Washington University, St Louis.

Dr. Advani has over 10-years' experience in healthcare epidemiology research and operations. Her current research focuses on improving the diagnosis of UTIs in older adults, implementation of diagnostic stewardship interventions, and de-prescribing antibiotics for asymptomatic bacteriuria. She was awarded the K12 Urologic Career Development Award, Pepper Center Career Development Award, and SHEA Research Scholar Award to continue her UTI related research. In addition, she is one of the key investigators for CDC Prevention Epicenter Program and CDC SHEPheRD Contract for the Use of Race, Ethnicity, and Social Determinants of Health Data in NHSN Measures to Promote Health Equity.

Dr. Advani currently serves on the SHEA Program Planning Committee, SHEA Research Committee, SHEA Diagnostic Stewardship Task Force, SHEA Steering Committee for the LEAP Fellowship, and IDSA Antimicrobial Stewardship Workgroup. She is contributing to the upcoming SHEA CAUTI Compendium, SHEA Nursing Home Infection Prevention Guidance, AUGS Bacteriuria Consensus Guidance, and SHEA HAI Research Agenda.

Current Research Interests

My main research interests include prevention of catheter-related harm, implementation of diagnostic stewardship interventions, quality improvement, and improving metrics to better align with outcomes.

Current Appointments & Affiliations

Assistant Professor of Medicine, Medicine, Infectious Diseases, Medicine 2021

Contact Information

Hanes House Room 154, Box 102359, Durham, NC 27710
sonali.advani@duke.edu (919) 681-8150

Background
Education, Training, & Certifications
- Co-chief Fellow, Infectious Diseases, University of Alabama Birmingham 2016 - 2017
- Infectious Diseases Fellowship, University of Alabama Birmingham 2015 - 2017
- Internal Medicine Residency, University of Alabama Birmingham 2012 - 2015
- Research Fellow, Infectious Diseases & Hospital Epidemiology, Johns Hopkins University School of Medicine 2010 - 2012
- M.P.H., Johns Hopkins Unversity, Bloomberg School of Public Health 2010
- M.B.B.S., Padmashree Dr. D. Y. Patil Medical College (India) 2008
Medical Licensure
- 2019-00743. North Carolina. 2019
Previous Appointments & Affiliations
- Assistant Professor of Medicine, Medicine, Infectious Diseases, Medicine 2019 - 2020
Leadership & Clinical Positions at Duke
- Co-Medical Director, Duke Infection Control Outreach Network (DICON)
  Associate Medical Director, Duke Infection Control and Hospital Epidemiology (IPHE)
Academic Positions Outside Duke
- Associate Medical Director of Infection Prevention, Yale New Haven Hospital. 2017 - 2019
- Assistant Professor of Medicine, Yale School of Medicine, New Haven, CT. 2017 - 2019
Recognition
In the News
- JUL 27, 2019 Infectious Disease News
  
  Inappropriate urine culture practices contribute to overdiagnosis of CAUTIs
- APR 14, 2019 Infectious Disease News
  
  Q&A: The evolution of CAUTI and need for better metrics
- FEB 19, 2019 IDSA Foundation
  
  ID WOMEN OF THE FUTURE
- FEB 6, 2019 Medscape and SHEA Editorial Collaboration
  
  Pre-op Urine Screening: Changing Our Culture
- JAN 15, 2019 Medscape and SHEA Editorial Collaboration
  
  The Latest Dirt on Hospital Cleanliness
- JAN 1, 2019 Infectious Disease News
  
  #BeASteward: IDSA develops antimicrobial stewardship curriculum for ID fellows
- NOV 28, 2018 New York Times
  
  A Rash on Her Palms and the Bottoms of Her Feet Was the Clue That Turned the Case
- OCT 18, 2018 Infectious Disease News
  
  Algorithm reduces urine culture orders and CAUTIs
- JUL 12, 2018 Medscape and SHEA Editorial Collaboration
  
