Scholars@Duke
Susan Crawford

Susan Crawford

Adjunct Professor in the Department of Pathology
Pathology

Current Appointments & Affiliations

Adjunct Professor in the Department of Pathology · 2023 - Present Pathology, Clinical Science Departments

Recent Publications

DGAT1 Inhibition Enhances Olaparib-Induced Lipotoxic Apoptosis in Metastatic Castration-Resistant Prostate Cancer.

Journal Article FASEB J · August 15, 2025 Despite the initial success of poly (ADP-ribose) polymerase (PARP) inhibitors, achieving durable responses and effective treatment outcomes in metastatic castration-resistant prostate cancer (mCRPC) remains challenging. Resistance to the PARP inhibitor Ola ... Full text Link to item Cite

Obesity-Facilitated Colon Cancer Progression Is Mediated by Increased Diacylglycerol O-Acyltransferases 1 and 2 Levels.

Journal Article Gastroenterology · February 2025 BACKGROUND & AIMS: The obesity epidemic is associated with increased colon cancer progression. As lipid droplets (LDs) fuel tumor growth, we aimed to determine the significance of diacyltransferases (diacylglycerol o-acyltransferases 1 and 2 [DGAT1/2]), re ... Full text Link to item Cite

Gut-liver axis calibrates intestinal stem cell fitness.

Journal Article Cell · February 15, 2024 The gut and liver are recognized to mutually communicate through the biliary tract, portal vein, and systemic circulation. However, it remains unclear how this gut-liver axis regulates intestinal physiology. Through hepatectomy and transcriptomic and prote ... Full text Link to item Cite
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