Scholars@Duke
Keith Michael Sullivan

Keith Michael Sullivan

James B. Wyngaarden Distinguished Professor Emeritus of Medicine
Medicine, Hematologic Malignancies and Cellular Therapy
sulli025@mc.duke.edu
Box 3961 Med Ctr, Durham, NC 27710
Cellular Therapy ABMT, Box 3961 DUMC, Durham, NC 27705

Featured Works

Polymyositis as a manifestation of chronic graft-versus-host disease.

Journal article Rheumatology (Oxford) · January 2003 Featured Work OBJECTIVE: Chronic graft-versus-host disease (GVHD) after haematopoietic stem cell transplantation (HSCT) has similarities to some idiopathic autoimmune diseases, including polymyositis. To investigate the relationship between chronic GVHD and idiopathic m ... Full text Link to item Cite

High-dose immunosuppressive therapy for severe systemic sclerosis: initial outcomes.

Journal article Blood · September 1, 2002 Featured Work Systemic sclerosis (SSc) is a multisystem disease of presumed autoimmune pathogenesis for which no proven effective treatment exists. High-dose immunosuppressive therapy (HDIT) has been proposed as an investigational treatment for severe autoimmune disease ... Link to item Cite

Bone marrow transplantation for non-malignant disease.

Journal article Int J Hematol · August 2002 Featured Work Full text Link to item Cite

Morbidity and mortality of chronic GVHD after hematopoietic stem cell transplantation from HLA-identical siblings for patients with aplastic or refractory anemias.

Journal article Biol Blood Marrow Transplant · 2002 Featured Work We analyzed effects of successive changes in prevention and treatment of chronic GVHD in 405 patients with aplastic anemia and refractory anemia given HLA-matched hematopoietic stem cell transplantation (HSCT) from 1970-1997. For analysis, patients were di ... Full text Link to item Cite

Busulfan plus cyclophosphamide compared with total-body irradiation plus cyclophosphamide before marrow transplantation for myeloid leukemia: long-term follow-up of 4 randomized studies.

Journal article Blood · December 15, 2001 Featured Work In the early 1990s, 4 randomized studies compared conditioning regimens before transplantation for leukemia with either cyclophosphamide (CY) and total-body irradiation (TBI), or busulfan (Bu) and CY. This study analyzed the long-term outcomes for 316 pati ... Full text Link to item Cite

Immunity of patients surviving 20 to 30 years after allogeneic or syngeneic bone marrow transplantation.

Journal article Blood · December 15, 2001 Featured Work The duration of immunodeficiency following marrow transplantation is not known. Questionnaires were used to study the infection rates in 72 patients surviving 20 to 30 years after marrow grafting. Furthermore, in 33 of the 72 patients and in 16 donors (sib ... Full text Link to item Cite

Bone density loss after allogeneic hematopoietic stem cell transplantation: a prospective study.

Journal article Biol Blood Marrow Transplant · 2001 Featured Work The incidence and course of bone density abnormalities following hematopoietic stem cell transplantation are poorly understood and complicated by the impact of multiple factors. Hip, spine, and wrist bone mineral densities (BMDs) were measured in 104 adult ... Full text Link to item Cite

Secondary failure of platelet recovery after hematopoietic stem cell transplantation.

Journal article Biol Blood Marrow Transplant · 2001 Featured Work After primary recovery of platelet counts after transplantation, there can be a late persistent decline called secondary failure of platelet recovery (SFPR), which may occur although the counts of other cell lineages remain within the normal range. SFPR wa ... Full text Link to item Cite

Preventing opportunistic infections after hematopoietic stem cell transplantation: the Centers for Disease Control and Prevention, Infectious Diseases Society of America, and American Society for Blood and Marrow Transplantation Practice Guidelines and beyond.

Journal article Hematology Am Soc Hematol Educ Program · 2001 Featured Work This review presents evidence-based guidelines for the prevention of infection after blood and marrow transplantation. Recommendations apply to all myeloablative transplants regardless of recipient (adult or child), type (allogeneic or autologous) or sourc ... Full text Link to item Cite

Stable mixed hematopoietic chimerism after bone marrow transplantation for sickle cell anemia.

Journal article Biol Blood Marrow Transplant · 2001 Featured Work A multicenter investigation of allogeneic bone marrow transplantation for children with sickle cell disease was conducted that included 27 European and North American transplant centers. Fifty-nine patients who ranged in age from 3.3 to 15.9 years (median, ... Full text Link to item Cite

Impact of a randomized, controlled trial of liberal vs conservative hospital discharge criteria on energy, protein, and fluid intake in patients who received marrow transplants.

Journal article J Am Diet Assoc · September 2000 Featured Work OBJECT: To determine if adult patients who received marrow transplants had faster resumption of oral energy and nutrient intake and shorter duration of intravenous (i.v.) fluid requirement if discharged from the hospital earlier than is customary. DESIGN: ... Full text Link to item Cite

Impact of bone marrow transplantation for symptomatic sickle cell disease: an interim report. Multicenter investigation of bone marrow transplantation for sickle cell disease.

