Eugene William St. Clair

Journal article J Rheumatol · June 2011 Featured Publication OBJECTIVE: There remains a need for biomarkers to guide therapy in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Our objective was to determine whether measures of platelet activation or inflammation are associated with disease activity ... Full text Link to item Cite

Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells.

Journal article Blood · January 13, 2011 Featured Publication Regulatory B cells control inflammation and autoimmunity in mice, including the recently identified IL-10-competent B10 cell subset that represents 1% to 3% of spleen B cells. In this study, a comparable IL-10-competent B10 cell subset was characterized in ... Full text Link to item Cite

Alpha₁-antitrypsin deficiency-related alleles Z and S and the risk of Wegener's granulomatosis.

Journal article Arthritis Rheum · December 2010 Featured Publication OBJECTIVE: Deficiency of α(1) -antitrypsin (α(1) AT) may be a determinant of susceptibility to Wegener's granulomatosis (WG). Several previous, mainly small, case-control studies have shown that 5-27% of patients with WG carried the α(1) AT deficiency Z al ... Full text Link to item Cite

Analysis of the workforce and workplace for rheumatology and the research activities of rheumatologists early in their careers.

Journal article Arthritis Rheum · December 2010 Featured Publication OBJECTIVE: To assess the workforce and workplace in rheumatology, and the research work of early-career rheumatologists. METHODS: Early-career rheumatologists were defined as practicing physicians who joined the American College of Rheumatology (ACR) in 19 ... Full text Link to item Cite

The Immune Tolerance Network at 10 years: tolerance research at the bedside.

Journal article Nat Rev Immunol · November 2010 Featured Publication Immune tolerance-inducing therapies reprogramme immune cells to eliminate pathogenic immune responses while preserving protective immunity. The Immune Tolerance Network (ITN), sponsored by the US National Institutes of Health, was established in 1999 to ev ... Full text Link to item Cite

Rituximab versus cyclophosphamide for ANCA-associated vasculitis.

Journal article N Engl J Med · July 15, 2010 Featured Publication BACKGROUND: Cyclophosphamide and glucocorticoids have been the cornerstone of remission-induction therapy for severe antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis for 40 years. Uncontrolled studies suggest that rituximab is effective and ... Full text Link to item Cite

Good and bad memories following rituximab therapy.

Journal article Arthritis Rheum · January 2010 Featured Publication Full text Link to item Cite

Novel targeted therapies for autoimmunity.

Journal article Curr Opin Immunol · December 2009 Featured Publication The emergence of new targeted therapies is rapidly improving the treatment of autoimmune disease. These drugs have been variably designed to deplete specific T and B cell subsets, interrupt receptor-ligand interactions, and inhibit the activity of inflamma ... Full text Link to item Cite

Progression of radiographic joint damage in rheumatoid arthritis: independence of erosions and joint space narrowing.

Journal article Ann Rheum Dis · October 2009 Featured Publication OBJECTIVE: To compare the progression of erosions and joint space narrowing (JSN) in patients with early active rheumatoid arthritis (RA) using data obtained in the "Active-controlled Study of Patients receiving Infliximab for the treatment of Rheumatoid a ... Full text Link to item Cite

A pilot risk model for the prediction of rapid radiographic progression in rheumatoid arthritis.

Journal article Rheumatology (Oxford) · September 2009 Featured Publication OBJECTIVES: Identifying patients with RA at high risk of rapid radiographic progression (RRP) is critical for making appropriate treatment decisions. We developed an exploratory prediction model for the risk of RRP using an RA study population undergoing e ... Full text Link to item Cite

T cell large granular lymphocyte leukemia associated with rheumatoid arthritis and neutropenia.

