Scholars@Duke
Susan Kay Murphy

Susan Kay Murphy

Associate Professor Emeritus in Obstetrics and Gynecology
Obstetrics and Gynecology, Reproductive Sciences
Duke PO Box 90534, the Chesterfield Building, Durham, NC 27701
701 W. Main Street, Suite 510, Room 5140, Durham, NC 27701

Scholarly Works - Journal articles

Associations of Placental Oxidative Stress with Exposure to Gestational Air Pollution: Evidence from the UPSIDE Cohort.

Journal article Environ Res · July 9, 2026 BACKGROUND: Increased placental oxidative stress is frequently documented in pregnant women with adverse maternal outcomes such as preeclampsia. However, environmental determinants of placental oxidative stress remain poorly understood. OBJECTIVES: To dete ... Full text Link to item Cite

Placental toxic metal concentrations and preterm birth: Modification by social stressors.

Journal article Reprod Toxicol · June 16, 2026 The placenta facilitates vital nutrient and gas exchange between mother and fetus. Metals such as cadmium (Cd), lead (Pb) and arsenic (As) have been associated with decreased placental vascularization, suboptimal invasion, and poorer birth outcomes. Althou ... Full text Link to item Cite

Endocrine Disruption and Male Fertility.

Journal article Curr Environ Health Rep · June 3, 2026 PURPOSE OF REVIEW: Endocrine-disrupting chemicals affect nearly every human on the planet and are known to interfere with reproduction. Most studies have focused on gestational exposure effects in females. Emerging evidence indicates that preconception exp ... Full text Link to item Cite

Ascites protects against ferroptosis and enables the peritoneal growth of ovarian cancer.

Journal article Nat Commun · May 11, 2026 The peritoneum is a frequent site of metastasis in ovarian cancer (OVCA), often accompanied by the accumulation of ascites in the peritoneal cavity. Despite its prevalence, ascites and its role in the peritoneal growth of OVCA remain poorly understood. OVC ... Full text Link to item Cite

Maternal adversity and peripheral proinflammatory cytokine concentrations in pregnancy.

Journal article Brain Behav Immun Health · May 2026 BACKGROUND: Psychosocial stressors such as adverse childhood experiences (ACEs) and financial hardship have been linked to inflammatory phenotypes. Few studies have investigated the role of childhood and current stressors on inflammatory marker concentrati ... Full text Link to item Cite

UV irradiation alters TFAM binding specificity and compaction of DNA.

Journal article Elife · March 25, 2026 Mitochondria lack nucleotide excision repair; however, mitochondrial DNA (mtDNA) is resistant to mutation accumulation following DNA damage. These observations suggest additional damage sensing or protection mechanisms. Transcription Factor A, Mitochondria ... Full text Link to item Cite

Progeny effects of rotenone exposure depend on parental toxicity.

Journal article Toxicol Sci · March 2, 2026 Parental exposure to toxicants can affect progeny health. However, laboratory studies often employ exposures that result in loading of pollutants to gametes or toxic effects to parents, which could indirectly affect germ cell or gamete health. Here, we too ... Full text Link to item Cite

Cannabidiol and neurodevelopment: Is perception outpacing proof?

Journal article Current Opinion in Toxicology · March 1, 2026 Cannabidiol (CBD) use has rapidly increased among adolescents, young adults, and pregnant individuals over the last decade. This trend is, in part, fueled by the perception of CBD as relatively harmless, a notion bolstered by its nonpsychoactive nature and ... Full text Cite

Prenatal Cannabis and Tobacco: Studies in Animal Models.

Journal article Adv Exp Med Biol · 2026 Prenatal exposure to cannabis and tobacco can significantly disrupt critical stages of fetal development, resulting in long-lasting consequences for offspring's health. Prenatal THC exposure has been shown to impair offspring neurodevelopment, alter metabo ... Full text Link to item Cite

Environmental exposures and epigenetic alterations in common chronic diseases: insights and challenges.

Journal article Environ Epigenet · 2026 Exposure to environmental factors including contaminants and social conditions is implicated in a substantial proportion of common non-communicable diseases, and data from model systems repeatedly demonstrate that the process from environmental contributio ... Full text Link to item Cite

Putative Imprinting Control Regions with Aberrant Blood-Based DNA Methylation are Associated with Hepatocellular Carcinoma Risk.

Journal article J Hepatocell Carcinoma · 2026 INTRODUCTION: Site-specific 5-methylcytosine levels measured in blood can be suitable surrogate markers for epigenetic alterations in inaccessible tissues and are associated with hepatocellular carcinoma (HCC) risk. However, replication has been limited du ... Full text Link to item Cite

Age-specific DNA methylation alterations in sperm at imprint control regions may contribute to the risk of autism spectrum disorder in offspring.

Journal article Aging (Albany NY) · December 29, 2025 Research findings suggest that advanced paternal age is associated with an increased risk of autism spectrum disorder (ASD) in children. The biological process behind this father-to-child inheritance of a disease may be driven by sperm epigenetic marks. Th ... Full text Link to item Cite

Differential methylation patterns in cord blood associated with prenatal exposure to neighborhood crime: an epigenome-wide association study and regional analysis.

Journal article Epigenetics · December 2025 Exposure to prenatal social stressors during pregnancy is associated with adverse birth outcomes and has been linked to epigenetic changes in DNA methylation (DNAm); however, less understood is the effect of neighborhood-level stressors like crime during p ... Full text Link to item Cite

Short-chain per- and polyfluoroalkyl substances associate with elevated alanine aminotransferase: Cross-sectional analysis results from the STRIVE cohort.

Journal article Environ Res · October 15, 2025 BACKGROUND: The impact of short-chain, low molecular weight polyfluoroalkyl substances (PFAS) and long-chain, high molecular weight PFAS on elevated alanine aminotransferase (ALT) remains unclear. Additionally, demographic and behavioral factors influencin ... Full text Link to item Cite

High exposure variance enables candidate biomarker detection in a small EWAS of methylmercury-exposed Peruvian adults.

Journal article BMC Genom Data · September 29, 2025 BACKGROUND: Epigenome-wide association studies (EWAS) are a highly promising approach that can inform precision environmental health. However, current EWAS are underpowered and increasing sample sizes will require substantial resources. Therefore, alternat ... Full text Link to item Cite

UV irradiation alters TFAM binding to mitochondrial DNA.

Journal article bioRxiv · September 15, 2025 Mitochondria lack nucleotide excision repair; however, mitochondrial DNA (mtDNA) is resistant to mutation accumulation following DNA damage. These observations suggest additional damage sensing or protection mechanisms. Transcription Factor A, Mitochondria ... Full text Link to item Cite

Effects of Ambient Temperature During Pregnancy on Newborn Birthweight.

Journal article bioRxiv · June 15, 2025 This study evaluates the association between ambient temperature exposure during pregnancy and newborn birthweight, using a penalized generalized additive model (GAM) framework with distributed lag non-linear models (DLNM) to identify sensitive windows of ... Full text Link to item Cite

Epigenome-wide differential methylation and differential variability as predictors of high-grade cervical intraepithelial neoplasia (CIN2+).

Journal article Am J Epidemiol · April 8, 2025 CpG site methylation patterns have potential to improve differentiation of high-grade screening-detected cervical abnormalities. We assessed CpG differential methylation (DM) and differential variability (DV) in high-grade (CIN2+) vs low-grade (≤ CIN1) les ... Full text Link to item Cite

PedBE age and age acceleration in umbilical vein endothelial cells: an examination of infant birth outcomes.

Journal article J Dev Orig Health Dis · March 12, 2025 The current study examines the application of the Pediatric-Buccal-Epigenetic (PedBE) clock, designed for buccal epithelial cells, to endothelia. We evaluate the association of PedBE epigenetic age and age acceleration estimated from human umbilical vein e ... Full text Link to item Cite

Gestational exposure to PM2.5, NO2, and sex steroid hormones: Identifying critical windows of exposure in the Rochester UPSIDE Cohort.

Journal article Environ Epidemiol · February 2025 BACKGROUND: Sex steroid hormones are critical for maintaining pregnancy and optimal fetal development. Air pollutants are potential endocrine disruptors that may disturb sex steroidogenesis during pregnancy, potentially leading to adverse health outcomes. ... Full text Link to item Cite

Regulation of Age-Related Lipid Metabolism in Ovarian Cancer.

Journal article Int J Mol Sci · January 1, 2025 The mortality rate of ovarian cancer (OC) remains the highest among female gynecological malignancies. Advanced age is the highest risk factor for OC development and progression, yet little is known about the role of the aged tumor microenvironment (TME). ... Full text Link to item Cite

Maternal adverse childhood experiences (ACEs) and offspring imprinted gene DMR methylation at birth.

Journal article Epigenetics · December 2024 Adverse childhood experiences (ACEs) contribute to numerous negative health outcomes across the life course and across generations. Here, we extend prior work by examining the association of maternal ACEs, and their interaction with financial stress and di ... Full text Open Access Link to item Cite

Short term air pollution exposure during pregnancy and associations with maternal immune markers.

Journal article Environ Res · November 1, 2024 BACKGROUND: Air pollution exposure during pregnancy has been associated with numerous adverse pregnancy, birth, and child health outcomes. One proposed mechanism underlying these associations is maternal immune activation and dysregulation. We examined ass ... Full text Link to item Cite

Tobacco Exposures are Associated With Healthcare Utilization and Healthcare Costs in Pregnant Persons and Their Newborn Babies.

Journal article Nicotine Tob Res · October 22, 2024 INTRODUCTION: Identifying healthcare utilization and costs associated with active and passive smoking during pregnancy could help improve health management strategies. AIMS AND METHODS: Data are from the Newborn Epigenetics STudy (NEST), a birth cohort enr ... Full text Link to item Cite

Implications of Prenatal Cannabis Exposure on Childhood Neurodevelopmental Outcomes: A Summary of the Clinical Evidence.

Journal article Obstet Gynecol Surv · October 2024 IMPORTANCE: Cannabis is commonly used by pregnant patients for alleviation of pregnancy-associated symptoms. Multiple national medical associations have recommended against prenatal cannabis use, yet misinformation regarding its safety and efficacy remains ... Full text Link to item Cite

Associations of Gestational Exposure to Air Pollution and Polycyclic Aromatic Hydrocarbons with Placental Inflammation.

Journal article Environ Health (Wash) · September 20, 2024 Restricted fetal growth (RFG) is a leading contributor to perinatal mortality and has been associated with gestational exposure to air pollution, such as fine particulate matter (PM2.5), nitrogen dioxide (NO2), and polycyclic aromatic hydrocarbons (PAHs). ... Full text Link to item Cite

Exposure to Low-Level Air Pollution and Hyperglycemia Markers during Pregnancy: A Repeated Measure Analysis.

Journal article Environ Sci Technol · September 10, 2024 Epidemiologic evidence has emerged showing an association between exposure to air pollution and increased risks of gestational diabetes mellitus (GDM). This study examines the effect of low-level air pollution exposure on a subclinical biomarker of hypergl ... Full text Link to item Cite

Influence of substance use on male reproductive health and offspring outcomes.

Journal article Nat Rev Urol · September 2024 The prevalence of substance use globally is rising and is highest among men of reproductive age. In Africa, and South and Central America, cannabis use disorder is most prevalent and in Eastern and South-Eastern Europe, Central America, Canada and the USA, ... Full text Link to item Cite

Persisting neurobehavioral consequences of daily or intermittent paternal cannabis administration in F1 and F2 Rats.

Journal article Neurotoxicology · July 2024 Repeated paternal preconception exposure to Δ9-tetrahydrocannabinol (Δ9-THC) alone or together with the other constituents in a cannabis extract has been shown in our earlier studies in rats to cause significant neurobehavioral impairment in their offsprin ... Full text Link to item Cite

Urinary 1-hydroxypyrene in pregnant women in a Northeastern U.S. city: socioeconomic disparity and contributions from air pollution sources.

Journal article J Expo Sci Environ Epidemiol · May 2024 BACKGROUND: Maternal exposure to polycyclic aromatic hydrocarbons (PAHs), ubiquitous constituents of air pollution, has been associated with adverse birth outcomes. Yet it remains unclear whether and how socioeconomic status (SES) affects gestational PAH e ... Full text Link to item Cite

Lack of detectable sex differences in the mitochondrial function of Caenorhabditis elegans.

Journal article BMC Ecol Evol · April 26, 2024 BACKGROUND: Sex differences in mitochondrial function have been reported in multiple tissue and cell types. Additionally, sex-variable responses to stressors including environmental pollutants and drugs that cause mitochondrial toxicity have been observed. ... Full text Link to item Cite

Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence.

Journal article Mol Psychiatry · February 2024 Maternal educational attainment (MEA) shapes offspring health through multiple potential pathways. Differential DNA methylation may provide a mechanistic understanding of these long-term associations. We aimed to quantify the associations of MEA with offsp ... Full text Open Access Link to item Cite

Maternal Childhood Adversity and Infant Epigenetic Aging: Moderation by Restless Sleep During Pregnancy.

Journal article Dev Psychobiol · February 2024 Maternal exposure to childhood adversity is associated with detrimental health outcomes throughout the lifespan and may have implications for offspring. Evidence links maternal adverse childhood experiences (ACEs) to detrimental birth outcomes, yet the imp ... Full text Open Access Link to item Cite

Association of maternal prenatal copper concentration with gestational duration and preterm birth: a multicountry meta-analysis.

Journal article Am J Clin Nutr · January 2024 BACKGROUND: Copper (Cu), an essential trace mineral regulating multiple actions of inflammation and oxidative stress, has been implicated in risk for preterm birth (PTB). OBJECTIVES: This study aimed to determine the association of maternal Cu concentratio ... Full text Open Access Link to item Cite

The use of race terms in epigenetics research: considerations moving forward.

Journal article Front Genet · 2024 The field of environmental epigenetics is uniquely suited to investigate biologic mechanisms that have the potential to link stressors to health disparities. However, it is common practice in basic epigenetic research to treat race as a covariable in large ... Full text Open Access Link to item Cite

Periostin facilitates ovarian cancer recurrence by enhancing cancer stemness.

