Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellow in Cardiology, Medicine, Duke University 2001 - 2005
  • Medical Resident, Medicine, Children's Hospital Boston 1998 - 2001
  • M.D., University of Washington 1998
  • M.H.S., Johns Hopkins University 1994
• 

  Duke Appointment History

  • Associate Research Professor of Global Health, Duke Global Health Institute, University Institutes and Centers 2011 - 2015
  • Associate Professor of Medicine, Medicine, Cardiology, Medicine 2012 - 2015
  • Associate Professor in the School of Nursing, School of Nursing, Duke University 2012 - 2013
  • Assistant Professor of Medicine, Medicine, Cardiology, Medicine 2005 - 2011
  • Assistant Professor in the School of Nursing, School of Nursing, Duke University 2007 - 2011
  • Instructor, Temporary in the Department of Medicine, Medicine, Cardiology, Medicine 2005
• Recognition
• 

  In the News

  • NOV 6, 2015

    Cellular stress process identified in cardiovascular disease

  • JAN 13, 2014

    Global Research, Domestic Benefits
• 

  Awards & Honors

  • Judson Daland Prize. American Philosophical Society. 2011
• Expertise
• 

  Global Scholarship

  • Research

    • India (Country) 
• Research
• 

  Selected Grants

  • The Branched Chain Ketoacid Dehydrogenase Kinase-Phosphatase System as a New Regulatory Node in Mycocardial Fuel Section awarded by National Institutes of Health 2018 - 2023
  • A Clinic-Based Behavioral Intervention to Reduce Cardiovascular Disease Risk in Persons Living with HIV awarded by National Institutes of Health 2018 - 2022
  • Duke Training Grant in Nephrology awarded by National Institutes of Health 1995 - 2022
  • Postdoctoral training in genomic medicine research awarded by National Institutes of Health 2017 - 2022
  • Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health 2005 - 2021
  • Multidisciplinary Heart and Vascular Diseases awarded by National Institutes of Health 1975 - 2021
  • A Personalized Metabolomic Approach to Human Obesity and Weight Loss awarded by National Institutes of Health 2016 - 2019
  • Endocrinology and Metabolism Training Program awarded by National Institutes of Health 2014 - 2019
  • Biomarkers of Mental Stress Induced Myocardial Ischemia and CHD Prognosis awarded by National Institutes of Health 2014 - 2019
  • Postdoctoral Training in Cardiovascular Clinical Research awarded by National Institutes of Health 2014 - 2019
  • Collaborative Study on Biomarkers of Fatty Liver Diseases awarded by Pfizer, Inc. 2017 - 2018
  • Systems Biology Approaches for Predicting Cardiometabolic Risk in Persons Living with HIV awarded by National Institutes of Health 2015 - 2018
  • An integrated and diverse genomic medicine program for undiagnosed diseases awarded by National Institutes of Health 2014 - 2018
  • Metabolomic Biomarkers Predictores of Long-term Success Following Bariatric Surgery awarded by Columbia University 2015 - 2018
  • Integrated Biostatistical Training for CVD Research awarded by North Carolina State University 2017 - 2018
  • Analysis of NMR lipoprotein and metabolite data of plasma obtained from CATHGEN and STRRIDE study participants awarded by Liposcience Inc. 2017 - 2018
  • Air Quality by Genomics Interactions in a Cardiovascular Disease Cohort awarded by Health Effects Institute 2014 - 2017
  • Risk Factors for Sudden Cardiac Death in Patients with Chronic Kidney Disease awarded by National Institutes of Health 2014 - 2017
  • Metabolomic Quantitative Trait Locus (mQTL) Genetic Mapping in Human CVD awarded by National Institutes of Health 2009 - 2016
  • Metabolic Regulators of Insulin Secretion and Insulin Resistance awarded by National Institutes of Health 2013 - 2015
  • Expanding Evidence of Genetic Contributions to Survivorship in CAD awarded by National Institutes of Health 2011 - 2014
  • Genetic Mediators of Metabolic Cardiovascular Disease Risk awarded by National Institutes of Health 2009 - 2012
  • Survival and Age Biases in Gene Associations with Coronary Disease awarded by National Institutes of Health 2009 - 2011
  • Genetic Epidemiology of Pelvic Organ Prolapse awarded by National Institutes of Health 2009 - 2011
  • Molecular Genetics of Muscle Specialization awarded by National Institutes of Health 2001 - 2009
• Publications & Artistic Works
• 

  Selected Publications

  • Conference Papers

    • de Denus, S, Rouleau, JL, Mann, DL, Huggins, GS, Cappola, TP, Shah, SH, Keleti, J, Zada, YF, Provost, S, Bardhadi, A, Phillips, MS, Normand, V, Mongrain, I, and Dubé, M-P. "A pharmacogenetic investigation of intravenous furosemide in decompensated heart failure: a meta-analysis of three clinical trials." March 2017.  Full Text
    • Kelly, JP, Hunter, WG, McGarrah, RW, Craig, D, Haynes, C, Velazquez, EJ, Felker, GM, Hernandez, AF, Newgard, CB, Shah, SH, and Kraus, WE. "Novel Protein Glycan Inflammatory Biomarkers Predict Adverse Events in Heart Failure with Preserved Ejection Fraction." August 2015.  Full Text
    • Aras, MA, Craig, DM, Haynes, C, Bain, JR, Muehlbauer, MJ, Stevens, RD, Ilkayeva, O, Velazquez, EJ, Hernandez, AF, Newgard, C, Kraus, WE, and Shah, SH. "Peripheral Metabolite Profiles Predict Cardiomyopathy in a Cohort of Cardiac Catheterization Patients." November 26, 2013.  Link to Item
    • Dokun, AO, Okutsu, M, Craig, D, Shah, SH, Jones, WS, Marchuk, DA, Lye, RJ, and Annex, BH. "ADAM12 Modifies Severity of Peripheral Arterial Disease; Evidence From Preclinical and Human Studies." November 26, 2013.  Link to Item
    • Li, JH, Suchindran, S, Shah, SH, Kraus, WE, Ginsburg, GS, and Voora, D. "Effect of SLCO1B1*5 on Low-Density Lipoprotein Cholesterol Levels and Long-Term Clinical Events in Patients During Statin Therapy Following Cardiac Catheterization." November 26, 2013.  Link to Item
    • McGarrah, RW, Craig, DM, Haynes, C, Dowdy, ZE, Shah, SH, and Kraus, WE. "High-density Lipoprotein Particle Concentration Has a Stronger Inverse Association With Cardiovascular Events Than High-density Lipoprotein Cholesterol in a Coronary Catheterization Population." November 26, 2013.  Link to Item
    • Shah, SH, Kraus, WE, Ilkaveva, O, Stevens, R, Haynes, C, Lewis, GD, Newgard, CB, and Gerszten, RE. "Metabolomic Profiling in a Human Model of Myocardial Infarction Identifies Novel Early Biomarkers of Cellular Damage." November 26, 2013.  Link to Item
    • Shah, SH, Kwee, L, Stitziel, N, Hauser, ER, Haynes, C, Kathiresan, S, Gregory, SG, and Kraus, WE. "Rare Variants Identified With Whole Exome Chip Genotyping Are Associated With Insulin Resistance and Glycemic Control." November 26, 2013.  Link to Item
    • Chan, K, Patel, RS, Newcombe, P, Nelson, CP, Qasim, A, Epstein, SE, Burnett, S, Vaccarino, VL, Zafari, AM, Shah, SH, Anderson, JL, Carlquist, JF, Hartiala, J, Allayee, H, Hinohara, K, Lee, BS, Erl, A, Ellis, KL, Goel, A, Schaefer, AS, Mokhtari, NE, Goldstein, BA, Hlatky, MA, Go, AS, Shen, GQ, Gong, Y, Pepine, C, Laxton, RC, Wittaker, JC, Tang, WHW, Johnson, JA, Wang, QK, Assimes, TL, Nöthlings, U, Farrall, M, Watkins, H, Richards, AM, Cameron, VA, Muendlein, A, Drexel, H, Koch, W, and Park, JE et al. "126 CHROMOSOME 9P21 LOCUS AND ANGIOGRAPHIC CORONARY ARTERY DISEASE BURDEN: A COLLABORATIVE META-ANALYSIS." May 2013.  Full Text
    • Kraus, WE, Donahue, MP, Shah, SH, Whellan, DJ, Hellkamp, A, O'Connor, CM, and Felker, GM. "Association of Small Molecule Metabolic Intermediates that Predict Cardiovascular Mortality with Peak VO2 in a Heart Failure Population." March 26, 2013.  Link to Item
    • Kraus, WE, Feng, S, Hauser, ER, Gregory, SG, Haynes, C, Dowdy, ZE, Craig, DM, and Shah, SH. "Association of Gene Expression Signatures with Small Molecule Metabolic Intermediates that Predict Cardiovascular Mortality in CATHGEN." March 26, 2013.  Link to Item
    • Ward-Caviness, C, Neas, L, Haynes, C, Blachi, C, Cascio, W, Devlin, R, Diaz-Sanchez, D, Kraus, WE, Shah, SH, Miranda, ML, and Hauser, ER. "Mobile Source Air Pollution is Associated with the Plasma Concentration of Multiple Acylcarnitines in a Large Cardiovascular Cohort." March 26, 2013.  Link to Item
    • Shah, AA, Craig, DM, Haynes, C, Sebek, JK, Grass, E, Abramson, K, Smith, PK, Hauser, ER, Gregory, SG, Kraus, WE, and Shah, SH. "Genome-Wide Association Identifies Genetic Variants Associated With Vein Graft Stenosis After Coronary Artery Bypass Grafting." November 22, 2011.  Link to Item
    • Shah, AA, Craig, DM, Williams, JB, Bhattacharya, SD, Andersen, ND, Shah, SH, McCann, RL, and Hughes, GC. "Risk Factors for Non-Procedure Related Mortality One Year after Thoracic Endovascular Aortic Repair." June 2011.  Full Text  Link to Item

