Sundar Khadka | Scholars@Duke

Sundar Khadka
Postdoctoral Associate

Postdoctoral Research Associate, Shinohara laboratory

Current Research Interests

Sundar received his PhD in Neuroimmunology/Neurovirology from the Kindai University Faculty of Medicine, Japan, as a MEXT scholar (2018-2023). During his doctoral degree, he worked on both autoimmune (experimental autoimmune encephalomyelitis) and viral (Theiler's murine encephalomyelitis virus) models of multiple sclerosis(MS). His project focused on gut microbiota alternation in animal models of MS by adjuvant, curcumin, or lipid A. His doctoral thesis title was “Curcumin β-D-glucuronide modulates an autoimmune model of multiple sclerosis with altered gut microbiota in the ileum and feces”.

Sundar joined Shinohara Lab in 2023 and works on cell specific mechanism mediated by dectin-1 in animal models of multiple sclerosis. He earned master degree in clinical microbiology and worked as microbiologist in WHO HIV drug resistance project at the National Public Health Laboratory (NPHL), Kathmandu, Nepal for 3 years.

Current Appointments & Affiliations

Postdoctoral Associate, Integrative Immunobiology, Basic Science Departments

Contact Information

sundar.khadka@duke.edu +1 919 613 6977

Publications & Artistic Works
Selected Publications
- Academic Articles
  - Khadka, S., Omura, S., Sato, F., & Tsunoda, I. (2023). Adjuvant Injections Altered the Ileal and Fecal Microbiota Differently with Changes in Immunoglobulin Isotypes and Antimycobacterial Antibody Responses. International Journal of Molecular Sciences, 24(3), 2818. https://doi.org/10.3390/ijms24032818
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  - Park, A.-M., Khadka, S., Sato, F., Omura, S., Fujita, M., Hashiwaki, K., & Tsunoda, I. (2022). Bacterial and fungal isolation from face masks under the COVID-19 pandemic. Scientific Reports, 12(1), 11361. https://doi.org/10.1038/s41598-022-15409-x
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  - Leong, K. W. C., Gautam, S. S., Pradhan, M., Singh, Y. I., Kc, R., Rajbhandari, S. K., … O’Toole, R. F. (2022). Comparative genomic analyses of multi-drug resistant Mycobacterium tuberculosis from Nepal and other geographical locations. Genomics, 114(2), 110278. https://doi.org/10.1016/j.ygeno.2022.110278
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  - Sato, F., Nakamura, Y., Katsuki, A., Khadka, S., Ahmad, I., Omura, S., … Tsunoda, I. (2022). Curdlan, a Microbial β-Glucan, Has Contrasting Effects on Autoimmune and Viral Models of Multiple Sclerosis. Frontiers in Cellular and Infection Microbiology, 12, 805302. https://doi.org/10.3389/fcimb.2022.805302
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  - Khadka, S., Omura, S., Sato, F., Nishio, K., Kakeya, H., & Tsunoda, I. (2021). Curcumin β-D-Glucuronide Modulates an Autoimmune Model of Multiple Sclerosis with Altered Gut Microbiota in the Ileum and Feces. Frontiers in Cellular and Infection Microbiology, 11, 772962. https://doi.org/10.3389/fcimb.2021.772962
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  - Khadka, S., Pandit, R., Dhital, S., Baniya, J. B., Tiwari, S., Shrestha, B., … Mishra, S. K. (2020). Evaluation of Five International HBV Treatment Guidelines: Recommendation for Resource-Limited Developing Countries Based on the National Study in Nepal. Pathophysiology : The Official Journal of the International Society for Pathophysiology, 27(1), 3–13. https://doi.org/10.3390/pathophysiology27010002
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  - Mishra, S. K., Shrestha, L., Pandit, R., Khadka, S., Shrestha, B., Dhital, S., … Das Manandhar, K. (2020). Establishment of reference range of CD4 T-lymphocyte in healthy Nepalese adults. Bmc Research Notes, 13(1), 316. https://doi.org/10.1186/s13104-020-05156-5
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  - Gautam, S. S., Leong, K. W. C., Pradhan, M., Singh, Y. I., Rajbhandari, S. K., Ghimire, G. R., … O’Toole, R. F. (2020). Draft Genome Sequence of an Isolate of Extensively Drug-Resistant Mycobacterium tuberculosis from Nepal. Microbiology Resource Announcements, 9(4), e01404–e01419. https://doi.org/10.1128/mra.01404-19
