Scholars@Duke
Steven Patierno

Steven Patierno

Charles D. Watts Distinguished Professor Emeritus of Medicine
Medicine, Medical Oncology
steven.patierno@duke.edu
DUMC-3917, Durham, NC 27710
10 Bryan Searle Drive, Seeley Mudd Building, Suite 413, Durham, NC 27710

Featured Works

A bioenergetic profile of non-transformed fibroblasts uncovers a link between death-resistance and enhanced spare respiratory capacity.

Journal article Mitochondrion · November 2013 Featured Publication Apoptosis-resistance and metabolic imbalances are prominent features of cancer cells. We have recently reported on populations of human fibroblasts that exhibit resistance to mitochondrial-mediated apoptosis, acquired as a result of a single genotoxic expo ... Full text Link to item Cite

Patient navigation significantly reduces delays in breast cancer diagnosis in the District of Columbia.

Journal article Cancer Epidemiol Biomarkers Prev · October 2012 Featured Publication BACKGROUND: Patient Navigation (PN) originated in Harlem as an intervention to help poor women overcome access barriers to timely breast cancer treatment. Despite rapid, nationally widespread adoption of PN, empirical evidence on its effectiveness is lacki ... Full text Link to item Cite

Protein tyrosine phosphatase (PTP) inhibition enhances chromosomal stability after genotoxic stress: decreased chromosomal instability (CIN) at the expense of enhanced genomic instability (GIN)?

Journal article Mutat Res · July 1, 2012 Featured Publication Inappropriate survival signaling after DNA damage may facilitate clonal expansion of genetically compromised cells, and it is known that protein tyrosine phosphatase (PTP) inhibitors activate key survival pathways. In this study we employed the genotoxican ... Full text Link to item Cite

Acquisition of mitochondrial dysregulation and resistance to mitochondrial-mediated apoptosis after genotoxic insult in normal human fibroblasts: a possible model for early stage carcinogenesis.

Journal article Biochim Biophys Acta · February 2012 Featured Publication Acquisition of death-resistance is critical in the evolution of neoplasia. Our aim was to model the early stages of carcinogenesis by examining intracellular alterations in cells that have acquired apoptosis-resistance after exposure to a complex genotoxin ... Full text Link to item Cite

Having health insurance does not eliminate race/ethnicity-associated delays in breast cancer diagnosis in the District of Columbia.

Journal article Cancer · August 15, 2011 Featured Publication BACKGROUND: Delays in follow-up after breast cancer screening contribute to disparities in breast cancer outcomes. The objective of this research was to determine the impact of race/ethnicity and health insurance on diagnostic time, defined as number of da ... Full text Link to item Cite

Survivorship navigation outcome measures: a report from the ACS patient navigation working group on survivorship navigation.

Journal article Cancer · August 2011 Featured Publication Survivorship navigation is a relatively new concept in the field of patient navigation but an important one. This article highlights the essential functions of the survivorship navigator and defines core outcomes and measures for navigation in the survivor ... Full text Link to item Cite

Chromium genotoxicity: A double-edged sword.

Journal article Chem Biol Interact · November 5, 2010 Featured Publication Certain forms of hexavalent chromium [Cr(VI)] are known respiratory carcinogens that induce a broad spectrum of DNA damage. Cr(VI)-carcinogenesis may be initiated or promoted through several mechanistic processes including, the intracellular metabolic redu ... Full text Link to item Cite

Identification of differentially methylated genes in normal prostate tissues from African American and Caucasian men.

Journal article Clin Cancer Res · July 15, 2010 Featured Publication PURPOSE: Aberrant DNA methylation changes are common somatic alterations in prostate carcinogenesis. We examined the methylation status of six genes in prostate tissue specimens from African American (AA) and Caucasian (Cau) males. EXPERIMENTAL DESIGN: We ... Full text Link to item Cite

Polo-like kinase 1 enhances survival and mutagenesis after genotoxic stress in normal cells through cell cycle checkpoint bypass.

Journal article Carcinogenesis · May 2010 Featured Publication Polo-like kinase 1 (Plk1) is a key regulator of mitosis. Aberrant Plk1 activity is found in tumors, but little is known regarding its role in the DNA damage response of normal cells and its potential contribution to the early stages of carcinogenesis. Inap ... Full text Link to item Cite

Prostate apoptosis response protein 4 sensitizes human colon cancer cells to chemotherapeutic 5-FU through mediation of an NF kappaB and microRNA network.

Journal article Mol Cancer · April 30, 2010 Featured Publication BACKGROUND: Diminished expression or activity of prostate apoptosis response protein 4 (Par-4) has been demonstrated in a number of cancers, although reports on Par-4 expression during colon cancer progression are lacking. An understanding of the molecular ... Full text Link to item Cite

AKT1 mediates bypass of the G1/S checkpoint after genotoxic stress in normal human cells.

Journal article Cell Cycle · May 15, 2009 Featured Publication Certain forms of hexavalent chromium [Cr(VI)] are human carcinogens. Our recent work has shown that a broad range protein tyrosine phosphatase (PTP) inhibitor, sodium orthovanadate (SOV), abrogated both Cr(VI)-induced growth arrest and clonogenic lethality ... Full text Link to item Cite

Lung injury, inflammation and Akt signaling following inhalation of particulate hexavalent chromium.

Journal article Toxicol Appl Pharmacol · February 15, 2009 Featured Publication Certain particulate hexavalent chromium [Cr(VI)] compounds are human respiratory carcinogens that release genotoxic soluble chromate, and are associated with fibrosis, fibrosarcomas, adenocarcinomas and squamous cell carcinomas of the lung. We postulate th ... Full text Link to item Cite

Bypass of hexavalent chromium-induced growth arrest by a protein tyrosine phosphatase inhibitor: enhanced survival and mutagenesis.

Journal article Mutat Res · January 15, 2009 Featured Publication Although the consequences of genotoxic injury include cell cycle arrest and apoptosis, cell survival responses after genotoxic injury can produce intrinsic death-resistance and contribute to the development of a transformed phenotype. Protein tyrosine phos ... Full text Link to item Cite

Excision repair is required for genotoxin-induced mutagenesis in mammalian cells.

Journal article Carcinogenesis · May 2008 Featured Publication Certain hexavalent chromium [Cr(VI)] compounds are human lung carcinogens. Although much is known about Cr-induced DNA damage, very little is known about mechanisms of Cr(VI) mutagenesis and the role that DNA repair plays in this process. Our goal was to i ... Full text Link to item Cite