Susan Kay Murphy

Journal article Environ Epigenet · 2021 Featured Publication Cannabis use alters sperm DNA methylation, but the potential reversibility of these changes is unknown. Semen samples from cannabis users and non-user controls were collected at baseline and again following a 77-day period of cannabis abstinence (one sperm ... Full text Open Access Link to item Cite

Gender-specific methylation differences in relation to prenatal exposure to cigarette smoke.

Journal article Gene · February 15, 2012 Featured Publication Epigenetic alterations may mechanistically explain the developmental origins of adult disease, namely the hypothesis that many complex adult chronic diseases originate as a result of conditions encountered in utero. If true, epigenetically regulated imprin ... Full text Link to item Cite

Differentially methylated regions of imprinted genes in prenatal, perinatal and postnatal human tissues.

Journal article PLoS One · 2012 Featured Publication Epigenetic plasticity in relation to in utero exposures may mechanistically explain observed differences in the likelihood of developing common complex diseases including hypertension, diabetes and cardiovascular disease through the cumulative effects of s ... Full text Link to item Cite

Epigenetic suppression of the TGF-beta pathway revealed by transcriptome profiling in ovarian cancer.

Journal article Genome Res · January 2011 Featured Publication Epithelial ovarian cancer is the leading cause of death among gynecologic malignancies. Diagnosis usually occurs after metastatic spread, largely reflecting vague symptoms of early disease combined with lack of an effective screening strategy. Epigenetic m ... Full text Link to item Cite

Targeting slow-proliferating ovarian cancer cells.

Journal article Int J Cancer · May 15, 2010 Featured Publication Advanced ovarian cancer has a high rate of recurrence and mortality despite relative chemosensitivity at the time of initial treatment. Conventional chemotherapeutic agents typically target rapidly dividing cells. Disease relapse may therefore result from ... Full text Link to item Cite

Identification of an ovarian clear cell carcinoma gene signature that reflects inherent disease biology and the carcinogenic processes.

Journal article Oncogene · March 25, 2010 Featured Publication Ovarian clear cell carcinoma (OCCC) shows unique clinical features including an association with endometriosis and poor prognosis. We previously reported that the contents of endometriotic cysts, especially high concentrations of free iron, are a possible ... Full text Link to item Cite

Elevated MAL expression is accompanied by promoter hypomethylation and platinum resistance in epithelial ovarian cancer.

Journal article Int J Cancer · March 15, 2010 Featured Publication We previously found that the gene encoding the Myelin and Lymphocyte protein, MAL, was among the most highly expressed genes in serous ovarian cancers from short-term survivors (<3 years) relative to those of long-term survivors (>7 years). In the present ... Full text Link to item Cite

Targeting ovarian cancer-initiating cells.

Journal article Anticancer Agents Med Chem · February 2010 Featured Publication Evidence supports that a variety of cancers are sparked by the growth of cells that exhibit characteristics of stem cells. Such cancer-initiating cells are capable of populating a tumor with a heterogeneous group of daughter cells while still maintaining t ... Full text Link to item Cite

Imprint regulatory elements as epigenetic biosensors of exposure in epidemiological studies.

Journal article J Epidemiol Community Health · September 2009 Featured Publication In the etiologic investigation of complex diseases and neuro-developmental disorders, the interaction of genetic factors and the environment have been evaluated by comparing disease risk as a function of environmental exposure in individuals who carry gene ... Full text Link to item Cite

Yin yang 1 modulates taxane response in epithelial ovarian cancer.

Journal article Mol Cancer Res · February 2009 Featured Publication Survival of ovarian cancer patients is largely dictated by their response to chemotherapy, which depends on underlying molecular features of the malignancy. We previously identified YIN YANG 1 (YY1) as a gene whose expression is positively correlated with ... Full text Link to item Cite

Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells.

Journal article Oncogene · January 15, 2009 Featured Publication The cancer stem cell hypothesis posits that malignant growth arises from a rare population of progenitor cells within a tumor that provide it with unlimited regenerative capacity. Such cells also possess increased resistance to chemotherapeutic agents. Res ... Full text Link to item Cite

Perspectives: the possible influence of assisted reproductive technologies on transgenerational reproductive effects of environmental endocrine disruptors.

Journal article Toxicol Sci · April 2007 Featured Publication Demasculinization by environmental endocrine-disrupting chemicals (EDCs) is observed in many animal species but less evident in humans. Rodent studies with gestational exposure to either the fungicide vinclozolin or the insecticide methoxychlor demonstrate ... Full text Link to item Cite

Cancer susceptibility: epigenetic manifestation of environmental exposures.

