Scholars@Duke

• Research
• 

  Selected Grants

  • Structures of initial CD4 engagement with pre-fusion, closed HIV-1 Envelope trimer and early CD4-induced conformational changes required for infection awarded by National Institutes of Health 2019 - 2024
  • Structural Biological Development of Fungal-Specific Calcineurin Inhibitors awarded by National Institutes of Health 2014 - 2022
  • Structure, dynamics and evolution of the HIV-1 Phe-43 cavity awarded by National Institutes of Health 2020 - 2021
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Gobeil, Sophie M-C, Katarzyna Janowska, Shana McDowell, Katayoun Mansouri, Robert Parks, Victoria Stalls, Megan F. Kopp, et al. “Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity.” Science (New York, N.Y.) 373, no. 6555 (August 2021). https://doi.org/10.1126/science.abi6226.
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    • Saunders, Kevin O., Esther Lee, Robert Parks, David R. Martinez, Dapeng Li, Haiyan Chen, Robert J. Edwards, et al. “Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses.” Nature 594, no. 7864 (June 2021): 553–59. https://doi.org/10.1038/s41586-021-03594-0.
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    • Williams, Wilton B., R Ryan Meyerhoff, R. J. Edwards, Hui Li, Kartik Manne, Nathan I. Nicely, Rory Henderson, et al. “Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies.” Cell 184, no. 11 (May 27, 2021): 2955-2972.e25. https://doi.org/10.1016/j.cell.2021.04.042.
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    • Martinez, David R., Alexandra Schaefer, Sophie Gobeil, Dapeng Li, Gabriela De la Cruz, Robert Parks, Xiaozhi Lu, et al. “A broadly neutralizing antibody protects against SARS-CoV, pre-emergent bat CoVs, and SARS-CoV-2 variants in mice.” Biorxiv, April 28, 2021. https://doi.org/10.1101/2021.04.27.441655.
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    • Gobeil, Sophie M-C, Katarzyna Janowska, Shana McDowell, Katayoun Mansouri, Robert Parks, Victoria Stalls, Megan F. Kopp, et al. “Effect of natural mutations of SARS-CoV-2 on spike structure, conformation and antigenicity.” Biorxiv, March 15, 2021. https://doi.org/10.1101/2021.03.11.435037.
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    • Li, Dapeng, Robert J. Edwards, Kartik Manne, David R. Martinez, Alexandra Schäfer, S Munir Alam, Kevin Wiehe, et al. “The functions of SARS-CoV-2 neutralizing and infection-enhancing antibodies in vitro and in mice and nonhuman primates.” Biorxiv, February 18, 2021. https://doi.org/10.1101/2020.12.31.424729.
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    • Saunders, Kevin O., Esther Lee, Robert Parks, David R. Martinez, Dapeng Li, Haiyan Chen, Robert J. Edwards, et al. “SARS-CoV-2 vaccination induces neutralizing antibodies against pandemic and pre-emergent SARS-related coronaviruses in monkeys.” Biorxiv, February 17, 2021. https://doi.org/10.1101/2021.02.17.431492.
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    • Edwards, Robert J., Katayoun Mansouri, Victoria Stalls, Kartik Manne, Brian Watts, Rob Parks, Katarzyna Janowska, et al. “Cold sensitivity of the SARS-CoV-2 spike ectodomain.” Nat Struct Mol Biol 28, no. 2 (February 2021): 128–31. https://doi.org/10.1038/s41594-020-00547-5.
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    • Edwards, Robert J., Katayoun Mansouri, Victoria Stalls, Kartik Manne, Brian Watts, Rob Parks, Katarzyna Janowska, et al. “Cold sensitivity of the SARS-CoV-2 spike ectodomain.” Biorxiv, October 13, 2020. https://doi.org/10.1101/2020.07.12.199588.
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    • Gobeil, Sophie, Katarzyna Janowska, Shana McDowell, Katayoun Mansouri, Robert Parks, Kartik Manne, Victoria Stalls, et al. “D614G mutation alters SARS-CoV-2 spike conformational dynamics and protease cleavage susceptibility at the S1/S2 junction.” Biorxiv, October 12, 2020. https://doi.org/10.1101/2020.10.11.335299.
