Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., University of Pennsylvania 2011
• 

  Previous Appointments & Affiliations

  • Assistant Professor -Track V in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2020
• Research
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  Selected Grants

  • Precise neural circuit editing using engineered electrical synapses awarded by National Institutes of Health 2022 - 2027
  • MULTIREGIONAL ELECTRICAL ENCODING OF SOCIAL AGGRESSION awarded by National Institutes of Health 2021 - 2026
  • Dissecting and modifying temporal dynamics underlying stress dysfunction awarded by National Institutes of Health 2019 - 2024
  • Reversing Brain Network Mechanisms Underlying Depression Vulnerability and Depression Pathology awarded by Hope for Depression Research Foundation 2020 - 2023
  • Environmental Toxins and Microglia-Synapse Interactions in Autism awarded by National Institutes of Health 2016 - 2021
  • Multilevel integration to understand, treat, and prevent depression awarded by Hope for Depression Research Foundation 2019 - 2020
  • Enabling Stress Resistance awarded by National Institutes of Health 2012 - 2018
  • A novel neural circuit analysis paradigm to model autism in mice awarded by National Institutes of Health 2014 - 2017
• Publications & Artistic Works
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  Selected Publications

  • Academic Articles

    • Block, Carina L., Oznur Eroglu, Stephen D. Mague, Caroline J. Smith, Alexis M. Ceasrine, Chaichontat Sriworarat, Cameron Blount, et al. “Prenatal environmental stressors impair postnatal microglia function and adult behavior in males.” Cell Rep 40, no. 5 (August 2, 2022): 111161. https://doi.org/10.1016/j.celrep.2022.111161.
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    • Mague, Stephen D., Austin Talbot, Cameron Blount, Kathryn K. Walder-Christensen, Lara J. Duffney, Elise Adamson, Alexandra L. Bey, et al. “Brain-wide electrical dynamics encode individual appetitive social behavior.” Neuron 110, no. 10 (May 18, 2022): 1728-1741.e7. https://doi.org/10.1016/j.neuron.2022.02.016.
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    • Hultman, Rainbo, Kyle Ulrich, Benjamin D. Sachs, Cameron Blount, David E. Carlson, Nkemdilim Ndubuizu, Rosemary C. Bagot, et al. “Brain-wide Electrical Spatiotemporal Dynamics Encode Depression Vulnerability.” Cell 173, no. 1 (March 22, 2018): 166-180.e14. https://doi.org/10.1016/j.cell.2018.02.012.
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    • Carlson, David, Lisa K. David, Neil M. Gallagher, Mai-Anh T. Vu, Matthew Shirley, Rainbo Hultman, Joyce Wang, et al. “Dynamically Timed Stimulation of Corticolimbic Circuitry Activates a Stress-Compensatory Pathway.” Biol Psychiatry 82, no. 12 (December 15, 2017): 904–13. https://doi.org/10.1016/j.biopsych.2017.06.008.
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    • Hultman, Rainbo, Stephen D. Mague, Qiang Li, Brittany M. Katz, Nadine Michel, Lizhen Lin, Joyce Wang, et al. “Dysregulation of Prefrontal Cortex-Mediated Slow-Evolving Limbic Dynamics Drives Stress-Induced Emotional Pathology.” Neuron 91, no. 2 (July 20, 2016): 439–52. https://doi.org/10.1016/j.neuron.2016.05.038.
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    • Russell, Shayla E., Daniel J. Puttick, Allison M. Sawyer, David N. Potter, Stephen Mague, William A. Carlezon, and Elena H. Chartoff. “Nucleus Accumbens AMPA Receptors Are Necessary for Morphine-Withdrawal-Induced Negative-Affective States in Rats.” J Neurosci 36, no. 21 (May 25, 2016): 5748–62. https://doi.org/10.1523/JNEUROSCI.2875-12.2016.
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    • Wang, Xiaoming, Alexandra L. Bey, Brittany M. Katz, Alexandra Badea, Namsoo Kim, Lisa K. David, Lara J. Duffney, et al. “Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism.” Nat Commun 7 (May 10, 2016): 11459. https://doi.org/10.1038/ncomms11459.
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    • Mague, Stephen D., Russell G. Port, Michael E. McMullen, Greg C. Carlson, and Jill R. Turner. “Mouse model of OPRM1 (A118G) polymorphism has altered hippocampal function.” Neuropharmacology 97 (October 2015): 426–35. https://doi.org/10.1016/j.neuropharm.2015.04.032.
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    • Huang, Peng, Chongguang Chen, Stephen D. Mague, Julie A. Blendy, and Lee-Yuan Liu-Chen. “A common single nucleotide polymorphism A118G of the μ opioid receptor alters its N-glycosylation and protein stability.” Biochem J 441, no. 1 (January 1, 2012): 379–86. https://doi.org/10.1042/BJ20111050.
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    • Mague, Stephen D., and Julie A. Blendy. “OPRM1 SNP (A118G): involvement in disease development, treatment response, and animal models.” Drug Alcohol Depend 108, no. 3 (May 1, 2010): 172–82. https://doi.org/10.1016/j.drugalcdep.2009.12.016.
