Scholars@Duke
Steven Patierno

Steven Patierno

Charles D. Watts Distinguished Professor Emeritus of Medicine
Medicine, Medical Oncology
steven.patierno@duke.edu
DUMC-3917, Durham, NC 27710
10 Bryan Searle Drive, Seeley Mudd Building, Suite 413, Durham, NC 27710

Scholarly Works - Conferences

Abstract A001: Differential alternative RNA splicing and transcription events between Black and White prostate cancer patients involve genes promoting cancer aggressiveness and associate with patient survival

Conference Cancer Research · June 2, 2023 AbstractBlack patients suffer disproportionately from prostate cancer (PCa) progression to lethal disease compared with Asian and White patients. Comparing the molecular landscape of PCa in Black and White m ... Full text Cite

Abstract C053: Differences in hallmark gene sets in the Molecular Signatures Database between tumors from African American and White patients

Conference Cancer Epidemiology, Biomarkers & Prevention · January 1, 2023 AbstractTo improve cancer outcomes, it is of critical importance to understand biological differences in tumors that ultimately accompany progression to a lethal phenotype. Compared to Whites (Ws), African A ... Full text Cite

Characterization of a castrate-resistant prostate cancer xenograft derived from a patient of West African ancestry.

Conference Prostate Cancer Prostatic Dis · September 2022 BACKGROUND: Prostate cancer is a clinically and molecularly heterogeneous disease, with highest incidence and mortality among men of African ancestry. To date, prostate cancer patient-derived xenograft (PCPDX) models to study this disease have been difficu ... Full text Open Access Link to item Cite

Abstract PO-137: Comparative transcriptomic analysis of prostate cancer from African American and Caucasian American men by Gleason score and race

Conference Cancer Epidemiology, Biomarkers & Prevention · January 1, 2022 AbstractAfrican American (AA) men exhibit 2-3 times higher mortality from prostate cancer compared with Caucasian American (CA) men. Factors contributing to the disparity include societal-, neighborhood- and ... Full text Cite

Implementation and Impact of a Risk-Stratified Prostate Cancer Screening Algorithm as a Clinical Decision Support Tool in a Primary Care Network.

Conference J Gen Intern Med · January 2021 BACKGROUND: Implementation methods of risk-stratified cancer screening guidance throughout a health care system remains understudied. OBJECTIVE: Conduct a preliminary analysis of the implementation of a risk-stratified prostate cancer screening algorithm i ... Full text Link to item Cite

Abstract 3507: Race-related genetic variation and response to secondary hormonal therapy in metastatic castration-resistant prostate cancer

Conference Cancer Research · August 15, 2020 AbstractProstate cancer (PCa) is the second most common cancer diagnosed in men globally, after lung cancer. PCa incidence, aggressiveness and mortality are significantly higher among African Americans (AAs) ... Full text Cite

Abstract B071: Genomic differences between non-small cell lung cancer (NSCLC) in African American and white patients

Conference Cancer Epidemiology, Biomarkers & Prevention · June 1, 2020 AbstractBackground: Racial disparities in lung cancer exist, as African Americans (AAs) have the highest incidence of lung cancer and rate of lung cancer-related death and develop lung cancer at an earlier a ... Full text Cite

Abstract A114: Characterization of a metastatic prostate cancer xenograft derived from a patient of African ancestry

Conference Cancer Epidemiology, Biomarkers & Prevention · June 1, 2020 AbstractBackground: Prostate cancer (PCa) is a clinically and molecularly heterogeneous disease, with differences in incidence and mortality among and between racial groups, which grade and stage only partia ... Full text Cite

Abstract B064: Race-related genetic variation and response to secondary hormonal therapy in metastatic castration-resistant prostate cancer

Conference Cancer Epidemiology, Biomarkers & Prevention · June 1, 2020 AbstractProstate cancer (PCa) is the most prevalent cancer and third leading cause of cancer death among men in the United States. PCa incidence, aggressiveness and mortality are significantly higher among A ... Full text Cite

Abstract B063: Race-related LMO7 exon skipping enhances prostate tumor invasion

Conference Cancer Epidemiology, Biomarkers & Prevention · June 1, 2020 AbstractProstate cancer (PCa) affects disproportionally African American (AA) men in comparison with white or Asian men. According to the Surveillance, Epidemiology, and End Results Program (SEER), the morta ... Full text Cite

Abstract D064: Race-related RNA splicing dysregulation of PI3Kd signaling: A therapeutic target for aggressive prostate cancer

Conference Cancer Epidemiology, Biomarkers & Prevention · June 1, 2020 AbstractBackground: Age-adjusted incidence and mortality rates for prostate cancer (PCa) among African Americans (AAs) are greater than among whites. The more aggressive characteristics of PCa in AAs contrib ... Full text Cite

Abstract A080: Rates of Invitation, participation, and willingness to engage in medical and clinical research: Findings from attendees at two gender-specific community-based screening programs

Conference Cancer Epidemiology, Biomarkers & Prevention · June 1, 2020 AbstractIntroduction: Community-based screening programs are associated with increased access to care, particularly for traditionally underserved people of color, the poor, and those who face barriers to hea ... Full text Cite

Abstract B050: Identification of differentially expressed and spliced genes between breast, colon, lung, and prostate cancer from African American and white patients