  • Journal Articles

    • Butler, J, Kalogeropoulos, AP, Anstrom, KJ, Hsue, PY, Kim, RJ, Scherzer, R, Shah, SJ, Shah, SH, Velazquez, EJ, Hernandez, AF, Desvigne-Nickens, P, and Braunwald, E. "Diastolic Dysfunction in Individuals With Human Immunodeficiency Virus Infection: Literature Review, Rationale and Design of the Characterizing Heart Function on Antiretroviral Therapy (CHART) Study." Journal of cardiac failure 24, no. 4 (April 2018): 255-265.  Full Text
    • Turcot, V, Lu, Y, Highland, HM, Schurmann, C, Justice, AE, Fine, RS, Bradfield, JP, Esko, T, Giri, A, Graff, M, Guo, X, Hendricks, AE, Karaderi, T, Lempradl, A, Locke, AE, Mahajan, A, Marouli, E, Sivapalaratnam, S, Young, KL, Alfred, T, Feitosa, MF, Masca, NGD, Manning, AK, Medina-Gomez, C, Mudgal, P, Ng, MCY, Reiner, AP, Vedantam, S, Willems, SM, Winkler, TW, Abecasis, G, Aben, KK, Alam, DS, Alharthi, SE, Allison, M, Amouyel, P, Asselbergs, FW, Auer, PL, Balkau, B, Bang, LE, and Barroso, I et al. "Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity." Nature genetics (March 16, 2018).  Full Text
    • Turcot, V, Lu, Y, Highland, HM, Schurmann, C, Justice, AE, Fine, RS, Bradfield, JP, Esko, T, Giri, A, Graff, M, Guo, X, Hendricks, AE, Karaderi, T, Lempradl, A, Locke, AE, Mahajan, A, Marouli, E, Sivapalaratnam, S, Young, KL, Alfred, T, Feitosa, MF, Masca, NGD, Manning, AK, Medina-Gomez, C, Mudgal, P, Ng, MCY, Reiner, AP, Vedantam, S, Willems, SM, Winkler, TW, Abecasis, G, Aben, KK, Alam, DS, Alharthi, SE, Allison, M, Amouyel, P, Asselbergs, FW, Auer, PL, Balkau, B, Bang, LE, and Barroso, I et al. "Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity." Nature genetics (March 16, 2018).  Full Text
    • McGarrah, RW, and Shah, SH. "Integrative Omics: Harnessing the Proteome to Maximize the Potential of the Genome." Circulation 137, no. 11 (March 2018): 1173-1175.  Full Text
    • Okeke, NL, Craig, DM, Muehlbauer, MJ, Ilkayeva, O, Clement, ME, Naggie, S, and Shah, SH. "Metabolites predict cardiovascular disease events in persons living with HIV: a pilot case–control study." Metabolomics 14, no. 3 (March 1, 2018).  Full Text
    • Ward-Caviness, CK, Kraus, WE, Blach, C, Haynes, CS, Dowdy, E, Miranda, ML, Devlin, R, Diaz-Sanchez, D, Cascio, WE, Mukerjee, S, Stallings, C, Smith, LA, Gregory, SG, Shah, SH, Neas, LM, and Hauser, ER. "Associations Between Residential Proximity to Traffic and Vascular Disease in a Cardiac Catheterization Cohort." Arteriosclerosis, thrombosis, and vascular biology 38, no. 1 (January 2018): 275-282.  Full Text
    • Shah, SH, and Hunter, WG. "Realizing the Potential of Metabolomics in Heart Failure: Signposts on the Path to Clinical Utility." JACC. Heart failure 5, no. 11 (November 2017): 833-836.  Full Text
    • Wang, H, Muehlbauer, MJ, O'Neal, SK, Newgard, CB, Hauser, ER, Bain, JR, and Shah, SH. "Recommendations for Improving Identification and Quantification in Non-Targeted, GC-MS-Based Metabolomic Profiling of Human Plasma." Metabolites 7, no. 3 (August 25, 2017).  Full Text
    • Jiang, R, Babyak, MA, Brummett, BH, Hauser, ER, Shah, SH, Becker, RC, Siegler, IC, Singh, A, Haynes, C, Chryst-Ladd, M, Craig, DM, and Williams, RB. "Brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism is associated with disease severity and incidence of cardiovascular events in a patient cohort." American heart journal 190 (August 2017): 40-45.  Full Text
    • Wang, H, Anstrom, K, Ilkayeva, O, Muehlbauer, MJ, Bain, JR, McNulty, S, Newgard, CB, Kraus, WE, Hernandez, A, Felker, GM, Redfield, M, and Shah, SH. "Sildenafil Treatment in Heart Failure With Preserved Ejection Fraction: Targeted Metabolomic Profiling in the RELAX Trial." JAMA cardiology 2, no. 8 (August 2017): 896-901.  Full Text
    • Lawler, PR, Akinkuolie, AO, Chu, AY, Shah, SH, Kraus, WE, Craig, D, Padmanabhan, L, Glynn, RJ, Ridker, PM, Chasman, DI, and Mora, S. "Atherogenic Lipoprotein Determinants of Cardiovascular Disease and Residual Risk Among Individuals With Low Low-Density Lipoprotein Cholesterol." Journal of the American Heart Association 6, no. 7 (July 21, 2017).  Full Text
    • Dewey, FE, Gusarova, V, Dunbar, RL, O'Dushlaine, C, Schurmann, C, Gottesman, O, McCarthy, S, Van Hout, CV, Bruse, S, Dansky, HM, Leader, JB, Murray, MF, Ritchie, MD, Kirchner, HL, Habegger, L, Lopez, A, Penn, J, Zhao, A, Shao, W, Stahl, N, Murphy, AJ, Hamon, S, Bouzelmat, A, Zhang, R, Shumel, B, Pordy, R, Gipe, D, Herman, GA, Sheu, WHH, Lee, I-T, Liang, K-W, Guo, X, Rotter, JI, Chen, Y-DI, Kraus, WE, Shah, SH, Damrauer, S, Small, A, Rader, DJ, Wulff, AB, Nordestgaard, BG, and Tybjærg-Hansen, A et al. "Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease." The New England journal of medicine 377, no. 3 (July 2017): 211-221.  Full Text
    • Christophersen, IE, Rienstra, M, Roselli, C, Yin, X, Geelhoed, B, Barnard, J, Lin, H, Arking, DE, Smith, AV, Albert, CM, Chaffin, M, Tucker, NR, Li, M, Klarin, D, Bihlmeyer, NA, Low, S-K, Weeke, PE, Müller-Nurasyid, M, Smith, JG, Brody, JA, Niemeijer, MN, Dörr, M, Trompet, S, Huffman, J, Gustafsson, S, Schurmann, C, Kleber, ME, Lyytikäinen, L-P, Seppälä, I, Malik, R, Horimoto, ARVR, Perez, M, Sinisalo, J, Aeschbacher, S, Thériault, S, Yao, J, Radmanesh, F, Weiss, S, Teumer, A, and Choi, SH et al. "Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation." Nature genetics 49, no. 6 (June 2017): 946-952.  Full Text
    • Guimarães, PO, Sun, J-L, Kragholm, K, Shah, SH, Pieper, KS, Kraus, WE, Hauser, ER, Granger, CB, Kristin Newby, L, MURDOCK Horizon 1 Cardiovascular Study Investigators Durham, and NC, . "Corrigendum to 'Association of Standard Clinical and Laboratory Variables with Red Blood Cell Distribution Width (RDW)'[Am. Heart J. (2016) 22-28]." American heart journal 188 (June 2017): 196-.  Full Text
    • Saleheen, D, Zhao, W, Young, R, Nelson, CP, Ho, W, Ferguson, JF, Rasheed, A, Ou, K, Nurnberg, ST, Bauer, RC, Goel, A, Do, R, Stewart, AFR, Hartiala, J, Zhang, W, Thorleifsson, G, Strawbridge, RJ, Sinisalo, J, Kanoni, S, Sedaghat, S, Marouli, E, Kristiansson, K, Hua Zhao, J, Scott, R, Gauguier, D, Shah, SH, Smith, AV, van Zuydam, N, Cox, AJ, Willenborg, C, Kessler, T, Zeng, L, Province, MA, Ganna, A, Lind, L, Pedersen, NL, White, CC, Joensuu, A, Edi Kleber, M, Hall, AS, März, W, and Salomaa, V et al. "Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions." Circulation 135, no. 24 (June 2017): 2336-2353.  Full Text
    • Wang, A, Kwee, LC, Grass, E, Neely, ML, Gregory, SG, Fox, KAA, Armstrong, PW, White, HD, Ohman, EM, Roe, MT, Shah, SH, and Chan, MY. "Whole blood sequencing reveals circulating microRNA associations with high-risk traits in non-ST-segment elevation acute coronary syndrome." Atherosclerosis 261 (June 2017): 19-25.  Full Text
    • Mirowsky, JE, Devlin, RB, Diaz-Sanchez, D, Cascio, W, Grabich, SC, Haynes, C, Blach, C, Hauser, ER, Shah, S, Kraus, W, Olden, K, and Neas, L. "A novel approach for measuring residential socioeconomic factors associated with cardiovascular and metabolic health." Journal of exposure science & environmental epidemiology 27, no. 3 (May 2017): 281-289.  Full Text
    • Cheng, S, Shah, SH, Corwin, EJ, Fiehn, O, Fitzgerald, RL, Gerszten, RE, Illig, T, Rhee, EP, Srinivas, PR, Wang, TJ, Jain, M, American Heart Association Council on Functional Genomics and Translational Biology, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, and and Stroke Council, . "Potential Impact and Study Considerations of Metabolomics in Cardiovascular Health and Disease: A Scientific Statement From the American Heart Association." Circulation. Cardiovascular genetics 10, no. 2 (April 2017). (Review)  Full Text
    • Stitziel, NO, Khera, AV, Wang, X, Bierhals, AJ, Vourakis, AC, Sperry, AE, Natarajan, P, Klarin, D, Emdin, CA, Zekavat, SM, Nomura, A, Erdmann, J, Schunkert, H, Samani, NJ, Kraus, WE, Shah, SH, Yu, B, Boerwinkle, E, Rader, DJ, Gupta, N, Frossard, PM, Rasheed, A, Danesh, J, Lander, ES, Gabriel, S, Saleheen, D, Musunuru, K, Kathiresan, S, and PROMIS and Myocardial Infarction Genetics Consortium Investigators, . "ANGPTL3 Deficiency and Protection Against Coronary Artery Disease." Journal of the American College of Cardiology 69, no. 16 (April 2017): 2054-2063.  Full Text
    • Luo, N, Craig, D, Ilkayeva, O, Muehlbauer, M, Kraus, WE, Newgard, CB, Shah, SH, and Rajagopal, S. "Plasma acylcarnitines are associated with pulmonary hypertension." Pulmonary circulation 7, no. 1 (March 2017): 211-218.  Full Text
    • Marouli, E, Graff, M, Medina-Gomez, C, Lo, KS, Wood, AR, Kjaer, TR, Fine, RS, Lu, Y, Schurmann, C, Highland, HM, Rüeger, S, Thorleifsson, G, Justice, AE, Lamparter, D, Stirrups, KE, Turcot, V, Young, KL, Winkler, TW, Esko, T, Karaderi, T, Locke, AE, Masca, NGD, Ng, MCY, Mudgal, P, Rivas, MA, Vedantam, S, Mahajan, A, Guo, X, Abecasis, G, Aben, KK, Adair, LS, Alam, DS, Albrecht, E, Allin, KH, Allison, M, Amouyel, P, Appel, EV, Arveiler, D, Asselbergs, FW, Auer, PL, Balkau, B, Banas, B, and Bang, LE et al. "Rare and low-frequency coding variants alter human adult height." Nature 542, no. 7640 (February 2017): 186-190.  Full Text