Journal article Sci Rep · December 4, 2023 The lethality of epithelial ovarian cancer (OC) is largely due to a high rate of recurrence and development of chemoresistance, which requires synergy between cancer cells and the tumor microenvironment (TME) and is thought to involve cancer stem cells. Ou ... Full text Open Access Link to item Cite

An epigenome-wide association study of child appetitive traits and DNA methylation.

Journal article Appetite · December 1, 2023 The etiology of childhood appetitive traits is poorly understood. Early-life epigenetic processes may be involved in the developmental programming of appetite regulation in childhood. One such process is DNA methylation (DNAm), whereby a methyl group is ad ... Full text Open Access Link to item Cite

Epigenome-wide methylation and progression to high-grade cervical intraepithelial neoplasia (CIN2+): a prospective cohort study in the United States.

Journal article BMC Cancer · November 6, 2023 BACKGROUND: Methylation levels may be associated with and serve as markers to predict risk of progression of precancerous cervical lesions. We conducted an epigenome-wide association study (EWAS) of CpG methylation and progression to high-grade cervical in ... Full text Open Access Link to item Cite

AHRR Hypomethylation mediates the association between maternal smoking and metabolic profiles in children.

Journal article Hepatol Commun · October 1, 2023 BACKGROUND: Tobacco smoking during pregnancy is associated with metabolic dysfunction in children, but mechanistic insights remain limited. Hypomethylation of cg05575921 in the aryl hydrocarbon receptor repressor (AHRR) gene is associated with in utero tob ... Full text Open Access Link to item Cite

Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude.

Journal article Clin Epigenetics · September 11, 2023 BACKGROUND: Seasonal variations in environmental exposures at birth or during gestation are associated with numerous adult traits and health outcomes later in life. Whether DNA methylation (DNAm) plays a role in the molecular mechanisms underlying the asso ... Full text Open Access Link to item Cite

An epigenome-wide association study of child appetitive traits and DNA methylation.

Journal article bioRxiv · July 18, 2023 Childhood appetitive traits are consistently associated with obesity risk, and yet their etiology is poorly understood. Appetitive traits are complex phenotypes which are hypothesized to be influenced by both genetic and environmental factors, as well as t ... Full text Link to item Cite

Prenatal delta-9-tetrahydrocannabinol exposure is associated with changes in rhesus macaque DNA methylation enriched for autism genes.

Journal article Clin Epigenetics · July 6, 2023 BACKGROUND: With the growing availability of cannabis and the popularization of additional routes of cannabis use beyond smoking, including edibles, the prevalence of cannabis use in pregnancy is rapidly increasing. However, the potential effects of prenat ... Full text Link to item Cite

Cessation of chronic delta-9-tetrahydrocannabinol use partially reverses impacts on male fertility and the sperm epigenome in rhesus macaques.

Journal article Fertil Steril · July 2023 OBJECTIVE: To determine whether discontinuation of delta-9-tetrahydrocannabinol (THC) use mitigates THC-associated changes in male reproductive health using a rhesus macaque model of daily THC edible consumption. DESIGN: Research animal study. SETTING: Res ... Full text Link to item Cite

An epigenetic clock for gestational age based on human umbilical vein endothelial cells from a diverse population of newborns.

Journal article Res Sq · June 30, 2023 BACKGROUND: Epigenetic clocks are emerging as a useful tool in many areas of research. Many epigenetic clocks have been developed for adults; however, there are fewer clocks focused on newborns and most are trained using blood from European ancestry popula ... Full text Link to item Cite

Prenatal and Childhood Smoke Exposure Associations with Cognition, Language, and Attention-Deficit/Hyperactivity Disorder.

Journal article J Pediatr · May 2023 OBJECTIVE: To assess the relationships of prenatal and childhood smoke exposure with specific neurodevelopmental and behavioral problems during early childhood. STUDY DESIGN: A subsample (n = 386) of mother-child dyads from the Newborn Epigenetic Study (NE ... Full text Link to item Cite

An epigenetic synopsis of parental substance use.

Journal article Epigenomics · April 2023 The rate of substance use is rising, especially among reproductive-age individuals. Emerging evidence suggests that paternal pre-conception and maternal prenatal substance use may alter offspring epigenetic regulation (changes to gene expression without mo ... Full text Link to item Cite

Financial stress as a mediator of the association between maternal childhood adversity and infant birth weight, gestational age, and NICU admission.

Journal article BMC Public Health · March 30, 2023 BACKGROUND: To examine whether financial stress during pregnancy mediates the association between maternal exposure to adverse childhood experiences (ACEs) and three birth outcomes (i.e., gestational age, birth weight, and admission to the neonatal intensi ... Full text Link to item Cite

Maternal exposure to perfluorobutane sulfonate (PFBS) during pregnancy: evidence of adverse maternal and fetoplacental effects in New Zealand White (NZW) rabbits.

Journal article Toxicol Sci · February 17, 2023 Perfluorobutanesulfonic acid (PFBS) is a replacement for perfluorooctanesulfonic acid (PFOS) that is increasingly detected in drinking water and human serum. Higher PFBS exposure is associated with risk for preeclampsia, the leading cause of maternal and i ... Full text Link to item Cite

Sex-specific DNA methylation and associations with in utero tobacco smoke exposure at nuclear-encoded mitochondrial genes.

Journal article Epigenetics · December 2022 Sex-linked differences in mitochondrial ATP production, enzyme activities, and reactive oxygen species generation have been reported in multiple tissue and cell types. While the effects of reproductive hormones underlie many of these differences, regulatio ... Full text Link to item Cite

Maternal diet disrupts the placenta-brain axis in a sex-specific manner.

Journal article Nat Metab · December 2022 High maternal weight is associated with detrimental outcomes in offspring, including increased susceptibility to neurological disorders such as anxiety, depression and communicative disorders. Despite widespread acknowledgement of sex biases in the develop ... Full text Link to item Cite

Tobacco Retail Outlets, Neighborhood Deprivation and the Risk of Prenatal Smoke Exposure.

Journal article Nicotine Tob Res · November 12, 2022 INTRODUCTION: Smoking and smoke exposure among pregnant women remain persistent public health issues. Recent estimates suggest that approximately one out of four nonsmokers have measurable levels of cotinine, a marker indicating regular exposure to secondh ... Full text Link to item Cite

Alterations in DNA methylation associate with fatty liver and metabolic abnormalities in a multi-ethnic cohort of pre-teenage children.

Journal article Epigenetics · November 2022 Non-Alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease in children. Epigenetic alterations, such as through DNA methylation (DNAm), may link adverse childhood exposures and fatty liver and provide non-invasive methods for i ... Full text Link to item Cite

Maternal Mediterranean Diet Adherence and Its Associations with Maternal Prenatal Stressors and Child Growth.

Journal article Curr Dev Nutr · November 2022 BACKGROUND: Psychosocial and physiologic stressors, such as depression and obesity, during pregnancy can have negative consequences, such as increased systemic inflammation, contributing to chronic disease for both mothers and their unborn children. These ... Full text Link to item Cite

Neighborhood Deprivation is Associated with Increased Risk of Prenatal Smoke Exposure.

Journal article Prev Sci · October 2022 Despite years of advisories against the behavior, smoking among pregnant women remains a persistent public health issue in the USA. Recent estimates suggest that 9.4% of women smoke before pregnancy and 7.1% during pregnancy in the USA. Epidemiological res ... Full text Link to item Cite

Evaluating maternal exposure to an environmental per and polyfluoroalkyl substances (PFAS) mixture during pregnancy: Adverse maternal and fetoplacental effects in a New Zealand White (NZW) rabbit model.

Journal article Sci Total Environ · September 10, 2022 Mixtures of per- and polyfluoroalkyl substances (PFAS) are often found in drinking water, and serum PFAS are detected in up to 99% of the population. However, very little is known about how exposure to mixtures of PFAS affects maternal and fetal health. Th ... Full text Link to item Cite

Sperm DNA methylation alterations from cannabis extract exposure are evident in offspring.

Journal article Epigenetics Chromatin · September 10, 2022 BACKGROUND: Cannabis legalization is expanding and men are the predominant users. We have limited knowledge about how cannabis impacts sperm and whether the effects are heritable. RESULTS: Whole genome bisulfite sequencing (WGBS) data were generated for sp ... Full text Open Access Link to item Cite

Clomifene and Assisted Reproductive Technology in Humans Are Associated with Sex-Specific Offspring Epigenetic Alterations in Imprinted Control Regions.

Journal article Int J Mol Sci · September 9, 2022 Children conceived with assisted reproductive technology (ART) have an increased risk of adverse outcomes, including congenital malformations and imprinted gene disorders. In a retrospective North Carolina-based-birth-cohort, we examined the effect of ovul ... Full text Link to item Cite

Extended Human Papillomavirus Genotyping to Predict Progression to High-Grade Cervical Precancer: A Prospective Cohort Study in the Southeastern United States.

Journal article Cancer Epidemiol Biomarkers Prev · August 2, 2022 BACKGROUND: High-risk human papillomavirus (hrHPV) testing is utilized in primary cervical cancer screening, generally along with cytology, to triage abnormalities to colposcopy. Most screening-based hrHPV testing involves pooled detection of any hrHPV or ... Full text Link to item Cite

Informing women about the risks of exposing babies to tobacco smoke: outreach and education efforts using Facebook "boost posts".

Journal article Transl Behav Med · May 26, 2022 Maternal smoking is associated with a host of negative health outcomes, including an increased risk of children developing attention-deficit/hyperactivity disorder (ADHD). This study evaluated the efficacy of health messages disseminated through Facebook A ... Full text Link to item Cite

Developmental nicotine exposure and masculinization of the rat preoptic area.

Journal article Neurotoxicology · March 2022 Nicotine is a neuroteratogenic component of tobacco smoke, e-cigarettes, and other products and can exert sex-specific effects in the developing brain, likely mediated through sex hormones. Estradiol modulates expression of nicotinic acetylcholine receptor ... Full text Open Access Link to item Cite

Maternal tobacco smoke exposure is associated with increased DNA methylation at human metastable epialleles in infant cord blood.

Journal article Environ Epigenet · 2022 Metastable epialleles (MEs) are genomic regions that are stochastically methylated prior to germ layer specification and exhibit high interindividual but low intra-individual variability across tissues. ME methylation is vulnerable to environmental stresso ... Full text Link to item Cite

Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation.

Journal article Mutat Res Rev Mutat Res · 2022 BACKGROUND: Among children, sex-specific differences in disease prevalence, age of onset, and susceptibility have been observed in health conditions including asthma, immune response, metabolic health, some pediatric and adult cancers, and psychiatric diso ... Full text Link to item Cite

Validation of differential DNA methylation in newborns exposed to tobacco smoke during gestation using bisulfite pyrosequencing.

Journal article MicroPubl Biol · 2022 Maternal exposure to tobacco smoke during pregnancy has been associated with many negative child health outcomes. Tobacco smoke exposure alters DNA methylation in the developing embryo/fetus and may be a mechanism that increases risk of later life disease. ... Full text Link to item Cite

Cannabis alters DNA methylation at maternally imprinted and autism candidate genes in spermatogenic cells.

Journal article Syst Biol Reprod Med · 2022 Cannabis use in the United States is increasing, with highest consumption among men at their peak reproductive years. We previously demonstrated widespread changes in sperm DNA methylation with cannabis exposure in humans and rats, including genes importan ... Full text Link to item Cite

Racial disparities in liver cancer: Evidence for a role of environmental contaminants and the epigenome.

Journal article Front Oncol · 2022 Liver cancer incidence has tripled since the early 1980s, making this disease one of the fastest rising types of cancer and the third leading cause of cancer-related deaths worldwide. In the US, incidence varies by geographic location and race, with the hi ... Full text Open Access Link to item Cite

Periconceptional Maternal Diet Characterized by High Glycemic Loading Is Associated with Offspring Behavior in NEST.

Journal article Nutrients · September 13, 2021 Maternal periconceptional diets have known associations with proper offspring neurodevelopment. Mechanisms for such associations include improper energy/nutrient balances between mother and fetus, as well as altered offspring epigenetics during development ... Full text Link to item Cite

Association of maternal prenatal selenium concentration and preterm birth: a multicountry meta-analysis.

Journal article BMJ Glob Health · September 2021 BACKGROUND: Selenium (Se), an essential trace mineral, has been implicated in preterm birth (PTB). We aimed to determine the association of maternal Se concentrations during pregnancy with PTB risk and gestational duration in a large number of samples coll ... Full text Link to item Cite

Associations between maternal obesity, gestational cytokine levels and child obesity in the NEST cohort.

Journal article Pediatr Obes · July 2021 BACKGROUND: Although maternal systemic inflammation is hypothesized to link maternal pre-pregnancy obesity to offspring metabolic dysfunction, patient empirical data are limited. OBJECTIVES: In this study, we hypothesized that pre-pregnancy obesity alters ... Full text Link to item Cite

Association between PEG3 DNA methylation and high-grade cervical intraepithelial neoplasia.

Journal article Infect Agent Cancer · June 13, 2021 BACKGROUND: Epigenetic mechanisms are hypothesized to contribute substantially to the progression of cervical intraepithelial neoplasia (CIN) to cervical cancer, although empirical data are limited. METHODS: Women (n = 419) were enrolled at colposcopic eva ... Full text Open Access Link to item Cite

Identifying the Best Questions for Rapid Screening of Secondhand Smoke Exposure Among Children.

Journal article Nicotine Tob Res · June 8, 2021 INTRODUCTION: Many children suffer from secondhand smoke exposure (SHSe), which leads to a variety of negative health consequences. However, there is no consensus on how clinicians can best query parents for possible SHSe among children. We employed a data ... Full text Link to item Cite

Smoke-Free Home Rules and Association with Child Secondhand Smoke Exposure among Mother-Child Dyad Relationships.