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    • Isiegas, Carolina, Stephen D. Mague, and Julie A. Blendy. “Sex differences in response to nicotine in C57Bl/6:129SvEv mice.” Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco 11, no. 7 (July 2009): 851–58. https://doi.org/10.1093/ntr/ntp076.
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    • Mague, Stephen D., Carolina Isiegas, Peng Huang, Lee-Yuan Liu-Chen, Caryn Lerman, and Julie A. Blendy. “Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior.” Proc Natl Acad Sci U S A 106, no. 26 (June 30, 2009): 10847–52. https://doi.org/10.1073/pnas.0901800106.
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    • Chartoff, Elena H., Matthew F. Barhight, Steve D. Mague, Allison M. Sawyer, and William A. Carlezon. “Anatomically dissociable effects of dopamine D1 receptor agonists on reward and relief of withdrawal in morphine-dependent rats.” Psychopharmacology (Berl) 204, no. 2 (June 2009): 227–39. https://doi.org/10.1007/s00213-008-1454-7.
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    • Carr, Gregory V., and Stephen D. Mague. “p38: the link between the kappa-opioid receptor and dysphoria.” J Neurosci 28, no. 10 (March 5, 2008): 2299–2300. https://doi.org/10.1523/JNEUROSCI.5679-07.2008.
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    • Harris, G. C., M. Hummel, M. Wimmer, S. D. Mague, and G. Aston-Jones. “Elevations of FosB in the nucleus accumbens during forced cocaine abstinence correlate with divergent changes in reward function.” Neuroscience 147, no. 3 (July 13, 2007): 583–91. https://doi.org/10.1016/j.neuroscience.2007.04.050.
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    • Chartoff, Elena H., Stephen D. Mague, Matthew F. Barhight, Andrew M. Smith, and William A. Carlezon. “Behavioral and molecular effects of dopamine D1 receptor stimulation during naloxone-precipitated morphine withdrawal.” J Neurosci 26, no. 24 (June 14, 2006): 6450–57. https://doi.org/10.1523/JNEUROSCI.0491-06.2006.
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    • Tomasiewicz, Hilarie C., Stephen D. Mague, Bruce M. Cohen, and William A. Carlezon. “Behavioral effects of short-term administration of lithium and valproic acid in rats.” Brain Res 1093, no. 1 (June 6, 2006): 83–94. https://doi.org/10.1016/j.brainres.2006.03.102.
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    • Carlezon, William A., Michael L. Rohan, Stephen D. Mague, Edward G. Meloni, Aram Parsegian, Kenroy Cayetano, Hilarie C. Tomasiewicz, Elizabeth D. Rouse, Bruce M. Cohen, and Perry F. Renshaw. “Antidepressant-like effects of cranial stimulation within a low-energy magnetic field in rats.” Biol Psychiatry 57, no. 6 (March 15, 2005): 571–76. https://doi.org/10.1016/j.biopsych.2004.12.011.
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    • Carlezon, William A., Stephen D. Mague, Aimee M. Parow, Andrew L. Stoll, Bruce M. Cohen, and Perry F. Renshaw. “Antidepressant-like effects of uridine and omega-3 fatty acids are potentiated by combined treatment in rats.” Biol Psychiatry 57, no. 4 (February 15, 2005): 343–50. https://doi.org/10.1016/j.biopsych.2004.11.038.
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    • Mague, Stephen D., Susan L. Andersen, and William A. Carlezon. “Early developmental exposure to methylphenidate reduces cocaine-induced potentiation of brain stimulation reward in rats.” Biol Psychiatry 57, no. 2 (January 15, 2005): 120–25. https://doi.org/10.1016/j.biopsych.2004.10.037.
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    • Kelsey, John E., Stephen D. Mague, Reyna S. Pijanowski, Ryan C. Harris, Nancy W. Kleckner, and Russell T. Matthews. “NMDA receptor antagonists ameliorate the stepping deficits produced by unilateral medial forebrain bundle injections of 6-OHDA in rats.” Psychopharmacology (Berl) 175, no. 2 (September 2004): 179–88. https://doi.org/10.1007/s00213-004-1799-5.
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    • Carlezon, William A., Stephen D. Mague, and Susan L. Andersen. “Enduring behavioral effects of early exposure to methylphenidate in rats.” Biol Psychiatry 54, no. 12 (December 15, 2003): 1330–37. https://doi.org/10.1016/j.biopsych.2003.08.020.
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    • Mague, Stephen D., Andrea M. Pliakas, Mark S. Todtenkopf, Hilarie C. Tomasiewicz, Yan Zhang, William C. Stevens, Robert M. Jones, Philip S. Portoghese, and William A. Carlezon. “Antidepressant-like effects of kappa-opioid receptor antagonists in the forced swim test in rats.” J Pharmacol Exp Ther 305, no. 1 (April 2003): 323–30. https://doi.org/10.1124/jpet.102.046433.
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