    • Voora, D, Coles, A, Lee, KL, Hoffmann, U, Wingrove, JA, Rhees, B, Huang, L, Daniels, SE, Monane, M, Rosenberg, S, Shah, SH, Kraus, WE, Ginsburg, GS, and Douglas, PS. "An age- and sex-specific gene expression score is associated with revascularization and coronary artery disease: Insights from the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial." American heart journal 184 (February 2017): 133-140.  Full Text
    • Wang, H, Pun, PH, Kwee, L, Craig, D, Haynes, C, Chryst-Ladd, M, Svetkey, LP, Patel, UD, Hauser, ER, Pollak, MR, Kraus, WE, and Shah, SH. "Apolipoprotein L1 Genetic Variants Are Associated with Chronic Kidney Disease but Not with Cardiovascular Disease in a Population Referred for Cardiac Catheterization." Cardiorenal medicine 7, no. 2 (February 2017): 96-103.  Full Text
    • Webb, TR, Erdmann, J, Stirrups, KE, Stitziel, NO, Masca, NGD, Jansen, H, Kanoni, S, Nelson, CP, Ferrario, PG, König, IR, Eicher, JD, Johnson, AD, Hamby, SE, Betsholtz, C, Ruusalepp, A, Franzén, O, Schadt, EE, Björkegren, JLM, Weeke, PE, Auer, PL, Schick, UM, Lu, Y, Zhang, H, Dube, M-P, Goel, A, Farrall, M, Peloso, GM, Won, H-H, Do, R, van Iperen, E, Kruppa, J, Mahajan, A, Scott, RA, Willenborg, C, Braund, PS, van Capelleveen, JC, Doney, ASF, Donnelly, LA, Asselta, R, Merlini, PA, and Duga, S et al. "Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease." Journal of the American College of Cardiology 69, no. 7 (February 2017): 823-836.  Full Text
    • Brænne, I, Zeng, L, Willenborg, C, Tragante, V, Kessler, T, CARDIoGRAM Consortium, , CARDIoGRAMplusC4D Consortium, , Willer, CJ, Laakso, M, Wallentin, L, Franks, PW, Salomaa, V, Dehghan, A, Meitinger, T, Samani, NJ, Asselbergs, FW, Erdmann, J, and Schunkert, H. "Genomic correlates of glatiramer acetate adverse cardiovascular effects lead to a novel locus mediating coronary risk." PloS one 12, no. 8 (January 2017): e0182999-.  Full Text
    • McGarrah, RW, Kelly, JP, Craig, DM, Haynes, C, Jessee, RC, Huffman, KM, Kraus, WE, and Shah, SH. "A Novel Protein Glycan-Derived Inflammation Biomarker Independently Predicts Cardiovascular Disease and Modifies the Association of HDL Subclasses with Mortality." Clinical chemistry 63, no. 1 (January 2017): 288-296.  Full Text
    • Ward-Caviness, CK, Neas, LM, Blach, C, Haynes, CS, LaRocque-Abramson, K, Grass, E, Dowdy, ZE, Devlin, RB, Diaz-Sanchez, D, Cascio, WE, Miranda, ML, Gregory, SG, Shah, SH, Kraus, WE, and Hauser, ER. "A genome-wide trans-ethnic interaction study links the PIGR-FCAMR locus to coronary atherosclerosis via interactions between genetic variants and residential exposure to traffic." PloS one 12, no. 3 (January 2017): e0173880-.  Full Text
    • Breitner, S, Schneider, A, Devlin, RB, Ward-Caviness, CK, Diaz-Sanchez, D, Neas, LM, Cascio, WE, Peters, A, Hauser, ER, Shah, SH, and Kraus, WE. "Associations among plasma metabolite levels and short-term exposure to PM2.5 and ozone in a cardiac catheterization cohort." Environment international 97 (December 2016): 76-84.  Full Text
    • Nüesch, E, Dale, C, Palmer, TM, White, J, Keating, BJ, van Iperen, EP, Goel, A, Padmanabhan, S, Asselbergs, FW, EPIC-Netherland Investigators, , Verschuren, WM, Wijmenga, C, Van der Schouw, YT, Onland-Moret, NC, Lange, LA, Hovingh, GK, Sivapalaratnam, S, Morris, RW, Whincup, PH, Wannamethe, GS, Gaunt, TR, Ebrahim, S, Steel, L, Nair, N, Reiner, AP, Kooperberg, C, Wilson, JF, Bolton, JL, McLachlan, S, Price, JF, Strachan, MW, Robertson, CM, Kleber, ME, Delgado, G, März, W, and Melander, O et al. "Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis." International journal of epidemiology 45, no. 6 (December 2016): 1927-1937.  Full Text
    • Hampel, R, Breitner, S, Kraus, WE, Hauser, E, Shah, S, Ward-Caviness, CK, Devlin, R, Diaz-Sanchez, D, Neas, L, Cascio, W, Peters, A, and Schneider, A. "Short-term effects of air temperature on plasma metabolite concentrations in patients undergoing cardiac catheterization." Environmental research 151 (November 2016): 224-232.  Full Text
    • Loley, C, Alver, M, Assimes, TL, Bjonnes, A, Goel, A, Gustafsson, S, Hernesniemi, J, Hopewell, JC, Kanoni, S, Kleber, ME, Lau, KW, Lu, Y, Lyytikäinen, L-P, Nelson, CP, Nikpay, M, Qu, L, Salfati, E, Scholz, M, Tukiainen, T, Willenborg, C, Won, H-H, Zeng, L, Zhang, W, Anand, SS, Beutner, F, Bottinger, EP, Clarke, R, Dedoussis, G, Do, R, Esko, T, Eskola, M, Farrall, M, Gauguier, D, Giedraitis, V, Granger, CB, Hall, AS, Hamsten, A, Hazen, SL, Huang, J, Kähönen, M, Kyriakou, T, Laaksonen, R, and Lind, L et al. "No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis." Scientific reports 6 (October 12, 2016): 35278-.  Full Text
    • McGarrah, RW, and Shah, SH. "Exomes, Proteins, and Cardiovascular Disease: Making Sense of the Signals." Circulation. Cardiovascular genetics 9, no. 4 (August 2016): 318-319.  Full Text
    • Hunter, WG, Kelly, JP, McGarrah, RW, Khouri, MG, Craig, D, Haynes, C, Ilkayeva, O, Stevens, RD, Bain, JR, Muehlbauer, MJ, Newgard, CB, Felker, GM, Hernandez, AF, Velazquez, EJ, Kraus, WE, and Shah, SH. "Metabolomic Profiling Identifies Novel Circulating Biomarkers of Mitochondrial Dysfunction Differentially Elevated in Heart Failure With Preserved Versus Reduced Ejection Fraction: Evidence for Shared Metabolic Impairments in Clinical Heart Failure." Journal of the American Heart Association 5, no. 8 (July 29, 2016).  Full Text  Open Access Copy
    • Samad, Z, Vora, AN, Dunning, A, Schulte, PJ, Shaw, LK, Al-Enezi, F, Ersboll, M, McGarrah, RW, Vavalle, JP, Shah, SH, Kisslo, J, Glower, D, Harrison, JK, and Velazquez, EJ. "Aortic valve surgery and survival in patients with moderate or severe aortic stenosis and left ventricular dysfunction." European heart journal 37, no. 28 (July 2016): 2276-2286.  Full Text
    • Hunter, WG, Kelly, JP, McGarrah, RW, Kraus, WE, and Shah, SH. "Metabolic Dysfunction in Heart Failure: Diagnostic, Prognostic, and Pathophysiologic Insights From Metabolomic Profiling." Current heart failure reports 13, no. 3 (June 2016): 119-131. (Review)  Full Text
    • Nioi, P, Sigurdsson, A, Thorleifsson, G, Helgason, H, Agustsdottir, AB, Norddahl, GL, Helgadottir, A, Magnusdottir, A, Jonasdottir, A, Gretarsdottir, S, Jonsdottir, I, Steinthorsdottir, V, Rafnar, T, Swinkels, DW, Galesloot, TE, Grarup, N, Jørgensen, T, Vestergaard, H, Hansen, T, Lauritzen, T, Linneberg, A, Friedrich, N, Krarup, NT, Fenger, M, Abildgaard, U, Hansen, PR, Galløe, AM, Braund, PS, Nelson, CP, Hall, AS, Williams, MJA, van Rij, AM, Jones, GT, Patel, RS, Levey, AI, Hayek, S, and Shah, SH et al. "Variant ASGR1 Associated with a Reduced Risk of Coronary Artery Disease." The New England journal of medicine 374, no. 22 (June 2016): 2131-2141.  Full Text
    • Pagidipati, NJ, Hemal, K, Coles, A, Mark, DB, Dolor, RJ, Pellikka, PA, Hoffmann, U, Litwin, SE, Udelson, J, Daubert, MA, Shah, SH, Martinez, B, Lee, KL, and Douglas, PS. "Sex Differences in Functional and CT Angiography Testing in Patients With Suspected Coronary Artery Disease." Journal of the American College of Cardiology 67, no. 22 (June 2016): 2607-2616.  Full Text
    • Sun, H, Olson, KC, Gao, C, Prosdocimo, DA, Zhou, M, Wang, Z, Jeyaraj, D, Youn, J-Y, Ren, S, Liu, Y, Rau, CD, Shah, S, Ilkayeva, O, Gui, W-J, William, NS, Wynn, RM, Newgard, CB, Cai, H, Xiao, X, Chuang, DT, Schulze, PC, Lynch, C, Jain, MK, and Wang, Y. "Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure." Circulation 133, no. 21 (May 2016): 2038-2049.  Full Text
    • Guimarães, PO, Sun, J-L, Kragholm, K, Shah, SH, Pieper, KS, Kraus, WE, Hauser, ER, Granger, CB, Newby, LK, and MURDOCK Horizon 1 Cardiovascular Study Investigators, . "Association of standard clinical and laboratory variables with red blood cell distribution width." American heart journal 174 (April 2016): 22-28.  Full Text
    • Hemal, K, Pagidipati, NJ, Coles, A, Dolor, RJ, Mark, DB, Pellikka, PA, Hoffmann, U, Litwin, SE, Daubert, MA, Shah, SH, Ariani, K, Bullock-Palmer, RP, Martinez, B, Lee, KL, and Douglas, PS. "Sex Differences in Demographics, Risk Factors, Presentation, and Noninvasive Testing in Stable Outpatients With Suspected Coronary Artery Disease: Insights From the PROMISE Trial." JACC. Cardiovascular imaging 9, no. 4 (April 2016): 337-346.  Full Text
    • Pereira, NL, Geske, JB, Mayr, M, Shah, SH, and Rihal, CS. "Pharmacogenetics of Clopidogrel: An Unresolved Issue." Circulation. Cardiovascular genetics 9, no. 2 (April 2016): 185-188.  Full Text
    • Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators, , Stitziel, NO, Stirrups, KE, Masca, NGD, Erdmann, J, Ferrario, PG, König, IR, Weeke, PE, Webb, TR, Auer, PL, Schick, UM, Lu, Y, Zhang, H, Dube, M-P, Goel, A, Farrall, M, Peloso, GM, Won, H-H, Do, R, van Iperen, E, Kanoni, S, Kruppa, J, Mahajan, A, Scott, RA, Willenberg, C, Braund, PS, van Capelleveen, JC, Doney, ASF, Donnelly, LA, Asselta, R, Merlini, PA, Duga, S, Marziliano, N, Denny, JC, Shaffer, CM, and El-Mokhtari, NE et al. "Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease." The New England journal of medicine 374, no. 12 (March 2, 2016): 1134-1144.  Full Text