Journal article Blood · March 15, 2000 Featured Work Fifty children who had symptomatic sickle cell disease received matched sibling marrow allografts between September 1991 and March 1999, with Kaplan-Meier probabilities of survival and event-free survival of 94% and 84%, respectively. Twenty-six patients ( ... Link to item Cite

New malignant diseases after allogeneic marrow transplantation for childhood acute leukemia.

Journal article J Clin Oncol · January 2000 Featured Work PURPOSE: To determine the incidence of and risk factors for second malignancies after allogeneic bone marrow transplantation (BMT) for childhood leukemia. PATIENTS AND METHODS: We studied a cohort of 3, 182 children diagnosed with acute leukemia before the ... Full text Link to item Cite

Conditional and unconditional estimation of multidimensional quality of life after hematopoietic stem cell transplantation: a longitudinal follow-up of 415 patients.

Journal article Biol Blood Marrow Transplant · 2000 Featured Work Emerging literature suggests that quality of life (QOL) after bone marrow transplantation is relatively good but is accompanied in some patients by a variety of residual difficulties. The studies supporting this finding, however, have been somewhat limited ... Full text Link to item Cite

Bone Marrow Transplantation for Non-Malignant Disease.

Journal article Hematology Am Soc Hematol Educ Program · 2000 Featured Work This article reviews the experience in hematopoietic stem cell transplantation (HSCT) for non-malignant disease. HSCT has long been applied as treatment of life-threatening congenital immunodeficiency and metabolic diseases. In Section I, Dr. Parkman revie ... Full text Link to item Cite

Cirrhosis of the liver in long-term marrow transplant survivors.

Journal article Blood · May 15, 1999 Featured Work Patients who survive hematopoietic cell transplantation (HCT) have multiple risk factors for chronic liver disease, including hepatitis virus infection, iron overload, and chronic graft-versus-host disease (GVHD). We studied 3,721 patients who had survived ... Link to item Cite

Reduced dose intravenous immunoglobulin does not decrease transplant-related complications in adults given related donor marrow allografts.

Journal article Biol Blood Marrow Transplant · 1999 Featured Work Graft-vs.-host disease (GVHD) and infection are major complications of allogeneic bone marrow transplantation. Intravenous immunoglobulin (IVIg) given at a dose of 500 mg/kg/wk has been shown to decrease the risk of acute GVHD, interstitial pneumonia, and ... Full text Link to item Cite

Association between pretransplant interferon-alpha and outcome after unrelated donor marrow transplantation for chronic myelogenous leukemia in chronic phase.

Journal article Blood · July 15, 1998 Featured Work Treatment options for patients diagnosed with chronic myelogenous leukemia (CML) in chronic phase (CP) who lack a suitable related donor for marrow transplantation include hydroxyurea, interferon-alpha (IFN-alpha), or transplantation from an unrelated dono ... Link to item Cite

Current and future preparative regimens for bone marrow transplantation in thalassemia.

Journal article Ann N Y Acad Sci · June 30, 1998 Featured Work Preparative regimens for marrow allografts in thalassemia have two objectives. One is eradication of diseased marrow and the other suppression of host-versus-graft (HVG) reactions so that the allograft survives. A common regimen to accomplish these goals h ... Full text Link to item Cite

Unrelated and HLA-nonidentical related donor marrow transplantation for thalassemia and leukemia. A combined report from the Seattle Marrow Transplant Team and the International Bone Marrow Transplant Registry.

Journal article Ann N Y Acad Sci · June 30, 1998 Featured Work Allogeneic marrow transplantation is curative therapy for thalassemia, but fewer than 30% of patients have an HLA-identical sibling marrow donor. Selection of alternative donors of hematopoietic stem cells (unrelated individuals or HLA-nonidentical family ... Full text Link to item Cite

Long-term outcome after marrow transplantation for severe aplastic anemia.

Journal article Blood · May 15, 1998 Featured Work We reviewed the records and reevaluated 212 patients with aplastic anemia transplanted at the Fred Hutchinson Cancer Research Center (FHCRC) between 1970 and 1993 who survived >/=2 years and who have been followed for up to 26 years. Parameters analyzed in ... Link to item Cite

Bone marrow transplants from unrelated donors for patients with chronic myeloid leukemia.

Journal article N Engl J Med · April 2, 1998 Featured Work BACKGROUND: Chronic myeloid leukemia can be cured by marrow transplantation from an HLA-identical sibling donor. The use of transplants from unrelated donors is an option for the 70 percent of patients without an HLA-identical sibling, but the morbidity an ... Full text Link to item Cite

Course of Crohn's disease after allogeneic marrow transplantation.

Journal article Gastroenterology · March 1998 Featured Work BACKGROUND & AIMS: Remission of several autoimmune diseases has been described after allogeneic marrow transplantation. The aim of this study was to determine if the natural history of Crohn's disease was altered by hematopoietic cell transplants from heal ... Full text Link to item Cite

Avascular necrosis following bone marrow transplantation: a case-control study.

