Svati Hasmukh Shah | Scholars@Duke

Svati Hasmukh Shah
Professor of Medicine

Current Appointments & Affiliations

Professor of Medicine, Medicine, Cardiology, Medicine 2019
Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2021
Member in the Duke Clinical Research Institute, Duke Clinical Research Institute, Institutes and Centers 2010
Member of Duke Molecular Physiology Institute, Duke Molecular Physiology Institute, Duke Molecular Physiology Institute 2013

Contact Information

DUMC Box 3445, Durham, NC 27710
Duke Box 104775, Durham, NC 27701
svati.shah@duke.edu (919) 684-1808

Background
Education, Training, & Certifications
- Fellow in Cardiology, Medicine, Duke University 2001 - 2005
- Medical Resident, Medicine, Children's Hospital Boston 1998 - 2001
- M.D., University of Washington 1998
- M.H.S., Johns Hopkins University 1994
Previous Appointments & Affiliations
- Associate Professor of Medicine, Medicine, Cardiology, Medicine 2015 - 2019
- Associate Research Professor of Global Health, Duke Global Health Institute, University Institutes and Centers 2011 - 2015
- Associate Professor of Medicine, Medicine, Cardiology, Medicine 2012 - 2015
- Associate Professor in the School of Nursing, School of Nursing, Duke University 2012 - 2013
- Assistant Professor of Medicine, Medicine, Cardiology, Medicine 2005 - 2011
- Assistant Professor in the School of Nursing, School of Nursing, Duke University 2007 - 2011
- Instructor, Temporary in the Department of Medicine, Medicine, Cardiology, Medicine 2005
Recognition
In the News
- JUN 1, 2021 School of Medicine Magnify
  
  Asking New Questions in the Fight Against Childhood Obesity
- NOV 6, 2015
  
  Cellular stress process identified in cardiovascular disease
- JAN 13, 2014
  
  Global Research, Domestic Benefits
Awards & Honors
- Judson Daland Prize. American Philosophical Society. 2011
Expertise
Global Scholarship
- Research
  - India (Country)
Research
Selected Grants
- Biomarkers of Dietary Intake and Exposure Data Coordinating Center awarded by National Institutes of Health 2021 - 2026
- Integrated Training in Anesthesiology Research awarded by National Institutes of Health 1996 - 2026
- Unified Program for Therapeutics in Children awarded by National Institutes of Health 2019 - 2024
- Postdoctoral Training in Cardiovascular Clinical Research awarded by National Institutes of Health 2013 - 2024
- Cardiovascular Risk Prediction for Improved Maternal Health awarded by Foundation for Anesthesia Education and Research 2022 - 2023
- Immunogenetic Profiling for Risk of Primary Graft Dysfunction after Heart Transplantation awarded by National Institutes of Health 2021 - 2023
- Clinical and Molecular Epidemiology of High Risk Coronary Plaque awarded by National Institutes of Health 2019 - 2023
- The Baseline Study awarded by Baseline Study LLC 2016 - 2023
- Inflammatory and Metabolic Biomarkers in Cardiovascular Complications with SARS-CoV-2 awarded by National Institutes of Health 2021 - 2023
- The Branched Chain Ketoacid Dehydrogenase Kinase-Phosphatase System as a New Regulatory Node in Myocardial Fuel Section awarded by National Institutes of Health 2018 - 2023
- Right Ventricular Metabolic Dysregulation after Surgery for Heart Failure awarded by International Anesthesia Research Society 2021 - 2023
- A Multidisciplinary Approach to Primary Cardiovascular Disease Prevention in HIV-infected (K23) awarded by National Institutes of Health 2018 - 2022
- Proteomic Profiles and Cardiac Dysfunction in Children and Adolescents with HIV awarded by National Institutes of Health 2021 - 2022
- Duke Resident Physician-Scientist Program- NHLBI awarded by National Institutes of Health 2018 - 2022
- Duke Training Grant in Nephrology awarded by National Institutes of Health 1995 - 2022
- Postdoctoral Training in Genomic Medicine Research awarded by National Institutes of Health 2017 - 2022
