Scholars@Duke
Sudarshan Rajagopal

Sudarshan Rajagopal

Associate Professor of Medicine
Medicine, Cardiology
Box 102147, DUMC, Durham, NC 27710
Duke University Medical Center, Box 3126, Durham, NC 27710

Scholarly Works - Conferences

Evaluating Large Language Models for Automated Clinical Abstraction in Pulmonary Embolism Registries: Performance Across Model Sizes, Versions, and Parameters

Conference Lecture Notes in Computer Science · January 1, 2026 Pulmonary embolism (PE) registries accelerate practice-improving research but depend on resource-intensive manual abstraction of radiology reports. We evaluated whether openly available large-language models (LLMs) can automate concept extraction from comp ... Full text Cite

Abstract 4370695: Effects of RAMP expression on location-biased signaling by CLR

Conference Circulation · November 4, 2025 Background: Chronic thromboembolic pulmonary hypertension (CTEPH) is a lung blood vessel disease characterized by abnormal pulmonary arterial endothelial cell (PAEC) function. Adrenome ... Full text Cite

Abstract 4370217: Biased small molecule RXFP1 agonists ameliorate experimental pulmonary hypertension and RV hypertrophy

Conference Circulation · November 4, 2025 Background: Human Relaxin-2 (RLN2) signals via G-protein coupled receptor (GPCR) relaxin family peptide receptor 1 (RXFP1), and exerts vasodilatory, anti-inflammatory, and anti-fibroti ... Full text Cite

Combining hyperpolarized 129Xe MR imaging and spectroscopy to noninvasively estimate pulmonary vascular resistance.

Conference J Appl Physiol (1985) · March 1, 2025 Hyperpolarized 129Xe MRI/MRS enables quantitative mapping of function in lung airspaces, membrane tissue, and red blood cells (RBCs) within the pulmonary capillaries. The RBC signal also exhibits cardiogenic oscillations that are reduced in precapillary pu ... Full text Link to item Cite

Abstract 4146456: Biased Activation of RXFP1 signaling via ML290 Attenuates Experimental Pulmonary Hypertension

Conference Circulation · November 12, 2024 Background: Dysregulated smooth muscle cell (SMC) hypertrophy and proliferation contribute to vascular remodeling in pulmonary arterial hypertension (PAH). Relaxin-2 (RLN2), a peptide hormone known to ... Full text Cite

Abstract 4146849: Reassessing Thresholds for Pulmonary Hypertension in Healthy and Early Stage Heart Failure - Project Baseline Health Study

Conference Circulation · November 12, 2024 Background: There is increasing evidence that current thresholds for diagnosing pulmonary hypertension (PH) may underestimate its prevalence and importance in clinical practice. ... Full text Cite

Right ventricular dysfunction parameters at echocardiography in patients with acute pulmonary embolism: meta-analysis of individual participant data

Conference European Heart Journal · October 28, 2024 AbstractBackground & AimEchocardiography has a crucial role for decision making on management of patient with acute pulmonary embo ... Full text Cite

Location Biased G Protein-Coupled Receptor Signaling Modulates Distinct Spatial Conformations of β-arrestins

Conference The Journal of Pharmacology and Experimental Therapeutics · June 2023 Full text Cite

Noninvasive diagnosis of pulmonary hypertension with hyperpolarised 129Xe magnetic resonance imaging and spectroscopy.

Conference ERJ Open Res · April 2022 BACKGROUND: The diagnosis of pulmonary hypertension (PH) remains challenging. Pre- and post-capillary PH have different signatures on noninvasive 129Xe gas-exchange magnetic resonance imaging (MRI) and dynamic MR spectroscopy (MRS). We tested the accuracy ... Full text Link to item Cite

Receptor Endocytosis as a Mechanism of Biased Agonism at CXCR3

Conference The FASEB Journal · May 2021 G Protein Coupled Receptors (GPCRs) are the largest class of receptors in the human genome. They are expressed in virtually every cell type and are implicated in numerous physiological processes. GPCR signaling is highly specific due to biased agon ... Full text Cite

Differential GRK Recruitment and the Phosphorylation Barcode as a Mechanism for Biased Agonism at G Protein‐Coupled Receptors

Conference The FASEB Journal · May 2021 G Protein‐Coupled Receptors (GPCRs) are the largest and most diverse family of cell receptors in the human genome and account for ~30% of all FDA‐approved drugs. GPCR signaling is mediated by various effectors, including G prot ... Full text Cite

Sympathetic and Parasympathetic Regulation of NF‐κB by GPCRs through the modulation of interactions between p65/RelA and the β‐arrestins

Conference The FASEB Journal · May 2021 Study Objective:This project sought to elucidate the biological mechanisms and physiological significance of β2 adrenergic receptor (B2AR)‐ and M1 muscarinic receptor (M1R)‐mediated modulation of NF‐κB signaling ... Full text Cite

β‐arrestin‐biased ACKR3 Promotes Gαi:β‐arrestin Complex Formation

Conference The FASEB Journal · May 2021 Atypical chemokine receptor 3 (ACKR3)—previously known as CXC‐chemokine receptor 7 (CXCR7)—is involved in a wide range of physiological processes including angiogenesis, neuronal development, and tumorigenesis. As a β‐arrestin biased G protein‐coup ... Full text Cite

Biased Agonism at CXCR3 Drives Differential Phosphoproteomic and Transcriptomic Profiles and Cellular Outputs

Conference The FASEB Journal · April 2020 ObjectiveTo demonstrate that the endogenous agonists of the chemokine receptor CXCR3 differentially impact the phosphoproteome and transcriptome to drive distinct cellular ... Full text Cite

Biased agonists of the chemokine receptor CXCR3 differentially drive formation of Gαi and β‐arrestin complexes

Conference The FASEB Journal · April 2020 G‐protein‐coupled receptors (GPCRs) are the most common cell surface receptor class and influence nearly every biological process within a cell. Approximately 3 ... Full text Cite

ACKR3 Regulates Endothelial Cell Function with Non‐canonical Integration of Gαi and β‐arrestin

Conference The FASEB Journal · April 2020 Atypical Chemokine receptor 3 (ACKR3), also known as C‐X‐C chemokine receptor type 7 (CXCR7), is a G protein‐coupled receptor (GPCR) implicated in several physi ... Full text Cite

EXTRA VOLUME: PULMONARY HYPERTENSION CAUSED BY EXTRA-CARDIAC AND INTRA-CARDIAC SHUNTING

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · March 24, 2020 Link to item Cite

Toward Theranostic Biomarkers In Pulmonary Hypertension

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2016 Link to item Cite

Predictors Of 30-Day Survival In Acute Pulmonary Embolism

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2015 Link to item Cite

How do signaling photoreceptors respond to light?

Conference Acta Crystallographica Section A Foundations of Crystallography · August 23, 2005 Full text Cite

Protein kinetics: relaxations on atomic length scales

Conference Acta Crystallographica Section A Foundations of Crystallography · August 26, 2004 Full text Cite

Application of singular value decomposition to time-resolved X-ray data; simulations and experiments

Conference Acta Crystallographica Section A Foundations of Crystallography · August 6, 2002 Full text Cite

Time-resolved macromolecular crystallography: molecular movies?

Conference Acta Crystallographica Section A Foundations of Crystallography · August 6, 2002 Full text Cite