Journal article Bone · January 1998 Featured Work The role of specific immunosuppressive agents in the development of avascular necrosis (AVN) following hematopoietic stem cell and solid organ transplantation remains unclear. To further explore this question, we conducted a case-control study of patients ... Full text Link to item Cite

CARE-PARTNER: a computerized knowledge-support system for stem-cell post-transplant long-term follow-up on the World-Wide-Web.

Journal article Proc AMIA Symp · 1998 Featured Work Evidence-based practice in medicine promotes the performance of medicine based upon proven and validated practice. The CARE-PARTNER system presented here is a computerized knowledge-support system for stem-cell post-transplant long-term follow-up (LTFU) ca ... Link to item Cite

Allogeneic peripheral blood stem cell transplantation may be associated with a high risk of chronic graft-versus-host disease.

Journal article Blood · December 15, 1997 Featured Work Chronic graft-versus-host disease (GVHD) is likely caused by donor T lymphocytes. Because unmodified blood stem cell grafts contain one log more T lymphocytes than unmodified marrow grafts, we evaluated the incidence of chronic GVHD in previously reported ... Link to item Cite

Safeguarding the administration of high-dose chemotherapy: a national practice survey by the American Society for Blood and Marrow Transplantation.

Journal article Biol Blood Marrow Transplant · December 1997 Featured Work Overdoses of high-dose chemotherapy before hematopoietic cell transplantation are serious adverse events, but their frequency and etiology are unknown. The American Society for Blood and Marrow Transplantation (ASBMT) conducted an anonymous national survey ... Link to item Cite

Collaborative multicenter investigation of marrow transplantation for sickle cell disease: current results and future directions.

Journal article Biol Blood Marrow Transplant · December 1997 Featured Work We present updated results of a multicenter collaborative investigation of bone marrow transplantation for sickle cell disease. Between September 1991 and April 1997, thirty-four children less than 16 years of age with severe sickle cell disease received m ... Link to item Cite

Methotrexate and cyclosporine for graft-vs.-host disease prevention: what length of therapy with cyclosporine?

Journal article Biol Blood Marrow Transplant · October 1997 Featured Work One hundred three patients with leukemia, aplastic anemia, or myelodysplastic syndrome were treated by marrow transplantation from genotypically HLA-identical siblings (n = 92) or HLA haploidentical family members differing for one HLA antigen on the nonsh ... Link to item Cite

Marrow transplants from unrelated donors for treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia.

Journal article Blood · August 15, 1997 Featured Work Transplantation of marrow from unrelated donors was investigated in patients with Philadelphia chromosome-positive (Ph1+) acute lymphoblastic leukemia (ALL) who lacked a suitable family donor. Eighteen patients underwent transplantation at our center betwe ... Link to item Cite

Transplantation of marrow cells from unrelated donors for treatment of high-risk acute leukemia: the effect of leukemic burden, donor HLA-matching, and marrow cell dose.

Journal article Blood · June 1, 1997 Featured Work Transplantation of hematopoietic stem cells from an HLA-compatible unrelated volunteer is an option for patients with acute leukemia lacking a family match. However, criteria for patient and donor selection and the most effective transplant procedures, inc ... Link to item Cite

Cyclosporine or cyclosporine plus methylprednisolone for prophylaxis of graft-versus-host disease: a prospective, randomized trial.

Journal article Blood · May 15, 1997 Featured Work Patients with a lymphohematopoietic malignancy considered to be at high risk for posttransplant relapse were enrolled in a study to compare the use of cyclosporine (CSP) as a single agent with a combination of methylprednisolone (MP) and CSP for graft-vers ... Link to item Cite

Longterm followup and quality of life after hematopoietic stem cell transplantation.

Journal article J Rheumatol Suppl · May 1997 Featured Work The success of marrow or blood stem cell transplantation may depend upon events arising months to years later. Transplant regimen related toxicity may include cataract formation due to corticosteroids or total body irradiation (TBI) and endocrine or gonada ... Link to item Cite

The evolving role of blood and marrow transplantation for the treatment of autoimmune diseases.

Journal article J Rheumatol Suppl · May 1997 Featured Work With over 4 decades of seminal contributions to the development and application of BMT, Dr. Thomas stresses the importance of collaboration between rheumatologists and transplant clinicians in developing this evolving area of treatment. While the debate co ... Link to item Cite

Pre-existing autoimmune disease in patients with long-term survival after allogeneic bone marrow transplantation.

Journal article J Rheumatol Suppl · May 1997 Featured Work We reviewed the experience with allogeneic bone marrow transplantation (BMT) at Fred Hutchinson Cancer Research Center and affiliated Seattle hospitals for patients with preexisting autoimmune diseases. The review was limited to patients who received trans ... Link to item Cite

Development of a protocol for allogeneic marrow transplantation for severe systemic sclerosis: paradigm for autoimmune disease.