Journal article Int J Environ Res Public Health · May 14, 2021 Smoke-free home rules restrict smoking in the home, but biomarkers of secondhand smoke exposure are needed to help understand the association between smoke-free homes and child secondhand smoke exposure. Participants (n = 346) were majority Black/African A ... Full text Link to item Cite

DNA Methylation in Babies Born to Nonsmoking Mothers Exposed to Secondhand Smoke during Pregnancy: An Epigenome-Wide Association Study.

Journal article Environ Health Perspect · May 2021 BACKGROUND: Maternal smoking during pregnancy is related to altered DNA methylation in infant umbilical cord blood. The extent to which low levels of smoke exposure among nonsmoking pregnant women relates to offspring DNA methylation is unknown. OBJECTIVE: ... Full text Open Access Link to item Cite

Male obesity impacts DNA methylation reprogramming in sperm.

Journal article Clin Epigenetics · January 25, 2021 BACKGROUND: Male obesity has profound effects on morbidity and mortality, but relatively little is known about the impact of obesity on gametes and the potential for adverse effects of male obesity to be passed to the next generation. DNA methylation contr ... Full text Open Access Link to item Cite

Targeting Dormant Ovarian Cancer Cells In Vitro and in an In Vivo Mouse Model of Platinum Resistance.

Journal article Mol Cancer Ther · January 2021 Spheroids exhibit drug resistance and slow proliferation, suggesting involvement in cancer recurrence. The protein kinase C inhibitor UCN-01 (7-hydroxystaurosporine) has shown higher efficacy against slow proliferating and/or quiescent ovarian cancer cells ... Full text Link to item Cite

Epigenetic Regulation of Claudin-1 in the Development of Ovarian Cancer Recurrence and Drug Resistance.

Journal article Front Oncol · 2021 Over 21,000 women are diagnosed with ovarian cancer (OC) in the United States each year and over half that number succumb to this disease annually, often due to recurrent disease. A deeper understanding of the molecular events associated with recurrent dis ... Full text Open Access Link to item Cite

Opposing Epigenetic Signatures in Human Sperm by Intake of Fast Food Versus Healthy Food.

Journal article Front Endocrinol (Lausanne) · 2021 Animal experiments have demonstrated that diets high in fats create a harmful environment for developing sperm cells, contributing to impaired reproductive health and induced risk for chronic diseases in the next generation. Changes at the level of the epi ... Full text Link to item Cite

Cell-Type Specific Changes in DNA Methylation of SNCA Intron 1 in Synucleinopathy Brains.

Journal article Front Neurosci · 2021 Parkinson's disease (PD) and dementia with Lewy body (DLB) are the most common synucleinopathies. SNCA gene is a major genetic risk factor for these diseases group, and dysregulation of its expression has been implicated in the genetic etiologies of severa ... Full text Link to item Cite

Direct comparisons of bisulfite pyrosequencing versus targeted bisulfite sequencing.

Journal article MicroPubl Biol · 2021 DNA methylation is an important epigenetic mechanism involved in proper genome function. Bisulfite pyrosequencing (PSQ) is a commonly used technique to quantify DNA methylation. Although very accurate, bisulfite pyrosequencing can be expensive and time con ... Full text Open Access Link to item Cite

Refraining from use diminishes cannabis-associated epigenetic changes in human sperm.

Journal article Environ Epigenet · 2021 Featured Publication Cannabis use alters sperm DNA methylation, but the potential reversibility of these changes is unknown. Semen samples from cannabis users and non-user controls were collected at baseline and again following a 77-day period of cannabis abstinence (one sperm ... Full text Open Access Link to item Cite

Epigenetic alterations in cytochrome P450 oxidoreductase (Por) in sperm of rats exposed to tetrahydrocannabinol (THC)

Journal article Scientific Reports · December 1, 2020 As marijuana legalization is increasing, research regarding possible long-term risks for users and their offspring is needed. Little data exists on effects of paternal tetrahydrocannabinol (THC) exposure prior to reproduction. This study determined if chro ... Full text Open Access Cite

Paternal cannabis extract exposure in rats: Preconception timing effects on neurodevelopmental behavior in offspring.

Journal article Neurotoxicology · December 2020 Maternal toxicant exposure during gestation can have deleterious effects on neurobehavioral development of the offspring. The potential risks engendered by paternal toxicant exposure prior to conception have been largely understudied. Recently, we found th ... Full text Open Access Link to item Cite

DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies.

Journal article Genome Med · November 25, 2020 BACKGROUND: DNA methylation has been shown to be associated with adiposity in adulthood. However, whether similar DNA methylation patterns are associated with childhood and adolescent body mass index (BMI) is largely unknown. More insight into this relatio ... Full text Link to item Cite

Association between DNA methylation and ADHD symptoms from birth to school age: a prospective meta-analysis.

Journal article Transl Psychiatry · November 12, 2020 Attention-deficit and hyperactivity disorder (ADHD) is a common childhood disorder with a substantial genetic component. However, the extent to which epigenetic mechanisms play a role in the etiology of the disorder is unknown. We performed epigenome-wide ... Full text Link to item Cite

Replicated umbilical cord blood DNA methylation loci associated with gestational age at birth.

Journal article Epigenetics · November 2020 DNA methylation is highly sensitive to in utero perturbations and has an established role in both embryonic development and regulation of gene expression. The foetal genetic component has been previously shown to contribute significantly to the timing of b ... Full text Link to item Cite

Sperm DNA methylation altered by THC and nicotine: Vulnerability of neurodevelopmental genes with bivalent chromatin.

Journal article Sci Rep · September 29, 2020 Men consume the most nicotine and cannabis products but impacts on sperm epigenetics are poorly characterized. Evidence suggests that preconception exposure to these drugs alters offspring neurodevelopment. Epigenetics may in part facilitate heritability. ... Full text Open Access Link to item Cite

Epigenetic alterations in cytochrome P450 oxidoreductase (Por) in sperm of rats exposed to tetrahydrocannabinol (THC).

Journal article Sci Rep · July 23, 2020 As marijuana legalization is increasing, research regarding possible long-term risks for users and their offspring is needed. Little data exists on effects of paternal tetrahydrocannabinol (THC) exposure prior to reproduction. This study determined if chro ... Full text Open Access Link to item Cite

Associations between attention deficit hyperactivity disorder symptoms and eating behaviors in early childhood.

Journal article Pediatr Obes · July 2020 BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) symptoms have been linked with eating behaviors and obesity adolescence and young adulthood. Yet, little is known about whether these associations occur during early childhood and few studies have ... Full text Link to item Cite

Paternal factors in neurodevelopmental toxicology: THC exposure of male rats causes long-lasting neurobehavioral effects in their offspring.

Journal article Neurotoxicology · May 2020 The potential health risks of cannabis are of growing concern, including effects on reproduction and development. Extensive research has investigated risks associated with maternal exposure to THC during gestation and its impacts on the development of offs ... Full text Open Access Link to item Cite

Effect of Prenatal Smoke Exposure on Birth Weight: The Moderating Role of Maternal Depressive Symptoms.

Journal article Nicotine Tob Res · January 27, 2020 INTRODUCTION: Both prenatal smoke exposure and depression have been linked to lower birth weight, a risk factor for morbidity and mortality. Few studies have looked at the interaction between these risk factors and none have used a biomarker to objectively ... Full text Open Access Link to item Cite

Cannabis use is associated with potentially heritable widespread changes in autism candidate gene DLGAP2 DNA methylation in sperm.

Journal article Epigenetics · 2020 Parental cannabis use has been associated with adverse neurodevelopmental outcomes in offspring, but how such phenotypes are transmitted is largely unknown. Using reduced representation bisulphite sequencing (RRBS), we recently demonstrated that cannabis u ... Full text Open Access Link to item Cite

A TAZ-ANGPTL4-NOX2 Axis Regulates Ferroptotic Cell Death and Chemoresistance in Epithelial Ovarian Cancer.

Journal article Mol Cancer Res · January 2020 Ovarian cancer is the deadliest gynecologic cancer. Despite recent advances, clinical outcomes remain poor, necessitating novel therapeutic approaches. To investigate metabolic susceptibility, we performed nutrigenetic screens on a panel of clear cell and ... Full text Link to item Cite

Cannabis use and the sperm epigenome: a budding concern?

Journal article Environ Epigenet · January 2020 The United States is swiftly moving toward increased legalization of medical and recreational cannabis. Currently considered the most commonly used illicit psychoactive drug, recreational cannabis is legal in 11 states and Washington, DC, and male use is a ... Full text Open Access Link to item Cite

Snacking frequency and dietary intake in toddlers and preschool children.

Journal article Appetite · November 1, 2019 Understanding the relationship between snacking and dietary intake in early life years is one key but understudied area. In this study, we examined snacking patterns in toddlers and preschool children and the associations between snacking frequency and dai ... Full text Link to item Cite

Acquisition of a side population fraction augments malignant phenotype in ovarian cancer.

Journal article Sci Rep · October 2, 2019 Side population (SP) cells harbor malignant phenotypes in cancer. The aim of this study was to identify genes that modulate the proportion of ovarian cancer SP cells. Using a shRNA library targeting 15,000 genes, a functional genomics screen was performed ... Full text Link to item Cite

Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking.

Journal article Epigenomics · October 2019 Aim: Cigarette smoking influences DNA methylation genome wide, in newborns from pregnancy exposure and in adults from personal smoking. Whether a unique methylation signature exists for in utero exposure in newborns is unknown. Materials & methods: We sepa ... Full text Link to item Cite

MTAP Loss Promotes Stemness in Glioblastoma and Confers Unique Susceptibility to Purine Starvation.

Journal article Cancer Res · July 1, 2019 Homozygous deletion of methylthioadenosine phosphorylase (MTAP) is one of the most frequent genetic alterations in glioblastoma (GBM), but its pathologic consequences remain unclear. In this study, we report that loss of MTAP results in profound epigenetic ... Full text Link to item Cite

Cadmium exposure and MEG3 methylation differences between Whites and African Americans in the NEST Cohort.

Journal article Environ Epigenet · July 2019 Cadmium (Cd) is a ubiquitous environmental pollutant associated with a wide range of health outcomes including cancer. However, obscure exposure sources often hinder prevention efforts. Further, although epigenetic mechanisms are suspected to link these as ... Full text Link to item Cite

Epigenome-wide meta-analysis of DNA methylation and childhood asthma.

Journal article J Allergy Clin Immunol · June 2019 BACKGROUND: Epigenetic mechanisms, including methylation, can contribute to childhood asthma. Identifying DNA methylation profiles in asthmatic patients can inform disease pathogenesis. OBJECTIVE: We sought to identify differential DNA methylation in newbo ... Full text Link to item Cite

Role of β-3 adrenergic receptor polymorphism in overactive bladder.

Journal article Neurourol Urodyn · June 2019 AIMS: Women with overactive bladder (OAB) have a higher frequency of a single-nucleotide polymorphism (SNP) at codon 64 of the β-3 adrenergic receptor gene (ADRB3). Since the SNP results in an amino acid substitution that could theoretically alter receptor ... Full text Link to item Cite

Early prenatal vitamin D concentrations and social-emotional development in infants.

Journal article J Matern Fetal Neonatal Med · May 2019 BACKGROUND: Many pregnant women in the United States have suboptimal vitamin D, but the impact on infant development is unclear. Moreover, no pregnancy-specific vitamin D recommendations have been widely accepted. AIMS: Given the ubiquitous expression of v ... Full text Link to item Cite

Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight.

Journal article Nat Commun · April 23, 2019 Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigen ... Full text Link to item Cite

Maternal pre-pregnancy obesity, offspring cord blood DNA methylation, and offspring cardiometabolic health in early childhood: an epigenome-wide association study.

Journal article Epigenetics · April 2019 Pre-pregnancy obesity is an established risk factor for adverse sex-specific cardiometabolic health in offspring. Epigenetic alterations, such as in DNA methylation (DNAm), are a hypothesized link; however, sex-specific epigenomic targets remain unclear. L ... Full text Link to item Cite

Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models.

Journal article J Vis Exp · March 29, 2019 The use of hiPSC-derived cells represents a valuable approach to study human neurodegenerative diseases. Here, we describe an optimized protocol for the differentiation of hiPSCs derived from a patient with the triplication of the alpha-synuclein gene (SNC ... Full text Link to item Cite

Pre-Pregnancy Weight and Symptoms of Attention Deficit Hyperactivity Disorder and Executive Functioning Behaviors in Preschool Children.

Journal article Int J Environ Res Public Health · February 25, 2019 This study examines pre-pregnancy Body Mass Index (BMI) and gestational weight gain (GWG) in relation to early childhood Attention Deficit Hyperactivity Disorder (ADHD) symptoms and related executive self-regulation behaviors. The analyses sample (n = 331) ... Full text Open Access Link to item Cite

Associations between imprinted gene differentially methylated regions, appetitive traits and body mass index in children.

Journal article Pediatr Obes · February 2019 BACKGROUND: Knowledge regarding genetic influences on eating behaviours is expanding; yet less is known regarding contributions of epigenetic variation to appetitive traits and body mass index (BMI) in children. OBJECTIVE: The purpose of this study was to ... Full text Link to item Cite

Elevated metabolites of acetaminophen in cord blood of children with obesity.

Journal article Pediatr Obes · January 2019 BACKGROUND: High-throughput metabolomics has been used cross-sectionally to evaluate differential metabolic profiles associated with human obesity. OBJECTIVES: This study longitudinally assessed the cord blood metabolome to explore if metabolic signatures ... Full text Link to item Cite

Urine RNA Processing in a Clinical Setting: Comparison of 3 Protocols.

Journal article Female Pelvic Med Reconstr Surg · 2019 OBJECTIVE: The objective of this study was to compare quantitative and qualitative RNA extraction results from clinical voided urine samples between 3 commercially available extraction protocols. METHODS: For phase 1, fresh voided urine samples from 10 fem ... Full text Link to item Cite

Paternal THC exposure in rats causes long-lasting neurobehavioral effects in the offspring.