  What's the Verdict for UTIs in Women and Children?
- MAR 22, 2018 Medscape and SHEA Editorial Collaboration
  
  Survival of the Slimiest: The Persistent Nature of Biofilms
- NOV 11, 2013 Infectious Disease News
  
  CLABSI risk increased by central catheter dwell time
- AUG 1, 2012
  
  Nucleic acid tests helpful in identifying respiratory viruses, but caution urged
Awards & Honors
Expertise
Subject Headings
Research
Selected Grants
Fellowships, Supported Research, & Other Grants
- Multidisciplinary K12 Urologic Research Career Development Program awarded by Duke University/NIH 2020 - 2021
- The Duke-UNC Prevention Epicenters Program awarded by Centers for Disease Control and Prevention 2020 - 2021
- SHEPheRD awarded by Centers for Disease Control and Prevention 2018 - 2020
- The Duke-UNC Prevention Epicenters Program awarded by Centers for Disease Control and Prevention 2016 - 2021
External Relationships
- BioMerieux, Inc.
- GlaxoSmithKline
- IPEC experts, LLC
- Infectious Diseases Society of America
- Locus Biosciences
- Sysmex America
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Advani SD, Turner NA, Schmader KE, Wrenn RH, Moehring RW, Polage CR, et al. Optimizing reflex urine cultures: Using a population-specific approach to diagnostic stewardship. Infect Control Hosp Epidemiol. 2023 Jan 10;1–4.
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  - Advani SD, Smith BA, Seidelman J, Turner N, Anderson DJ, Lewis SS. Comparison of metrics used to track central-line-associated bloodstream infections (CLABSIs) and catheter-associated urinary tract infections (CAUTIs) across a regional network. Infect Control Hosp Epidemiol. 2022 Nov;43(11):1712–4.
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  - Advani SD, Claeys K. Cefepime/Enmetazobactam for Complicated Urinary Tract Infections. Jama. 2022 Oct;328(13):1299–301.
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  - Raglow Z, Advani SD, Aitken SL, Patel PK. Antimicrobial stewardship in solid organ transplant recipients: Current challenges and proposed metrics. Transpl Infect Dis. 2022 Oct;24(5):e13883.
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  - Seidelman JL, Ge M, Baker AW, Lewis S, Advani SD, Smith B, et al. Colon surgical-site infections and the impact of "present at the time of surgery (PATOS)" in a large network of community hospitals. Infect Control Hosp Epidemiol. 2022 Sep 22;1–6.
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  - Advani SD, Sickbert-Bennett E, Moehring R, Cromer A, Lokhnygina Y, Dodds-Ashley E, et al. The Disproportionate Impact of COVID-19 Pandemic on Healthcare-Associated Infections in Community Hospitals: Need for Expanding the Infectious Disease Workforce. Clin Infect Dis. 2022 Aug 23;
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  - Advani SD, Schmader KE, Mody L. Clin-Star corner: What's new at the interface of geriatrics, infectious diseases, and antimicrobial stewardship. J Am Geriatr Soc. 2022 Aug;70(8):2214–8.
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  - Seidelman JL, Baker AW, Lewis SS, Advani SD, Smith B, Anderson D, et al. Surgical site infection trends in community hospitals from 2013 to 2018. Infect Control Hosp Epidemiol. 2022 Jul 18;1–6.
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  - Reynolds SS, Sova CD, Lewis SS, Smith BA, Wrenn RH, Turner NA, et al. Sustained reduction in catheter-associated urinary tract infections using multi-faceted strategies led by champions: A quality improvement initiative. Infect Control Hosp Epidemiol. 2022 Jul;43(7):925–9.
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  - Spicer JO, Armstrong WS, Schwartz BS, Abbo LM, Advani SD, Barsoumian AE, et al. Evaluation of the Infectious Diseases Society of America's Core Antimicrobial Stewardship Curriculum for Infectious Diseases Fellows. Clin Infect Dis. 2022 Mar 23;74(6):965–72.
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  - Gao CA, Datta R, Dunne D, Dembry L-M, Martinello RA, Juthani-Mehta M, et al. Comparison of traditional instruction versus nontraditional learning to improve trainee knowledge of urine culture practices in catheterized patients. Antimicrob Steward Healthc Epidemiol. 2022;2(1).