    • McGarrah, RW, Craig, DM, Haynes, C, Dowdy, ZE, Shah, SH, and Kraus, WE. "High-density lipoprotein subclass measurements improve mortality risk prediction, discrimination and reclassification in a cardiac catheterization cohort." Atherosclerosis 246 (March 2016): 229-235.  Full Text
    • Voora, D, and Shah, SH. "Pharmacometabolomics Meets Genetics: A "Natural" Clinical Trial of Statin Effects." Journal of the American College of Cardiology 67, no. 10 (March 2016): 1211-1213.  Full Text
    • Wolf, MJ, Noeth, D, Rammohan, C, and Shah, SH. "Complexities of Genetic Testing in Familial Dilated Cardiomyopathy." Circulation. Cardiovascular genetics 9, no. 1 (February 2016): 95-99.  Full Text
    • Ahmad, T, Kelly, JP, McGarrah, RW, Hellkamp, AS, Fiuzat, M, Testani, JM, Wang, TS, Verma, A, Samsky, MD, Donahue, MP, Ilkayeva, OR, Bowles, DE, Patel, CB, Milano, CA, Rogers, JG, Felker, GM, O'Connor, CM, Shah, SH, and Kraus, WE. "Prognostic Implications of Long-Chain Acylcarnitines in Heart Failure and Reversibility With Mechanical Circulatory Support." Journal of the American College of Cardiology 67, no. 3 (January 2016): 291-299.  Full Text
    • Dungan, JR, Qin, X, Horne, BD, Carlquist, JF, Singh, A, Hurdle, M, Grass, E, Haynes, C, Gregory, SG, Shah, SH, Hauser, ER, and Kraus, WE. "Case-Only Survival Analysis Reveals Unique Effects of Genotype, Sex, and Coronary Disease Severity on Survivorship." PloS one 11, no. 5 (January 2016): e0154856-.  Full Text
    • Shah, SH, Arnett, D, Houser, SR, Ginsburg, GS, MacRae, C, Mital, S, Loscalzo, J, and Hall, JL. "Opportunities for the Cardiovascular Community in the Precision Medicine Initiative." Circulation 133, no. 2 (January 2016): 226-231.  Full Text
    • Ward-Caviness, CK, Neas, LM, Blach, C, Haynes, CS, LaRocque-Abramson, K, Grass, E, Dowdy, E, Devlin, RB, Diaz-Sanchez, D, Cascio, WE, Lynn Miranda, M, Gregory, SG, Shah, SH, Kraus, WE, and Hauser, ER. "Genetic Variants in the Bone Morphogenic Protein Gene Family Modify the Association between Residential Exposure to Traffic and Peripheral Arterial Disease." PloS one 11, no. 4 (January 2016): e0152670-.  Full Text
    • Kraus, WE, Muoio, DM, Stevens, R, Craig, D, Bain, JR, Grass, E, Haynes, C, Kwee, L, Qin, X, Slentz, DH, Krupp, D, Muehlbauer, M, Hauser, ER, Gregory, SG, Newgard, CB, and Shah, SH. "Metabolomic Quantitative Trait Loci (mQTL) Mapping Implicates the Ubiquitin Proteasome System in Cardiovascular Disease Pathogenesis." PLoS genetics 11, no. 11 (November 5, 2015): e1005553-.  Full Text  Open Access Copy
    • Kraus, WE, Granger, CB, Sketch, MH, Donahue, MP, Ginsburg, GS, Hauser, ER, Haynes, C, Newby, LK, Hurdle, M, Dowdy, ZE, and Shah, SH. "A Guide for a Cardiovascular Genomics Biorepository: the CATHGEN Experience." Journal of cardiovascular translational research 8, no. 8 (November 2015): 449-457. (Review)  Full Text
    • Nikpay, M, Goel, A, Won, H-H, Hall, LM, Willenborg, C, Kanoni, S, Saleheen, D, Kyriakou, T, Nelson, CP, Hopewell, JC, Webb, TR, Zeng, L, Dehghan, A, Alver, M, Armasu, SM, Auro, K, Bjonnes, A, Chasman, DI, Chen, S, Ford, I, Franceschini, N, Gieger, C, Grace, C, Gustafsson, S, Huang, J, Hwang, S-J, Kim, YK, Kleber, ME, Lau, KW, Lu, X, Lu, Y, Lyytikäinen, L-P, Mihailov, E, Morrison, AC, Pervjakova, N, Qu, L, Rose, LM, Salfati, E, Saxena, R, Scholz, M, Smith, AV, Tikkanen, E, and Uitterlinden, A et al. "A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease." Nature genetics 47, no. 10 (October 2015): 1121-1130.  Full Text
    • Stafford-Smith, M, Li, Y-J, Mathew, JP, Li, Y-W, Ji, Y, Phillips-Bute, BG, Milano, CA, Newman, MF, Kraus, WE, Kertai, MD, Shah, SH, Podgoreanu, MV, and Duke Perioperative Genetics and Safety Outcomes (PEGASUS) Investigative Team, . "Genome-wide association study of acute kidney injury after coronary bypass graft surgery identifies susceptibility loci." Kidney international 88, no. 4 (October 2015): 823-832.  Full Text  Open Access Copy
    • Ward-Caviness, CK, Kraus, WE, Blach, C, Haynes, CS, Dowdy, E, Miranda, ML, Devlin, RB, Diaz-Sanchez, D, Cascio, WE, Mukerjee, S, Stallings, C, Smith, LA, Gregory, SG, Shah, SH, Hauser, ER, and Neas, LM. "Association of Roadway Proximity with Fasting Plasma Glucose and Metabolic Risk Factors for Cardiovascular Disease in a Cross-Sectional Study of Cardiac Catheterization Patients." Environmental health perspectives 123, no. 10 (October 2015): 1007-1014.  Full Text
    • Burke, LE, Ma, J, Azar, KMJ, Bennett, GG, Peterson, ED, Zheng, Y, Riley, W, Stephens, J, Shah, SH, Suffoletto, B, Turan, TN, Spring, B, Steinberger, J, and Quinn, CC et al. "Current Science on Consumer Use of Mobile Health for Cardiovascular Disease Prevention: A Scientific Statement From the American Heart Association." Circulation 132, no. 12 (September 2015): 1157-1213. (Review)  Full Text
    • Dokun, AO, Chen, L, Okutsu, M, Farber, CR, Hazarika, S, Jones, WS, Craig, D, Marchuk, DA, Lye, RJ, Shah, SH, and Annex, BH. "ADAM12: a genetic modifier of preclinical peripheral arterial disease." American journal of physiology. Heart and circulatory physiology 309, no. 5 (September 2015): H790-H803.  Full Text
    • Kertai, MD, Li, Y-J, Ji, Y, Qi, W, Lombard, FW, Shah, SH, Kraus, WE, Stafford-Smith, M, Newman, MF, Milano, CA, Waldron, N, Podgoreanu, MV, Mathew, JP, and Duke Perioperative Genetics and Safety Outcomes (PEGASUS) Investigative Team, . "Genome-wide association study of new-onset atrial fibrillation after coronary artery bypass grafting surgery." American heart journal 170, no. 3 (September 2015): 580-90.e28.  Full Text
    • Parikh, KS, Rajagopal, S, Arges, K, Ahmad, T, Sivak, J, Kaul, P, Shah, SH, Tapson, V, Velazquez, EJ, Douglas, PS, and Samad, Z. "Use of outcome measures in pulmonary hypertension clinical trials." American heart journal 170, no. 3 (September 2015): 419-29.e3. (Review)  Full Text
    • Singh, A, Babyak, MA, Brummett, BH, Jiang, R, Watkins, LL, Barefoot, JC, Kraus, WE, Shah, SH, Siegler, IC, Hauser, ER, and Williams, RB. "Computing a Synthetic Chronic Psychosocial Stress Measurement in Multiple Datasets and its Application in the Replication of G × E Interactions of the EBF1 Gene." Genetic epidemiology 39, no. 6 (September 2015): 489-497.  Full Text
    • Shah, AA, Gregory, SG, Krupp, D, Feng, S, Dorogi, A, Haynes, C, Grass, E, Lin, SS, Hauser, ER, Kraus, WE, Shah, SH, and Hughes, GC. "Epigenetic profiling identifies novel genes for ascending aortic aneurysm formation with bicuspid aortic valves." The heart surgery forum 18, no. 4 (August 30, 2015): E134-E139.  Full Text
    • Ghosh, S, Vivar, J, Nelson, CP, Willenborg, C, Segrè, AV, Mäkinen, V-P, Nikpay, M, Erdmann, J, Blankenberg, S, O'Donnell, C, März, W, Laaksonen, R, Stewart, AFR, Epstein, SE, Shah, SH, Granger, CB, Hazen, SL, Kathiresan, S, Reilly, MP, Yang, X, Quertermous, T, Samani, NJ, Schunkert, H, Assimes, TL, and McPherson, R. "Systems Genetics Analysis of Genome-Wide Association Study Reveals Novel Associations Between Key Biological Processes and Coronary Artery Disease." Arteriosclerosis, thrombosis, and vascular biology 35, no. 7 (July 2015): 1712-1722.  Full Text
    • Singh, A, Babyak, MA, Nolan, DK, Brummett, BH, Jiang, R, Siegler, IC, Kraus, WE, Shah, SH, Williams, RB, and Hauser, ER. "Gene by stress genome-wide interaction analysis and path analysis identify EBF1 as a cardiovascular and metabolic risk gene." European journal of human genetics : EJHG 23, no. 6 (June 2015): 854-862.  Full Text
    • Nelson, CP, Hamby, SE, Saleheen, D, Hopewell, JC, Zeng, L, Assimes, TL, Kanoni, S, Willenborg, C, Burgess, S, Amouyel, P, Anand, S, Blankenberg, S, Boehm, BO, Clarke, RJ, Collins, R, Dedoussis, G, Farrall, M, Franks, PW, Groop, L, Hall, AS, Hamsten, A, Hengstenberg, C, Hovingh, GK, Ingelsson, E, Kathiresan, S, Kee, F, König, IR, Kooner, J, Lehtimäki, T, März, W, McPherson, R, Metspalu, A, Nieminen, MS, O'Donnell, CJ, Palmer, CNA, Peters, A, Perola, M, Reilly, MP, Ripatti, S, and Roberts, R et al. "Genetically determined height and coronary artery disease." The New England journal of medicine 372, no. 17 (April 8, 2015): 1608-1618.  Full Text
    • Shah, SH, and Newgard, CB. "Integrated metabolomics and genomics: systems approaches to biomarkers and mechanisms of cardiovascular disease." Circulation. Cardiovascular genetics 8, no. 2 (April 2015): 410-419. (Review)  Full Text
    • Shah, AA, Haynes, C, Craig, DM, Sebek, J, Grass, E, Abramson, K, Hauser, E, Gregory, SG, Kraus, WE, Smith, PK, and Shah, SH. "Genetic variants associated with vein graft stenosis after coronary artery bypass grafting." The heart surgery forum 18, no. 1 (February 27, 2015): E1-E5.  Full Text