Journal article Neurotoxicol Teratol · 2019 Developmental neurotoxicity of a wide variety of toxicants mediated via maternal exposure during gestation is very well established. In contrast, the impacts of paternal toxicant exposure on offspring neurobehavioral function are much less well studied. A ... Full text Open Access Link to item Cite

Paternal nicotine exposure in rats produces long-lasting neurobehavioral effects in the offspring.

Journal article Neurotoxicol Teratol · 2019 Studies of intergenerational effects of parental chemical exposure have principally focused on maternal exposure, particularly for studies of adverse neurobehavioral consequences on the offspring. Maternal nicotine exposure has long been known to cause adv ... Full text Open Access Link to item Cite

Large expert-curated database for benchmarking document similarity detection in biomedical literature search.

Journal article Database (Oxford) · January 1, 2019 Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields ... Full text Link to item Cite

Downregulation of SNCA Expression by Targeted Editing of DNA Methylation: A Potential Strategy for Precision Therapy in PD.

Journal article Mol Ther · November 7, 2018 Elevated levels of SNCA have been implicated in the pathogenesis of Parkinson's disease (PD), while normal physiological levels of SNCA are needed to maintain neuronal function. We ought to develop new therapeutic strategies targeting the regulation of SNC ... Full text Link to item Cite

DNA methylation of imprinted gene control regions in the regression of low-grade cervical lesions.

Journal article Int J Cancer · August 1, 2018 The role of host epigenetic mechanisms in the natural history of low-grade cervical intraepithelial neoplasia (CIN1) is not well characterized. We explored differential methylation of imprinted gene regulatory regions as predictors of the risk of CIN1 regr ... Full text Link to item Cite

Self-reported prenatal tobacco smoke exposure, AXL gene-body methylation, and childhood asthma phenotypes.

Journal article Clin Epigenetics · July 20, 2018 BACKGROUND: Epigenetic modifications, including DNA methylation, act as one potential mechanism underlying the detrimental effects associated with prenatal tobacco smoke (PTS) exposure. Methylation in a gene called AXL was previously reported to differ in ... Full text Link to item Cite

DNA methylation of imprinted genes in Mexican-American newborn children with prenatal phthalate exposure.

Journal article Epigenomics · July 2018 AIM: Imprinted genes exhibit expression in a parent-of-origin-dependent manner and are critical for child development. Recent limited evidence suggests that prenatal exposure to phthalates, ubiquitous endocrine disruptors, can affect their epigenetic dysre ... Full text Link to item Cite

Cadmium exposure increases the risk of juvenile obesity: a human and zebrafish comparative study.

Journal article Int J Obes (Lond) · July 2018 OBJECTIVE: Human obesity is a complex metabolic disorder disproportionately affecting people of lower socioeconomic strata, and ethnic minorities, especially African Americans and Hispanics. Although genetic predisposition and a positive energy balance are ... Full text Link to item Cite

Associations between maternal cytokine levels during gestation and measures of child cognitive abilities and executive functioning.

Journal article Brain Behav Immun · May 2018 Preclinical studies demonstrate that environmentally-induced alterations in inflammatory cytokines generated by the maternal and fetal immune system can significantly impact fetal brain development. Yet, the relationship between maternal cytokines during g ... Full text Link to item Cite

Maternal vitamin D, DNA methylation at imprint regulatory regions and offspring weight at birth, 1 year and 3 years.

Journal article Int J Obes (Lond) · April 2018 BACKGROUND/OBJECTIVE: Vitamin D deficiency during pregnancy is associated with poor birth outcomes in some studies, but few have examined weight beyond birth. In addition, little is known about how vitamin D influences DNA methylation of regulatory regions ... Full text Link to item Cite

A genome-scale DNA methylation study in women with interstitial cystitis/bladder pain syndrome.

Journal article Neurourol Urodyn · April 2018 AIMS: To assess the feasibility of using voided urine samples to perform a DNA methylation study in females with interstitial cystitis/bladder pain syndrome (IC/BPS) as compared to age- and race-matched controls. A unique methylation profile could lead to ... Full text Link to item Cite

Folic acid throughout pregnancy: too much?

Journal article Am J Clin Nutr · April 1, 2018 Full text Link to item Cite

Impact of Smoking Ban on Passive Smoke Exposure in Pregnant Non-Smokers in the Southeastern United States.

Journal article Int J Environ Res Public Health · January 6, 2018 Prenatal passive smoke exposure raises risk for negative birth outcomes. Legislation regulating public smoking has been shown to impact exposure levels, though fewer studies involving pregnant women have been conducted within the U.S. where bans are incons ... Full text Link to item Cite

DNA methylation of imprinted genes at birth is associated with child weight status at birth, 1 year, and 3 years.

Journal article Clin Epigenetics · 2018 BACKGROUND: This study assessed the associations between nine differentially methylated regions (DMRs) of imprinted genes in DNA derived from umbilical cord blood leukocytes in males and females and (1) birth weight for gestational age z score, (2) weight- ... Full text Link to item Cite

Branched chain amino acid transaminase 1 (BCAT1) is overexpressed and hypomethylated in patients with non-alcoholic fatty liver disease who experience adverse clinical events: A pilot study.

Journal article PLoS One · 2018 BACKGROUND AND OBJECTIVES: Although the burden of non-alcoholic fatty liver disease (NAFLD) continues to increase worldwide, genetic factors predicting progression to cirrhosis and decompensation in NAFLD remain poorly understood. We sought to determine wh ... Full text Open Access Link to item Cite

Periconceptional Maternal Mediterranean Diet Is Associated With Favorable Offspring Behaviors and Altered CpG Methylation of Imprinted Genes.

Journal article Front Cell Dev Biol · 2018 Background: Maternal diet during pregnancy has been shown to influence the child neuro-developmental outcomes. Studies examining effects of dietary patterns on offspring behavior are sparse. Objective: Determine if maternal adherence to a Mediterranean die ... Full text Link to item Cite

Cannabinoid exposure and altered DNA methylation in rat and human sperm.

Journal article Epigenetics · 2018 Little is known about the reproductive effects of paternal cannabis exposure. We evaluated associations between cannabis or tetrahydrocannabinol (THC) exposure and altered DNA methylation in sperm from humans and rats, respectively. DNA methylation, measur ... Full text Open Access Link to item Cite

Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium.

Journal article Hum Mol Genet · October 15, 2017 Pre-pregnancy maternal obesity is associated with adverse offspring outcomes at birth and later in life. Individual studies have shown that epigenetic modifications such as DNA methylation could contribute. Within the Pregnancy and Childhood Epigenetics (P ... Full text Open Access Link to item Cite

Histone H3.3K27M Represses p16 to Accelerate Gliomagenesis in a Murine Model of DIPG.

Journal article Mol Cancer Res · September 2017 Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive pediatric brainstem tumor genetically distinguished from adult GBM by the high prevalence of the K27M mutation in the histone H3 variant H3.3 (H3F3A). This mutation reprograms the H3K27me3 epig ... Full text Link to item Cite

Blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis.

Journal article Nat Commun · August 30, 2017 Little is known regarding the epigenetic basis of atherosclerosis. Here we present the CD14+ blood monocyte transcriptome and epigenome signatures associated with human atherosclerosis. The transcriptome signature includes transcription coactivator, ARID5B ... Full text Link to item Cite

Maternal inflammatory diet and adverse pregnancy outcomes: Circulating cytokines and genomic imprinting as potential regulators?

Journal article Epigenetics · August 2017 Excessive inflammation during pregnancy alters homeostatic mechanisms of the developing fetus and has been linked to adverse pregnancy outcomes. An anti-inflammatory diet could be a promising avenue to combat the pro-inflammatory state of pregnancy, partic ... Full text Link to item Cite

Low maternal adherence to a Mediterranean diet is associated with increase in methylation at the MEG3-IG differentially methylated region in female infants.

Journal article Environ Epigenet · May 2017 Diet is dictated by the surrounding environment, as food access and availability may change depending on where one lives. Maternal diet during pregnancy is an important part of the in utero environment, and may affect the epigenome. Studies looking at over ... Full text Link to item Cite

Maternal blood cadmium, lead and arsenic levels, nutrient combinations, and offspring birthweight.

Journal article BMC Public Health · April 24, 2017 BACKGROUND: Cadmium (Cd), lead (Pb) and arsenic (As) are common environmental contaminants that have been associated with lower birthweight. Although some essential metals may mitigate exposure, data are inconsistent. This study sought to evaluate the rela ... Full text Open Access Link to item Cite

Small-Magnitude Effect Sizes in Epigenetic End Points are Important in Children's Environmental Health Studies: The Children's Environmental Health and Disease Prevention Research Center's Epigenetics Working Group.

Journal article Environ Health Perspect · April 2017 BACKGROUND: Characterization of the epigenome is a primary interest for children's environmental health researchers studying the environmental influences on human populations, particularly those studying the role of pregnancy and early-life exposures on la ... Full text Link to item Cite

Temporal Trends in Exposure to Organophosphate Flame Retardants in the United States.

Journal article Environ Sci Technol Lett · March 14, 2017 During the past decade, use of organophosphate compounds as flame retardants and plasticizers has increased. Numerous studies investigating biomarkers (i.e., urinary metabolites) demonstrate ubiquitous human exposure and suggest that human exposure may be ... Full text Link to item Cite

NAFLD is associated with methylation shifts with relevance for the expression of genes involved in lipoprotein particle composition.

Journal article Biochim Biophys Acta Mol Cell Biol Lipids · March 2017 Non-alcoholic fatty liver disease (NAFLD) is characterized by the accumulation of triglycerides, cholesterol and toxic free fatty acids and is related to low vitamin D levels. In an analysis of specific gene sets we elucidate to what extent NAFLD associate ... Full text Link to item Cite

Disparities in Cervical Cancer Incidence and Mortality: Can Epigenetics Contribute to Eliminating Disparities?

Journal article Adv Cancer Res · 2017 Screening for uterine cervical intraepithelial neoplasia (CIN) followed by aggressive treatment has reduced invasive cervical cancer (ICC) incidence and mortality. However, ICC cases and carcinoma in situ (CIS) continue to be diagnosed annually in the Unit ... Full text Link to item Cite

Epigenetic regulation of AXL and risk of childhood asthma symptoms.

Journal article Clin Epigenetics · 2017 BACKGROUND: AXL is one of the TAM (TYRO3, AXL and MERTK) receptor tyrosine kinases and may affect numerous immune-related health conditions. However, the role for AXL in asthma, including its epigenetic regulation, has not been extensively studied. METHODS ... Full text Link to item Cite

Human exposure to flame-retardants is associated with aberrant DNA methylation at imprinted genes in sperm.

Journal article Environ Epigenet · January 2017 Emerging evidence suggests that early exposure to endocrine disrupting chemicals has long-term consequences that can influence disease risk in offspring. During gametogenesis, imprinted genes are reasonable epigenetic targets with the ability to retain and ... Full text Link to item Cite

Suppression of ABHD2, identified through a functional genomics screen, causes anoikis resistance, chemoresistance and poor prognosis in ovarian cancer.

Journal article Oncotarget · July 26, 2016 Anoikis resistance is a hallmark of cancer, and relates to malignant phenotypes, including chemoresistance, cancer stem like phenotypes and dissemination. The aim of this study was to identify key factors contributing to anoikis resistance in ovarian cance ... Full text Link to item Cite

A targeted analysis reveals relevant shifts in the methylation and transcription of genes responsible for bile acid homeostasis and drug metabolism in non-alcoholic fatty liver disease.

Journal article BMC Genomics · June 14, 2016 BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is associated with a high risk for liver cirrhosis and cancer. Recent studies demonstrate that NAFLD significantly impacts on the genome wide methylation and expression reporting top hit genes to be ass ... Full text Link to item Cite

Association between Prepregnancy Body Mass Index and Gestational Weight Gain with Size, Tempo, and Velocity of Infant Growth: Analysis of the Newborn Epigenetic Study Cohort.

Journal article Child Obes · June 2016 BACKGROUND: The first 1000 days of life is a critical period of infant growth that has been linked to future adult health. Understanding prenatal factors that contribute to variation in growth during this period could inform successful prevention strategie ... Full text Link to item Cite

Lead Exposure during Early Human Development and DNA Methylation of Imprinted Gene Regulatory Elements in Adulthood.

Journal article Environ Health Perspect · May 2016 BACKGROUND: Lead exposure during early development causes neurodevelopmental disorders by unknown mechanisms. Epidemiologic studies have focused recently on determining associations between lead exposure and global DNA methylation; however, such approaches ... Full text Link to item Cite

Establishment of a Novel Histopathological Classification of High-Grade Serous Ovarian Carcinoma Correlated with Prognostically Distinct Gene Expression Subtypes.

Journal article Am J Pathol · May 2016 Recently, The Cancer Genome Atlas data revealed four molecular subtypes of high-grade serous ovarian carcinoma (HGSOC) exhibiting distinct prognoses. We developed four novel HGSOC histopathological subtypes by focusing on tumor microenvironment: mesenchyma ... Full text Link to item Cite

Effects of Pubertal Exposure to Dietary Soy on Estrogen Receptor Activity in the Breast of Cynomolgus Macaques.

Journal article Cancer Prev Res (Phila) · May 2016 Endogenous estrogens influence mammary gland development during puberty and breast cancer risk during adulthood. Early-life exposure to dietary or environmental estrogens may alter estrogen-mediated processes. Soy foods contain phytoestrogenic isoflavones ... Full text Link to item Cite

DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis.

Journal article Am J Hum Genet · April 7, 2016 Epigenetic modifications, including DNA methylation, represent a potential mechanism for environmental impacts on human disease. Maternal smoking in pregnancy remains an important public health problem that impacts child health in a myriad of ways and has ... Full text Link to item Cite

The BMP signaling pathway leads to enhanced proliferation in serous ovarian cancer-A potential therapeutic target.