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  - Shoff CJ, Spires SS, Yen C, Advani SD. Navigating the 2021 update to the IDSA/SHEA Clostridioides difficile guidelines: An ethical approach to equitable patient care. Antimicrob Steward Healthc Epidemiol. 2022;2(1):e70.
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  - Whelan P, Nelson A, Kim CJ, Tabib C, Preminger G, Turner NA, et al. Investigating Risk Factors for Urine Culture Contamination in Outpatient Clinics: A New Avenue for Diagnostic Stewardship. Antimicrob Steward Healthc Epidemiol. 2022;2(1).
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  - Advani SD, Cromer A, Wood B, Baker E, Crawford KL, Crane L, et al. The impact of coronavirus disease 2019 (COVID-19) response on hospital infection prevention programs and practices in the southeastern United States. Infect Control Hosp Epidemiol. 2021 Nov 2;1–4.
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  - Advani S, Vaughn VM. Quality Improvement Interventions and Implementation Strategies for Urine Culture Stewardship in the Acute Care Setting: Advances and Challenges. Curr Infect Dis Rep. 2021 Oct;23(10).
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  - Murthy AR, Hanrahan JA, Advani SD, Ashraf MS, Mills JP, Mody L, et al. Preparing nursing homes for a second wave of coronavirus disease 2019 (COVID-19). Infect Control Hosp Epidemiol. 2021 Oct;42(10):1251–4.
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  - Luther VP, Shnekendorf R, Logan A, Advani SD, Barsoumian AE, Beeler C, et al. Investing in the Future: A Role for Professional Societies to Prepare the Next Generation of Healthcare Leaders Through Curriculum Development and Dissemination. Clin Infect Dis. 2021 Sep 7;73(5):911–8.
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  - Nguyen KA, Le DQ, Bui YT, Advani SD, Renzulli J, Kenney PA, et al. Incidence, risk factors, and outcome of Clostridioides difficile infection following urological surgeries. World J Urol. 2021 Aug;39(8):2995–3003.
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  - Advani SD, Anderson DJ. Chlorhexidine for skin antisepsis: making the case to keep peripheral venous catheters CLEAN. Lancet Infect Dis. 2021 Jul;21(7):902–3.
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  - Advani SD, Yarrington ME, Smith BA, Anderson DJ, Sexton DJ. Are we forgetting the "universal" in universal masking? Current challenges and future solutions. Infect Control Hosp Epidemiol. 2021 Jun;42(6):784–5.
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  - Fakih MG, Advani SD. Striving to Reach the Optimal Measure for Catheter-Associated Urinary Tract Infection (CAUTI): Moving to Catheter Harm. Clin Infect Dis. 2021 May 4;72(9):e424.
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  - Advani SD, Baker E, Cromer A, Wood B, Crawford KL, Crane L, et al. Assessing severe acute respiratory coronavirus virus 2 (SARS-CoV-2) preparedness in US community hospitals: A forgotten entity. Infect Control Hosp Epidemiol. 2021 May;42(5):600–3.
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  - Advani SD, Polage CR, Fakih MG. Deconstructing the urinalysis: A novel approach to diagnostic and antimicrobial stewardship. Antimicrob Steward Healthc Epidemiol. 2021;1(1).
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  - Ling D, Seidelman J, Dodds-Ashley E, Lewis S, Moehring RW, Anderson DJ, et al. Navigating reflex urine culture practices in community hospitals: Need for a validated approach. Am J Infect Control. 2020 Dec;48(12):1549–51.
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  - Seidelman JL, Lewis SS, Advani SD, Akinboyo IC, Epling C, Case M, et al. Universal masking is an effective strategy to flatten the severe acute respiratory coronavirus virus 2 (SARS-CoV-2) healthcare worker epidemiologic curve. Infect Control Hosp Epidemiol. 2020 Dec;41(12):1466–7.
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  - Advani SD, Smith BA, Lewis SS, Anderson DJ, Sexton DJ. Universal masking in hospitals in the COVID-19 era: Is it time to consider shielding? Infect Control Hosp Epidemiol. 2020 Sep;41(9):1066–7.
