Scholarly Works - Book sections
Book section
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January 1, 2025
This chapter provides an overview of the basic principles involved in the design and analysis of phase III immune-oncology clinical trials, which includes the choice of the endpoints, the statistical analysis of the main analysis for the primary endpoint, ...
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Book section
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January 1, 2022
Factorial clinical trials test the effects of two or more therapies using a design that can estimate interaction between therapies (Piantadosi 2017). (This chapter revises, updates, and expands upon reference (Piantadosi 2017)) A factorial structure is the ...
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Book section
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April 24, 2019
Some of the recommended methods can be generally adapted and applied to
combination studies; however, at this point, ... O'Quigley J, Pepe M, Fisher L.
Continual reassessment method: A practical design for phase I clinical trials in
cancer. ...
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