Journal article Mol Carcinog · April 2016 Members of the transforming growth factor-β (TGF-β) superfamily transduce signals via SMAD proteins. SMAD2 and SMAD3 mediate TGF-β signaling, whereas SMAD1, SMAD5, and SMAD8/9 transduce bone morphogenetic protein (BMP) signals. We would like to identify th ... Full text Link to item Cite

Abstract A38: Identification through functional genomics screening of factors whose downregulation enhances the side population in ovarian cancer.

Journal article Clinical Cancer Research · January 15, 2016 AbstractCancer stem cells (CSC) play a role in chemoresistance and cancer relapse. CSCs are enriched for a side population (SP) of cells as detected by efflux of hoechst dye. In this research, we performed a ... Full text Cite

Maternal B vitamins: effects on offspring weight and DNA methylation at genomically imprinted domains.

Journal article Clin Epigenetics · 2016 BACKGROUND: Inadequate maternal nutrition during early fetal development can create permanent alterations in the offspring, leading to poor health outcomes. While nutrients involved in one-carbon cycle metabolism are important to fetal growth, associations ... Full text Link to item Cite

Neighborhood and Family Environment of Expectant Mothers May Influence Prenatal Programming of Adult Cancer Risk: Discussion and an Illustrative DNA Methylation Example.

Journal article Biodemography Soc Biol · 2016 Childhood stressors including physical abuse predict adult cancer risk. Prior research portrays this finding as an indirect mechanism that operates through coping behaviors, including adult smoking, or through increased toxic exposures during childhood. Li ... Full text Link to item Cite

Obesity-related DNA methylation at imprinted genes in human sperm: Results from the TIEGER study.

Journal article Clin Epigenetics · 2016 BACKGROUND: Epigenetic reprogramming in mammalian gametes resets methylation marks that regulate monoallelic expression of imprinted genes. In males, this involves erasure of the maternal methylation marks and establishment of paternal-specific methylation ... Full text Link to item Cite

DNA Methylation of Regulatory Regions of Imprinted Genes at Birth and Its Relation to Infant Temperament.

Journal article Genet Epigenet · 2016 BACKGROUND: DNA methylation of the differentially methylated regions (DMRs) of imprinted genes is relevant to neurodevelopment. METHODS: DNA methylation status of the DMRs of nine imprinted genes in umbilical cord blood leukocytes was analyzed in relation ... Full text Link to item Cite

Distinct Epigenetic Effects of Tobacco Smoking in Whole Blood and among Leukocyte Subtypes.

Journal article PLoS One · 2016 Tobacco smoke exposure dramatically alters DNA methylation in blood cells and may mediate smoking-associated complex diseases through effects on immune cell function. However, knowledge of smoking effects in specific leukocyte subtypes is limited. To bette ... Full text Link to item Cite

Maternal blood lead concentrations, DNA methylation of MEG3 DMR regulating the DLK1/MEG3 imprinted domain and early growth in a multiethnic cohort.

Journal article Environ Epigenet · 2016 Prenatal exposure to lead (Pb) is known to decrease fetal growth; but its effects on postnatal growth and mechanistic insights linking Pb to growth are not clearly defined. Genomically imprinted genes are powerful regulators of growth and energy utilizatio ... Full text Link to item Cite

Epigenetic silencing of Kruppel like factor-3 increases expression of pro-metastatic miR-182.

Journal article Cancer Lett · December 1, 2015 Accumulating evidence indicates that microRNAs (miRs) regulate cancer metastasis. We have shown that miR-182 drives sarcoma metastasis in vivo by coordinated regulation of multiple genes. Recently, we also demonstrated that in a subset of primary sarcomas ... Full text Link to item Cite

Chemotherapy Induces Programmed Cell Death-Ligand 1 Overexpression via the Nuclear Factor-κB to Foster an Immunosuppressive Tumor Microenvironment in Ovarian Cancer.

Journal article Cancer Res · December 1, 2015 Emerging evidence has highlighted the host immune system in modulating the patient response to chemotherapy, but the mechanism of this modulation remains unclear. The aim of this study was to analyze the effect of chemotherapy on antitumor immunity in the ... Full text Link to item Cite

Mitochondrial Superoxide Dismutase Has a Protumorigenic Role in Ovarian Clear Cell Carcinoma.

Journal article Cancer Res · November 15, 2015 Epithelial ovarian cancer (EOC) is the fourth leading cause of death due to cancer in women and comprises distinct histologic subtypes, which vary widely in their genetic profiles and tissues of origin. It is therefore imperative to understand the etiology ... Full text Link to item Cite

Epigenetic Regulation of GDF2 Suppresses Anoikis in Ovarian and Breast Epithelia.

Journal article Neoplasia · November 2015 Anoikis, a cell death mechanism triggered upon cell-matrix detachment, is regarded as a physiological suppressor of metastasis that can be regulated by a diverse array of signals. The protein encoded by GDF2 is BMP9 and is a member of the bone morphogeneti ... Full text Link to item Cite

Geographic clustering of elevated blood heavy metal levels in pregnant women.

Journal article BMC Public Health · October 9, 2015 BACKGROUND: Cadmium (Cd), lead (Pb), mercury (Hg), and arsenic (As) exposure is ubiquitous and has been associated with higher risk of growth restriction and cardiometabolic and neurodevelopmental disorders. However, cost-efficient strategies to identify a ... Full text Link to item Cite

Alterations of a Cellular Cholesterol Metabolism Network Are a Molecular Feature of Obesity-Related Type 2 Diabetes and Cardiovascular Disease.

Journal article Diabetes · October 2015 Obesity is linked to type 2 diabetes (T2D) and cardiovascular diseases; however, the underlying molecular mechanisms remain unclear. We aimed to identify obesity-associated molecular features that may contribute to obesity-related diseases. Using circulati ... Full text Link to item Cite

ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate.

Journal article PLoS Genet · October 2015 In order to propagate a solid tumor, cancer cells must adapt to and survive under various tumor microenvironment (TME) stresses, such as hypoxia or lactic acidosis. To systematically identify genes that modulate cancer cell survival under stresses, we perf ... Full text Open Access Link to item Cite

Genotype-Epigenotype Interaction at the IGF2 DMR.

Journal article Genes (Basel) · August 28, 2015 Paternally expressed Insulin-like Growth Factor II (IGF2) encodes a gene whose protein product functions as a potent growth mitogen. Overexpression of IGF2 has been implicated in a wide number of disorders and diseases. IGF2 is regulated in part by differe ... Full text Link to item Cite

Maternal cadmium, iron and zinc levels, DNA methylation and birth weight.

Journal article BMC Pharmacol Toxicol · July 15, 2015 BACKGROUND: Cadmium (Cd) is a ubiquitous and environmentally persistent toxic metal that has been implicated in neurotoxicity, carcinogenesis and obesity and essential metals including zinc (Zn) and iron (Fe) may alter these outcomes. However mechanisms un ... Full text Link to item Cite

Epigenetic regulation of Newborns' imprinted genes related to gestational growth: patterning by parental race/ethnicity and maternal socioeconomic status.

Journal article J Epidemiol Community Health · July 2015 BACKGROUND: Children born to parents with lower income and education are at risk for obesity and later-life risk of common chronic diseases, and epigenetics has been hypothesised to link these associations. However, epigenetic targets are unknown. We focus ... Full text Link to item Cite

Menstrual cyclic change of metastin/GPR54 in endometrium.

Journal article Med Mol Morphol · June 2015 Metastin/kisspeptin is encoded by KISS1 and functions as an endogenous ligand of GPR54. Interaction of metastin with GPR54 suppresses metastasis and also regulates release of gonadotropin-releasing hormone, which promotes secretion of estradiol (E2) and pr ... Full text Link to item Cite

Newborns of obese parents have altered DNA methylation patterns at imprinted genes

Journal article International Journal of Obesity · April 9, 2015 Background:Several epidemiologic studies have demonstrated associations between periconceptional environmental exposures and health status of the offspring in later life. Although these environmentally related effects have been attributed to epigenetic cha ... Full text Open Access Cite

In vitro lead exposure changes DNA methylation and expression of IGF2 and PEG1/MEST.

Journal article Toxicol In Vitro · April 2015 Epigenetic processes, such as changes in DNA methylation, likely mediate the link between environmental exposures in utero and altered gene expression. Differentially methylated regions (DMRs) that regulate imprinted genes may be especially vulnerable to e ... Full text Link to item Cite

Comprehensive profiling of amino acid response uncovers unique methionine-deprived response dependent on intact creatine biosynthesis.

Journal article PLoS Genet · April 2015 Besides being building blocks for protein synthesis, amino acids serve a wide variety of cellular functions, including acting as metabolic intermediates for ATP generation and for redox homeostasis. Upon amino acid deprivation, free uncharged tRNAs trigger ... Full text Link to item Cite

Newborns of obese parents have altered DNA methylation patterns at imprinted genes.

Journal article Int J Obes (Lond) · April 2015 BACKGROUND: Several epidemiologic studies have demonstrated associations between periconceptional environmental exposures and health status of the offspring in later life. Although these environmentally related effects have been attributed to epigenetic ch ... Full text Open Access Link to item Cite

Invasion of uterine cervical squamous cell carcinoma cells is facilitated by locoregional interaction with cancer-associated fibroblasts via activating transforming growth factor-beta.

Journal article Gynecol Oncol · January 2015 OBJECTIVE: Local invasion is a common pattern of spread in uterine cervical squamous cell carcinoma (CSCC). Although transforming growth factor-beta (TGF-β) facilitates invasion of various types of cancer cells, the role of the TGF-β pathway in CSCC is unc ... Full text Link to item Cite

IL-10, IL-15, IL-17, and GMCSF levels in cervical cancer tissue of Tanzanian women infected with HPV16/18 vs. non-HPV16/18 genotypes.

Journal article Infect Agent Cancer · 2015 BACKGROUND: Despite comparable screening rates for precancerous lesions, higher incidence and mortality related to cervical cancer in minority women persists. Recent evidence suggests that minority women with precancerous cervical lesions harbor a wider ra ... Full text Open Access Link to item Cite

Ascites Increases Expression/Function of Multidrug Resistance Proteins in Ovarian Cancer Cells.

Journal article PLoS One · 2015 Chemotherapy resistance is the major reason for the failure of ovarian cancer treatment. One mechanism behind chemo-resistance involves the upregulation of multidrug resistance (MDR) genes (ABC transporters) that effectively transport (efflux) drugs out of ... Full text Link to item Cite

Associations between prenatal physical activity, birth weight, and DNA methylation at genomically imprinted domains in a multiethnic newborn cohort.

Journal article Epigenetics · 2015 Birth weight is a commonly used indicator of the fetal environment and a predictor of future health outcomes. While the etiology of birth weight extremes is likely multifactorial, epidemiologic data suggest that prenatal physical activity (PA) may play an ... Full text Link to item Cite

Hepatocyte nuclear factor-1β (HNF-1β) promotes glucose uptake and glycolytic activity in ovarian clear cell carcinoma.

Journal article Mol Carcinog · January 2015 Ovarian clear cell carcinoma (OCCC) is a morphologically and biologically distinct subtype of ovarian carcinomas that often arises in ovarian endometriosis. We previously reported that a unique carcinogenic environment, especially iron-induced oxidative st ... Full text Link to item Cite

STAT1 drives tumor progression in serous papillary endometrial cancer.

Journal article Cancer Res · November 15, 2014 Recent studies of the interferon-induced transcription factor STAT1 have associated its dysregulation with poor prognosis in some cancers, but its mechanistic contributions are not well defined. In this study, we report that the STAT1 pathway is constituti ... Full text Link to item Cite

Abstract B22: Altered methylation profiles of imprinted genes in response to prenatal exposure to cigarette smoke in the Newborn Epigenetic STudy (NEST) cohort

Journal article Cancer Epidemiology, Biomarkers & Prevention · November 1, 2014 AbstractBackground: Early life environmental exposures have adverse consequences on health and development but the mechanisms underlying these effects are unclear. Epigenetic deregulation resulting from ciga ... Full text Cite

Epigenetic determinants of ovarian clear cell carcinoma biology.

Journal article Int J Cancer · August 1, 2014 Targeted approaches have revealed frequent epigenetic alterations in ovarian cancer, but the scope and relation of these changes to histologic subtype of disease is unclear. Genome-wide methylation and expression data for 14 clear cell carcinoma (CCC), 32 ... Full text Link to item Cite

Erythrocyte folate concentrations, CpG methylation at genomically imprinted domains, and birth weight in a multiethnic newborn cohort.

Journal article Epigenetics · August 2014 Epigenetic mechanisms are proposed to link maternal concentrations of methyl group donor nutrients with the risk of low birth weight. However, empirical data are lacking. We have examined the association between maternal folate and birth weight and assesse ... Full text Open Access Link to item Cite

HPV genotypes and cervical intraepithelial neoplasia in a multiethnic cohort in the southeastern USA.

Journal article Cancer Causes Control · August 2014 PURPOSE: For poorly understood reasons, invasive cervical cancer (ICC) incidence and mortality rates are higher in women of African descent. Oncogenic human papillomavirus (HPV) genotypes distribution may vary between European American (EA) and African-Ame ... Full text Open Access Link to item Cite

Obesity: Paternal obesity--a risk factor for autism?

Journal article Nat Rev Endocrinol · July 2014 Full text Link to item Cite

Imprinted genes and the environment: links to the toxic metals arsenic, cadmium, lead and mercury.

Journal article Genes (Basel) · June 11, 2014 Imprinted genes defy rules of Mendelian genetics with their expression tied to the parent from whom each allele was inherited. They are known to play a role in various diseases/disorders including fetal growth disruption, lower birth weight, obesity, and c ... Full text Link to item Cite

A paternal environmental legacy: evidence for epigenetic inheritance through the male germ line.

