Sonali J. Bracken

Journal article Arthritis Rheumatol · August 4, 2026 OBJECTIVE: We evaluated baseline characteristics, treatment patterns, and outcomes in patients with systemic autoimmune rheumatic disease-associated progressive pulmonary fibrosis (SARD-PPF) and evaluated whether outcomes differed by SARD subtype. METHODS: ... Full text Link to item Cite

Revisiting the CD40-CD40L axis: from mechanistic insight to therapeutic renewal in autoimmune disease.

Journal article Curr Opin Rheumatol · May 1, 2026 PURPOSE OF REVIEW: CD40 ligand (CD40L, CD154) is a costimulatory molecule required for adaptive immune responses. It arms CD4 + T cells to provide critical "help" to B cells, dendritic cells, and other antigen-presenting cells through interactions with CD4 ... Full text Link to item Cite

Use of Nintedanib for the Treatment of Systemic Sclerosis-associated Interstitial Lung Disease at Expert Scleroderma Centers in the United States.

Journal article Ann Am Thorac Soc · August 2025 Full text Link to item Cite

What's atypical about human B cells after allogeneic stem cell transplantation?

Journal article J Leukoc Biol · May 7, 2025 Atypical B cells or age-associated B cells represent an alternative lineage of memory B cells. Emerging evidence suggests that context influences the apparent functional heterogeneity of age-associated B cells. While data support a protective role for age- ... Full text Link to item Cite

Heightened TLR7 signaling primes BCR-activated B cells in chronic graft-versus-host disease for effector functions.

Journal article Blood advances · February 2024 AbstractChronic graft-versus-host disease (cGVHD) is a debilitating, autoimmune-like syndrome that can occur after allogeneic hematopoietic stem cell transplantation. Constitutively activated B cells contribute to ongoing alloreactivity and autore ... Full text Open Access Cite

Single-cell landscape analysis unravels molecular programming of the human B cell compartment in chronic GVHD.

Journal article JCI Insight · June 8, 2023 Alloreactivity can drive autoimmune syndromes. After allogeneic hematopoietic stem cell transplantation (allo-HCT), chronic graft-versus-host disease (cGVHD), a B cell-associated autoimmune-like syndrome, commonly occurs. Because donor-derived B cells cont ... Full text Open Access Link to item Cite

A Phase I Trial of SYK Inhibition with Fostamatinib in the Prevention and Treatment of Chronic Graft-Versus-Host Disease.

Journal article Transplant Cell Ther · March 2023 Despite the exciting advancement of novel therapies, chronic graft-versus-host disease (cGVHD) remains the most common cause of non-relapse mortality after allogeneic hematopoietic stem cell transplantation (HCT). Frontline treatment of cGVHD involves syst ... Full text Link to item Cite

A Mimic of Ankylosing Spondylitis, Ochronosis: Case Report and Review of the Literature.

Journal article Curr Allergy Asthma Rep · March 5, 2021 PURPOSE OF REVIEW: Ochronosis and alkaptonuria are manifestations of the same condition-a rare autosomal recessive disorder resulting from a constitutional lack of homogentisate 1,2-dioxygenase (HGD) with the consequent accumulation of homogentisic acid (H ... Full text Open Access Link to item Cite

Autoimmune Theories of Chronic Spontaneous Urticaria.

Journal article Front Immunol · 2019 Urticaria (hives) is a highly prevalent skin disorder that can occur with or without associated angioedema. Chronic spontaneous urticaria (CSU) is a condition which persists for more than 6 weeks in duration and occurs in the absence of an identifiable pro ... Full text Link to item Cite

Early-life antibiotics attenuate regulatory T cell generation and increase the severity of murine house dust mite-induced asthma.

Journal article Pediatr Res · September 2018 INTRODUCTION: Early-life exposure to antibiotics (ABX) has been linked to increases in asthma severity and prevalence in both children and laboratory animals. We explored the immunologic mechanisms behind this association using a mouse model of house dust ... Full text Link to item Cite

Regulation of IgE activity in inhalational tolerance via formation of IgG anti-IgE/IgE immune complexes.

Journal article Clin Mol Allergy · 2018 BACKGROUND: Allergic asthma is an inflammatory disorder of the airways that results from inappropriate production of IgE against harmless, environmental antigens. Sequestration of free IgE using humanized IgG anti-IgE is an effective therapy for asthma and ... Full text Link to item Cite

Breathing Better Through Bugs: Asthma and the Microbiome.

Journal article Yale J Biol Med · September 2016 Asthma is a highly heterogeneous disease characterized by inflammation of the airways, which invokes symptoms such as wheeze, dyspnea, and chest tightness. Asthma is the product of multiple interconnected immunological processes and represents a constellat ... Link to item Cite

Poor Long-Term Efficacy of Prevnar-13 in Sickle Cell Disease Mice Is Associated with an Inability to Sustain Pneumococcal-Specific Antibody Titers.

Journal article PLoS One · 2016 BACKGROUND: One of the most common causes of morbidity and mortality in children with sickle cell disease (SCD) is infection with the pneumococcal bacterium (Streptococcus pneumoniae). Unfortunately, the polysaccharide-conjugate vaccine appears to be less ... Full text Link to item Cite

Long-Term Exposure to House Dust Mite Leads to the Suppression of Allergic Airway Disease Despite Persistent Lung Inflammation.

Journal article Int Arch Allergy Immunol · 2015 BACKGROUND: Allergic asthma is a major cause of worldwide morbidity and results from inadequate immune regulation in response to innocuous, environmental antigens. The need exists to understand the mechanisms that promote nonreactivity to human-relevant al ... Full text Link to item Cite

Transgenic sickle cell disease mice have high mortality and dysregulated immune responses after vaccination.

Journal article Pediatr Res · August 2013 BACKGROUND: Children with sickle cell disease (SCD) are susceptible to recurrent infections, which are often life threatening and necessitate frequent vaccinations. Given the altered baseline immunity and proinflammatory state associated with SCD, we sough ... Full text Link to item Cite