Mark Stafford-Smith

Journal article Adv Chronic Kidney Dis · July 2008 Featured Publication Kidney dysfunction is common after cardiac surgery and predicts mortality risk and poorer long-term outcome, particularly when acute injury superimposes upon chronic kidney disease. Numerous insults contribute to perioperative renal impairment including ma ... Full text Link to item Cite

The effect of aprotinin on outcome after coronary-artery bypass grafting.

Journal article N Engl J Med · February 21, 2008 Featured Publication BACKGROUND: Aprotinin has recently been associated with adverse outcomes in patients undergoing cardiac surgery. We reviewed our experience with this agent in patients undergoing cardiac surgery at Duke University Medical Center. METHODS: We retrieved data ... Full text Link to item Cite

Trends in acute renal failure associated with coronary artery bypass graft surgery in the United States.

Journal article Crit Care Med · October 2007 Featured Publication OBJECTIVE: Acute renal failure remains a major complication of coronary artery bypass graft surgery that is strongly associated with in-hospital mortality. Based on similar observations in other clinical settings, we tested the hypothesis that the diagnosi ... Full text Link to item Cite

Efficacy and safety of heparinase I versus protamine in patients undergoing coronary artery bypass grafting with and without cardiopulmonary bypass.

Journal article Anesthesiology · August 2005 Featured Publication BACKGROUND: Hemodynamic protamine reactions with heparin reversal during cardiac surgery are common and associated with adverse outcomes. As an alternative to protamine, the authors examined heparinase I reversal of heparin after aortocoronary bypass graft ... Full text Link to item Cite

Genetic factors contribute to bleeding after cardiac surgery.

Journal article J Thromb Haemost · June 2005 Featured Publication BACKGROUND: Postoperative bleeding remains a common, serious problem for cardiac surgery patients, with striking inter-patient variability poorly explained by clinical, procedural, and biological markers. OBJECTIVE: We tested the hypothesis that genetic po ... Full text Link to item Cite

Association of genetic polymorphisms with risk of renal injury after coronary bypass graft surgery.

Journal article Am J Kidney Dis · March 2005 Featured Publication BACKGROUND: Post-cardiac surgery renal dysfunction is a common, serious, multifactorial disorder, with interpatient variability predicted poorly by preoperative clinical, procedural, and biological markers. Therefore, we tested the hypothesis that selected ... Full text Link to item Cite

Hemodynamic changes after protamine administration: association with mortality after coronary artery bypass surgery.

Journal article Anesthesiology · February 2005 Featured Publication BACKGROUND: Protamine sulfate is standard therapy to reverse heparin anticoagulation. Hemodynamic responses to protamine are common, ranging from minor perturbations to cardiovascular collapse. Although severe fatal reactions occur, the relation of less ex ... Full text Link to item Cite