Journal article Bioessays · April 2014 Literature on maternal exposures and the risk of epigenetic changes or diseases in the offspring is growing. Paternal contributions are often not considered. However, some animal and epidemiologic studies on various contaminants, nutrition, and lifestyle-r ... Full text Link to item Cite

A paternal environmental legacy: Evidence for epigenetic inheritance through the male germ line

Journal article Bioessays · April 1, 2014 Literature on maternal exposures and the risk of epigenetic changes or diseases in the offspring is growing. Paternal contributions are often not considered. However, some animal and epidemiologic studies on various contaminants, nutrition, and lifestyle-r ... Full text Cite

PEG1/MEST and IGF2 DNA methylation in CIN and in cervical cancer

Journal article Clinical and Translational Oncology · March 1, 2014 Introduction: Although most invasive cervical cancer (ICC) harbor <20 human papillomavirus (HPV) genotypes, use of HPV screening to predict ICC from HPV has low specificity, resulting in multiple and costly follow-up visits and overtreatment. We examined D ... Full text Cite

Dasatinib (BMS-35482) interacts synergistically with docetaxel, gemcitabine, topotecan, and doxorubicin in ovarian cancer cells with high SRC pathway activation and protein expression.

Journal article Int J Gynecol Cancer · February 2014 PURPOSE: This study aimed to explore the activity of dasatinib in combination with docetaxel, gemcitabine, topotecan, and doxorubicin in ovarian cancer cells. METHODS: Cells with previously determined SRC pathway and protein expression (SRC pathway/SRC pro ... Full text Link to item Cite

Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease.

Journal article Hepatology · February 2014 UNLABELLED: Clinicians rely upon the severity of liver fibrosis to segregate patients with well-compensated nonalcoholic fatty liver disease (NAFLD) into subpopulations at high- versus low-risk for eventual liver-related morbidity and mortality. We compare ... Full text Link to item Cite

Investigating Epigenetic Effects of Prenatal Exposure to Toxic Metals in Newborns: Challenges and Benefits.

Journal article Med Epigenet · 2014 Increasing evidence suggest that epigenetic alterations can greatly impact human health, and that epigenetic mechanisms (DNA methylation, histone modifications, and microRNAs) may be particularly relevant in responding to environmental toxicant exposure ea ... Full text Link to item Cite

Differential Angiogenic Gene Expression in TP53 Wild-Type and Mutant Ovarian Cancer Cell Lines.

Journal article Front Oncol · 2014 OBJECTIVES: Underlying mechanisms regulating angiogenesis in ovarian cancer have not been completely elucidated. Evidence suggests that the TP53 tumor suppressor pathway and tumor microenvironment play integral roles. We utilized microarray technology to s ... Full text Link to item Cite

HPV genotypes and cervical intraepithelial Neoplasiain a multiethnic cohort in the southeastern United States

Journal article Journal of Vaccines and Vaccination · January 1, 2014 Background: For poorly understood reasons, invasive cervical cancer (ICC) incidence and mortality rates are higher in women of African descent. Oncogenic human papillomavirus (HPV) genotypes distribution may vary between European American (EA) and African ... Full text Cite

What are the implications of distinct HPV genotypes in women of different ethnic/racial ancestry?

Journal article Journal of Vaccines and Vaccination · January 1, 2014 Invasive cervical cancer incidence and mortality continue to disproportionately affect racial/ethnic minorities, and the distribution of HPV genotypes varies by race/ethnicity, providing a potential explanation for such differences in incidence and mortali ... Full text Cite

HPV genotypes and cervical intraepithelial neoplasia in a multiethnic cohort in the southeastern USA

Journal article Cancer Causes and Control · January 1, 2014 Purpose: For poorly understood reasons, invasive cervical cancer (ICC) incidence and mortality rates are higher in women of African descent. Oncogenic human papillomavirus (HPV) genotypes distribution may vary between European American (EA) and African-Ame ... Full text Cite

Maternal stress, preterm birth, and DNA methylation at imprint regulatory sequences in humans.

Journal article Genet Epigenet · 2014 In infants exposed to maternal stress in utero, phenotypic plasticity through epigenetic events may mechanistically explain increased risk of preterm birth (PTB), which confers increased risk for neurodevelopmental disorders, cardiovascular disease, and ca ... Full text Open Access Link to item Cite

Epigenetic and genetic dispositions of ovarian carcinomas.

Journal article Oncoscience · 2014 Ovarian clear cell carcinoma has unique clinical characteristics with slow growth and a stress-resistant phenotype that is epigenetically induced during cancer progression in an inflammatory microenvironment. We refer to this as an epigenetic disposition, ... Full text Link to item Cite

Utilization of genomic signatures to identify high-efficacy candidate drugs for chemorefractory endometrial cancers.

Journal article Int J Cancer · November 2013 Endometrial cancer, one of the most common gynecologic malignancies, is increasing in Japan, nearly doubling over the last decade. High-grade disease patients are often resistant to conventional chemotherapy with platinum agents; therefore, discovery of ef ... Full text Link to item Cite

Relationship between methylome and transcriptome in patients with nonalcoholic fatty liver disease.

Journal article Gastroenterology · November 2013 BACKGROUND & AIMS: Cirrhosis and liver cancer are potential outcomes of advanced nonalcoholic fatty liver disease (NAFLD). It is not clear what factors determine whether patients will develop advanced or mild NAFLD, limiting noninvasive diagnosis and treat ... Full text Link to item Cite

Abstract A83: Induction of PD-L1 expression by cytotoxic agents through activation of NF-kB signal

Journal article Clinical Cancer Research · October 1, 2013 AbstractRecently, growing evidence has shown that the therapeutic efficacy of chemotherapy largely depends on the host immune system. We analyzed gene expression microarray dataset GSE13525 to examine how cy ... Full text Cite

Abstract B19: Functional genomics approach links anchorage-independence with tumor dormancy in ovarian cancer

Journal article Clinical Cancer Research · October 1, 2013 AbstractAlthough a number of genes are aberrantly regulated in ovarian cancer, little is known about which genes are functionally important. The aim of this study was to identify new genes relevant to anchor ... Full text Cite

Abstract PR08: HNF1β confers resistance to oxidative stress of ovarian clear cell carcinoma

Journal article Clinical Cancer Research · October 1, 2013 AbstractOvarian clear cell carcinoma (OCCC) is a histologic subtype of epithelial ovarian cancer (EOC) with unique characteristics including chemoresistance and carcinogenic origins from endometriotic cysts. ... Full text Cite

Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring.

Journal article Int J Obes (Lond) · July 2013 OBJECTIVES: Low birth weight (LBW) has been associated with common adult-onset chronic diseases, including obesity, cardiovascular disease, type II diabetes and some cancers. The etiology of LBW is multi-factorial. However, recent evidence suggests exposur ... Full text Open Access Link to item Cite

Prenatal sensitization of a postnatal trigger for metabolic disease.

Journal article J Clin Invest · July 2013 Intrahepatic cholestasis of pregnancy (ICP), marked by elevated maternal serum bile acid levels, occurs in late pregnancy and is often associated with poor perinatal outcomes. In this issue of the JCI, Papacleovoulou et al. analyze the long-term consequenc ... Full text Link to item Cite

DNA methylation at imprint regulatory regions in preterm birth and infection.

Journal article Am J Obstet Gynecol · May 2013 OBJECTIVE: To aid in understanding long-term health consequences of intrauterine infections in preterm birth, we evaluated DNA methylation at 9 differentially methylated regions that regulate imprinted genes by type of preterm birth (spontaneous preterm la ... Full text Link to item Cite

Validation of ovarian cancer gene expression signatures for survival and subtype in formalin fixed paraffin embedded tissues.

Journal article Gynecol Oncol · April 2013 INTRODUCTION: Gene expression signatures have been identified for epithelial ovarian cancer survival (TCGA) and intrinsic subtypes (Tothill et al.). One obstacle to clinical translation is that these signatures were developed using frozen tissue, whereas u ... Full text Link to item Cite

Paternal obesity is associated with IGF2 hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort.

Journal article BMC Med · February 6, 2013 BACKGROUND: Data from epidemiological and animal model studies suggest that nutrition during pregnancy may affect the health status of subsequent generations. These transgenerational effects are now being explained by disruptions at the level of the epigen ... Full text Open Access Link to item Cite

Associations between birth and one year anthropometric measurements and IGF2 and IGF2R genetic variants in African American and Caucasian American infants.

Journal article J Pediatr Genet · 2013 Insulin-like growth factor 2 receptor (IGF2R) and insulin-like growth factor 2 (IGF2) genetic variants have been inconsistently associated with low birth weight and birth length in Caucasian and Asian infants, however few studies have included African Amer ... Full text Open Access Link to item Cite

Associations between methylation of paternally expressed gene 3 (PEG3), cervical intraepithelial neoplasia and invasive cervical cancer.

Journal article PLoS One · 2013 Cytology-based screening for invasive cervical cancer (ICC) lacks sensitivity and specificity to discriminate between cervical intraepithelial neoplasia (CIN) likely to persist or progress from cases likely to resolve. Genome-wide approaches have been used ... Full text Link to item Cite

Increased Intragenic IGF2 Methylation is Associated with Repression of Insulator Activity and Elevated Expression in Serous Ovarian Carcinoma.

Journal article Front Oncol · 2013 Overexpression of insulin-like growth factor-II (IGF2) is a prominent characteristic of many epithelial ovarian malignancies. IGF2 imprinting and transcription are regulated in part through DNA methylation, which in turn regulates binding of the insulator ... Full text Link to item Cite

Maternal BMI, IGF-I Levels, and Birth Weight in African American and White Infants.

Journal article Int J Pediatr · 2013 At birth, elevated IGF-I levels have been linked to birth weight extremes; high birth weight and low birth weight are risk factors for adult-onset chronic diseases including obesity, cardiovascular disease, and type 2 diabetes. We examined associations bet ... Full text Open Access Link to item Cite

Bisulfite pyrosequencing.

Journal article Methods Mol Biol · 2013 Bisulfite pyrosequencing is a sequencing-by-synthesis method used to quantitatively determine the methylation of individual CG cytosines from PCR amplicons of a region up to 115 bases in length. The procedure relies on prior bisulfite conversion of all pot ... Full text Link to item Cite

Bisulfite sequencing of cloned alleles.

Journal article Methods Mol Biol · 2013 Bisulfite sequencing of cloned alleles is a widely used method for capturing the methylation profiles of single alleles. This method combines PCR amplification of the bisulfite-modified DNA with the subcloning of the amplicons into plasmids followed by tra ... Full text Link to item Cite

Methylation-specific PCR.

Journal article Methods Mol Biol · 2013 Defining DNA methylation patterns in the genome has become essential for understanding diverse biological processes including the regulation of gene expression, imprinted genes, and X chromosome inactivation and how these patterns are deregulated in human ... Full text Link to item Cite

Main principles and outcomes of DNA methylation analysis.

Journal article Methods Mol Biol · 2013 Epigenetic modifications, including DNA methylation, are critically important mediators of normal cell function over the course of our lives. These modifications therefore also can play prominent roles in the development of disorders and diseases, includin ... Full text Link to item Cite

Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring

Journal article International Journal of Obesity · 2013 Objectives: Low birth weight (LBW) has been associated with common adult-onset chronic diseases, including obesity, cardiovascular disease, type II diabetes and some cancers. The etiology of LBW is multi-factorial. However, recent evidence suggests exposur ... Full text Open Access Cite

TP53 Status is Associated with Thrombospondin1 Expression In vitro.

Journal article Front Oncol · 2013 OBJECTIVES: To elucidate the association between thrombospondin1 (THBS1) expression and TP53 status and THBS1 promoter methylation in epithelial ovarian cancer (EOC). METHODS: Epithelial ovarian cancer cell lines with known TP53 status were analyzed for TH ... Full text Link to item Cite

DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.

Journal article Gynecol Oncol · October 2012 OBJECTIVES: Cell lines derived from human ovarian and endometrial cancers, and their immortalized non-malignant counterparts, are critical tools to investigate and characterize molecular mechanisms underlying gynecologic tumorigenesis, and facilitate devel ... Full text Link to item Cite

450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy.

Journal article Environ Health Perspect · October 2012 BACKGROUND: Epigenetic modifications, such as DNA methylation, due to in utero exposures may play a critical role in early programming for childhood and adult illness. Maternal smoking is a major risk factor for multiple adverse health outcomes in children ... Full text Link to item Cite

Convergent and divergent evolution of genomic imprinting in the marsupial Monodelphis domestica.

Journal article BMC Genomics · August 16, 2012 BACKGROUND: Genomic imprinting is an epigenetic phenomenon resulting in parent-of-origin specific monoallelic gene expression. It is postulated to have evolved in placental mammals to modulate intrauterine resource allocation to the offspring. In this stud ... Full text Link to item Cite

Insulin-like growth factor 2/H19 methylation at birth and risk of overweight and obesity in children.

Journal article J Pediatr · July 2012 OBJECTIVE: To determine whether aberrant DNA methylation at differentially methylated regions (DMRs) regulating insulin-like growth factor 2 (IGF2) expression in umbilical cord blood is associated with overweight or obesity in a multiethnic cohort. STUDY D ... Full text Open Access Link to item Cite

Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements.

Journal article Epigenetics · July 2012 Depressed mood in pregnancy has been linked to low birth weight (LBW, < 2,500 g), a risk factor for adult-onset chronic diseases in offspring. We examined maternal depressed mood in relation to birth weight and evaluated the role of DNA methylation at regu ... Full text Open Access Link to item Cite

Abstract LB-87: Methylated-mediated repression of ZNF154 in ovarian cancer is associated with poor overall survival

Journal article Cancer Research · April 15, 2012 AbstractObjectives: Epigenetic gene regulation plays an important role in the development of cancer. We previously found that Zinc Finger Protein 154 (ZNF154), a Krüppel family zinc finger protein, is ubiqui ... Full text Cite

Abstract 5363: Aggregation rather than monoclonal expansion explains ovarian cancer spheroid formation

Journal article Cancer Research · April 15, 2012 AbstractPurpose: It is thought that a subpopulation of ovarian cancer cells possess stem cell like properties and are responsible for both the emergence of cancer and for subsequent chemoresistance and recur ... Full text Cite

Association of cord blood methylation fractions at imprinted insulin-like growth factor 2 (IGF2), plasma IGF2, and birth weight.