    • Do, R, Stitziel, NO, Won, H-H, Jørgensen, AB, Duga, S, Angelica Merlini, P, Kiezun, A, Farrall, M, Goel, A, Zuk, O, Guella, I, Asselta, R, Lange, LA, Peloso, GM, Auer, PL, NHLBI Exome Sequencing Project, , Girelli, D, Martinelli, N, Farlow, DN, DePristo, MA, Roberts, R, Stewart, AFR, Saleheen, D, Danesh, J, Epstein, SE, Sivapalaratnam, S, Hovingh, GK, Kastelein, JJ, Samani, NJ, Schunkert, H, Erdmann, J, Shah, SH, Kraus, WE, Davies, R, Nikpay, M, Johansen, CT, Wang, J, Hegele, RA, and Hechter, E et al. "Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction." Nature 518, no. 7537 (February 2015): 102-106.  Full Text
    • Halim, SA, Neely, ML, Pieper, KS, Shah, SH, Kraus, WE, Hauser, ER, Califf, RM, Granger, CB, and Newby, LK. "Simultaneous consideration of multiple candidate protein biomarkers for long-term risk for cardiovascular events." Circulation. Cardiovascular genetics 8, no. 1 (February 2015): 168-177.  Full Text
    • Ahmad, T, Wang, T, O'Brien, EC, Samsky, MD, Pura, JA, Lokhnygina, Y, Rogers, JG, Hernandez, AF, Craig, D, Bowles, DE, Milano, CA, Shah, SH, Januzzi, JL, Felker, GM, and Patel, CB. "Effects of left ventricular assist device support on biomarkers of cardiovascular stress, fibrosis, fluid homeostasis, inflammation, and renal injury." JACC. Heart failure 3, no. 1 (January 2015): 30-39.  Full Text
    • Li, JH, Suchindran, S, Shah, SH, Kraus, WE, Ginsburg, GS, and Voora, D. "SLCO1B1 genetic variants, long-term low-density lipoprotein cholesterol levels and clinical events in patients following cardiac catheterization." Pharmacogenomics 16, no. 5 (January 2015): 449-458.  Full Text
    • Schick, UM, Auer, PL, Bis, JC, Lin, H, Wei, P, Pankratz, N, Lange, LA, Brody, J, Stitziel, NO, Kim, DS, Carlson, CS, Fornage, M, Haessler, J, Hsu, L, Jackson, RD, Kooperberg, C, Leal, SM, Psaty, BM, Boerwinkle, E, Tracy, R, Ardissino, D, Shah, S, Willer, C, Loos, R, Melander, O, Mcpherson, R, Hovingh, K, Reilly, M, Watkins, H, Girelli, D, Fontanillas, P, Chasman, DI, Gabriel, SB, Gibbs, R, Nickerson, DA, Kathiresan, S, Peters, U, Dupuis, J, Wilson, JG, Rich, SS, Morrison, AC, and Benjamin, EJ et al. "Association of exome sequences with plasma C-reactive protein levels in >9000 participants." Human molecular genetics 24, no. 2 (January 2015): 559-571.  Full Text
    • Shah, AA, Haynes, C, Craig, DM, Sebek, J, Grass, E, Abramson, K, Hauser, ER, Gregory, SG, Kraus, WE, Smith, PK, and Shah, SH. "Genetic variants associated with vein graft stenosis after coronary artery bypass grafting." Heart Surgery Forum 18, no. 1 (January 1, 2015): E1-E5.  Full Text
    • Singh, A, Babyak, MA, Nolan, DK, Brummett, BH, Jiang, R, Siegler, IC, Kraus, WE, Shah, SH, Williams, RB, and Hauser, ER. "Gene by stress genome-wide interaction analysis and path analysis identify EBF1 as a cardiovascular and metabolic risk gene." European Journal of Human Genetics 23, no. 6 (January 1, 2015): 854-862.  Full Text
    • Lim, ET, Würtz, P, Havulinna, AS, Palta, P, Tukiainen, T, Rehnström, K, Esko, T, Mägi, R, Inouye, M, Lappalainen, T, Chan, Y, Salem, RM, Lek, M, Flannick, J, Sim, X, Manning, A, Ladenvall, C, Bumpstead, S, Hämäläinen, E, Aalto, K, Maksimow, M, Salmi, M, Blankenberg, S, Ardissino, D, Shah, S, Horne, B, McPherson, R, Hovingh, GK, Reilly, MP, Watkins, H, Goel, A, Farrall, M, Girelli, D, Reiner, AP, Stitziel, NO, Kathiresan, S, Gabriel, S, Barrett, JC, Lehtimäki, T, Laakso, M, Groop, L, and Kaprio, J et al. "Distribution and medical impact of loss-of-function variants in the Finnish founder population." PLoS genetics 10, no. 7 (July 31, 2014): e1004494-.  Full Text
    • Mäkinen, V-P, Civelek, M, Meng, Q, Zhang, B, Zhu, J, Levian, C, Huan, T, Segrè, AV, Ghosh, S, Vivar, J, Nikpay, M, Stewart, AFR, Nelson, CP, Willenborg, C, Erdmann, J, Blakenberg, S, O'Donnell, CJ, März, W, Laaksonen, R, Epstein, SE, Kathiresan, S, Shah, SH, Hazen, SL, Reilly, MP, Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Consortium, , Lusis, AJ, Samani, NJ, Schunkert, H, Quertermous, T, McPherson, R, Yang, X, and Assimes, TL. "Integrative genomics reveals novel molecular pathways and gene networks for coronary artery disease." PLoS genetics 10, no. 7 (July 17, 2014): e1004502-.  Full Text
    • Peloso, GM, Auer, PL, Bis, JC, Voorman, A, Morrison, AC, Stitziel, NO, Brody, JA, Khetarpal, SA, Crosby, JR, Fornage, M, Isaacs, A, Jakobsdottir, J, Feitosa, MF, Davies, G, Huffman, JE, Manichaikul, A, Davis, B, Lohman, K, Joon, AY, Smith, AV, Grove, ML, Zanoni, P, Redon, V, Demissie, S, Lawson, K, Peters, U, Carlson, C, Jackson, RD, Ryckman, KK, Mackey, RH, Robinson, JG, Siscovick, DS, Schreiner, PJ, Mychaleckyj, JC, Pankow, JS, Hofman, A, Uitterlinden, AG, Harris, TB, Taylor, KD, and Stafford, JM et al. "Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks." American journal of human genetics 94, no. 2 (February 2014): 223-232.  Full Text
    • Bhattacharya, S, Granger, CB, Craig, D, Haynes, C, Bain, J, Stevens, RD, Hauser, ER, Newgard, CB, Kraus, WE, Newby, LK, and Shah, SH. "Validation of the association between a branched chain amino acid metabolite profile and extremes of coronary artery disease in patients referred for cardiac catheterization." Atherosclerosis 232, no. 1 (January 2014): 191-196.  Full Text  Link to Item
    • Brummett, BH, Babyak, MA, Jiang, R, Shah, SH, Becker, RC, Haynes, C, Chryst-Ladd, M, Craig, DM, Hauser, ER, Siegler, IC, Kuhn, CM, Singh, A, and Williams, RB. "A Functional Polymorphism in the 5HTR2C Gene Associated with Stress Responses Also Predicts Incident Cardiovascular Events." Edited by SK Ahuja. PLoS ONE 8, no. 12 (December 18, 2013): e82781-e82781.  Full Text  Open Access Copy
    • Connelly, JJ, Cherepanova, OA, Doss, JF, Karaoli, T, Lillard, TS, Markunas, CA, Nelson, S, Wang, T, Ellis, PD, Langford, CF, Haynes, C, Seo, DM, Goldschmidt-Clermont, PJ, Shah, SH, Kraus, WE, Hauser, ER, and Gregory, SG. "Epigenetic regulation of COL15A1 in smooth muscle cell replicative aging and atherosclerosis." Human Molecular Genetics 22, no. 25 (December 1, 2013): 5107-5120.  Full Text
    • Patel, MJ, Batch, BC, Svetkey, LP, Bain, JR, Turer, CB, Haynes, C, Muehlbauer, MJ, Stevens, RD, Newgard, CB, and Shah, SH. "Race and sex differences in small-molecule metabolites and metabolic hormones in overweight and obese adults." OMICS 17, no. 12 (December 2013): 627-635.  Full Text  Link to Item
    • Ward-Caviness, C, Haynes, C, Blach, C, Dowdy, E, Gregory, SG, Shah, SH, Horne, BD, Kraus, WE, and Hauser, ER. "Gene-smoking interactions in multiple Rho-GTPase pathway genes in an early-onset coronary artery disease cohort." Human Genetics 132, no. 12 (December 1, 2013): 1371-1382.  Full Text
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    • Batch, BC, Shah, SH, Newgard, CB, Turer, CB, Haynes, C, Bain, JR, Muehlbauer, M, Patel, MJ, Stevens, RD, Appel, LJ, Newby, LK, and Svetkey, LP. "Branched chain amino acids are novel biomarkers for discrimination of metabolic wellness." Metabolism 62, no. 7 (July 2013): 961-969.  Full Text  Link to Item
    • Shah, AA, Craig, DM, Andersen, ND, Williams, JB, Bhattacharya, SD, Shah, SH, McCann, RL, and Hughes, GC. "Risk factors for 1-year mortality after thoracic endovascular aortic repair." J Thorac Cardiovasc Surg 145, no. 5 (May 2013): 1242-1247.  Full Text  Link to Item
    • Chan, K, Patel, RS, Newcombe, P, Nelson, CP, Qasim, A, Epstein, SE, Burnett, S, Vaccarino, VL, Zafari, AM, Shah, SH, Anderson, JL, Carlquist, JF, Hartiala, J, Allayee, H, Hinohara, K, Lee, B-S, Erl, A, Ellis, KL, Goel, A, Schaefer, AS, El Mokhtari, NE, Goldstein, BA, Hlatky, MA, Go, AS, Shen, G-Q, Gong, Y, Pepine, C, Laxton, RC, Whittaker, JC, Tang, WHW, Johnson, JA, Wang, QK, Assimes, TL, Nöthlings, U, Farrall, M, Watkins, H, Richards, AM, Cameron, VA, Muendlein, A, Drexel, H, and Koch, W et al. "Association between the chromosome 9p21 locus and angiographic coronary artery disease burden: a collaborative meta-analysis." Journal of the American College of Cardiology 61, no. 9 (March 2013): 957-970.  Full Text
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    • Becker, RC, Voora, D, and Shah, SH. "Hemostasis and Thrombosis." Genomic and Personalized Medicine 2 (2013): 602-611.  Full Text
    • CARDIoGRAMplusC4D Consortium, , Deloukas, P, Kanoni, S, Willenborg, C, Farrall, M, Assimes, TL, Thompson, JR, Ingelsson, E, Saleheen, D, Erdmann, J, Goldstein, BA, Stirrups, K, König, IR, Cazier, J-B, Johansson, A, Hall, AS, Lee, J-Y, Willer, CJ, Chambers, JC, Esko, T, Folkersen, L, Goel, A, Grundberg, E, Havulinna, AS, Ho, WK, Hopewell, JC, Eriksson, N, Kleber, ME, Kristiansson, K, Lundmark, P, Lyytikäinen, L-P, Rafelt, S, Shungin, D, Strawbridge, RJ, Thorleifsson, G, and Tikkanen, E et al. "Large-scale association analysis identifies new risk loci for coronary artery disease." Nature genetics 45, no. 1 (January 2013): 25-33.  Full Text
    • Nolan, D, Kraus, WE, Hauser, E, Li, Y-J, Thompson, DK, Johnson, J, Chen, H-C, Nelson, S, Haynes, C, Gregory, SG, Kraus, VB, and Shah, SH. "Genome-wide linkage analysis of cardiovascular disease biomarkers in a large, multigenerational family. (Published online)" PLoS One 8, no. 8 (2013): e71779-.  Full Text  Open Access Copy  Link to Item
