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Stephen D Mague

Assistant Professor in Psychiatry and Behavioral Sciences
Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences
3209, Bryan Research Building; Rm 361, Durham, NC 27710
3209, Bryan Research Building; Rm 421, Durham, NC 27710

Current Duke Appointments & Affiliations


Assistant Professor in Psychiatry and Behavioral Sciences · 2021 - Present Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences, Psychiatry & Behavioral Sciences

Recent Scholarly Works


Long-term editing of brain circuits using an engineered electrical synapse.

Journal article Nature · May 13, 2026 Electrical signalling across distinct populations of brain cells underpins cognitive and emotional function. However, approaches that selectively regulate electrical signalling between two cellular components of a mammalian neural circuit remain sparse. He ... Full text Link to item Cite

Sleep-Wake States Are Encoded across Emotion Regulation Regions of the Mouse Brain.

Journal article eNeuro · November 2025 Emotional dysregulation is highly comorbid with sleep disturbances. Sleep is composed of unique physiological states that are reflected by conserved brain oscillations. Though the role of these state-dependent oscillations in cognitive function has been we ... Full text Link to item Cite

Electome network factors: Capturing emotional brain networks related to health and disease.

Journal article Cell Rep Methods · January 22, 2024 Therapeutic development for mental disorders has been slow despite the high worldwide prevalence of illness. Unfortunately, cellular and circuit insights into disease etiology have largely failed to generalize across individuals that carry the same diagnos ... Full text Link to item Cite
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Recent Grants


Editing affective network relays to prevent stress induced behavioral pathology

ResearchCo Investigator · Awarded by Hope for Depression Research Foundation · 2026 - 2029

Precise neural circuit editing using engineered electrical synapses

ResearchResearch Scientist · Awarded by National Institutes of Health · 2022 - 2027

MULTIREGIONAL ELECTRICAL ENCODING OF SOCIAL AGGRESSION

ResearchCo Investigator · Awarded by National Institute of Mental Health · 2021 - 2026

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Education


University of Pennsylvania · 2011 Ph.D.