- Integrated Biostatistical Training for CVD Research awarded by North Carolina State University 2017 - 2022
- Analysis of NMR lipoprotein and metabolite data of plasma obtained from CATHGEN and STRRIDE study participants awarded by Liposcience Inc. 2017 - 2022
- Multidisciplinary Heart and Vascular Diseases awarded by National Institutes of Health 1975 - 2022
- Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health 2005 - 2021
- Exploration of Cardiovascular Phenotypes in the CATHGEN Study (the "Project") awarded by Eli Lilly and Company 2020 - 2021
- A Personalized Metabolomic Approach to Human Obesity and Weight Loss awarded by National Institutes of Health 2016 - 2019
- Urine TCA-Cycle Organic Anions in Diabetic Kidney Disease awarded by Augusta University 2018 - 2019
- Metabolomic Biomarkers Predictores of Long-term Success Following Bariatric Surgery awarded by Columbia University 2015 - 2019
- Biomarkers of Mental Stress Induced Myocardial Ischemia and CHD Prognosis awarded by National Institutes of Health 2014 - 2019
- Collaborative Study on Biomarkers of Fatty Liver Diseases awarded by Pfizer, Inc. 2017 - 2018
- Systems Biology Approaches for Predicting Cardiometabolic Risk in Persons Living with HIV awarded by National Institutes of Health 2015 - 2018
- Air Quality by Genomics Interactions in a Cardiovascular Disease Cohort awarded by Health Effects Institute 2014 - 2017
- Risk Factors for Sudden Cardiac Death in Patients with Chronic Kidney Disease awarded by National Institutes of Health 2014 - 2017
- Metabolomic Quantitative Trait Locus (mQTL) Genetic Mapping in Human CVD awarded by National Institutes of Health 2009 - 2016
- Metabolic Regulators of Insulin Secretion and Insulin Resistance awarded by National Institutes of Health 2013 - 2015
- Expanding Evidence of Genetic Contributions to Survivorship in CAD awarded by National Institutes of Health 2011 - 2014
- Genetic Mediators of Metabolic Cardiovascular Disease Risk awarded by National Institutes of Health 2009 - 2012
- Survival and Age Biases in Gene Associations with Coronary Disease awarded by National Institutes of Health 2009 - 2011
- Genetic Epidemiology of Pelvic Organ Prolapse awarded by National Institutes of Health 2009 - 2011
- Molecular Genetics of Muscle Specialization awarded by National Institutes of Health 2001 - 2009
External Relationships
- American Heart Association
- AstraZeneca
- Baylis Medical
- Biosense Webster (Johnson & Johnson)
- Cardivia Medical
- Lilly
- McGraw-Hill Publishing
- National Institutes of Health
- NewPace
- Project Baseline, LLC
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Truby, Lauren K., Lydia Coulter Kwee, Richa Agarwal, Elizabeth Grass, Adam D. DeVore, Chetan B. Patel, Dongfeng Chen, et al. “Proteomic profiling identifies CLEC4C expression as a novel biomarker of primary graft dysfunction after heart transplantation.” J Heart Lung Transplant 40, no. 12 (December 2021): 1589–98. https://doi.org/10.1016/j.healun.2021.07.024.
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  - Selvaraj, Senthil, Ray Hu, Mahesh K. Vidula, Supritha Dugyala, Ann Tierney, Bonnie Ky, Kenneth B. Margulies, Svati H. Shah, Daniel P. Kelly, and Paco E. Bravo. “Acute Echocardiographic Effects of Exogenous Ketone Administration in Healthy Participants.” Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography, November 17, 2021. https://doi.org/10.1016/j.echo.2021.10.017.
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  - Edmonston, Daniel L., Roland Matsouaka, Svati H. Shah, Sudarshan Rajagopal, and Myles Wolf. “Noninvasive Risk Score to Screen for Pulmonary Hypertension With Elevated Pulmonary Vascular Resistance in Diseases of Chronic Volume Overload.” Am J Cardiol 159 (November 15, 2021): 113–20. https://doi.org/10.1016/j.amjcard.2021.08.016.