Journal article Cancer J · 2007 Featured Publication Cancer is a disease that results from both genetic and epigenetic changes. Discordant phenotypes and varying incidences of complex diseases such as cancer in monozygotic twins as well as genetically identical laboratory animals have long been attributed to ... Full text Link to item Cite

Frequent IGF2/H19 domain epigenetic alterations and elevated IGF2 expression in epithelial ovarian cancer.

Journal article Mol Cancer Res · April 2006 Featured Publication Overexpression of the imprinted insulin-like growth factor-II (IGF2) is a prominent characteristic of gynecologic malignancies. The purpose of this study was to determine whether IGF2 loss of imprinting (LOI), aberrant H19 expression, and/or epigenetic der ... Full text Link to item Cite

Callipyge mutation affects gene expression in cis: a potential role for chromatin structure.

Journal article Genome Res · March 2006 Featured Publication Muscular hypertrophy in callipyge sheep results from a single nucleotide substitution located in the genomic interval between the imprinted Delta, Drosophila, Homolog-like 1 (DLK1) and Maternally Expressed Gene 3 (MEG3). The mechanism linking the mutation ... Full text Link to item Cite

High throughput detection of M6P/IGF2R intronic hypermethylation and LOH in ovarian cancer.

Journal article Nucleic Acids Res · 2006 Featured Publication Cell surface mannose 6-phosphate/insulin-like growth factor II receptors (M6P/IGF2R) bind and target exogenous insulin-like growth factor II (IGF2) to the prelysosomes where it is degraded. Loss of heterozygosity (LOH) for M6P/IGF2R is found in cancers, wi ... Full text Link to item Cite

Patterns of gene expression that characterize long-term survival in advanced stage serous ovarian cancers.

Journal article Clin Cancer Res · May 15, 2005 Featured Publication PURPOSE: A better understanding of the underlying biology of invasive serous ovarian cancer is critical for the development of early detection strategies and new therapeutics. The objective of this study was to define gene expression patterns associated wi ... Full text Link to item Cite

Abnormal postnatal maintenance of elevated DLK1 transcript levels in callipyge sheep.

Journal article Mamm Genome · March 2005 Featured Publication The underlying mechanism of the callipyge muscular hypertrophy phenotype in sheep (Ovis aries) is not presently understood. This phenotype, characterized by increased glycolytic type II muscle proportion and cell size accompanied by decreased adiposity, is ... Full text Link to item Cite

Epigenetic detection of human chromosome 14 uniparental disomy.

Journal article Hum Mutat · July 2003 Featured Publication The recent demonstration of genomic imprinting of DLK1 and MEG3 on human chromosome 14q32 indicates that these genes might contribute to the discordant phenotypes associated with uniparental disomy (UPD) of chromosome 14. Regulation of imprinted expression ... Full text Link to item Cite

Imprinting evolution and the price of silence.

Journal article Bioessays · June 2003 Featured Publication In contrast to the biallelic expression of most genes, expression of genes subject to genomic imprinting is monoallelic and based on the sex of the transmitting parent. Possession of only a single active allele can lead to deleterious health consequences i ... Full text Link to item Cite

Identification of the single base change causing the callipyge muscle hypertrophy phenotype, the only known example of polar overdominance in mammals.

Journal article Genome Res · October 2002 Featured Publication A small genetic region near the telomere of ovine chromosome 18 was previously shown to carry the mutation causing the callipyge muscle hypertrophy phenotype in sheep. Expression of this phenotype is the only known case in mammals of paternal polar overdom ... Full text Link to item Cite

Imprinting of PEG3, the human homologue of a mouse gene involved in nurturing behavior.

Journal article Genomics · January 1, 2001 Featured Publication The paternally expressed Peg3 gene in mice encodes an unusual Krüppel-type zinc finger protein implicated in critical cellular and behavioral functions including growth, apoptosis, and maternal nurturing behavior. Methylation and expression analyses were u ... Full text Link to item Cite

Novel imprinted DLK1/GTL2 domain on human chromosome 14 contains motifs that mimic those implicated in IGF2/H19 regulation.

Journal article Genome Res · November 2000 Featured Publication The evolution of genomic imprinting in mammals occurred more than 100 million years ago, and resulted in the formation of genes that are functionally haploid because of parent-of-origin-dependent expression. Despite ample evidence from studies in a number ... Full text Link to item Cite

Imprinted genes as potential genetic and epigenetic toxicologic targets.

Journal article Environ Health Perspect · March 2000 Featured Publication Genomic imprinting is an epigenetic phenomenon in eutherian mammals that results in the differential expression of the paternally and maternally inherited alleles of a gene. Imprinted genes are necessary for normal mammalian development. This requirement h ... Full text Link to item Cite