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    • Henderson, Rory, Robert J. Edwards, Katayoun Mansouri, Katarzyna Janowska, Victoria Stalls, Sophie M. C. Gobeil, Megan Kopp, et al. “Controlling the SARS-CoV-2 spike glycoprotein conformation.” Nat Struct Mol Biol 27, no. 10 (October 2020): 925–33. https://doi.org/10.1038/s41594-020-0479-4.
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    • Henderson, Rory, Robert J. Edwards, Katayoun Mansouri, Katarzyna Janowska, Victoria Stalls, Sophie Gobeil, Megan Kopp, et al. “Controlling the SARS-CoV-2 Spike Glycoprotein Conformation.” Biorxiv, May 18, 2020. https://doi.org/10.1101/2020.05.18.102087.
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    • Gobeil, Sophie M-C, Benjamin Bobay, Praveen Juvvadi, Christopher Cole, Joseph Heitman, William Steinbach, Ronald Venters, and Leonard Spicer. “Leveraging Fungal Calcineurin-Inhibitor Structures, Biophysics and Dynamics to Design Selective and Non-Immunosuppressive FK506 Analogs,” April 15, 2020. https://doi.org/10.1101/2020.04.14.039800.
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    • Juvvadi, Praveen R., David Fox, Benjamin G. Bobay, Michael J. Hoy, Sophie M. C. Gobeil, Ronald A. Venters, Zanetta Chang, et al. “Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents.” Nat Commun 10, no. 1 (September 19, 2019): 4275. https://doi.org/10.1038/s41467-019-12199-1.
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    • Gobeil, Sophie M. C., Maximillian C. C. J. C. Ebert, Jaeok Park, Donald Gagné, Nicolas Doucet, Albert M. Berghuis, Jürgen Pleiss, and Joelle N. Pelletier. “The Structural Dynamics of Engineered β-Lactamases Vary Broadly on Three Timescales yet Sustain Native Function.” Scientific Reports 9, no. 1 (April 30, 2019): 6656. https://doi.org/10.1038/s41598-019-42866-8.
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    • Gobeil, Sophie M. C., Benjamin G. Bobay, Leonard D. Spicer, and Ronald A. Venters. “15N, 13C and 1H resonance assignments of FKBP12 proteins from the pathogenic fungi Mucor circinelloides and Aspergillus fumigatus.” Biomol Nmr Assign 13, no. 1 (April 2019): 207–12. https://doi.org/10.1007/s12104-019-09878-x.
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    • Gobeil, Sophie M. C., Donald Gagné, Nicolas Doucet, and Joelle N. Pelletier. “15N, 13C and 1H backbone resonance assignments of an artificially engineered TEM-1/PSE-4 class A β-lactamase chimera and its deconvoluted mutant.” Biomolecular Nmr Assignments 10, no. 1 (April 2016): 93–99. https://doi.org/10.1007/s12104-015-9645-8.
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    • Gobeil, Sophie M. C., Christopher M. Clouthier, Jaeok Park, Donald Gagné, Albert M. Berghuis, Nicolas Doucet, and Joelle N. Pelletier. “Maintenance of native-like protein dynamics may not be required for engineering functional proteins.” Chemistry & Biology 21, no. 10 (October 2014): 1330–40. https://doi.org/10.1016/j.chembiol.2014.07.016.
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    • Clouthier, Christopher M., Sébastien Morin, Sophie M. C. Gobeil, Nicolas Doucet, Jonathan Blanchet, Elisabeth Nguyen, Stéphane M. Gagné, and Joelle N. Pelletier. “Chimeric β-lactamases: global conservation of parental function and fast time-scale dynamics with increased slow motions.” Plos One 7, no. 12 (January 2012): e52283. https://doi.org/10.1371/journal.pone.0052283.
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    • Morin, Sébastien, Christopher M. Clouthier, Sophie Gobeil, Joelle N. Pelletier, and Stéphane M. Gagné. “Backbone resonance assignments of an artificially engineered TEM-1/PSE-4 Class A β-lactamase chimera.” Biomolecular Nmr Assignments 4, no. 2 (October 2010): 127–30. https://doi.org/10.1007/s12104-010-9227-8.
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