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  - White, Phillip J., Robert W. McGarrah, Mark A. Herman, James R. Bain, Svati H. Shah, and Christopher B. Newgard. “Insulin action, type 2 diabetes, and branched-chain amino acids: A two-way street.” Mol Metab 52 (October 2021): 101261. https://doi.org/10.1016/j.molmet.2021.101261.
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  - Colaco, Nalini A., Teresa S. Wang, Yifei Ma, Rebecca Scherzer, Olga R. Ilkayeva, Patrice Desvigne-Nickens, Eugene Braunwald, et al. “Transmethylamine-N-Oxide Is Associated With Diffuse Cardiac Fibrosis in People Living With HIV.” J Am Heart Assoc 10, no. 16 (August 17, 2021): e020499. https://doi.org/10.1161/JAHA.120.020499.
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  - Truby, Lauren K., Jessica A. Regan, Stephanie N. Giamberardino, Olga Ilkayeva, James Bain, Christopher B. Newgard, Christopher M. O’Connor, et al. “Circulating long chain acylcarnitines and outcomes in diabetic heart failure: an HF-ACTION clinical trial substudy.” Cardiovasc Diabetol 20, no. 1 (August 3, 2021): 161. https://doi.org/10.1186/s12933-021-01353-z.
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  - Akbari, Parsa, Ankit Gilani, Olukayode Sosina, Jack A. Kosmicki, Lori Khrimian, Yi-Ya Fang, Trikaldarshi Persaud, et al. “Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity.” Science 373, no. 6550 (July 2, 2021). https://doi.org/10.1126/science.abf8683.
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  - Breeze, Charles E., Anna Batorsky, Mi Kyeong Lee, Mindy D. Szeto, Xiaoguang Xu, Daniel L. McCartney, Rong Jiang, et al. “Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci.” Genome Med 13, no. 1 (April 30, 2021): 74. https://doi.org/10.1186/s13073-021-00877-z.
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  - Kammerlander, Andreas A., Thomas Mayrhofer, Maros Ferencik, Neha J. Pagidipati, Julia Karady, Geoffrey S. Ginsburg, Michael T. Lu, et al. “Association of Metabolic Phenotypes With Coronary Artery Disease and Cardiovascular Events in Patients With Stable Chest Pain.” Diabetes Care 44, no. 4 (April 2021): 1038–45. https://doi.org/10.2337/dc20-1760.
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  - McCann, Jessica R., Nathan A. Bihlmeyer, Kimberly Roche, Cameron Catherine, Jayanth Jawahar, Lydia Coulter Kwee, Noelle E. Younge, et al. “The Pediatric Obesity Microbiome and Metabolism Study (POMMS): Methods, Baseline Data, and Early Insights.” Obesity (Silver Spring) 29, no. 3 (March 2021): 569–78. https://doi.org/10.1002/oby.23081.
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  - Kwee, Lydia Coulter, Olga Ilkayeva, Michael J. Muehlbauer, Nathan Bihlmeyer, Bruce Wolfe, Jonathan Q. Purnell, F. Xavier Pi-Sunyer, et al. “Metabolites and diabetes remission after weight loss.” Nutr Diabetes 11, no. 1 (February 24, 2021): 10. https://doi.org/10.1038/s41387-021-00151-6.
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  - Virani, Salim S., Alvaro Alonso, Hugo J. Aparicio, Emelia J. Benjamin, Marcio S. Bittencourt, Clifton W. Callaway, April P. Carson, et al. “Heart Disease and Stroke Statistics-2021 Update: A Report From the American Heart Association.” Circulation 143, no. 8 (February 23, 2021): e254–743. https://doi.org/10.1161/CIR.0000000000000950.
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  - Perak, Amanda M., Nicola Lancki, Alan Kuang, Darwin R. Labarthe, Norrina B. Allen, Svati H. Shah, Lynn P. Lowe, et al. “Associations of Maternal Cardiovascular Health in Pregnancy With Offspring Cardiovascular Health in Early Adolescence.” Jama 325, no. 7 (February 16, 2021): 658–68. https://doi.org/10.1001/jama.2021.0247.