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  - Omura, S., Sato, F., Park, A.-M., Fujita, M., Khadka, S., Nakamura, Y., … Tsunoda, I. (2020). Bioinformatics Analysis of Gut Microbiota and CNS Transcriptome in Virus-Induced Acute Myelitis and Chronic Inflammatory Demyelination; Potential Association of Distinct Bacteria With CNS IgA Upregulation. Frontiers in Immunology, 11, 1138. https://doi.org/10.3389/fimmu.2020.01138
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  - Park, A.-M., Khadka, S., Sato, F., Omura, S., Fujita, M., Hsu, D. K., … Tsunoda, I. (2020). Galectin-3 as a Therapeutic Target for NSAID-Induced Intestinal Ulcers. Frontiers in Immunology, 11, 550366. https://doi.org/10.3389/fimmu.2020.550366
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  - Khadka, S., Shrestha, R., Pandit, S., Pandit, R., & Bastola, A. (2019). Late Response of Antiretroviral Therapy in an HIV-1-Infected Patient due to Hepatitis B and C Coinfections: The First Case Report in Nepal. Case Reports in Medicine, 2019, 2070973. https://doi.org/10.1155/2019/2070973
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  - Khadka, S., Dhital, S., Pandit, R., & Bastola, A. (2018). Sustained Viremic Control in HIV-Infected Patient: Case Report from Nepal. Case Reports in Infectious Diseases, 2018, 5279595. https://doi.org/10.1155/2018/5279595
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  - Geeta, S., Raj, K. M., Sundar, K., Subhash, D., Jagat, B. B., Lilee, S., … Bishnu, P. U. (2017). A study of outcomes of seven years viral load testing at the National Public Health Laboratory, Nepal. Journal of Aids and Hiv Research, 9(12), 233–236. https://doi.org/10.5897/jahr2017.0437
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  - Dhital, S., Sherchand, J. B., Pokharel, B. M., Parajuli, K., Mishra, S. K., Sharma, S., … Rijal, B. (2017). Antimicrobial susceptibility pattern of Shigella spp. isolated from children under 5 years of age attending tertiary care hospitals, Nepal along with first finding of ESBL-production. Bmc Research Notes, 10(1), 192. https://doi.org/10.1186/s13104-017-2512-1
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  - Khadka, S., Sherchand, J. B., Pokhrel, B. M., Parajuli, K., Mishra, S. K., Sharma, S., … Rijal, B. P. (2017). Isolation, speciation and antifungal susceptibility testing of Candida isolates from various clinical specimens at a tertiary care hospital, Nepal. Bmc Research Notes, 10(1), 218. https://doi.org/10.1186/s13104-017-2547-3
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  - Dhital, S., Sherchand, J. B., Pokhrel, B. M., Parajuli, K., Shah, N., Mishra, S. K., … Rijal, B. (2017). Molecular epidemiology of Rotavirus causing diarrhea among children less than five years of age visiting national level children hospitals, Nepal. Bmc Pediatrics, 17(1), 101. https://doi.org/10.1186/s12887-017-0858-0
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  - Khadka, S., Sherchand, J., Pokhrel, B., Dhital, S., Manjhi, R., & Rijal, B. (2017). Antifungal Susceptibility Testing of Dermatophytes by Agar Based Disk Diffusion Assay in Tertiary Care Hospital, Nepal. Microbiology Research Journal International, 19(2), 1–5. https://doi.org/10.9734/mrji/2017/31827
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  - Mishra, S. K., Khadka, S., Dhital, S., Mahto, R. K., & Manandhar, K. D. (2017). Biomarkers in Immune Reconstitution Inflammatory Syndrome (IRIS) among People Living with Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS). Journal of Aids &Amp; Clinical Research, 08(09). https://doi.org/10.4172/2155-6113.1000728
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  - Shrestha, R., Khadka, S., Wagle, S. R., & Sapkota, A. (2016). Detection of Latent HIV-1 Infection and Drug Resistant Mutation Testing in Nepal: HIV-1 env V3 DNA Sequence and RT Gene (M184V) Mutation. Nepal Journal of Biotechnology, 4(1), 18–25. https://doi.org/10.3126/njb.v4i1.16342
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  - Khadka, S., Sherchand, J. B., Pokharel, D. B., Pokhrel, B. M., Mishra, S. K., Dhital, S., & Rijal, B. (2016). Clinicomycological Characterization of Superficial Mycoses from a Tertiary Care Hospital in Nepal. Dermatology Research and Practice, 2016, 9509705. https://doi.org/10.1155/2016/9509705
    Full Text Open Access Copy

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Selected Publications

Academic Articles