Scholars@Duke
Sophia Dorcheva Sarafova

Sophia Dorcheva Sarafova

Adjunct Associate Professor in the Department of Immunology
Integrative Immunobiology
sophia.sarafova@duke.edu
Immunology, Box 3010, Durham, NC 27710

Scholarly Works - Conferences

Verification of the T-cell developmental stage at which RLM11 and AKR1G1 thymoma cell lines are arrested 9062

Conference The Journal of Immunology · November 1, 2025 Abstract Description A variety of cell lines are used routinely for in vitro studies as fair representation of developmental st ... Full text Cite

Abstract eBook of the 18th International Congress of Immunology

Conference Abstract eBook of the 18th International Congress of Immunology · March 18, 2024 Full text Cite

Contribution of the Microbiome to Maintenance of the CD4:CD8 Ratio in Inbred and Congenic Mouse Strains

Conference The Journal of Immunology · May 1, 2020 AbstractThe gut microbiome is known to play an integral role in the regulation of the immune system. Previous studies indicate that species diversity and overall abundance of commensal bacteria in the gut in ... Full text Cite

Deletion of the highly conserved functional region of the Cd4 enhancer NCE in RLM11 cells using CRISPR/Cas9 reduces CD4 expression

Conference The Journal of Immunology · May 1, 2018 AbstractThe glycoprotein cell surface marker CD4 is a key mediator in the adaptive immune response and T-cell development. Signaled CD4+ CD8+ double positive cells (DP) upregulate CD4 on the cell surface, al ... Full text Cite

Identification of a novel, developmental-stage-specific enhancer in the Cd4 gene (P4442)

Conference The Journal of Immunology · May 1, 2013 AbstractCD4 helper T cells coordinate the immune response and are highly dependent on the expression of the Cd4 gene for proper development and function. The function of a promoter, proximal enhancer, and a ... Full text Cite

Characterization of a Mutant Mouse Strain with Altered Peripheral CD4 T Cell Homeostasis

Conference The mechanisms regulating peripheral CD4+ T cell homeostasis are not completely understood. Previous research at Davidson College has identified a mutant strain of mice with an inverted CD4/CD8 ratio in peripheral lymphoid organs and blood. Furthermore, th ... Link to item Cite

Dysregulated T cell homeostasis in B10.A/Cr mice correlates with decreased T helper function

Conference The mechanisms regulating peripheral T cell homeostasis are not completely understood. During routine screening we discovered that the B10.A/Cr mouse strain in our facility has a reduced frequency of CD4 T cells in the periphery, resulting in a reduced and ... Link to item Cite

Role of APOBEC Family Proteins in Immunoglobulin Class Switch Recombination

Conference Activation-induced cytidine deaminase (AID) functions in activated mammalian B cells to vary antibody effector function via deletion of immunoglobulin constant region DNA in the process of class switch recombination (CSR). AID deaminates cytidine to uridin ... Link to item Cite

Identification of a novel positive cis-control element in the Cd4 gene

Conference CD4 helper T cells coordinate the immune response and are highly dependent on the expression of the Cd4 gene for proper development and function. The function of a promoter, an enhancer and a silencer have been well documented and together explain how the ... Link to item Cite