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    • Shah, SH, Feng, S, Grass, E, Haynes, C, Chryst-Ladd, M, Craig, D, Hauser, ER, Newgard, CB, Kraus, WE, and Gregory, SG. "Integration of Whole Genome Methylation with Metabolomics Identifies Novel Cardiovascular Disease Genes." CIRCULATION 126, no. 21 (November 20, 2012).  Link to Item
    • Shah, SH, Thakkar, H, Shah, AA, Andersen, ND, Bain, J, Haynes, C, Muehlbauer, M, Stevens, R, Nilsson, K, Piccini, JP, Koontz, J, Sun, A, Newgard, CB, and Hranitzky, PM. "Metabolites Reporting on Mitochondrial Function Predict Response to Biventricular Pacing." CIRCULATION 126, no. 21 (November 20, 2012).  Link to Item
    • Thakkar, H, Piccini, JP, Sun, AY, Haynes, C, Grass, E, Nilsson, K, Koontz, JI, Hranitzky, P, and Shah, SH. "Connexin-43 Gene Variants are Associated with Risk of Ventricular Arrhythmias in Patients with a Depressed Ejection Fraction." CIRCULATION 126, no. 21 (November 20, 2012).  Link to Item
    • Ward-Caviness, C, Neas, L, Haynes, C, Blach, C, Burns, E, LaRocque-Abramson, K, Dowdy, E, Casco, W, Devlin, R, Diaz-Sanchez, D, Kraus, WE, Shah, SH, Gregory, SG, Miranda, ML, and Hauser, ER. "Genetic Variants in the Bone Morphogenic Protein (BMP) Family of Genes Interact with Mobile Source Air Pollution to Increase Risk of Peripheral Arterial Disease." CIRCULATION 126, no. 21 (November 20, 2012).  Link to Item
    • Levin, PJ, Visco, AG, Shah, SH, Fulton, RG, and Wu, JM. "Characterizing the phenotype of advanced pelvic organ prolapse." Female Pelvic Med Reconstr Surg 18, no. 5 (September 2012): 299-302.  Full Text  Link to Item
    • Wu, JM, Visco, AG, Grass, EA, Craig, DM, Fulton, RG, Haynes, C, Weidner, AC, and Shah, SH. "Matrix metalloproteinase-9 genetic polymorphisms and the risk for advanced pelvic organ prolapse." Obstet Gynecol 120, no. 3 (September 2012): 587-593.  Full Text  Link to Item
    • Shah, SH, Kraus, WE, and Newgard, CB. "Metabolomic profiling for the identification of novel biomarkers and mechanisms related to common cardiovascular diseases: form and function." Circulation 126, no. 9 (August 28, 2012): 1110-1120. (Review)  Full Text  Link to Item
    • Shah, SH, Sun, J-L, Stevens, RD, Bain, JR, Muehlbauer, MJ, Pieper, KS, Haynes, C, Hauser, ER, Kraus, WE, Granger, CB, Newgard, CB, Califf, RM, and Newby, LK. "Baseline metabolomic profiles predict cardiovascular events in patients at risk for coronary artery disease." Am Heart J 163, no. 5 (May 2012): 844-850.e1.  Full Text  Link to Item
    • Wu, JM, Visco, AG, Grass, EA, Craig, DM, Fulton, RG, Haynes, C, Amundsen, CL, and Shah, SH. "Comprehensive analysis of LAMC1 genetic variants in advanced pelvic organ prolapse." Am J Obstet Gynecol 206, no. 5 (May 2012): 447.e1-447.e6.  Full Text  Link to Item
    • Shah, AA, Craig, DM, Sebek, JK, Haynes, C, Stevens, RC, Muehlbauer, MJ, Granger, CB, Hauser, ER, Newby, LK, Newgard, CB, Kraus, WE, Hughes, GC, and Shah, SH. "Metabolic profiles predict adverse events after coronary artery bypass grafting." J Thorac Cardiovasc Surg 143, no. 4 (April 2012): 873-878.  Full Text  Link to Item
    • Nolan, DK, Sutton, B, Haynes, C, Johnson, J, Sebek, J, Dowdy, E, Crosslin, D, Crossman, D, Sketch, MH, Granger, CB, Seo, D, Goldschmidt-Clermont, P, Kraus, WE, Gregory, SG, Hauser, ER, and Shah, SH. "Fine mapping of a linkage peak with integration of lipid traits identifies novel coronary artery disease genes on chromosome 5. (Published online)" BMC Genet 13 (February 27, 2012): 12-.  Full Text  Link to Item
    • Shah, SH, Crosslin, DR, Haynes, CS, Nelson, S, Turer, CB, Stevens, RD, Muehlbauer, MJ, Wenner, BR, Bain, JR, Laferrère, B, Gorroochurn, P, Teixeira, J, Brantley, PJ, Stevens, VJ, Hollis, JF, Appel, LJ, Lien, LF, Batch, B, Newgard, CB, and Svetkey, LP. "Branched-chain amino acid levels are associated with improvement in insulin resistance with weight loss." Diabetologia 55, no. 2 (February 2012): 321-330.  Full Text  Link to Item
    • Davies, RW, Wells, GA, Stewart, AFR, Erdmann, J, Shah, SH, Ferguson, JF, Hall, AS, Anand, SS, Burnett, MS, Epstein, SE, Dandona, S, Chen, L, Nahrstaedt, J, Loley, C, König, IR, Kraus, WE, Granger, CB, Engert, JC, Hengstenberg, C, Wichmann, H-E, Schreiber, S, Tang, WHW, Ellis, SG, Rader, DJ, Hazen, SL, Reilly, MP, Samani, NJ, Schunkert, H, Roberts, R, and McPherson, R. "A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex." Circulation: Cardiovascular Genetics 5, no. 2 (2012): 217-225.  Full Text
    • Gurbel, PA, Roe, MT, Jakubowski, JA, Shah, S, Erlinge, D, Goodman, SG, Huber, K, Chan, MY, Cornel, JH, Tantry, US, and Ohman, EM. "Translational platelet research in patients with coronary artery disease: What are the major knowledge gaps?." Thrombosis and Haemostasis 108, no. 1 (2012): 12-20.  Full Text
    • Brunner, MP, Shah, SH, Craig, DM, Stevens, RD, Muehlbauer, MJ, Bain, JR, Newgard, CB, Kraus, WE, Granger, CB, Sketch, MH, and Newby, LK. "Effect of heparin administration on metabolomic profiles in samples obtained during cardiac catheterization." Circ Cardiovasc Genet 4, no. 6 (December 2011): 695-700.  Full Text  Link to Item
    • Williams, ES, Shah, SH, Piccini, JP, Sun, AY, Koontz, JI, Al-Khatib, SM, and Hranitzky, PM. "Predictors of mortality in patients with chronic kidney disease and an implantable defibrillator: an EPGEN substudy." Europace 13, no. 12 (December 2011): 1717-1722.  Full Text  Link to Item
    • Bhattacharya, S, Craig, D, Haynes, C, Granger, CB, Stevens, RD, Hauser, ER, Kraus, WE, Newgard, CB, Newby, LK, and Shah, SH. "Peripheral Metabolite Profiles Discriminate Coronary Artery Disease in a Sequential Cohort of Cardiac Catheterization Patients." CIRCULATION 124, no. 21 (November 22, 2011).  Link to Item
    • Lappé, JM, Horne, BD, Shah, SH, May, HT, Muhlestein, JB, Lappé, DL, Kfoury, AG, Carlquist, JF, Budge, D, Alharethi, R, Bair, TL, Kraus, WE, and Anderson, JL. "Red cell distribution width, C-reactive protein, the complete blood count, and mortality in patients with coronary disease and a normal comparison population." Clin Chim Acta 412, no. 23-24 (November 20, 2011): 2094-2099.  Full Text  Link to Item
    • "Large-Scale Gene-Centric Analysis Identifies Novel Variants for Coronary Artery Disease." Edited by PM Visscher. PLoS Genetics 7, no. 9 (September 22, 2011): e1002260-e1002260.  Full Text
    • Voora, D, Horton, J, Shah, SH, Shaw, LK, and Newby, LK. "Polymorphisms associated with in vitro aspirin resistance are not associated with clinical outcomes in patients with coronary artery disease who report regular aspirin use." Am Heart J 162, no. 1 (July 2011): 166-72.e1.  Full Text  Link to Item
    • Minear, MA, Crosslin, DR, Sutton, BS, Connelly, JJ, Nelson, SC, Gadson-Watson, S, Wang, T, Seo, D, Vance, JM, Sketch, MH, Haynes, C, Goldschmidt-Clermont, PJ, Shah, SH, Kraus, WE, Hauser, ER, and Gregory, SG. "Polymorphic variants in tenascin-C (TNC) are associated with atherosclerosis and coronary artery disease." Hum Genet 129, no. 6 (June 2011): 641-654.  Full Text  Link to Item
    • Shah, SH, Svetkey, LP, and Newgard, CB. "Branching out for detection of type 2 diabetes." Cell Metab 13, no. 5 (May 4, 2011): 491-492.  Full Text  Link to Item
    • Laferrère, B, Reilly, D, Arias, S, Swerdlow, N, Gorroochurn, P, Bawa, B, Bose, M, Teixeira, J, Stevens, RD, Wenner, BR, Bain, JR, Muehlbauer, MJ, Haqq, A, Lien, L, Shah, SH, Svetkey, LP, and Newgard, CB. "Differential metabolic impact of gastric bypass surgery versus dietary intervention in obese diabetic subjects despite identical weight loss." Sci Transl Med 3, no. 80 (April 27, 2011): 80re2-.  Full Text  Link to Item
    • Sun, AY, Koontz, JI, Shah, SH, Piccini, JP, Nilsson, KR, Craig, D, Haynes, C, Gregory, SG, Hranitzky, PM, and Pitt, GS. "The S1103Y cardiac sodium channel variant is associated with implantable cardioverter-defibrillator events in blacks with heart failure and reduced ejection fraction." Circ Cardiovasc Genet 4, no. 2 (April 2011): 163-168.  Full Text  Link to Item
    • Plant, SR, Samsa, GP, Shah, SH, and Goldstein, LB. "Exploration of a hypothesized independent association of a common 9p21.3 gene variant and ischemic stroke in patients with and without angiographic coronary artery disease." Cerebrovasc Dis 31, no. 2 (2011): 117-122.  Full Text  Link to Item
    • Shah, SH, Granger, CB, Hauser, ER, Kraus, WE, Sun, J-L, Pieper, K, Nelson, CL, Delong, ER, Califf, RM, Newby, LK, and MURDOCK Horizon 1 Cardiovascular Disease Investigators, . "Reclassification of cardiovascular risk using integrated clinical and molecular biosignatures: Design of and rationale for the Measurement to Understand the Reclassification of Disease of Cabarrus and Kannapolis (MURDOCK) Horizon 1 Cardiovascular Disease Study." Am Heart J 160, no. 3 (September 2010): 371-379.e2.  Full Text  Link to Item