Journal article J Rheumatol Suppl · May 1997 Featured Work Some types of severe autoimmune disease are associated with significant morbidity and a high mortality rate. Many of these cases occur in young adults who, even if they survive, become severely debilitated. Systemic sclerosis (SSc) is a paradigm for other ... Link to item Cite

Autologous stem cell transplantation for autoimmune diseases: issues in protocol development.

Journal article J Rheumatol Suppl · May 1997 Featured Work For patients with autoimmune disease resistant to conventional therapy, aggressive strategies employing high dose chemoradiotherapy and autologous stem cell transplant appear to be warranted. Support for this approach comes from animal studies employing ma ... Link to item Cite

Infectious morbidity in long-term survivors of allogeneic marrow transplantation is associated with low CD4 T cell counts.

Journal article Am J Hematol · February 1997 Featured Work Survivors of allogeneic marrow transplants are immunodeficient for at least 1 year after grafting. Multiple defects of immunity have been found; however, it is not known which defect primarily accounts for the high infectious morbidity of these patients. T ... Full text Link to item Cite

A double-blind randomized trial comparing outpatient parenteral nutrition with intravenous hydration: effect on resumption of oral intake after marrow transplantation.

Journal article JPEN J Parenter Enteral Nutr · 1997 Featured Work BACKGROUND: Outpatient parenteral nutrition (PN) is often given to marrow transplant recipients after high-dose chemoradiotherapy until the resumption of adequate oral intake; however, it may adversely prolong resumption or oral calorie intake by contribut ... Full text Link to item Cite

FK506 in combination with methotrexate for the prevention of graft-versus-host disease after marrow transplantation from matched unrelated donors.

Journal article Blood · November 1, 1996 Featured Work The safety and potential efficacy of FK506 in combination with a short course of methotrexate (MTX) for the prevention of acute graft-versus-host disease (GVHD) after marrow transplantation from HLA-matched unrelated donors was evaluated in a single-arm Ph ... Link to item Cite

Bone marrow transplantation for sickle cell disease.

Journal article N Engl J Med · August 8, 1996 Featured Work BACKGROUND: We investigated the risks and benefits of allogeneic bone marrow transplantation in children with complications of sickle cell disease. METHODS: Twenty-two children less than 16 years of age who had symptomatic sickle cell disease received marr ... Full text Link to item Cite

Evaluation of a CD5-specific immunotoxin for treatment of acute graft-versus-host disease after allogeneic marrow transplantation.

Journal article Blood · August 1, 1996 Featured Work Acute graft-versus-host disease (GVHD) is most often treated with high dose glucocorticoids, but less than half of patients have durable overall improvement. Previous phase I and phase II studies suggested that treatment with a CD5-specific immunotoxin (Xo ... Link to item Cite

Graft-versus-host reactions: anti-leukemia effects of donor T cells.

Journal article Transplant Proc · June 1996 Featured Work Link to item Cite

Immunomodulation in allogeneic marrow transplantation: use of intravenous immune globulin to suppress acute graft-versus-host disease.

Journal article Clin Exp Immunol · May 1996 Featured Work Intravenous immune globulin (IVIG) has been used with success to prevent and treat infection in patients with immunodeficiencies of humoral immune function. More recently, IVIG has been shown to modulate immune responses and to treat successfully several a ... Link to item Cite

Barriers to bone marrow transplantation for sickle cell anemia.

Journal article Biol Blood Marrow Transplant · May 1996 Featured Work While allogeneic marrow transplantation is curative therapy for patients with sickle cell anemia, only a small fraction of patients in the United States receive this treatment. We surveyed participants in our multicenter study of marrow transplantation for ... Link to item Cite

Marrow transplantation for hepatitis-associated aplastic anemia: a follow-up of long-term survivors.

Journal article Biol Blood Marrow Transplant · May 1996 Featured Work Between 1971 and 1989 we have treated 19 patients with hepatitis-associated aplastic anemia by marrow transplantation from their HLA-identical siblings following conditioning with 200 mg/kg cyclophosphamide (Cy) administered over a period of 4 days. One pa ... Link to item Cite

Unrelated donor marrow transplantation for myelodysplasia (MDS) and MDS-related acute myeloid leukaemia.

Journal article Br J Haematol · April 1996 Featured Work Allogeneic marrow transplantation using related marrow donors for myelodysplasia (MDS) and acute myeloid leukaemia (AML) arising from MDS results in 35-56% actuarial disease-free survival. Because the use of unrelated donors has not been well-characterized ... Full text Link to item Cite

Allogeneic marrow transplantation for aplastic anaemia associated with dyskeratosis congenita.

Journal article Br J Haematol · March 1996 Featured Work Eight patients with aplastic anaemia associated with dyskeratosis congenita received allogeneic marrow grafts from either HLA-identical siblings (six patients) or HLA-matched unrelated donors (two patients). Patients who received marrow from HLA-identical ... Full text Link to item Cite

Bone density loss during treatment of chronic GVHD.