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  - Advani SD, Schwartz IS, Spivak ES, Sutton JD. Re: 'Antibiotic treatment for 6 days versus 12 days in patients with severe cellulitis' by Cranendonk et al. Clin Microbiol Infect. 2020 May;26(5):654–5.
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  - Pepe DE, Maloney M, Leung V, Harizaj A, Banach DB, Dembry L-M, et al. An evaluation of metrics for assessing catheter-associated urinary tract infections (CAUTIs): A statewide comparison. Infect Control Hosp Epidemiol. 2020 Apr;41(4):481–3.
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  - Advani SD, Murray TS, Murdzek CM, Aniskiewicz MJ, Bizzarro MJ. Shifting focus toward healthcare-associated bloodstream infections: The need for neonatal intensive care unit-specific NHSN definitions. Infect Control Hosp Epidemiol. 2020 Feb;41(2):181–6.
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  - Advani SD, Gao CA, Datta R, Sann L, Smith C, Leapman MS, et al. Knowledge and Practices of Physicians and Nurses Related to Urine Cultures in Catheterized Patients: An Assessment of Adherence to IDSA Guidelines. Open Forum Infect Dis. 2019 Aug 1;6(8).
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  - Fakih MG, Advani SD, Vaughn VM. Diagnosis of urinary tract infections: need for a reflective rather than reflexive approach. Infect Control Hosp Epidemiol. 2019 Jul;40(7):834–5.
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  - Advani SD, Fakih MG. The evolution of catheter-associated urinary tract infection (CAUTI): Is it time for more inclusive metrics? Infect Control Hosp Epidemiol. 2019 Jun;40(6):681–5.
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  - Gaston DC, Peaper DR, Advani SD. Fever, Rash, and Migratory Polyarthralgias. Jama. 2019 May 21;321(19):1930–1.
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  - Advani SD, Nellore A, Hadjivassiliou G, Eckhoff DE, Salzman D, Lavie D, et al. Two Cases and a Review of Graft-Versus-Host Disease and the Role of Hepatitis C Treatment in Liver Transplant Patients. Prog Transplant. 2018 Sep;28(3):267–70.
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  - Luther VP, Shnekendorf R, Abbo LM, Advani S, Armstrong WS, Barsoumian AE, et al. Antimicrobial Stewardship Training for Infectious Diseases Fellows: Program Directors Identify a Curriculum Need. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. 2018 Sep;67(8):1285–7.
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  - Advani SD, Lee RA, Long M, Schmitz M, Camins BC. The Impact of 2015 NHSN Catheter-associated Urinary Tract Infection (CAUTI) Definition Change on Central Line-associated Bloodstream Infection (CLABSI) Rates and CLABSI Prevention Efforts at an Academic Medical Center. Infect Control Hosp Epidemiol. 2018 Jul;39(7):878–80.
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  - Datta R, Advani S, Rink A, Bianco L, Van Ness PH, Quagliarello V, et al. Increased Fluoroquinolone-Susceptibility and Preserved Nitrofurantoin-Susceptibility among Escherichia coli Urine Isolates from Women Long-Term Care Residents: A Brief Report. Open Access J Gerontol Geriatr Med. 2018 Apr;4(3).
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  - Javier-DesLoges JF, Ghabili Amirkhiz K, Su JJ, Kenney PA, Advani S, Hittelman AB, et al. MP80-02 LEVERAGING STRUCTURED DATA IN AN ENTERPRISE-WIDE ELECTRONIC HEALTH RECORD TO IDENTIFY RISK FACTORS FOR POSTOPERATIVE URINARY RETENTION. Journal of Urology. 2018 Apr;199(4S).
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  - Datta R, Advani S, Rink A, Bianco L, Van Ness PH, Quagliarello V, et al. Frequency of Infection during Fever Episodes among Long-Term Care Residents. J Gerontol Geriatr Res. 2018;7(2).
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  - Advani SD, Lee RA, Schmitz M, Camins BC. Impact of Changes to the National Healthcare Safety Network (NHSN) Definition on Catheter-Associated Urinary Tract Infection (CAUTI) Rates in Intensive Care Units at an Academic Medical Center. Infect Control Hosp Epidemiol. 2017 May;38(5):621–3.
