Overview
Although I no longer am actively involved in research, my prior work experience is given below:
My laboratory work focussed upon the cell biology of the lung epithelium: during development, including the processes of branching morphogenesis and second, during the maintenence of lung surface forces through the epithelial secretion known as surfactant.
We emphasized a morphologic approach utilizing the full range of ultrastructural techniques, supplemented with molecular biologic techniques that allow structure function correlations.
I have been involved in clinical trials examining vaccination against influenza and examining the value of inhaled steroids, both experiments in patients with COPD.
I am recognized mainly for work in surfactant and lung development.
Lung surfactant; alveolar type II cell; branching morphogenesis; lung development
My laboratory work focussed upon the cell biology of the lung epithelium: during development, including the processes of branching morphogenesis and second, during the maintenence of lung surface forces through the epithelial secretion known as surfactant.
We emphasized a morphologic approach utilizing the full range of ultrastructural techniques, supplemented with molecular biologic techniques that allow structure function correlations.
I have been involved in clinical trials examining vaccination against influenza and examining the value of inhaled steroids, both experiments in patients with COPD.
I am recognized mainly for work in surfactant and lung development.
Lung surfactant; alveolar type II cell; branching morphogenesis; lung development
Current Appointments & Affiliations
Professor Emeritus of Medicine
·
2016 - Present
Medicine, Pulmonary, Allergy, and Critical Care Medicine,
Medicine
Recent Publications
The opprobrium of Big Tobacco.
Journal Article Am J Respir Crit Care Med · May 1, 2012 Full text Link to item CiteStructure of Alveolar Epithelial Cells and the Surface Layer During Development
Chapter · January 1, 2011 Full text CiteImpact of a winter respiratory virus season on patients with COPD and association with influenza vaccination.
Journal Article Chest · October 2006 BACKGROUND: We assessed the effects of an influenza season on patients with COPD. Data from 2,215 veterans in a multicenter, randomized, double-blind influenza vaccine efficacy study were analyzed for changes in spirometric and functional status, comparing ... Full text Link to item CiteRecent Grants
Long-term Oxygen Treatment Trial (LOTT) - Regional Clinical Centers (RCCs)
ResearchCo Investigator · Awarded by National Institutes of Health · 2006 - 2012Leukocyte Chemokine Blockade to Preserve LungDevelopment
ResearchConsultant · Awarded by National Institutes of Health · 2002 - 2006Regulation of ryanodine receptor by nitrogen oxides
ResearchCollaborator · Awarded by National Institutes of Health · 1999 - 2004View All Grants
Education, Training & Certifications
University of California San Francisco, School of Medicine ·
1968
M.D.