Journal article Bone Marrow Transplant · March 1996 Featured Work Nine adult patients 31-47 (median 39) years of age treated with prednisone and cyclosporin A (CsA) for chronic graft-versus-host disease (GVHD) were evaluated for biochemical factors associated with skeletal turnover at initiation of immunosuppressive ther ... Link to item Cite

A controlled trial of long-term administration of intravenous immunoglobulin to prevent late infection and chronic graft-vs.-host disease after marrow transplantation: clinical outcome and effect on subsequent immune recovery.

Journal article Biol Blood Marrow Transplant · February 1996 Featured Work To determine whether intravenous immunoglobulin (IVIg) given monthly from day 90 to day 360 posttransplantation decreased the incidence of late infection, chronic graft-vs.-host disease (GVHD), and obliterative bronchiolitis after marrow transplantation, p ... Link to item Cite

Bone marrow transplantation for severe aplastic anemia from genotypically HLA-nonidentical relatives. An update of the Seattle experience.

Journal article Transplantation · January 15, 1996 Featured Work This report updates the results of marrow transplantation at the Fred Hutchinson Cancer Research Center for patients with severe aplastic anemia whose donors were HLA-nonidentical relatives. Between 1970 and 1993, 40 patients received transplants for sever ... Full text Link to item Cite

Secondary immunodeficiencies and stem cell transplantation: issues of administration and safety of intravenous immunoglobulin.

Journal article Clin Ther · 1996 Featured Work This article reviews the administration, efficacy, and safety of prophylactic intravenous immunoglobulin in patients with secondary immunodeficiency and those undergoing allogeneic bone marrow transplantation. Associated infections in these immunosuppresse ... Full text Link to item Cite

Malignancies after marrow transplantation for aplastic anemia and fanconi anemia: a joint Seattle and Paris analysis of results in 700 patients.

Journal article Blood · January 1, 1996 Featured Work Risk factors for the development of a new (secondary) malignancy after marrow transplantation are still incompletely defined. In the present study, we analyzed results in 700 patients with severe aplastic anemia treated with allogeneic marrow transplantati ... Link to item Cite

Allogeneic marrow transplantation for refractory anemia: a comparison of two preparative regimens and analysis of prognostic factors.

Journal article Blood · January 1, 1996 Featured Work From 1990 to 1993 we performed a prospective study of busulfan (16 mg/kg) and cyclophosphamide (120 mg/kg) in 30 patients with refractory anemia (RA) undergoing related (n = 17) or unrelated (n = 13) donor marrow transplantation. Nineteen patients survive ... Link to item Cite

A retrospective analysis of the long-term effect of splenectomy on late infections, graft-versus-host disease, relapse, and survival after allogeneic marrow transplantation for chronic myelogenous leukemia.

Journal article Blood · September 1, 1995 Featured Work The present study was performed as a retrospective analysis of the role of pretransplant splenectomy to determine the incidence of late bacterial infections, acute and chronic graft-versus-host disease (GVHD), relapse, and survival among 358 patients recei ... Link to item Cite

A toxicity study of trimetrexate used in combination with cyclosporine as acute graft-versus-host disease prophylaxis in HLA-mismatched, related donor bone marrow transplants.

Journal article Transplantation · July 15, 1995 Featured Work This study evaluated the acute toxicity of trimetrexate (TMTX) used in combination with cyclosporine (CsA) for prevention of acute graft-versus-host disease (GVHD) in patients undergoing allogeneic marrow transplantation from HLA-mismatched, related donors ... Full text Link to item Cite

Cataracts after bone marrow transplantation: long-term follow-up of adults treated with fractionated total body irradiation.

Journal article Int J Radiat Oncol Biol Phys · June 15, 1995 Featured Work PURPOSE: To determine the risk of, and risk factors for, developing cataracts after bone marrow transplantation. METHODS AND MATERIALS: Four hundred and ninety-two adults who underwent bone marrow transplantation in Seattle were followed for 2 to 18 (media ... Full text Link to item Cite

Neurologic complications after allogeneic marrow transplantation for sickle cell anemia.

Journal article Blood · February 15, 1995 Featured Work Seven of 21 patients with sickle cell anemia developed neurologic complications 5 to 243 days (median, 33 days) after allogeneic marrow transplantation. Among these 7 patients, indications for transplantation included either a past history of stroke (4 pat ... Link to item Cite

Quality of life of 125 adults surviving 6-18 years after bone marrow transplantation.

Journal article Soc Sci Med · February 1995 Featured Work BACKGROUND: Recent studies examining the medical and psychosocial sequelae of bone marrow transplantation have reported most survivors do relatively well while a smaller group continues to experience less than optimal quality of life (QOL). Many of these s ... Full text Link to item Cite

Complications of allogeneic bone marrow transplantation.

Journal article Curr Opin Hematol · November 1994 Featured Work Recent research has increased our understanding of the pathogenesis and prevention of the immediate and delayed complications of allogeneic bone marrow transplantation. Cytokines appear to play a major role in the pathogenesis of acute graft-versus-host di ... Link to item Cite

The management of chronic graft-versus-host disease.