Journal article Cancer Causes Control · April 2012 PURPOSE: Altered methylation at Insulin-like Growth Factor 2 (IGF2) regulatory regions has previously been associated with obesity, and several malignancies including colon, esophageal, and prostate adenocarcinomas, presumably via changes in expression and ... Full text Open Access Link to item Cite

Gender-specific methylation differences in relation to prenatal exposure to cigarette smoke.

Journal article Gene · February 15, 2012 Featured Publication Epigenetic alterations may mechanistically explain the developmental origins of adult disease, namely the hypothesis that many complex adult chronic diseases originate as a result of conditions encountered in utero. If true, epigenetically regulated imprin ... Full text Link to item Cite

Targeting the epigenome in ovarian cancer.

Journal article Future Oncol · February 2012 Epithelial ovarian cancer is the leading cause of death from gynecological cancers, largely owing to the development of recurrent intractable disease. Only a small number of distinct genetic mutations are known to contribute to ovarian carcinogenesis. Furt ... Full text Link to item Cite

The activated transforming growth factor-beta signaling pathway in peritoneal metastases is a potential therapeutic target in ovarian cancer.

Journal article Int J Cancer · January 1, 2012 Peritoneal dissemination including omental metastasis is the most frequent route of metastasis and an important prognostic factor in advanced ovarian cancer. We analyzed the publicly available microarray dataset (GSE2109) using binary regression and found ... Full text Link to item Cite

IGF2R genetic variants, circulating IGF2 concentrations and colon cancer risk in African Americans and Whites.

Journal article Dis Markers · 2012 The Mannose 6 Phosphate/Insulin-like Growth Factor Receptor-2 (IGF2R) encodes a type-1 membrane protein that modulates availability of the potent mitogen, IGF2. We evaluated the associations between IGF2R non-synonymous genetic variants (c.5002G>A, Gly1619 ... Full text Link to item Cite

Differentially methylated regions of imprinted genes in prenatal, perinatal and postnatal human tissues.

Journal article PLoS One · 2012 Featured Publication Epigenetic plasticity in relation to in utero exposures may mechanistically explain observed differences in the likelihood of developing common complex diseases including hypertension, diabetes and cardiovascular disease through the cumulative effects of s ... Full text Link to item Cite

The human imprintome: regulatory mechanisms, methods of ascertainment, and roles in disease susceptibility.

Journal article ILAR J · 2012 Imprinted genes form a special subset of the genome, exhibiting monoallelic expression in a parent-of-origin-dependent fashion. This monoallelic expression is controlled by parental-specific epigenetic marks, which are established in gametogenesis and earl ... Full text Link to item Cite

Ovarian cancer progenitor/stem cells: Therapeutic potential

Journal article · December 1, 2011 A number of studies provide evidence for the existence of ovarian cancer stem cells, defined by functional attributes, foremost the ability to reconstruct the heterogeneity of the original tumor in immunocompromised mice through asymmetric cell division. A ... Full text Cite

Quantitative detection of RASSF1A DNA promoter methylation in tumors and serum of patients with serous epithelial ovarian cancer.

Journal article Gynecol Oncol · December 2011 OBJECTIVE: Detection of cell free tumor-specific DNA methylation has been proposed as a potentially useful noninvasive mechanism to detect malignancies, including ovarian cancer, and to monitor response to treatment. However, there are few easily implement ... Full text Link to item Cite

Mouse models of epigenetic inheritance

Journal article · December 1, 2011 This chapter discusses the mouse models of epigenetic inheritance. The increasing evidence implicates epigenetic changes as a primary impetus in disease development. The epigenetic regulation alters gene expression to promote compensatory adjustments in me ... Full text Cite

Distribution of HPV genotypes in cervical intraepithelial lesions and cervical cancer in Tanzanian women.

Journal article Infect Agent Cancer · November 14, 2011 BACKGROUND: Infection with human papillomavirus (HPV) is associated with uterine cervical intraepithelial neoplasia (CIN) and invasive cancers (ICC). Approximately 80% of ICC cases are diagnosed in under-developed countries. Vaccine development relies on k ... Full text Open Access Link to item Cite

The regulation of MASPIN expression in epithelial ovarian cancer: association with p53 status, and MASPIN promoter methylation: a gynecologic oncology group study.

Journal article Gynecol Oncol · November 2011 OBJECTIVES: To elucidate the regulation of MASPIN expression in epithelial ovarian cancer (EOC) and associations with p53 status and MASPIN promoter methylation. METHODS: Seven EOC cell lines and 110 advanced stage EOC specimens were analyzed for MASPIN pr ... Full text Link to item Cite

The effects of depression and use of antidepressive medicines during pregnancy on the methylation status of the IGF2 imprinted control regions in the offspring.

Journal article Clin Epigenetics · October 26, 2011 In utero exposures to environmental factors may result in persistent epigenetic modifications affecting normal development and susceptibility to chronic diseases in later life. We explored the relationship between exposure of the growing fetus to maternal ... Full text Open Access Link to item Cite

Novel retrotransposed imprinted locus identified at human 6p25.

Journal article Nucleic Acids Res · July 2011 Differentially methylated regions (DMRs) are stable epigenetic features within or in proximity to imprinted genes. We used this feature to identify candidate human imprinted loci by quantitative DNA methylation analysis. We discovered a unique DMR at the 5 ... Full text Link to item Cite

Methylation variation at IGF2 differentially methylated regions and maternal folic acid use before and during pregnancy.

Journal article Epigenetics · July 2011 Folic acid (FA) supplementation before and during pregnancy has been associated with decreased risk of neural tube defects although recent reports suggest it may also increase the risk of other chronic diseases. We evaluated exposure to maternal FA supplem ... Full text Open Access Link to item Cite

Abstract 3014: Quantitative accuracy of Illumina HumanMethylation27 Infinium BeadChip data assessed by pyrosequencing

Journal article Cancer Research · April 15, 2011 AbstractPurpose. Aberrant DNA methylation can lead to changes in gene expression, and this alteration is highly relevant in the context of cancer. The ability to accurately assess DNA methylation status is t ... Full text Cite

Abstract 2754: Maternal use of antidepressants in pregnancy is associated with hypermethylation at the IGF2 imprinted control regions in the offspring in a race-dependent fashion

Journal article Cancer Research · April 15, 2011 AbstractIn utero exposures to environmental factors may result in persistent epigenetic modifications affecting normal development and susceptibility to chronic diseases in later life. We determined whether ... Full text Cite

GPR54 is a target for suppression of metastasis in endometrial cancer.

Journal article Mol Cancer Ther · April 2011 Invasion into deep myometrium and/or lymphovascular space is a well-known risk factor for endometrial cancer metastasis, resulting in poor prognosis. It is therefore clinically important to identify novel molecules that suppress tumor invasion. Reduced exp ... Full text Link to item Cite

Dasatinib (BMS-35482) has synergistic activity with paclitaxel and carboplatin in ovarian cancer cells.

Journal article Gynecol Oncol · April 2011 PURPOSE: To explore the activity of dasatinib alone and in combination with paclitaxel and carboplatin in ovarian cancer cells and to determine if dasatinib activity can be predicted based on evaluation of the SRC pathway. EXPERIMENTAL DESIGN: Microarray a ... Full text Link to item Cite

Folic acid supplementation before and during pregnancy in the Newborn Epigenetics STudy (NEST).

Journal article BMC Public Health · January 21, 2011 BACKGROUND: Folic acid (FA) added to foods during fortification is 70-85% bioavailable compared to 50% of folate occurring naturally in foods. Thus, if FA supplements also are taken during pregnancy, both mother and fetus can be exposed to FA exceeding the ... Full text Open Access Link to item Cite

Epigenetic suppression of the TGF-beta pathway revealed by transcriptome profiling in ovarian cancer.

Journal article Genome Res · January 2011 Featured Publication Epithelial ovarian cancer is the leading cause of death among gynecologic malignancies. Diagnosis usually occurs after metastatic spread, largely reflecting vague symptoms of early disease combined with lack of an effective screening strategy. Epigenetic m ... Full text Link to item Cite

Sorafenib efficacy in ovarian clear cell carcinoma revealed by transcriptome profiling.

Journal article Cancer Sci · December 2010 The purpose of this study was to investigate a new modality of therapy against ovarian clear cell carcinoma (OCCC), a chemoresistant subtype of ovarian cancer. Microarray datasets of ovarian cancer cell lines and cancer tissues were analyzed using bioinfor ... Full text Link to item Cite

Expression signatures of TP53 mutations in serous ovarian cancers.

Journal article BMC Cancer · May 26, 2010 BACKGROUND: Mutations in the TP53 gene are extremely common and occur very early in the progression of serous ovarian cancers. Gene expression patterns that relate to mutational status may provide insight into the etiology and biology of the disease. METHO ... Full text Open Access Link to item Cite

Targeting slow-proliferating ovarian cancer cells.

Journal article Int J Cancer · May 15, 2010 Featured Publication Advanced ovarian cancer has a high rate of recurrence and mortality despite relative chemosensitivity at the time of initial treatment. Conventional chemotherapeutic agents typically target rapidly dividing cells. Disease relapse may therefore result from ... Full text Link to item Cite

Identification of an ovarian clear cell carcinoma gene signature that reflects inherent disease biology and the carcinogenic processes.

Journal article Oncogene · March 25, 2010 Featured Publication Ovarian clear cell carcinoma (OCCC) shows unique clinical features including an association with endometriosis and poor prognosis. We previously reported that the contents of endometriotic cysts, especially high concentrations of free iron, are a possible ... Full text Link to item Cite

Elevated MAL expression is accompanied by promoter hypomethylation and platinum resistance in epithelial ovarian cancer.

Journal article Int J Cancer · March 15, 2010 Featured Publication We previously found that the gene encoding the Myelin and Lymphocyte protein, MAL, was among the most highly expressed genes in serous ovarian cancers from short-term survivors (<3 years) relative to those of long-term survivors (>7 years). In the present ... Full text Link to item Cite

Ovarian cancer tumor infiltrating T-regulatory (T(reg)) cells are associated with a metastatic phenotype.

Journal article Gynecol Oncol · March 2010 OBJECTIVE: The objective of this study was to examine the clinicopathologic correlates of T-regulatory (T(reg)) cell infiltration in serous ovarian cancers and to define gene signatures associated with high T(reg)s. METHODS: Tumor infiltrating T(reg) and c ... Full text Link to item Cite

Targeting ovarian cancer-initiating cells.

Journal article Anticancer Agents Med Chem · February 2010 Featured Publication Evidence supports that a variety of cancers are sparked by the growth of cells that exhibit characteristics of stem cells. Such cancer-initiating cells are capable of populating a tumor with a heterogeneous group of daughter cells while still maintaining t ... Full text Link to item Cite

High poly(adenosine diphosphate-ribose) polymerase expression and poor survival in advanced-stage serous ovarian cancer.

Journal article Obstet Gynecol · January 2010 OBJECTIVE: To estimate the range of poly(adenosine diphosphate [ADP]-ribose) polymerase expression in serous ovarian cancers and to determine whether expression is associated with response to therapy and outcome. METHODS: Immunostaining for poly(ADP-ribose ... Full text Link to item Cite

IGF2R polymorphisms and risk of esophageal and gastric adenocarcinomas.

Journal article Int J Cancer · December 1, 2009 The mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) encodes a protein that plays a critical role in tumor suppression, in part by modulating bioavailability of a potent mitogen, insulin-like growth factor-2 (IGF2). We tested the hypot ... Full text Link to item Cite

Genomic and epigenetic evidence for oxytocin receptor deficiency in autism.

Journal article BMC Med · October 22, 2009 BACKGROUND: Autism comprises a spectrum of behavioral and cognitive disturbances of childhood development and is known to be highly heritable. Although numerous approaches have been used to identify genes implicated in the development of autism, less than ... Full text Link to item Cite

Imprint regulatory elements as epigenetic biosensors of exposure in epidemiological studies.

Journal article J Epidemiol Community Health · September 2009 Featured Publication In the etiologic investigation of complex diseases and neuro-developmental disorders, the interaction of genetic factors and the environment have been evaluated by comparing disease risk as a function of environmental exposure in individuals who carry gene ... Full text Link to item Cite

Anchorage-independent cell growth signature identifies tumors with metastatic potential.

Journal article Oncogene · August 6, 2009 The oncogenic phenotype is complex, resulting from the accumulation of multiple somatic mutations that lead to the deregulation of growth regulatory and cell fate controlling activities and pathways. The ability to dissect this complexity, so as to reveal ... Full text Link to item Cite

MLH1 expression sensitises ovarian cancer cells to cell death mediated by XIAP inhibition.

Journal article Br J Cancer · July 21, 2009 BACKGROUND: The X-linked inhibitor of apoptosis protein (XIAP), an endogenous apoptosis suppressor, can determine the level of caspase accumulation and the resultant response to apoptosis-inducing agents such as cisplatin in epithelial ovarian cancer (EOC) ... Full text Link to item Cite

UCN-01 is effective in targeting ovarian cancer spheroids

Journal article CANCER RESEARCH · May 1, 2009 Link to item Cite

Stress affects uterine receptivity through an ovarian-independent pathway.

Journal article Hum Reprod · April 2009 BACKGROUND: Although stress is known to disturb natural fertility through the inhibition of the hypothalamic-pituitary-gonadal (HPG) axis, the impact of stress on infertile women who receive exogenous gonadal hormones is not well defined. This is probably ... Full text Link to item Cite

Microarray analysis of early stage serous ovarian cancers shows profiles predictive of favorable outcome.

Journal article Clin Cancer Res · April 1, 2009 PURPOSE: Although few women with advanced serous ovarian cancer are cured, detection of the disease at an early stage is associated with a much higher likelihood of survival. We previously used gene expression array analysis to distinguish subsets of advan ... Full text Link to item Cite

Inactivation of the MAL gene in breast cancer is a common event that predicts benefit from adjuvant chemotherapy.

