Scholars@Duke
Stanley J. Robboy

Stanley J. Robboy

Professor Emeritus of Pathology
Pathology
stanley.robboy@duke.edu
Duke Box 3712, Durham, NC 27710
M227 Davison Bldg, Durham, NC 27710

Featured Works

The villous stromal constituents of complete hydatidiform mole differ histologically in very early pregnancy from the normally developing placenta.

Journal article Am J Surg Pathol · February 2009 Featured Publication Histologic distinction between complete hydatidiform moles and nonmolar abortuses in early pregnancy is often extremely difficult. This study details the chronologic changes that occur in normal placenta, especially in the villous stroma during gestational ... Full text Link to item Cite

Cervical screening and general physical examination behaviors of women exposed in utero to diethylstilbestrol.

Journal article J Low Genit Tract Dis · April 2008 Featured Publication OBJECTIVE: To estimate whether women exposed in utero to diethylstilbestrol (DES) report receiving more cervical and general physical examinations compared to unexposed women. MATERIALS AND METHODS: 1994 Diethylstilbestrol Adenosis cohort data are used to ... Full text Link to item Cite

The association between in utero cigarette smoke exposure and age at menopause.

Journal article Am J Epidemiol · March 15, 2008 Featured Publication Menopause onset, on average, occurs earlier among women who smoke cigarettes than among women who do not smoke. Prenatal smoke exposure may also influence age at menopause through possible effects on follicle production in utero. Smoking information was ob ... Full text Link to item Cite

Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in human uterine leiomyomas.

Journal article Mol Med · 2008 Featured Publication Uterine leiomyomas (fibroids) are benign tumors that are prevalent in women of reproductive age. Research suggests that activated receptor tyrosine kinases (RTKs) play an important role in the enhanced proliferation observed in fibroids. In this study, a p ... Full text Link to item Cite

A primer of endometrial cytology with histological correlation.

Journal article Diagn Cytopathol · December 2007 Featured Publication Cytology is an effective method for assessing benign endometrium and for discovering premalignant and malignant endometrial states. In addition, it is useful for diagnosing non-neoplastic abnormalities of the endometrium. This overview compares endometrial ... Full text Link to item Cite

Cancer risk in women prenatally exposed to diethylstilbestrol.

Journal article Int J Cancer · July 15, 2007 Featured Publication Prenatal diethylstilbestrol (DES) exposure is associated with excess risks of clear cell adenocarcinoma (CCA), and breast cancer in older women. Whether overall cancer risk is also elevated is unclear. Total and site-specific cancer risks were evaluated in ... Full text Link to item Cite

Preeclampsia risk in women exposed in utero to diethylstilbestrol.

Journal article Obstet Gynecol · July 2007 Featured Publication OBJECTIVE: To assess whether preeclampsia risk is elevated in pregnancies of diethylstilbestrol (DES)-exposed daughters. METHODS: This study used data from the National Cancer Institute DES Combined Cohorts Follow-up Study. A total of 285 preeclampsia case ... Full text Link to item Cite

Benign endometrial hyperplasia sequence and endometrial intraepithelial neoplasia.

Journal article Int J Gynecol Pathol · April 2007 Featured Publication Endometrial "hyperplasia," as currently diagnosed, includes the changes caused by an abnormal hormonal state and those caused by a separate category of monoclonal premalignant disease. The appearance of the disease in these 2 functional categories is disco ... Full text Link to item Cite

Neoplasms and pathology of sexual developmental disorders (intersex).

Journal article Pathology · February 2007 Featured Publication Continuing new insights into the biology of sexual development and advances in chromosome analysis have led to early identification and prompt treatment of the intersexual patient, the results of which facilitate a more normal life for affected individuals ... Full text Link to item Cite

Dynamic behavioural interpretation of cervical intraepithelial neoplasia with molecular biomarkers.

Journal article J Clin Pathol · October 2006 Featured Publication The microscopic phenotype of cervical intraepithelial neoplasia (CIN) reflects a fine balance between factors that promote or reduce CIN development. A shortcoming of the current grading system is its reliance on static morphology and microscopic haematoxy ... Full text Link to item Cite

Transtubal spread of serous adenocarcinoma of the endometrium: an underrecognized mechanism of metastasis.

Journal article Int J Gynecol Pathol · April 2006 Featured Publication Most endometrial carcinomas metastasize by invading myometrial lymphatics and spreading to regional lymph nodes. However, uterine serous carcinomas (USCs) metastasize frequently to peritoneal surfaces even when only minimally invasive. This study examines ... Full text Link to item Cite

Lymphoma of the female genital tract: current status.

Journal article Int J Gynecol Pathol · January 2006 Featured Publication : Primary lymphomas affecting the female reproductive system are uncommon but often pose a diagnostic challenge if their existence is not suspected. This article reviews the pathological and clinical features of lymphomas occurring in various sites in the ... Full text Link to item Cite

Differential expression of p63 isoforms in female reproductive organs.

Journal article Mech Dev · September 2005 Featured Publication p63 is the identity switch for uterine/vaginal epithelial cell fate, and disruption of p63 expression by diethylstilbestrol (DES) induces cervical/vaginal adenosis in mice. In this article, we report the expression patterns of p63 isoforms (TA, DeltaN, alp ... Full text Link to item Cite

A diagnostically useful histopathologic feature of endometrial polyp: the long axis of endometrial glands arranged parallel to surface epithelium.

