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Stephen Greene

Associate Professor of Medicine
Medicine, Cardiology

Overview


I am a cardiologist with a clinical and research interest in heart failure. I take care of patients with various types of heart failure, including patients who are best treated with medications and patients who receive advanced therapies like heart transplantation and mechanical assist devices. I became a heart failure cardiologist to help patients manage their heart conditions and best achieve their goals for their health. I am strongly committed to helping patients thoroughly understand their medical conditions and helping them make informed medical decisions aligned with their preferences.

My research interests are focused on strategies and therapies to improve outcomes and quality of life for patients with heart failure. This involves research through clinical trials and through examining data from real-world clinical practice. Below, you will find my specific research interests:

  • Use and dosing of evidence-based heart failure medications
  • Management of worsening heart failure outside the hospital
  • Novel pharmacological and non-pharmacological approaches to heart failure
  • Improving outcomes following a hospitalization for heart failure
  • Surrogate and nonfatal endpoints in heart failure clinical trials
  • Clinical trial design and operations
  • Improving site-based heart failure research

Current Appointments & Affiliations


Associate Professor of Medicine · 2024 - Present Medicine, Cardiology, Medicine
Member in the Duke Clinical Research Institute · 2020 - Present Duke Clinical Research Institute, Institutes and Centers

In the News


Published May 27, 2025
New Dosing Can Reduce Risk of Heart Failure

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Recent Publications


Stroke mortality in the United States from 1968 to 2023: A CDC WONDER analysis.

Journal Article Int J Stroke · April 2026 BACKGROUND: Stroke remains a leading cause of mortality in the United States, with evolving epidemiologic patterns over five decades. This study analyzes stroke mortality trends from 1968 to 2023, focusing on disparities across age, sex, race, and geograph ... Full text Link to item Cite
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Recent Grants


PARACOR-19

Clinical TrialPrincipal Investigator · Awarded by Novartis Pharmaceuticals Corporation · 2021 - 2027

REFOCUS-HTN US

Clinical TrialPrincipal Investigator · Awarded by AstraZeneca Pharmaceuticals, LP · 2025 - 2027

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Education


Northwestern University, Feinberg School of Medicine · 2012 M.D.