    • Zhang, L, Connelly, JJ, Peppel, K, Brian, L, Shah, SH, Nelson, S, Crosslin, DR, Wang, T, Allen, A, Kraus, WE, Gregory, SG, Hauser, ER, and Freedman, NJ. "Aging-related atherosclerosis is exacerbated by arterial expression of tumor necrosis factor receptor-1: evidence from mouse models and human association studies." Hum Mol Genet 19, no. 14 (July 15, 2010): 2754-2766.  Full Text  Link to Item
    • Shah, SH, Bain, JR, Muehlbauer, MJ, Stevens, RD, Crosslin, DR, Haynes, C, Dungan, J, Newby, LK, Hauser, ER, Ginsburg, GS, Newgard, CB, and Kraus, WE. "Association of a peripheral blood metabolic profile with coronary artery disease and risk of subsequent cardiovascular events." Circ Cardiovasc Genet 3, no. 2 (April 2010): 207-214.  Full Text  Open Access Copy  Link to Item
    • Tai, ES, Tan, MLS, Stevens, RD, Low, YL, Muehlbauer, MJ, Goh, DLM, Ilkayeva, OR, Wenner, BR, Bain, JR, Lee, JJM, Lim, SC, Khoo, CM, Shah, SH, and Newgard, CB. "Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men." Diabetologia 53, no. 4 (April 2010): 757-767.  Full Text  Link to Item
    • Califf, RM, Shah, SH, and Newby, LK. "Biomarker bonanza?." J Am Coll Cardiol 55, no. 12 (March 23, 2010): 1197-1199.  Full Text  Link to Item
    • Chen, H-C, Kraus, VB, Li, Y-J, Nelson, S, Haynes, C, Johnson, J, Stabler, T, Hauser, ER, Gregory, SG, Kraus, WE, and Shah, SH. "Genome-wide linkage analysis of quantitative biomarker traits of osteoarthritis in a large, multigenerational extended family." Arthritis Rheum 62, no. 3 (March 2010): 781-790.  Full Text  Link to Item
    • Assimes, TL, Hlm, H, Kathiresan, S, Reilly, MP, Thorleifsson, G, Voight, BF, Erdmann, J, Willenborg, C, Vaidya, D, Xie, C, Patterson, CC, Morgan, TM, Burnett, MS, Li, M, Hlatky, MA, Knowles, JW, Thompson, JR, Absher, D, Iribarren, C, Go, A, Fortmann, SP, Sidney, S, Risch, N, Tang, H, Myers, RM, Berger, K, Stoll, M, Shah, SH, Thorgeirsson, G, Andersen, K, Havulinna, AS, Herrera, JE, Faraday, N, Kim, Y, Kral, BG, Mathias, RA, Ruczinski, I, Suktitipat, B, Wilson, AF, Yanek, LR, and Becker, LC et al. "Lack of Association between the Trp719Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies." Journal of the American College of Cardiology 56, no. 19 (2010): 1552-1563.  Full Text
    • Gretarsdottir, S, Baas, AF, Thorleifsson, G, Holm, H, Heijer, MD, Vries, J-PPMD, Kranendonk, SE, Zeebregts, CJAM, Sterkenburg, SMV, Geelkerken, RH, Rij, AMV, Williams, MJA, Boll, APM, Kostic, JP, Jonasdottir, A, Jonasdottir, A, Walters, GB, Masson, G, Sulem, P, Saemundsdottir, J, Mouy, M, Magnusson, KP, Tromp, G, Elmore, JR, Sakalihasan, N, Limet, R, Defraigne, J-O, Ferrell, RE, Ronkainen, A, Ruigrok, YM, Wijmenga, C, Grobbee, DE, Shah, SH, Granger, CB, Quyyumi, AA, Vaccarino, V, and Patel, RS et al. "Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm." Nature Genetics 42, no. 8 (2010): 692-697.  Full Text
    • Wallentin, L, James, S, Storey, RF, Armstrong, M, Barratt, BJ, Horrow, J, Husted, S, Katus, H, Steg, PG, Shah, SH, and Becker, RC. "Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: A genetic substudy of the PLATO trial." The Lancet 376, no. 9749 (2010): 1320-1328.  Full Text
    • Horne, BD, Hauser, ER, Wang, L, Muhlestein, JB, Anderson, JL, Carlquist, JF, Shah, SH, and Kraus, WE. "Validation study of genetic associations with coronary artery disease on chromosome 3q13-21 and potential effect modification by smoking." Ann Hum Genet 73, no. Pt 6 (November 2009): 551-558.  Full Text  Link to Item
    • Koontz, JI, Haithcock, D, Cumbea, V, Waldron, A, Stricker, K, Hughes, A, Nilsson, K, Sun, A, Piccini, JP, Kraus, WE, Pitt, GS, Shah, SH, and Hranitzky, P. "Rationale and design of the Duke Electrophysiology Genetic and Genomic Studies (EPGEN) biorepository." Am Heart J 158, no. 5 (November 2009): 719-725.  Full Text  Link to Item
    • Voora, D, Shah, SH, Spasojevic, I, Ali, S, Reed, CR, Salisbury, BA, and Ginsburg, GS. "The SLCO1B1*5 genetic variant is associated with statin-induced side effects." J Am Coll Cardiol 54, no. 17 (October 20, 2009): 1609-1616.  Full Text  Link to Item
    • Huffman, KM, Shah, SH, Stevens, RD, Bain, JR, Muehlbauer, M, Slentz, CA, Tanner, CJ, Kuchibhatla, M, Houmard, JA, Newgard, CB, and Kraus, WE. "Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women." Diabetes Care 32, no. 9 (September 2009): 1678-1683.  Full Text  Link to Item
    • Chan, M, Becker, RC, Shah, SH, and Levine, SR. "Coagulopathy and Stroke." (April 8, 2009): 152-169. (Chapter)  Full Text
    • Newgard, CB, An, J, Bain, JR, Muehlbauer, MJ, Stevens, RD, Lien, LF, Haqq, AM, Shah, SH, Arlotto, M, Slentz, CA, Rochon, J, Gallup, D, Ilkayeva, O, Wenner, BR, Yancy, WS, Eisenson, H, Musante, G, Surwit, RS, Millington, DS, Butler, MD, and Svetkey, LP. "A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance." Cell Metab 9, no. 4 (April 2009): 311-326.  Full Text  Link to Item
    • Shah, SH, and Pitt, GS. "Genetics of cardiac repolarization." Nat Genet 41, no. 4 (April 2009): 388-389.  Link to Item
    • Crosslin, DR, Shah, SH, Nelson, SC, Haynes, CS, Connelly, JJ, Gadson, S, Goldschmidt-Clermont, PJ, Vance, JM, Rose, J, Granger, CB, Seo, D, Gregory, SG, Kraus, WE, and Hauser, ER. "Genetic effects in the leukotriene biosynthesis pathway and association with atherosclerosis." Hum Genet 125, no. 2 (March 2009): 217-229.  Full Text  Link to Item
    • Gudbjartsson, DF, Bjornsdottir, US, Halapi, E, Helgadottir, A, Sulem, P, Jonsdottir, GM, Thorleifsson, G, Helgadottir, H, Steinthorsdottir, V, Stefansson, H, Williams, C, Hui, J, Beilby, J, Warrington, NM, James, A, Palmer, LJ, Koppelman, GH, Heinzmann, A, Krueger, M, Boezen, HM, Wheatley, A, Altmuller, J, Shin, HD, Uh, S-T, Cheong, HS, Jonsdottir, B, Gislason, D, Park, C-S, Rasmussen, LM, Porsbjerg, C, Hansen, JW, Backer, V, Werge, T, Janson, C, Jönsson, U-B, Ng, MCY, Chan, J, So, WY, and Ma, R et al. "Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction." Nature Genetics 41, no. 3 (2009): 342-347.  Full Text
    • Newgard, CB, An, J, Bain, JR, Muehlbauer, MJ, Stevens, RD, Lien, LF, Haqq, AM, Shah, SH, Arlotto, M, Slentz, CA, Rochon, J, Gallup, D, Ilkayeva, O, Wenner, BR, Jr, WSY, Eisenson, H, Musante, G, Surwit, R, Millington, DS, Butler, MD, and Svetkey, LP. "A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance (DOI:10.1016/j.cmet.2009.02.002)." Cell Metabolism 9, no. 6 (2009): 565-566.  Full Text
    • Rodgers, GP, Conti, JB, Feinstein, JA, Griffin, BP, Kennett, JD, Shah, S, Walsh, MN, Williams, ES, and Williams, JL. "ACC 2009 Survey Results and Recommendations: Addressing the Cardiology Workforce Crisis. A Report of the ACC Board of Trustees Workforce Task Force." Journal of the American College of Cardiology 54, no. 13 (2009): 1195-1208.  Full Text
    • Shah, SH, Freedman, NJ, Zhang, L, Crosslin, DR, Stone, DH, Haynes, C, Johnson, J, Nelson, S, Wang, L, Connelly, JJ, Muehlbauer, M, Ginsburg, GS, Crossman, DC, Jones, CJH, Vance, J, Sketch, MH, Granger, CB, Newgard, CB, Gregory, SG, Goldschmidt-Clermont, PJ, Kraus, WE, and Hauser, ER. "Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis." PLoS Genet 5, no. 1 (January 2009): e1000318-.  Full Text  Open Access Copy  Link to Item
    • Shah, SH, Hauser, ER, Bain, JR, Muehlbauer, MJ, Haynes, C, Stevens, RD, Wenner, BR, Dowdy, ZE, Granger, CB, Ginsburg, GS, Newgard, CB, and Kraus, WE. "High heritability of metabolomic profiles in families burdened with premature cardiovascular disease." Mol Syst Biol 5 (2009): 258-.  Full Text  Link to Item
    • Shah, SH, and Lemos, JAD. "Biomarkers and cardiovascular disease: Determining causality and quantifying contribution to risk assessment." JAMA - Journal of the American Medical Association 302, no. 1 (2009): 92-93.  Full Text
    • Chen, H-C, Shah, SH, Li, Y-J, Stabler, TV, Jordan, JM, and Kraus, VB. "Inverse association of general joint hypermobility with hand and knee osteoarthritis and serum cartilage oligomeric matrix protein levels." Arthritis Rheum 58, no. 12 (December 2008): 3854-3864.  Full Text  Link to Item
    • Voora, D, Shah, SH, Reed, CR, Zhai, J, Crosslin, DR, Messer, C, Salisbury, BA, and Ginsburg, GS. "Pharmacogenetic predictors of statin-mediated low-density lipoprotein cholesterol reduction and dose response." Circ Cardiovasc Genet 1, no. 2 (December 2008): 100-106.  Full Text  Link to Item
    • Samad, Z, Wang, TY, Frazier, CG, Shah, SH, Dolor, RJ, and Newby, LK. "Closing the gap: treating hypertension in women." Cardiol Rev 16, no. 6 (November 2008): 305-313. (Review)  Full Text  Link to Item
    • Shah, SH, Hauser, ER, Crosslin, D, Wang, L, Haynes, C, Connelly, J, Nelson, S, Johnson, J, Gadson, S, Nelson, CL, Seo, D, Gregory, S, Kraus, WE, Granger, CB, Goldschmidt-Clermont, P, and Newby, LK. "ALOX5AP variants are associated with in-stent restenosis after percutaneous coronary intervention." Atherosclerosis 201, no. 1 (November 2008): 148-154.  Full Text  Link to Item
    • Chen, H-C, Shah, S, Stabler, TV, Li, Y-J, and Kraus, VB. "Biomarkers associated with clinical phenotypes of hand osteoarthritis in a large multigenerational family: the CARRIAGE family study." Osteoarthritis Cartilage 16, no. 9 (September 2008): 1054-1059.  Full Text  Link to Item