Journal article Blood Rev · September 1994 Featured Work Chronic graft-versus-host disease (GVHD) is a major cause of late morbidity and mortality following allogeneic marrow transplantation. The pathogenesis and clinical features of chronic GVHD resemble those of several autoimmune diseases including progressiv ... Full text Link to item Cite

Reduction in transplant-related complications in patients given intravenous immuno globulin after allogeneic marrow transplantation.

Journal article Clin Exp Immunol · July 1994 Featured Work Bone marrow transplantation renders patients immunocompetent due to the need for supralethal doses of chemoradiotherapy prior to infusion of the donor stem cells. Multiple immunological deficiencies are seen and patients are at high risk of developing a va ... Link to item Cite

Spontaneous factor VIII inhibitor occurring in association with chronic graft-versus-host disease.

Journal article Am J Hematol · March 1994 Featured Work The development of spontaneously acquired Factor VIII inhibitors is rare and may lead to serious hemorrhagic sequelae. We report here the case of a patient who acquired a Factor VIII inhibitor two years after an allogeneic bone marrow transplant for CML. T ... Full text Link to item Cite

Bone marrow transplantation for sickle cell disease. The United States experience.

Journal article Am J Pediatr Hematol Oncol · February 1994 Featured Work PURPOSE: As of June 1992, five patients with sickle cell disease had been treated by matched sibling bone marrow transplantation in the United States. PATIENTS AND METHODS: Three patients underwent transplantations for complications related to sickle cell ... Link to item Cite

Bone marrow transplantation for thalassemia. The USA experience.

Journal article Am J Pediatr Hematol Oncol · February 1994 Featured Work PURPOSE: We have reviewed the results of bone marrow transplantation in 30 patients with thalassemia major who were treated in the United States. PATIENTS AND METHODS: Ten patients who underwent transplantation in Seattle and 20 patients from five other U. ... Link to item Cite

Marrow transplant experience for children with severe aplastic anemia.

Journal article Am J Pediatr Hematol Oncol · February 1994 Featured Work PURPOSE: The two major factors associated with lack of survival after allogeneic marrow transplant for severe aplastic anemia have been graft rejection and acute graft versus host disease (GVHD). As a result, survival for patients transplanted in the 1970s ... Link to item Cite

Marrow transplantation for disorders of hematopoiesis.

Journal article Leukemia · July 1993 Featured Work Link to item Cite

Long-term survival and cure after marrow transplantation for congenital hypoplastic anaemia (Diamond-Blackfan syndrome).

Journal article Br J Haematol · July 1993 Featured Work Four patients with Diamond-Blackfan syndrome (congenital hypoplastic anaemia) whose disease was resistant to corticosteroid treatment and who were red blood cell transfusion-dependent, were given marrow grafts from allogeneic human-leucocyte-antigen (HLA)- ... Full text Link to item Cite

Recovery after allogeneic marrow transplantation: prospective study of predictors of long-term physical and psychosocial functioning.

Journal article Bone Marrow Transplant · April 1993 Featured Work No prospective data have documented the physical and psychosocial functioning of patients before and after BMT. In this study 67 allogeneic transplant patients completed standardized self-report measures pre-transplant. Survivors were re-assessed at 90 day ... Link to item Cite

Fatal eosinophilia myalgia syndrome in a marrow transplant patient attributed to total parenteral nutrition with a solution containing tryptophan.

Journal article Bone Marrow Transplant · February 1993 Featured Work A 16-year-old white male with acute biphenotypic leukemia developed evidence of the eosinophilia myalgia syndrome associated with total parenteral nutritional support with solutions containing tryptophan, which were given during his initial induction chemo ... Link to item Cite

Quality of life of adult long-term survivors of bone marrow transplantation: a qualitative analysis of narrative data.

Journal article Oncol Nurs Forum · 1993 Featured Work Recently, clinicians and researchers alike have challenged the long-standing impression that survivors of bone marrow transplantation (BMT) experience a less than optimal quality of life (QOL). Despite the accumulating evidence suggesting that most adult s ... Link to item Cite

Allogeneic marrow transplantation during untreated first relapse of acute myeloid leukemia.

Journal article J Clin Oncol · November 1992 Featured Work PURPOSE: The purpose of this report was to review the Seattle experience in bone marrow transplantation (BMT) for acute myeloid leukemia (AML) during untreated first relapse. PATIENTS AND METHODS: Through 1990, 126 patients were transplanted during untreat ... Full text Link to item Cite

Two cases of transfusion-associated graft-vs-host disease after open heart surgery.

Journal article Arch Dermatol · November 1992 Featured Work BACKGROUND: Some cases of blood transfusion-associated (TA) graft-vs-host disease (GVHD) in immunocompetent patients have been reported, but those dermatologic findings were not precisely mentioned. We describe patients with clinicopathologically TA-GVHD a ... Link to item Cite

Treatment of acute graft-versus-host disease with a nonmitogenic anti-CD3 monoclonal antibody.

