Scholars@Duke
Susan Crawford

Susan Crawford

Adjunct Professor in the Department of Pathology
Pathology

Scholarly Works - Conferences

Pigment epithelium-derived factor induces CRX alterations in the mouse retina

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 2022 Link to item Cite

Abstract 5068: Distinct pro-inflammatory cytokines in prostate fibroblasts from African-Americans with prostate cancer increase the tumorigenicity of cancer cells

Conference Cancer Research · July 1, 2018 AbstractIntroduction: African-American (AA) men are disproportionately affected by prostate cancer (PCa) compared with Caucasian (CA) men. AA men have higher PCa incidence and, once diagnosed, a higher stage ... Full text Cite

Abstract 1451: A novel lipid-centrosomal axis in prostate cancer is regulated by PEDF

Conference Cancer Research · July 1, 2018 AbstractBackground: Prostate tumor cells undergo metabolic adaptations and revert to lipid stores to meet the energy demands of their high proliferative capacity. To fuel progression, cancer cells accumulate ... Full text Cite

Depletion of polymorphonuclear leukocytes has no effect on preterm delivery in a mouse model of Escherichia coli-induced labor.

Conference Am J Obstet Gynecol · November 2015 OBJECTIVE: The objective of the study was to investigate the role of polymorphonuclear leukocytes (PMNs) in a mouse model of Escherichia coli-induced labor. STUDY DESIGN: Intraperitoneal injection of rabbit antimouse PMN antiserum or control was performed ... Full text Link to item Cite

Elevated neonatal insulin-like growth factor I is associated with fetal hypertrophic cardiomyopathy in diabetic women.

Conference Am J Obstet Gynecol · September 2014 OBJECTIVE: We sought to determine if fetal hypertrophic cardiomyopathy (HCM) or cardiac dysfunction is associated with elevated maternal or neonatal insulin-like growth factor (IGF)-I levels in women with diabetes. STUDY DESIGN: In a prospective cohort stu ... Full text Link to item Cite

79: Elevated neonatal IGF-I is associated with fetal hypertrophic cardiomyopathy

Conference American Journal of Obstetrics and Gynecology · January 2014 Full text Cite

Abstract 5075: Targeting TSP1 and inhibiting angiogenesis in UV-induced skin cancer by apigenin.

Conference Cancer Research · April 15, 2013 AbstractNon-melanoma skin cancer (NMSC) is a major health problem in the United States, with over two million new cases diagnosed yearly. Among many genetic and environmental factors contributed to NMSC, ult ... Full text Cite

Peritumoral Expression of Adipokines and Fatty Acids in Breast Cancer

Conference ANNALS OF SURGICAL ONCOLOGY · February 2013 Link to item Cite

280: Gestational diabetes induces fetal hypertrophic cardiomyopathy in a rat model

Conference American Journal of Obstetrics and Gynecology · January 2013 Full text Cite

Abstract 4117: Increased pancreatic adipocyte hypertrophy in EL-Kras/PEDF null mice with versus without pancreatic cancer

Conference Cancer Research · April 15, 2012 AbstractUnderstanding non-parenchymal contributions to disease etiology and factors that assess risk and prognosis are currently key points of interest in pancreatic cancer research. One such focus is in reg ... Full text Cite

Abstract 545: Autocrine growth regulation by PEDF is mediated by ovarian steroid hormones: Implications in the pathogenesis of endometrial carcinoma

Conference Cancer Research · April 15, 2012 AbstractThe angiogenic inhibitor and neurotrophic factor, pigment epithelium-derived factor (PEDF) was first shown in the eye and is now shown to be expressed in a number of tissues and to function in apopto ... Full text Cite

Abstract 1499: Periprostatic fat from obese patients promotes prostate cancer growth

Conference Cancer Research · April 15, 2012 AbstractBackground: Obesity, particularly visceral obesity, increases the risk of prostate cancer (PCa) progression. However, the mechanism of this remains unclear. Here, we hypothesized that the visceral pe ... Full text Cite

Abstract 1523: Trafficking of intracytoplasmic lipid droplets in pancreatic cancer cells by pigment epithelium-derived factor alters triacylglycerol metabolism and cellular invasion

Conference Cancer Research · April 15, 2012 AbstractBackground: Pancreatic ductal adenocarcinoma (PDAC) is a rapidly progressing disease with high metastatic potential, thus, it requires a robust and renewable source of energy to meet its metabolic de ... Full text Cite

183: Maternal obesity and evidence of fetal programming of lipid metabolism

Conference American Journal of Obstetrics and Gynecology · January 2012 Full text Cite

Abstract LB-321: Metabolic profiles of periprostatic adipose tissue from prostate cancer patients using MR spectroscopy

Conference Cancer Research · April 15, 2011 AbstractObesity is associated with more aggressive prostate cancer (PCa), with visceral obesity conferring an even higher risk than generalized obesity. However, the mechanism by which obesity fuels PCa prog ... Full text Cite

Abstract 387: Prostate cancer cell invasion is stimulated by cross communication with human monocyte-lineage cells

Conference Cancer Research · April 15, 2011 AbstractTumor-associated macrophages (TAMs) produce factors that may stimulate tumor growth, angiogenesis and progression. In this study, co-cultures with monocyte-derived THP-1, U-937 cells or normal periph ... Full text Cite

196: Maternal adiposity reduces fetal growth in a leptin-deficient murine model

Conference American Journal of Obstetrics and Gynecology · January 2011 Full text Cite

Pigment epithelium-derived factor is an angiogenesis and lipid regulator that activates peroxisome proliferator-activated receptor alpha.

Conference Adv Exp Med Biol · 2008 Pigment epithelium-derived factor (PEDF) is an endogenous antiangiogenic protein that also possesses antitumor activity. The mechanisms by which PEDF exerts its actions remains poorly understood. We sought to understand the role of PEDF in hepatocellular c ... Full text Link to item Cite

Neoangiogenesis and placental vasculopathy in placentas of stillborn infants.

Conference JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION · February 2005 Link to item Cite

Inflammatory Pulmonary Nodules in Kawasaki Disease

Conference Pediatric Research · January 2003 Full text Cite

Inflammatory pulmonary nodules in Kawasaki disease

Conference PEDIATRIC RESEARCH · April 2002 Link to item Cite

Captopril reduces graft coronary artery disease in a rat heterotopic transplant model.

Conference Circulation · November 1993 BACKGROUND: Transplant coronary artery disease (CAD) is characterized by severe myointimal proliferation causing vascular stenosis. Nontransplant vascular injury models have shown that angiotensin converting enzyme (ACE) inhibitors reduce myointimal prolif ... Link to item Cite

Heart transplantation in neonates and in children.

Conference J Heart Lung Transplant · 1992 Between May 1988 and July 1991, 28 neonates and children underwent orthotopic heart transplantation at Children's Memorial Hospital in Chicago. Indications for heart transplantation were hypoplastic left heart syndrome (10), dilated cardiomyopathy (13), ao ... Link to item Cite