Journal article Am J Surg Pathol · August 2004 Featured Publication We describe a histologic feature useful in the diagnosis of endometrial polyps, namely, the parallel arrangement of the endometrial glands' long axis to the surface epithelium (PGE). Polyps that are removed intact are usually easy to diagnose because of th ... Full text Link to item Cite

Mucinous adenocarcinoma arising in rectovaginal fistulas associated with Crohn's disease.

Journal article Gynecol Oncol · April 2004 Featured Publication BACKGROUND: Crohn's disease is a chronic inflammatory disorder characterized by focal, transmural inflammation of the intestine. Gynecologic involvement, including rectovaginal fistula formation, is frequent. Case #1. A 53-year-old female with a 30-year hi ... Full text Link to item Cite

Placental site trophoblastic tumor arising from antecedent molar pregnancy.

Journal article Gynecol Oncol · February 2004 Featured Publication OBJECTIVE: Placental site trophoblastic tumor (PSTT) is a rare form of gestational trophoblastic disease. Little is known about its pathogenesis and natural history. METHODS: This report describes two cases that arose in patients with documented complete h ... Full text Link to item Cite

Prognostic value and reproducibility of koilocytosis in cervical intraepithelial neoplasia.

Journal article Int J Gynecol Pathol · July 2003 Featured Publication The purpose of this study was to evaluate the influence of koilocytosis on the progression of cervical intraepithelial neoplasia (CIN) to a higher grade during follow-up in cervical biopsy specimens with CIN 1 and 2. In adequate, consecutive, biopsy specim ... Full text Link to item Cite

Embolic microspheres within ovarian arterial vasculature after uterine artery embolization.

Journal article Obstet Gynecol · November 2002 Featured Publication BACKGROUND: Adverse events after uterine artery embolization, including hysterectomy and premature ovarian failure, are concerning for women who desire future fertility. CASE: A 39-year-old woman underwent emergency hysterectomy after uterine artery emboli ... Full text Link to item Cite

Cell proliferation and apoptosis in human uterine leiomyomas and myometria.

Journal article Virchows Arch · July 2002 Featured Publication To determine the role of cell proliferation and apoptosis in uterine leiomyoma growth, we studied protein expression of two major regulatory proteins of apoptosis -- Bcl-2 (anti-apoptotic) and Bax (pro-apoptotic) -- and two endogenous markers of cell repli ... Full text Link to item Cite

Incidence of squamous neoplasia of the cervix and vagina in women exposed prenatally to diethylstilbestrol (United States).

Journal article Cancer Causes Control · November 2001 Featured Publication OBJECTIVES: Women exposed prenatally to diethylstibestrol (DES) have an excess risk of clear-cell adenocarcinoma of the vagina and cervix, but the effect on the incidence of squamous neoplasia is uncertain. The purpose of the current study was to evaluate ... Full text Link to item Cite

Cancer risk in men exposed in utero to diethylstilbestrol.

Journal article J Natl Cancer Inst · April 4, 2001 Featured Publication BACKGROUND: An association between prenatal diethylstilbestrol (DES) exposure and cancer in men, especially testicular cancer, has been suspected, but findings from case-control studies have been inconsistent. This study was conducted to investigate the as ... Full text Link to item Cite

Malignancy in endometriosis: frequency and comparison of ovarian and extraovarian types.

Journal article Int J Gynecol Pathol · April 2001 Featured Publication One thousand consecutive cases of surgically proven endometriosis were reviewed to evaluate the frequency and types of pelvic cancers that were associated with ovarian and extraovarian endometriosis. The frequency and types of histologic abnormalities pres ... Full text Link to item Cite

K-ras mutations in Müllerian inclusion cysts associated with serous borderline tumors of the ovary.

Journal article Gynecol Oncol · February 2001 Featured Publication OBJECTIVE: Müllerian inclusion cysts (MIC) are small benign appearing glands that are occasionally noted in lymph nodes and peritoneal biopsies. They occur most frequently in women with serous ovarian tumors, with borderline tumors (SBOT) having a higher i ... Full text Link to item Cite

BOOK REVIEWS.

Journal article Int J Gynecol Pathol · January 2001 Featured Publication Link to item Cite

Pathology and pathophysiology of uterine smooth-muscle tumors.

Journal article Environ Health Perspect · October 2000 Featured Publication Smooth-muscle tumors of uterine origin encompass a broad family of neoplasms. The leiomyoma, by far the most common of all the neoplasms, generally is hormone sensitive, with rates of growth semiquantitatively related to estrogen and progesterone receptor ... Full text Link to item Cite

Bladder cancer: race differences in extent of disease at diagnosis.

Journal article Cancer · September 15, 2000 Featured Publication BACKGROUND: Blacks are less likely than whites to develop bladder cancer; although once diagnosed, blacks experience poorer survival. This study sought to examine multiple biological and behavioral factors and their influence on extent of disease. METHODS: ... Full text Link to item Cite

Some mullerian inclusion cysts in lymph nodes may sometimes be metastases from serous borderline tumors of the ovary.

Journal article Am J Surg Pathol · May 2000 Featured Publication Glandular inclusions that appear morphologically benign are occasionally found in lymph nodes as well as in peritoneal and omental biopsies. In patients with gynecologic malignancies, the nature and significance of these mullerian inclusion cysts (MIC) pre ... Full text Link to item Cite

The outcome of stage I-II clinically and surgically staged papillary serous and clear cell endometrial cancers when compared with endometrioid carcinoma.

Journal article Gynecol Oncol · April 2000 Featured Publication PURPOSE: The aim of this study was to compare survival and recurrence in clinical and surgical stage I-II papillary serous (PS), clear cell (CC), and endometrioid (EM) cancers of the endometrium and examine the prognostic utility of myometrial invasion. ME ... Full text Link to item Cite