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  - Perak, Amanda M., Nicola Lancki, Alan Kuang, Darwin R. Labarthe, Norrina B. Allen, Svati H. Shah, Lynn P. Lowe, et al. “Associations of gestational cardiovascular health with pregnancy outcomes: the Hyperglycemia and Adverse Pregnancy Outcome study.” Am J Obstet Gynecol 224, no. 2 (February 2021): 210.e1-210.e17. https://doi.org/10.1016/j.ajog.2020.07.053.
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  - Bihlmeyer, Nathan A., Lydia Coulter Kwee, Clary B. Clish, Amy Anderson Deik, Robert E. Gerszten, Neha J. Pagidipati, Blandine Laferrère, et al. “Metabolomic profiling identifies complex lipid species and amino acid analogues associated with response to weight loss interventions.” Plos One 16, no. 5 (2021): e0240764. https://doi.org/10.1371/journal.pone.0240764.
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  - Sayeed, Sabina, Robert Califf, Robert Green, Celeste Wong, Kenneth Mahaffey, Sanjiv Sam Gambhir, Jessica Mega, et al. “Return of individual research results: What do participants prefer and expect?” Plos One 16, no. 7 (2021): e0254153. https://doi.org/10.1371/journal.pone.0254153.
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  - Zeitouni, Michel, Robert M. Clare, Karen Chiswell, Jawan Abdulrahim, Nishant Shah, Neha P. Pagidipati, Svati H. Shah, Matthew T. Roe, Manesh R. Patel, and W Schuyler Jones. “Risk Factor Burden and Long-Term Prognosis of Patients With Premature Coronary Artery Disease.” J Am Heart Assoc 9, no. 24 (December 15, 2020): e017712. https://doi.org/10.1161/JAHA.120.017712.
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  - Ellison, Stephen, Jawan W. Abdulrahim, Lydia Coulter Kwee, Nathan A. Bihlmeyer, Neha Pagidipati, Robert McGarrah, James R. Bain, William E. Kraus, and Svati H. Shah. “Novel plasma biomarkers improve discrimination of metabolic health independent of weight.” Sci Rep 10, no. 1 (December 7, 2020): 21365. https://doi.org/10.1038/s41598-020-78478-w.
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  - Ward-Caviness, Cavin K., Armistead G. Russell, Anne M. Weaver, Erik Slawsky, Radhika Dhingra, Lydia Coulter Kwee, Rong Jiang, et al. “Accelerated epigenetic age as a biomarker of cardiovascular sensitivity to traffic-related air pollution.” Aging (Albany Ny) 12, no. 23 (December 7, 2020): 24141–55. https://doi.org/10.18632/aging.202341.
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  - Privratsky, Jamie R., Yi-Ju Li, Carol Haynes, Mihai Podgoreanu, Joseph Mathew, Svati H. Shah, and Mark Stafford-Smith. “Apolipoprotein L1 (APOL1) Coding Variants Are Associated With Creatinine Rise After Cardiac Surgery.” J Cardiothorac Vasc Anesth 34, no. 12 (December 2020): 3314–20. https://doi.org/10.1053/j.jvca.2020.04.017.
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  - Zuydam, Natalie R. van, Claes Ladenvall, Benjamin F. Voight, Rona J. Strawbridge, Juan Fernandez-Tajes, N William Rayner, Neil R. Robertson, et al. “Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus.” Circ Genom Precis Med 13, no. 6 (December 2020): e002769. https://doi.org/10.1161/CIRCGEN.119.002769.
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  - White, Phillip J., Amanda L. Lapworth, Robert W. McGarrah, Lydia Coulter Kwee, Scott B. Crown, Olga Ilkayeva, Jie An, et al. “Muscle-Liver Trafficking of BCAA-Derived Nitrogen Underlies Obesity-Related Glycine Depletion.” Cell Rep 33, no. 6 (November 10, 2020): 108375. https://doi.org/10.1016/j.celrep.2020.108375.
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  - Singh, Abanish, Michael A. Babyak, Mario Sims, Solomon K. Musani, Beverly H. Brummett, Rong Jiang, William E. Kraus, et al. “Evaluating the precision of EBF1 SNP x stress interaction association: sex, race, and age differences in a big harmonized data set of 28,026 participants.” Transl Psychiatry 10, no. 1 (October 20, 2020): 351. https://doi.org/10.1038/s41398-020-01028-5.