Journal article Transplantation · November 1992 Featured Work Treatment with the monoclonal antibody OKT3 specific for the CD3 complex associated with the T cell antigen receptor can reverse acute rejection of human renal allografts. However, efficacy of anti-CD3 antibodies for treatment of patients with acute graft- ... Full text Link to item Cite

Etoposide, cyclophosphamide and fractionated total body irradiation as a preparative regimen for marrow transplantation in patients with advanced hematological malignancies: a phase I study.

Journal article Bone Marrow Transplant · July 1992 Featured Work Thirty-seven patients with advanced hematologic malignancy were entered into a phase I study designed to define a maximum tolerable dose (MTD) of etoposide (VP-16) and cyclophosphamide (CY) combined with 12 Gy fractionated total body irradiation (TBI) as p ... Link to item Cite

Ursodeoxycholic acid treatment of refractory chronic graft-versus-host disease of the liver.

Journal article Ann Intern Med · April 15, 1992 Featured Work OBJECTIVE: To determine the safety and efficacy of ursodeoxycholic acid treatment in patients with chronic graft-versus-host disease (GVHD) of the liver. DESIGN: Open-label study in which each patient served as his or her own control. SETTING: Private prac ... Full text Link to item Cite

Marrow transplantation for Fanconi anemia with or without leukemic transformation: an update of the Seattle experience.

Journal article Bone Marrow Transplant · March 1992 Featured Work Between March 1973 and August 1990, 17 patients with Fanconi anemia (FA) underwent bone marrow transplantation in Seattle. Marrow donors were HLA identical siblings (n = 14), phenotypically HLA identical parents (n = 2) and a one antigen mismatched parent ... Link to item Cite

Mixed leukocyte culture reactivity and graft-versus-host disease in HLA-identical marrow transplantation for leukemia.

Journal article Bone Marrow Transplant · February 1992 Featured Work The results of pretransplant mixed leukocyte culture (MLC) assays were compared to subsequent risk of graft-versus-host disease (GVHD) in 783 patients receiving marrow transplants from HLA genotypically identical sibling donors. The mean MLC response obser ... Link to item Cite

Late complications of allogeneic and autologous marrow transplantation.

Journal article Bone Marrow Transplant · 1992 Featured Work Link to item Cite

Marrow transplantation following escalating doses of fractionated total body irradiation and cyclophosphamide--a phase I trial.

Journal article Int J Radiat Oncol Biol Phys · 1992 Featured Work Thirty-six patients with advanced hematologic malignancy were entered into a Phase I study designed to define the maximum tolerated dose of unshielded total body irradiation delivered from dual 60 Cobalt sources at an exposure rate of 8 cGy/min and given i ... Full text Link to item Cite

Photoinactivation of lymphohemopoietic cells: studies in transfusion medicine and bone marrow transplantation.

Journal article Blood Cells · 1992 Featured Work Ultraviolet (UV) irradiation affects eukaryotic cells in numerous ways. Exposure of blood transfusion products to UVC (200-280 nm) or UVB (280-320 nm) reduces or abrogates their immunogenicity and thereby prevents allosensitization and transfusion refracto ... Link to item Cite

Busulfan and cyclophosphamide as a preparative regimen for bone marrow transplantation in patients with prior chest radiotherapy.

Journal article Bone Marrow Transplant · September 1991 Featured Work In a previous study, we reported that patients with hematologic malignancies who had received prior chest radiotherapy had a 32% risk of developing fatal interstitial pneumonia (IP) when prepared for bone marrow transplantation (BMT) with a regimen contain ... Link to item Cite

Transfusions shortly before HLA-matched marrow transplantation for leukemia are associated with a decrease in chronic graft-versus-host disease.

Journal article Bone Marrow Transplant · April 1991 Featured Work The effect of random red cell transfusions given shortly before allogeneic bone marrow transplantation (BMT) was evaluated in 969 leukemic patients transplanted from an HLA-identical sibling donor. Patients were divided into two groups: 501 who received a ... Link to item Cite

Long-term follow-up of patients who received recombinant human granulocyte-macrophage colony stimulating factor after autologous bone marrow transplantation for lymphoid malignancy.

Journal article Bone Marrow Transplant · January 1991 Featured Work Twenty-seven patients with lymphoid neoplasia who underwent autologous bone marrow transplant (BMT) and who had received recombinant human granulocyte-macrophage colony stimulating factor (rhGM-CSF) were followed in order to examine the potential long-term ... Link to item Cite

Immunomodulatory and antimicrobial efficacy of intravenous immunoglobulin in bone marrow transplantation.

Journal article N Engl J Med · September 13, 1990 Featured Work BACKGROUND: Graft-versus-host disease (GVHD) and infection are major complications of allogeneic bone marrow transplantation. Since intravenous immunoglobulin has shown benefit in several immunodeficiency and autoimmune disorders, we studied its antimicrob ... Full text Link to item Cite

What role for prednisone in prevention of acute graft-versus-host disease in patients undergoing marrow transplants?