Conference Cancer Epidemiology, Biomarkers & Prevention · June 1, 2020 AbstractRacial/ethnic disparity in cancer refers to the disproportionate incidence of and/or mortality from various cancers among population groups. In addition to differences in social, lifestyle and struct ... Full text Cite

Abstract B006: Development of a novel therapeutic splice-switching oligonucleotide targeting race-related androgen receptor signaling and aggressive prostate cancer

Conference Cancer Epidemiology, Biomarkers & Prevention · June 1, 2020 AbstractBackground: Age-adjusted incidence and mortality rates for prostate cancer (PCa) among African American (AA) men are 1.6- and 2.4-fold greater, respectively, than among white men. The more aggressive ... Full text Cite

Abstract IA18: North Carolina Central University and Duke Cancer Institute's collaborative cancer research and education program: Connecting cancer disparities translational research, clinical trials operations, and community engagement

Conference Cancer Epidemiology, Biomarkers & Prevention · June 1, 2020 AbstractThree interrelated contributors to cancer disparities include the lack of diversity among investigators contributing to cancer research, the deficiency of minority participation in clinical trials an ... Full text Cite

Abstract B061: Mechanistic and functional interrogation of novel ancestry-related alternatively spliced androgen receptor signal genes in prostate cancer

Conference Cancer Epidemiology, Biomarkers & Prevention · June 1, 2020 AbstractThe age-adjusted incidence and mortality rates for prostate cancer (PCa) among African American (AA) men are significantly higher than among white men. Our studies address the urgent need to interrog ... Full text Cite

Digital Supportive Care Awareness and Navigation (D-SCAN): Results of a pilot randomized trial.

Conference Journal of Clinical Oncology · November 1, 2019 101 Background: Cancer patients face many supportive care needs. In crowded clinics with rising care complexity, clinicians struggle to assess and manage these needs. Duke Cancer Patient Support Program (DCPSP) services aim to br ... Full text Cite

Abstract 750: Ancestry-related differentially spliced and expressed genes in prostate cancer

Conference Cancer Research · July 1, 2019 AbstractProstate cancer (PCa) affects disproportionally men from different population groups. The Surveillance, Epidemiology, and End Results Program’s (SEER’s) 2018 report reveals that PCa incidence and ... Full text Cite

Abstract B038: Convergent hormone therapy resistance mediated by stress/dormancy-like pathways in prostate cancer

Conference Cancer Research · August 15, 2018 AbstractBackground: Novel agents that inhibit the androgen receptor (AR), including abiraterone acetate and enzalutamide, have significantly prolonged life in many men with metastatic castration-resistant pr ... Full text Cite

Abstract A79: Establishment of African American prostate cancer patient-derived primary cell lines and xenografts

Conference Cancer Epidemiology, Biomarkers & Prevention · July 1, 2018 AbstractBackground: Prostate cancer (PCa) is a clinically and molecularly heterogeneous disease, with differences in incidence and mortality among and between racial groups, which are only partially predicte ... Full text Cite

Abstract B59: Race-related differential splicing of the insulin receptor: A novel target underlying prostate cancer disparities

Conference Cancer Epidemiology, Biomarkers & Prevention · July 1, 2018 AbstractBackground: Age-adjusted incidence and mortality rates for prostate cancer (PCa) among African American (AA) men are significantly greater than among white men. Much of this disparity remains after c ... Full text Cite

Abstract IA26: Developing effective community and health system partnerships to advance health equity and health disparities research

Conference Cancer Epidemiology, Biomarkers & Prevention · July 1, 2018 AbstractEstablishing sustainable and impactful partnerships to advance health equity and health disparities research requires a multipronged approach to assessing and aligning community and organizational pr ... Full text Cite

Development of a digital patient navigation application: Preliminary results from patient interviews.

Conference Journal of Clinical Oncology · March 1, 2018 161 Background: People living with cancer face challenges too numerous to attend to during brief clinic visits, and thus may benefit from additional help with supportive care needs. While patient navigators offer promise, they ar ... Full text Cite

Abstract B58: Single-nucleotide polymorphisms of race-related alternatively spliced genes associate with prostate cancer risk, aggressiveness and/or survival

Conference Cancer Epidemiology, Biomarkers & Prevention · February 1, 2017 AbstractBackground: African American (AA) men exhibit nearly 2-fold higher incidence and 3-fold higher mortality rates from prostate cancer (PC) compared with white men. This disparity likely results from a ... Full text Cite

Abstract B18: Development of novel therapeutic splice-switching oligonucleotides against aggressive prostate cancer in men of African descent

Conference Cancer Epidemiology, Biomarkers & Prevention · March 1, 2016 AbstractAfrican American (AA) men exhibit a nearly 2-fold higher incidence and 3-fold higher mortality rate from prostate cancer compared to Caucasian American (CA) men and disparities in tumor aggressivenes ... Full text Cite

Abstract 1367: Item response theory analysis of the patient satisfaction with cancer-related care: psychometric validation in a multicultural sample of 1,296 participants.

Conference Cancer Research · April 15, 2013 AbstractBACKGROUND: Patient satisfaction (PS) is an important outcome measure of quality of cancer-related care. PS was one of the four core study outcomes of the National Cancer Institute and American Cance ... Full text Cite