Journal article Clin Immunol · August 2009 Featured Publication T cell large granular lymphocyte leukemia (T-LGL) is a disease characterized by clonal expansion of cytotoxic T cells (CTLs). It generally follows an indolent course and is notable for an association with chronic inflammation, neutropenia and rheumatoid ar ... Full text Link to item Cite

Radiographic changes in rheumatoid arthritis patients attaining different disease activity states with methotrexate monotherapy and infliximab plus methotrexate: the impacts of remission and tumour necrosis factor blockade.

Journal article Ann Rheum Dis · June 2009 Featured Publication OBJECTIVE: To examine the association of radiographic progression and disease activity states in patients with rheumatoid arthritis (RA) treated with methotrexate with or without infliximab. METHODS: Patients (n = 1049) with active RA for 3 years or less a ... Full text Link to item Cite

Glycosylation of proteinase 3 (PR3) is not required for its reactivity with antineutrophil cytoplasmic antibodies (ANCA) in Wegener's granulomatosis.

Journal article Clin Exp Rheumatol · 2009 Featured Publication OBJECTIVE: The glycosylation status of autoantigens appears to be crucial for the pathogenesis of some autoimmune diseases, since carbohydrates play a crucial role in the distinction of self from non-self. Proteinase 3 (PR3), the main target antigen for an ... Link to item Cite

Assessment of the item selection and weighting in the Birmingham vasculitis activity score for Wegener's granulomatosis.

Journal article Arthritis Rheum · June 15, 2008 Featured Publication OBJECTIVE: To assess the Birmingham Vasculitis Activity Score for Wegener's Granulomatosis (BVAS/WG) with respect to its selection and weighting of items. METHODS: This study used the BVAS/WG data from the Wegener's Granulomatosis Etanercept Trial. The sco ... Full text Link to item Cite

B-lymphocyte contributions to human autoimmune disease.

Journal article Immunol Rev · June 2008 Featured Publication Autoimmunity results from abnormal B- and T-cell recognition of self-antigens, which leads to autoantibody production in many cases. Autoantibodies produced by B-cell-derived plasma cells provide diagnostic markers for autoimmunity but also contribute sign ... Full text Link to item Cite

Effects of glucocorticoids on weight change during the treatment of Wegener's granulomatosis.

Journal article Arthritis Rheum · May 15, 2008 Featured Publication OBJECTIVE: Weight gain is a side effect of glucocorticoid (GC) use, but the natural history and health implications of changes in weight that occur during the treatment of inflammatory disease are not understood. METHODS: We evaluated data from the Wegener ... Full text Link to item Cite

Comparison of employability outcomes among patients with early or long-standing rheumatoid arthritis.

Journal article Arthritis Rheum · April 15, 2008 Featured Publication OBJECTIVE: To compare employability between patients with early and long-standing rheumatoid arthritis (RA) and examine the relationships between improvement in employability and disease stage after adjustment for demographic characteristics, disease activ ... Full text Link to item Cite

The calm after the cytokine storm: lessons from the TGN1412 trial.

Journal article J Clin Invest · April 2008 Featured Publication In March 2006, a phase I study of the superagonistic anti-CD28 antibody TGN1412 caused a massive cytokine storm and multiorgan failure in six healthy human volunteers. Such a profound impact on the immune system was not predicted by preclinical animal stud ... Full text Link to item Cite

Evaluating the adequacy of disease control in patients with rheumatoid arthritis: a RAND appropriateness panel.

Journal article Rheumatology (Oxford) · February 2008 Featured Publication OBJECTIVES: There is a lack of agreement on assessing disease activity in patients with RA and determining when the RA treatment should be changed or continued. A panel of rheumatologists was convened to develop guidelines to assess adequacy of disease con ... Full text Link to item Cite

B cell-directed therapies for autoimmune disease and correlates of disease response and relapse.

Journal article J Allergy Clin Immunol · January 2008 Featured Publication Recent advances have led to the development of mAbs that effectively deplete B cells in human beings and target pathways essential for B-cell development. B cell-directed therapies represent promising treatments for autoimmune disorders, although many ques ... Full text Link to item Cite