Journal article Blood · September 1, 1990 Featured Work One hundred forty-seven consecutive patients with leukemia, myelodysplastic syndrome, or aplastic anemia were treated by marrow grafts from genotypically HLA-identical siblings (n = 122) or HLA-haploidentical family members (n = 25). Haploidentical recipie ... Link to item Cite

Prevalence of nutrition-related problems among long-term survivors of allogeneic marrow transplantation.

Journal article J Am Diet Assoc · June 1990 Featured Work The nutritional status and prevalence of nutrition-related problems in 192 adult and child allogeneic marrow transplant recipients were evaluated 1 year after transplant in a retrospective chart review. Among these patients, 63% exhibited evidence of chron ... Link to item Cite

Autologous marrow transplantation for malignant lymphoma: a report of 101 cases from Seattle.

Journal article J Clin Oncol · April 1990 Featured Work Between October 1979 and January 1988, 101 patients with malignant lymphoma who failed initial induction treatment or relapsed received high-dose combination chemotherapy or chemoradiotherapy followed by infusion of autologous bone marrow. Twenty-eight of ... Full text Link to item Cite

Previous donor pregnancy as a risk factor for acute graft-versus-host disease in patients with aplastic anaemia treated by allogeneic marrow transplantation.

Journal article Br J Haematol · April 1990 Featured Work To determine if previous donor pregnancies influence the development of acute graft-versus-host disease (GVHD) we evaluated data from 136 patients with aplastic anaemia greater than 15 years of age and given marrow grafts from HLA-identical sibling donors. ... Full text Link to item Cite

Self-administration of morphine in bone marrow transplant patients reduces drug requirement.

Journal article Pain · February 1990 Featured Work Bone marrow transplant recipients were randomly assigned to receive morphine by either continuous infusion (32 patients) or self-administration of small boluses (patient-controlled analgesia (PCA), 26 patients) for control of chemoradiotherapy-induced oral ... Full text Link to item Cite

Recognition, incidence, and management of oral graft-versus-host disease.

Journal article NCI Monogr · 1990 Featured Work Acute and chronic graft-versus-host disease (GVHD) are significant complications of allogeneic bone marrow transplantation that occur when immunologically active T-cell lymphocytes are transplanted into an immunosuppressed recipient who is genetically disp ... Link to item Cite

Supportive care of the marrow transplant recipient: the Seattle Experience.

Journal article Haematol Blood Transfus · 1990 Featured Work It is now almost 2 decades after the first successful human marrow transplants from HLA-identical siblings for the treatment of life-threatening hematologic diseases. Results have improved, especially for patients transplanted earlier in the course of dise ... Full text Link to item Cite

Chronic graft-versus-host disease.

Journal article Cancer Treat Res · 1990 Featured Work Full text Link to item Cite

Intravenous immune globulin prophylaxis in recipients of a marrow transplant.

Journal article J Allergy Clin Immunol · October 1989 Featured Work Bone marrow transplantation is a worldwide activity involving more than 250 transplant centers in more than 40 countries. The ultimate success of the procedure depends in large measure on supportive care of the transplant recipient. A major component of th ... Full text Link to item Cite

Influence of acute and chronic graft-versus-host disease on relapse and survival after bone marrow transplantation from HLA-identical siblings as treatment of acute and chronic leukemia.

Journal article Blood · May 1, 1989 Featured Work To assess the influence of graft-versus-host disease (GVHD) on recurrent leukemia and survival after allogeneic marrow transplantation, we studied 1,202 patients with acute nonlymphocytic leukemia (ANL), acute lymphocytic leukemia (ALL), and chronic myelog ... Link to item Cite

Graft-versus-host disease as adoptive immunotherapy in patients with advanced hematologic neoplasms.

Journal article N Engl J Med · March 30, 1989 Featured Work The occurrence of graft-versus-host disease (GVHD) after allogeneic bone marrow transplantation for leukemia is thought to decrease the probability of recurrence. To study this effect (called adoptive immunotherapy) we modified the prophylaxis of GVHD in p ... Full text Link to item Cite

Assessment and management of donor pain following marrow harvest for allogeneic bone marrow transplantation.

Journal article Bone Marrow Transplant · March 1989 Featured Work We studied the time course and intensity of pain of multiple bone marrow aspirations in 30 healthy adult marrow donors receiving acetaminophen with codeine for analgesia immediately after marrow harvesting for allogeneic bone marrow transplantation. Upon d ... Link to item Cite

Chemoradiotherapy toxicity during bone marrow transplantation: time course and variation in pain and nausea.

Journal article Bone Marrow Transplant · March 1989 Featured Work Chemoradiotherapy-induced toxicity following unmodified allogeneic marrow grafting was studied. Patients with hematologic malignancy (n = 157) received cyclophosphamide (120 mg/kg) followed by single or fractionated total body irradiation (TBI); aplastic a ... Link to item Cite

Congress review: progress and prospects in bone marrow transplantation.

Journal article Transplant Proc · February 1989 Featured Work Link to item Cite

Long-term results of allogeneic bone marrow transplantation.

Journal article Transplant Proc · February 1989 Featured Work Link to item Cite