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  - Regan, Jessica A., and Svati H. Shah. “Obesity Genomics and Metabolomics: a Nexus of Cardiometabolic Risk.” Curr Cardiol Rep 22, no. 12 (October 10, 2020): 174. https://doi.org/10.1007/s11886-020-01422-x.
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  - Nomura, Akihiro, Connor A. Emdin, Hong Hee Won, Gina M. Peloso, Pradeep Natarajan, Diego Ardissino, John Danesh, et al. “Heterozygous ABCG5 Gene Deficiency and Risk of Coronary Artery Disease.” Circ Genom Precis Med 13, no. 5 (October 2020): 417–23. https://doi.org/10.1161/CIRCGEN.119.002871.
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  - Abdulrahim, Jawan W., Lydia Coulter Kwee, Fawaz Alenezi, Albert Y. Sun, Aris Baras, Teminioluwa A. Ajayi, Ricardo Henao, et al. “Identification of Undetected Monogenic Cardiovascular Disorders.” J Am Coll Cardiol 76, no. 7 (August 18, 2020): 797–808. https://doi.org/10.1016/j.jacc.2020.06.037.
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  - Landstrom, Andrew P., and Svati H. Shah. “Rare Things Being Common: Implications for Common Genetic Variants in Rare Diseases Like Long-QT Syndrome.” Circulation 142, no. 4 (July 27, 2020): 339–41. https://doi.org/10.1161/circulationaha.120.048339.
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  - Shah, Nishant P., Neha J. Pajidipati, Robert W. McGarrah, Ann Marie Navar, Sreekanth Vemulapalli, Michael A. Blazing, Svati H. Shah, Adrian F. Hernandez, and Manesh R. Patel. “Lipoprotein (a): An Update on a Marker of Residual Risk and Associated Clinical Manifestations.” Am J Cardiol 126 (July 1, 2020): 94–102. https://doi.org/10.1016/j.amjcard.2020.03.043.
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  - Armstrong, Sarah C., McAllister Windom, Nathan A. Bihlmeyer, Jennifer S. Li, Svati H. Shah, Mary Story, Nancy Zucker, et al. “Rationale and design of "Hearts & Parks": study protocol for a pragmatic randomized clinical trial of an integrated clinic-community intervention to treat pediatric obesity.” Bmc Pediatr 20, no. 1 (June 26, 2020): 308. https://doi.org/10.1186/s12887-020-02190-x.
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  - Chatterjee, Ranee, Clemontina A. Davenport, Lydia Kwee, David D’Alessio, Laura P. Svetkey, Pao-Hwa Lin, Cris A. Slentz, et al. “Preliminary evidence of effects of potassium chloride on a metabolomic path to diabetes and cardiovascular disease.” Metabolomics 16, no. 7 (June 18, 2020): 75. https://doi.org/10.1007/s11306-020-01696-w.
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  - Butler, Javed, Stephen J. Greene, Svati H. Shah, Sanjiv J. Shah, Kevin J. Anstrom, Raymond J. Kim, Andreas P. Kalogeropoulos, et al. “Diastolic Dysfunction in Patients With Human Immunodeficiency Virus Receiving Antiretroviral Therapy: Results From the CHART Study.” J Card Fail 26, no. 5 (May 2020): 371–80. https://doi.org/10.1016/j.cardfail.2019.10.011.
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  - Becker, Kristian C., Lydia Coulter Kwee, Megan L. Neely, Elizabeth Grass, Joseph A. Jakubowski, Keith A. A. Fox, Harvey D. White, et al. “Circulating MicroRNA Profiling in Non-ST Elevated Coronary Artery Syndrome Highlights Genomic Associations with Serial Platelet Reactivity Measurements.” Sci Rep 10, no. 1 (April 10, 2020): 6169. https://doi.org/10.1038/s41598-020-63263-6.