    • Wang, L, Hauser, ER, Shah, SH, Seo, D, Sivashanmugam, P, Exum, ST, Gregory, SG, Granger, CB, Haines, JL, Jones, CJH, Crossman, D, Haynes, C, Kraus, WE, Freedman, NJ, Pericak-Vance, MA, Goldschmidt-Clermont, PJ, and Vance, JM. "Polymorphisms of the tumor suppressor gene LSAMP are associated with left main coronary artery disease." Ann Hum Genet 72, no. Pt 4 (July 2008): 443-453.  Full Text  Link to Item
    • Sutton, BS, Crosslin, DR, Shah, SH, Nelson, SC, Bassil, A, Hale, AB, Haynes, C, Goldschmidt-Clermont, PJ, Vance, JM, Seo, D, Kraus, WE, Gregory, SG, and Hauser, ER. "Comprehensive genetic analysis of the platelet activating factor acetylhydrolase (PLA2G7) gene and cardiovascular disease in case-control and family datasets." Hum Mol Genet 17, no. 9 (May 1, 2008): 1318-1328.  Full Text  Link to Item
    • Connelly, JJ, Shah, SH, Doss, JF, Gadson, S, Nelson, S, Crosslin, DR, Hale, AB, Lou, X, Wang, T, Haynes, C, Seo, D, Crossman, DC, Mooser, V, Granger, CB, Jones, CJH, Kraus, WE, Hauser, ER, and Gregory, SG. "Genetic and functional association of FAM5C with myocardial infarction. (Published online)" BMC Med Genet 9 (April 22, 2008): 33-.  Full Text  Link to Item
    • Helgadottir, A, Thorleifsson, G, Magnusson, KP, Grétarsdottir, S, Steinthorsdottir, V, Manolescu, A, Jones, GT, Rinkel, GJE, Blankensteijn, JD, Ronkainen, A, Jääskeläinen, JE, Kyo, Y, Lenk, GM, Sakalihasan, N, Kostulas, K, Gottsäter, A, Flex, A, Stefansson, H, Hansen, T, Andersen, G, Weinsheimer, S, Borch-Johnsen, K, Jorgensen, T, Shah, SH, Quyyumi, AA, Granger, CB, Reilly, MP, Austin, H, Levey, AI, Vaccarino, V, Palsdottir, E, Walters, GB, Jonsdottir, T, Snorradottir, S, and Magnusdottir, D et al. "The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm." Nature Genetics 40, no. 2 (2008): 217-224.  Full Text
    • Crowley, AL, Patel, MR, Bashore, T, Borges-Neto, S, Jollis, JG, Judd, RM, Kim, RJ, Ryan, T, Shah, SH, and Douglas, PS. "Training cardiovascular specialists in imaging: a curriculum based on fundamental concepts required for multimodal imaging." Am Heart J 154, no. 5 (November 2007): 838-845. (Review)  Full Text  Link to Item
    • Ginsburg, GS, Shah, SH, and McCarthy, JJ. "Taking cardiovascular genetic association studies to the next level." J Am Coll Cardiol 50, no. 10 (September 4, 2007): 930-932.  Full Text  Link to Item
    • Shah, SH. "Gene polymorphisms and susceptibility to coronary artery disease." Pediatr Blood Cancer 48, no. 7 (June 15, 2007): 738-741. (Review)  Full Text  Link to Item
    • Wang, L, Hauser, ER, Shah, SH, Pericak-Vance, MA, Haynes, C, Crosslin, D, Harris, M, Nelson, S, Hale, AB, Granger, CB, Haines, JL, Jones, CJH, Crossman, D, Seo, D, Gregory, SG, Kraus, WE, Goldschmidt-Clermont, PJ, and Vance, JM. "Peakwide mapping on chromosome 3q13 identifies the kalirin gene as a novel candidate gene for coronary artery disease." Am J Hum Genet 80, no. 4 (April 2007): 650-663.  Full Text  Link to Item
    • Helgadottir, A, Thorleifsson, G, Manolescu, A, Gretarsdottir, S, Blondal, T, Jonasdottir, A, Jonasdottir, A, Sigurdsson, A, Baker, A, Palsson, A, Masson, G, Gudbjartsson, D, Magnusson, KP, Andersen, K, Levey, AI, Backman, VM, Matthiasdottir, S, Jonsdottir, T, Palsson, S, Einarsdottir, H, Gunnarsdottir, S, Gylfason, A, Vaccarino, V, Hooper, WC, Reilly, MP, Granger, CB, Austin, H, Rader, DJ, Shah, SH, Quyyumi, AA, Gulcher, JR, Thorgeirsson, G, Thorsteinsdottir, U, Kong, A, and Stefansson, K. "A common variant on chromosome 9p21 affects the risk of myocardial infarction." Obstetrical and Gynecological Survey 62, no. 9 (2007): 585-587.  Full Text
    • Helgadottir, A, Thorleifsson, G, Manolescu, A, Gretarsdottir, S, Blondal, T, Jonasdottir, A, Jonasdottir, A, Sigurdsson, A, Baker, A, Palsson, A, Masson, G, Gudbjartsson, DF, Magnusson, KP, Andersen, K, Levey, AI, Backman, VM, Matthiasdottir, S, Jonsdottir, T, Palsson, S, Einarsdottir, H, Gunnarsdottir, S, Gylfason, A, Vaccarino, V, Hooper, WC, Reilly, MP, Granger, CB, Austin, H, Rader, DJ, Shah, SH, Quyyumi, AA, Gulcher, JR, Thorgeirsson, G, Thorsteinsdottir, U, Kong, A, and Stefansson, K. "A common variant on chromosome 9p21 affects the risk of myocardial infarction." Science 316, no. 5830 (2007): 1491-1493.  Full Text
    • Shah, SH, Kraus, WE, Crossman, DC, Granger, CB, Haines, JL, Jones, CJH, Mooser, V, Huang, L, Haynes, C, Dowdy, E, Vega, GL, Grundy, SM, Vance, JM, and Hauser, ER. "Serum lipids in the GENECARD study of coronary artery disease identify quantitative trait loci and phenotypic subsets on chromosomes 3q and 5q." Ann Hum Genet 70, no. Pt 6 (November 2006): 738-748.  Full Text  Link to Item
    • Connelly, JJ, Wang, T, Cox, JE, Haynes, C, Wang, L, Shah, SH, Crosslin, DR, Hale, AB, Nelson, S, Crossman, DC, Granger, CB, Haines, JL, Jones, CJH, Vance, JM, Goldschmidt-Clermont, PJ, Kraus, WE, Hauser, ER, and Gregory, SG. "GATA2 is associated with familial early-onset coronary artery disease." PLoS Genet 2, no. 8 (August 25, 2006): e139-.  Full Text  Link to Item
    • Connelly, JJ, Wang, T, Cox, JE, Haynes, C, Wang, L, Shah, SH, Crosslin, DR, Hale, AB, Nelson, S, Crossman, DC, Granger, CB, Haines, JL, Jones, CJH, Vance, JM, Goldschmidt-Clermont, PJ, Kraus, WE, Hauser, ER, and Gregory, SG. "GATA2 is associated with familial early-onset coronary artery disease." PLoS Genetics 2, no. 8 (2006): 1265-1273.  Full Text
    • Shah, SH, Liebeskind, DS, Saver, JL, Starkman, S, Vinuela, F, Duckwiler, G, Jahan, R, Kim, D, Sanossian, N, Vespa, P, and Ovbiagele, B. "Influence of gender on outcomes after intra-arterial thrombolysis for acute ischemic stroke." Neurology 66, no. 11 (2006): 1745-1746.  Full Text
    • Shah, SH, Schmidt, MA, Mei, H, Scott, WK, Hauser, ER, and Schmidt, S. "Searching for epistatic interactions in nuclear families using conditional linkage analysis. (Published online)" BMC Genet 6 Suppl 1 (December 30, 2005): S148-.  Full Text  Link to Item
    • Frazier, CG, Shah, SH, Armstrong, PW, Bhapkar, MV, McGuire, DK, Sadowski, Z, Kristinsson, A, Aylward, PE, Klein, WW, Weaver, WD, Newby, LK, and SYMPHONY and the Second SYMPHONY Investigators, . "Prevalence and management of hypertension in acute coronary syndrome patients varies by sex: observations from the Sibrafiban versus aspirin to Yield Maximum Protection from ischemic Heart events postacute cOroNary sYndromes (SYMPHONY) randomized clinical trials." Am Heart J 150, no. 6 (December 2005): 1260-1267.  Full Text  Link to Item
    • Shah, S, Patel, M, Goyal, A, Amos, A, Baeza, R, Halabi, A, Lam, G, Mitchell, RG, Oliveira, G, and Valente, AM. "Highlights from the American Heart Association Annual Scientific Sessions 2004: November 7-10, 2004." American Heart Journal 149, no. 2 (2005): 240-253.  Full Text
    • Parsons, E, Newby, LK, Bhapkar, MV, Alexander, KP, White, HD, Shah, SH, Bushnell, CD, Califf, RM, and Symphony and 2nd Symphony Investigators, . "Postmenopausal hormone use in women with acute coronary syndromes." J Womens Health (Larchmt) 13, no. 8 (October 2004): 863-871.  Full Text  Link to Item
    • Hauser, ER, Crossman, DC, Granger, CB, Haines, JL, Jones, CJH, Mooser, V, McAdam, B, Winkelmann, BR, Wiseman, AH, Muhlestein, JB, Bartel, AG, Dennis, CA, Dowdy, E, Estabrooks, S, Eggleston, K, Francis, S, Roche, K, Clevenger, PW, Huang, L, Pedersen, B, Shah, S, Schmidt, S, Haynes, C, West, S, Asper, D, Booze, M, Sharma, S, Sundseth, S, Middleton, L, Roses, AD, Hauser, MA, Vance, JM, Pericak-Vance, MA, and Kraus, WE. "A genomewide scan for early-onset coronary artery disease in 438 families: the GENECARD Study." Am J Hum Genet 75, no. 3 (September 2004): 436-447.  Full Text  Link to Item
    • Shah, SH, Dery, J-P, Fischi, MC, Heitner, JF, Kunz, GA, Meine, TJ, Patel, MR, Valente, AM, Waters, RE, and Yager, J. "Highlights from the American College of Cardiology Annual Scientific Sessions 2004: March 9-12, 2004." Am Heart J 148, no. 2 (August 2004): 254-.  Link to Item
    • Shah, SH, and Newby, LK. "C-reactive protein: a novel marker of cardiovascular risk." Cardiol Rev 11, no. 4 (July 2003): 169-179. (Review)  Full Text  Link to Item
    • Shah, SH, Alexander, KP, and Peterson, ED. "PCI in women." Cardiology Review 20, no. 3 (2003): 24-29.
    • Shah, SH, Sketch, MH, and Tcheng, JE. "Acute myocardial infarction in a young male while playing paintball." J Invasive Cardiol 14, no. 11 (November 2002): 713-715.  Link to Item

  • Other Articles

    • Kertai, MD, Li, Y-W, Li, Y-J, Shah, SH, Kraus, WE, Fontes, ML, Stafford-Smith, M, Newman, MF, Podgoreanu, MV, Mathew, JP, and Duke Perioperative Genetics and Safety Outcomes (PEGASUS) Investigative Team, . "G protein-coupled receptor kinase 5 gene polymorphisms are associated with postoperative atrial fibrillation after coronary artery bypass grafting in patients receiving β-blockers." Circulation. Cardiovascular genetics 7, no. 5 (October 2014): 625-633.  Full Text

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