Journal article Mol Cancer Res · February 2009 Dysregulation of MAL (myelin and lymphocyte protein) has been implicated in several malignancies including esophageal, ovarian, and cervical cancers. The MAL protein functions in apical transport in polarized epithelial cells; therefore, its disruption may ... Full text Link to item Cite

Yin yang 1 modulates taxane response in epithelial ovarian cancer.

Journal article Mol Cancer Res · February 2009 Featured Publication Survival of ovarian cancer patients is largely dictated by their response to chemotherapy, which depends on underlying molecular features of the malignancy. We previously identified YIN YANG 1 (YY1) as a gene whose expression is positively correlated with ... Full text Link to item Cite

Imprinted Neuronatin: A potential epigenetie biomarker of ovarian cancer

Journal article GYNECOLOGIC ONCOLOGY · February 1, 2009 Link to item Cite

Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells.

Journal article Oncogene · January 15, 2009 Featured Publication The cancer stem cell hypothesis posits that malignant growth arises from a rare population of progenitor cells within a tumor that provide it with unlimited regenerative capacity. Such cells also possess increased resistance to chemotherapeutic agents. Res ... Full text Link to item Cite

Targeting dormant ovarian cancer cells

Journal article GYNECOLOGIC ONCOLOGY · March 1, 2008 Link to item Cite

Trophinin is a potent prognostic marker of ovarian cancer involved in platinum sensitivity.

Journal article Biochem Biophys Res Commun · August 24, 2007 Ovarian cancer is the leading cause of death in women with gynecological malignancies, with prognosis of advanced stage tumors determined by chemotherapeutic response and the success of tumor resection. Since aberrant RAS pathway activation is frequent in ... Full text Link to item Cite

Loss of betaglycan expression in ovarian cancer: role in motility and invasion.

Journal article Cancer Res · June 1, 2007 The transforming growth factor-beta (TGF-beta) superfamily members, TGF-beta, activin, and inhibin, all have prominent roles in regulating normal ovarian function. Betaglycan, or the type III TGF-beta receptor, is a coreceptor that regulates TGF-beta, acti ... Full text Link to item Cite

Regulation of the metastasis suppressor gene MKK4 in ovarian cancer.

Journal article Gynecol Oncol · May 2007 OBJECTIVES: MKK4 is a metastasis suppressor that is downregulated in some ovarian cancers. We sought to investigate whether promoter methylation, loss of heterozygosity, or changes in phosphorylation are involved in MKK4 dysregulation during ovarian carcin ... Full text Link to item Cite

Perspectives: the possible influence of assisted reproductive technologies on transgenerational reproductive effects of environmental endocrine disruptors.

Journal article Toxicol Sci · April 2007 Featured Publication Demasculinization by environmental endocrine-disrupting chemicals (EDCs) is observed in many animal species but less evident in humans. Rodent studies with gestational exposure to either the fungicide vinclozolin or the insecticide methoxychlor demonstrate ... Full text Link to item Cite

Global expression analysis of cancer/testis genes in uterine cancers reveals a high incidence of BORIS expression.

Journal article Clin Cancer Res · March 15, 2007 PURPOSE: Cancer/testis (CT) genes predominantly expressed in the testis (germ cells) and generally not in other normal tissues are aberrantly expressed in human cancers. This highly restricted expression provides a unique opportunity to use these CT genes ... Full text Link to item Cite

Trinucleotide repeat polymorphisms in the androgen receptor gene and risk of ovarian cancer.

Journal article Cancer Epidemiol Biomarkers Prev · March 2007 INTRODUCTION: Androgens may play a role in the development of ovarian cancers. Two trinucleotide repeat polymorphisms have been described in exon 1 of the androgen receptor (AR) gene that may affect its function. Previous studies of ovarian cancer and AR r ... Full text Link to item Cite

Genomic sweeping for hypermethylated genes.

Journal article Bioinformatics · February 1, 2007 MOTIVATION: Genes silenced by the aberrent methylation of nearby CpG islands can contribute to the onset or progression of cancer and represent potential biomarkers for diagnosis and prognosis. Relatively few have thus far been validated as hypermethylated ... Full text Link to item Cite

Cancer susceptibility: epigenetic manifestation of environmental exposures.

Journal article Cancer J · 2007 Featured Publication Cancer is a disease that results from both genetic and epigenetic changes. Discordant phenotypes and varying incidences of complex diseases such as cancer in monozygotic twins as well as genetically identical laboratory animals have long been attributed to ... Full text Link to item Cite

Imprinted expression of the canine IGF2R, in the absence of an anti-sense transcript or promoter methylation.

Journal article Evol Dev · 2007 Imprinted genes are epigenetically modified in a parent of origin-dependent manner, and as a consequence, are differentially expressed. Although the evolution of genomic imprinting is a subject of intense debate, imprinted genes have been studied primarily ... Full text Link to item Cite

Frequent IGF2/H19 domain epigenetic alterations and elevated IGF2 expression in epithelial ovarian cancer.

Journal article Mol Cancer Res · April 2006 Featured Publication Overexpression of the imprinted insulin-like growth factor-II (IGF2) is a prominent characteristic of gynecologic malignancies. The purpose of this study was to determine whether IGF2 loss of imprinting (LOI), aberrant H19 expression, and/or epigenetic der ... Full text Link to item Cite

Callipyge mutation affects gene expression in cis: a potential role for chromatin structure.

Journal article Genome Res · March 2006 Featured Publication Muscular hypertrophy in callipyge sheep results from a single nucleotide substitution located in the genomic interval between the imprinted Delta, Drosophila, Homolog-like 1 (DLK1) and Maternally Expressed Gene 3 (MEG3). The mechanism linking the mutation ... Full text Link to item Cite

High throughput detection of M6P/IGF2R intronic hypermethylation and LOH in ovarian cancer.

Journal article Nucleic Acids Res · 2006 Featured Publication Cell surface mannose 6-phosphate/insulin-like growth factor II receptors (M6P/IGF2R) bind and target exogenous insulin-like growth factor II (IGF2) to the prelysosomes where it is degraded. Loss of heterozygosity (LOH) for M6P/IGF2R is found in cancers, wi ... Full text Link to item Cite

Patterns of gene expression that characterize long-term survival in advanced stage serous ovarian cancers.

Journal article Clin Cancer Res · May 15, 2005 Featured Publication PURPOSE: A better understanding of the underlying biology of invasive serous ovarian cancer is critical for the development of early detection strategies and new therapeutics. The objective of this study was to define gene expression patterns associated wi ... Full text Link to item Cite

Transforming growth factor beta receptor I polyalanine repeat polymorphism does not increase ovarian cancer risk.

Journal article Gynecol Oncol · May 2005 OBJECTIVES: It has been suggested that the 6A allele of the type I TGFbeta receptor (TGFbetaR1) polyalanine repeat tract polymorphism may increase susceptibility to various types of cancer including ovarian cancer. METHODS: The TGFbetaR1 polyalanine polymo ... Full text Link to item Cite

Analysis of methylation-sensitive transcriptome identifies GADD45a as a frequently methylated gene in breast cancer.

Journal article Oncogene · April 14, 2005 Treatment of the breast cancer cell line, MDAMB468 with the DNA methylation inhibitor, 5-azacytidine (5-AzaC) results in growth arrest, whereas the growth of the normal breast epithelial line DU99 (telomerase immortalized) is relatively unaffected. Compari ... Full text Link to item Cite

Abnormal postnatal maintenance of elevated DLK1 transcript levels in callipyge sheep.

Journal article Mamm Genome · March 2005 Featured Publication The underlying mechanism of the callipyge muscular hypertrophy phenotype in sheep (Ovis aries) is not presently understood. This phenotype, characterized by increased glycolytic type II muscle proportion and cell size accompanied by decreased adiposity, is ... Full text Link to item Cite

Phylogenetic footprint analysis of IGF2 in extant mammals.

Journal article Genome Res · September 2004 Genomic imprinting results in monoallelic gene transcription that is directed by cis-acting regulatory elements epigenetically marked in a parent-of-origin-dependent manner. We performed phylogenetic sequence and epigenetic comparisons of IGF2 between the ... Full text Link to item Cite

Epigenetic detection of human chromosome 14 uniparental disomy.

Journal article Hum Mutat · July 2003 Featured Publication The recent demonstration of genomic imprinting of DLK1 and MEG3 on human chromosome 14q32 indicates that these genes might contribute to the discordant phenotypes associated with uniparental disomy (UPD) of chromosome 14. Regulation of imprinted expression ... Full text Link to item Cite

Imprinting evolution and the price of silence.

Journal article Bioessays · June 2003 Featured Publication In contrast to the biallelic expression of most genes, expression of genes subject to genomic imprinting is monoallelic and based on the sex of the transmitting parent. Possession of only a single active allele can lead to deleterious health consequences i ... Full text Link to item Cite

Identification of the single base change causing the callipyge muscle hypertrophy phenotype, the only known example of polar overdominance in mammals.

Journal article Genome Res · October 2002 Featured Publication A small genetic region near the telomere of ovine chromosome 18 was previously shown to carry the mutation causing the callipyge muscle hypertrophy phenotype in sheep. Expression of this phenotype is the only known case in mammals of paternal polar overdom ... Full text Link to item Cite

An imprinted PEG1/MEST antisense expressed predominantly in human testis and in mature spermatozoa.

Journal article J Biol Chem · April 19, 2002 PEG1 (or MEST) is an imprinted gene located on human chromosome 7q32 that is expressed predominantly from the paternal allele. In the mouse, Peg1/Mest is associated with embryonic growth and maternal behavior. Human PEG1 is transcribed from two promoters; ... Full text Link to item Cite

Development and characterization of a conditional M6p/Igf2r knockout mouse.

Journal article AMERICAN JOURNAL OF HUMAN GENETICS · October 1, 2001 Link to item Cite

NNATresides in a micro-imprinted domain on human chromosome 20q11.2.

Journal article AMERICAN JOURNAL OF HUMAN GENETICS · October 1, 2001 Link to item Cite

The neuronatin gene resides in a "micro-imprinted" domain on human chromosome 20q11.2.

Journal article Genomics · September 2001 A small fraction of the genome contains genes that are imprinted and thus expressed exclusively from one parental allele. We report here that the human neuronatin gene (NNAT) on chromosome 20q11.2 is imprinted and transcribed specifically from the paternal ... Full text Link to item Cite

RNA replication from the simian virus 5 antigenomic promoter requires three sequence-dependent elements separated by sequence-independent spacer regions.

Journal article J Virol · April 2001 We have previously shown for the paramyxovirus simian virus 5 (SV5) that a functional promoter for RNA replication requires proper spacing between two discontinuous elements: a 19-base segment at the 3' terminus (conserved region I [CRI]) and an 18-base in ... Full text Link to item Cite

Imprinting of PEG3, the human homologue of a mouse gene involved in nurturing behavior.

Journal article Genomics · January 1, 2001 Featured Publication The paternally expressed Peg3 gene in mice encodes an unusual Krüppel-type zinc finger protein implicated in critical cellular and behavioral functions including growth, apoptosis, and maternal nurturing behavior. Methylation and expression analyses were u ... Full text Link to item Cite

Novel imprinted DLK1/GTL2 domain on human chromosome 14 contains motifs that mimic those implicated in IGF2/H19 regulation.

Journal article Genome Res · November 2000 Featured Publication The evolution of genomic imprinting in mammals occurred more than 100 million years ago, and resulted in the formation of genes that are functionally haploid because of parent-of-origin-dependent expression. Despite ample evidence from studies in a number ... Full text Link to item Cite

Identification of a novel imprinted domain at human chromosome 14q32.

Journal article AMERICAN JOURNAL OF HUMAN GENETICS · October 1, 2000 Link to item Cite

Imprinting of PEG3, the human homolog of a gene involved in nurturing behaviour.

Journal article AMERICAN JOURNAL OF HUMAN GENETICS · October 1, 2000 Link to item Cite

Imprinted genes as potential genetic and epigenetic toxicologic targets.

Journal article Environ Health Perspect · March 2000 Featured Publication Genomic imprinting is an epigenetic phenomenon in eutherian mammals that results in the differential expression of the paternally and maternally inherited alleles of a gene. Imprinted genes are necessary for normal mammalian development. This requirement h ... Full text Link to item Cite

RNA replication for the paramyxovirus simian virus 5 requires an internal repeated (CGNNNN) sequence motif.

Journal article J Virol · January 1999 A functional RNA replication promoter for the paramyxovirus simian virus 5 (SV5) requires two essential and discontinuous elements: 19 bases at the 3' terminus (conserved region I) and an 18-base internal region (conserved region II [CRII]) that is contain ... Full text Link to item Cite

A functional antigenomic promoter for the paramyxovirus simian virus 5 requires proper spacing between an essential internal segment and the 3' terminus.

Journal article J Virol · January 1998 A previous analysis of naturally occurring defective interfering (DI) RNA genomes of the prototypic paramyxovirus simian virus 5 (SV5) indicated that 113 bases at the 3' terminus of the antigenome were sufficient to direct RNA encapsidation and replication ... Full text Link to item Cite

Genome nucleotide lengths that are divisible by six are not essential but enhance replication of defective interfering RNAs of the paramyxovirus simian virus 5.

Journal article Virology · May 26, 1997 For some members of the Paramyxoviridae family of negative strand RNA viruses, efficient genome replication only occurs when the total genome length is a multiple of six (6N length, where N is any integer). To determine if this "rule of six" requirement ap ... Full text Link to item Cite

Effects of temperature abuse on survival of Vibrio vulnificus in oysters.

Journal article Appl Environ Microbiol · September 1992 Opaque and translucent morphotypes of a TnphoA-containing strain of Vibrio vulnificus were fed to oysters, which were subsequently stored at temperatures ranging from 0.5 to 22 degrees C for 10 days. Samples of oysters were homogenized and plated at interv ... Full text Link to item Cite