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  - Advani S, Lee R, Schmitz M, Long M, Camins B. 2015 NHSN CAUTI Definition Change and Its Impact on CLABSI Rates at an Academic Medical Center. Open Forum Infectious Diseases. 2017 Jan;4(Suppl 1):S180–S180.
  - Advani S, Lee R, Schmitz M, Camins B. Impact of Change in the National Healthcare Safety Network (NHSN) Definition of Catheter-Associated Urinary Tract Infections (CAUTIs) on the CAUTI Rates in Intensive Care Units at an Academic Medical Center. Open Forum Infectious Diseases. 2016 Dec 1;3(suppl_1).
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  - Kovacich A, Tamma PD, Advani S, Popoola VO, Colantuoni E, Gosey L, et al. Peripherally Inserted Central Venous Catheter Complications in Children Receiving Outpatient Parenteral Antibiotic Therapy (OPAT). Infect Control Hosp Epidemiol. 2016 Apr;37(4):420–4.
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  - Morden A, Advani S, Gosey L, Popoola V, Milstone AM. 981Catheter Complications in Children Discharged with Peripherally Inserted Central Catheters (PICCs). Open Forum Infectious Diseases. 2014 Dec;1(Suppl 1):S285–S285.
  - Milstone AM, Reich NG, Advani S, Yuan G, Bryant K, Coffin SE, et al. Catheter dwell time and CLABSIs in neonates with PICCs: a multicenter cohort study. Pediatrics. 2013 Dec;132(6):e1609–15.
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  - Advani S, Sengupta A, Milstone AM. Postdischarge surveillance to identify subsequent methicillin-resistant Staphylococcus aureus infections in colonized children. Am J Infect Control. 2013 Oct;41(10):939–41.
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  - Chapman AK, Aucott SW, Gilmore MM, Advani S, Clarke W, Milstone AM. Absorption and tolerability of aqueous chlorhexidine gluconate used for skin antisepsis prior to catheter insertion in preterm neonates. J Perinatol. 2013 Oct;33(10):768–71.
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  - Jumani K, Advani S, Reich NG, Gosey L, Milstone AM. Risk factors for peripherally inserted central venous catheter complications in children. Jama Pediatrics. 2013 May;167(5):429–35.
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  - Advani S, Sengupta A, Forman M, Valsamakis A, Milstone AM. Detecting respiratory viruses in asymptomatic children. Pediatr Infect Dis J. 2012 Dec;31(12):1221–6.
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  - Forman MS, Advani S, Newman C, Gaydos CA, Milstone AM, Valsamakis A. Diagnostic performance of two highly multiplexed respiratory virus assays in a pediatric cohort. J Clin Virol. 2012 Oct;55(2):168–72.
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  - Advani S, Reich NG, Sengupta A, Gosey L, Milstone AM. Central line-associated bloodstream infection in hospitalized children with peripherally inserted central venous catheters: extending risk analyses outside the intensive care unit. Clin Infect Dis. 2011 May;52(9):1108–15.
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- Conference Papers
  - Advani S, Smith B, Seidelman J, Turner N, Hostler C, Anderson DJ, et al. Comparison of Metrics Used to Track CLABSIs and CAUTIs Across a Regional Network. In: Infection Control &Amp; Hospital Epidemiology. Cambridge University Press (CUP); 2020. p. s178–9.
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  - Ling D, Lewis S, Sarubbi C, Moehring R, Advani S, Anderson DJ, et al. Epidemiology of Posttransrectal Prostate Biopsy Bloodstream Infections and Impact of a Screening Program. In: Infection Control & Hospital Epidemiology. Cambridge University Press; 2020. p. s218–9.
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  - Ling D, Seidelman J, Ashley ED, Lewis S, Moehring R, Anderson DJ, et al. Reflex Urine Culture Practices in a Regional Community Hospital Network. In: Infection Control & Hospital Epidemiology. Cambridge University Press; 2020. p. s370–s370.
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Teaching & Mentoring
Teaching Activities
- Healthcare epidemiology at Yale School of Public Health YSPH EMD530 (Healthcare Epidemiology Course)
  
  Infectious Diseases Society of America Antibiotic Stewardship curriculum Workgroup member Basic Antibiotic Stewardship Curriculum and Advanced Stewardship Curriculum which is under development
Scholarly, Clinical, & Service Activities
Presentations & Appearances
Outreach & Engaged Scholarship
Service to the Profession
Academic & Administrative Activities
- University Committees
  2015-2016 House Staff Council, University of Alabama at Birmingham, Birmingham, AL
  2012-2013 House Staff Council, University of Alabama at Birmingham, Montgomery, AL
  2009-2010 Events coordinator, J.B. Grant International Health Society, Johns Hopkins Bloomberg School of Public Health, Baltimore MD
  
  Medical School Committees
  2018-2019 Intern Selection Committee, Yale School of Medicine, New Haven, CT
  2018-2019 Diversity Committee, Yale School of Medicine, New Haven, CT
  2018-2019 DOM Committee, Yale School of Medicine, New Haven, CT
  
  Hospital Boards & Committees
  2019-2019 Member, Sepsis Inpatient Clinical Redesign, Yale New Haven Health System
  2018-2019 Physician Lead, System CAUTI Committee, Yale New Haven Health System
  2017-2019 Alternate Chair, Infection Control Committee, Yale New Haven Hospital
  2017-2019 Co-chair, CAUTI Performance Improvement Team, Yale New Haven Hospital
  2017-2019 Co-chair, CLABSI Performance Improvement Team, Yale New Haven Hospital
  2017-2019 Member, C. difficile Performance Improvement Team, Yale New Haven Hospital
  2017-2019 Member, System CLABSI Committee, Yale New Haven Health System
  2015-2017 Member, Infection Control Committee, University of Alabama at Birmingham Hospital, AL
  2013-2015 Member, Infection Control Committee, Baptist South Medical Center, Montgomery, AL
  
  Regional, State and National Committees
  2017-2019 Member, Connecticut Department of Health (DPH) Reportable Diseases Committee
  2017-2019 Member, Connecticut DPH Healthcare Associated Infections Advisory Committee
  2017-2019 Member, Connecticut DPH Multi-Disciplinary AR/AMS Advisory Group

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Education, Training, & Certifications

Medical Licensure

Previous Appointments & Affiliations

Leadership & Clinical Positions at Duke

Academic Positions Outside Duke

In the News

Awards & Honors

Subject Headings

Selected Grants

Fellowships, Supported Research, & Other Grants

External Relationships

Selected Publications

Academic Articles

Conference Papers

Teaching Activities

Presentations & Appearances

Outreach & Engaged Scholarship

Service to the Profession

Academic & Administrative Activities