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  - Virani, Salim S., Alvaro Alonso, Emelia J. Benjamin, Marcio S. Bittencourt, Clifton W. Callaway, April P. Carson, Alanna M. Chamberlain, et al. “Heart Disease and Stroke Statistics-2020 Update: A Report From the American Heart Association.” Circulation 141, no. 9 (March 3, 2020): e139–596. https://doi.org/10.1161/CIR.0000000000000757.
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  - Arges, Kristine, Themistocles Assimes, Vikram Bajaj, Suresh Balu, Mustafa R. Bashir, Laura Beskow, Rosalia Blanco, et al. “The Project Baseline Health Study: a step towards a broader mission to map human health.” Npj Digit Med 3 (2020): 84. https://doi.org/10.1038/s41746-020-0290-y.
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  - Pagidipati, Neha J., Yinggan Zheng, Jennifer B. Green, Darren K. McGuire, Robert J. Mentz, Svati Shah, Pablo Aschner, et al. “Association of obesity with cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease: Insights from TECOS.” American Heart Journal 219 (January 2020): 47–57. https://doi.org/10.1016/j.ahj.2019.09.016.
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  - Abdulrahim, Jawan W., Lydia Coulter Kwee, Elizabeth Grass, Ilene C. Siegler, Redford Williams, Ravi Karra, William E. Kraus, Simon G. Gregory, and Svati H. Shah. “Epigenome-Wide Association Study for All-Cause Mortality in a Cardiovascular Cohort Identifies Differential Methylation in Castor Zinc Finger 1 (CASZ1).” J Am Heart Assoc 8, no. 21 (November 5, 2019): e013228. https://doi.org/10.1161/JAHA.119.013228.
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  - Kwee, Lydia Coulter, Megan L. Neely, Elizabeth Grass, Simon G. Gregory, Matthew T. Roe, E Magnus Ohman, Keith A. A. Fox, et al. “Associations of osteopontin and NT-proBNP with circulating miRNA levels in acute coronary syndrome.” Physiol Genomics 51, no. 10 (October 1, 2019): 506–15. https://doi.org/10.1152/physiolgenomics.00033.2019.
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  - Alenezi, Fawaz, Gerald S. Bloomfield, Nwora Lance Okeke, Poonam Velagapudi, Loai Abudaqa, Nkechinyere Ijioma, Allison Dunning, et al. “Global Longitudinal Strain and Immune Status in Patients Living With Human Immunodeficiency Virus.” Am J Cardiol 124, no. 6 (September 15, 2019): 966–71. https://doi.org/10.1016/j.amjcard.2019.06.013.
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  - Yu, Bing, Krista A. Zanetti, Marinella Temprosa, Demetrius Albanes, Nathan Appel, Clara Barrios Barrera, Yoav Ben-Shlomo, et al. “The Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies.” Am J Epidemiol 188, no. 6 (June 1, 2019): 991–1012. https://doi.org/10.1093/aje/kwz028.
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  - Harskamp, Ralf E., Thomas M. Granger, Robert M. Clare, Kyle R. White, Renato D. Lopes, Karen S. Pieper, Christopher B. Granger, Christopher B. Newgard, Svati H. Shah, and L Kristin Newby. “Peripheral blood metabolite profiles associated with new onset atrial fibrillation.” Am Heart J 211 (May 2019): 54–59. https://doi.org/10.1016/j.ahj.2019.01.010.
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  - Benjamin, Emelia J., Paul Muntner, Alvaro Alonso, Marcio S. Bittencourt, Clifton W. Callaway, April P. Carson, Alanna M. Chamberlain, et al. “Heart Disease and Stroke Statistics-2019 Update: A Report From the American Heart Association.” Circulation 139, no. 10 (March 5, 2019): e56–528. https://doi.org/10.1161/CIR.0000000000000659.
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  - Pagidipati, Neha J., Adrian Coles, Kshipra Hemal, Kerry L. Lee, Rowena J. Dolor, Patricia A. Pellikka, Daniel B. Mark, et al. “Sex differences in management and outcomes of patients with stable symptoms suggestive of coronary artery disease: Insights from the PROMISE trial.” Am Heart J 208 (February 2019): 28–36. https://doi.org/10.1016/j.ahj.2018.11.002.
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  - Hunter, Wynn G., Robert W. McGarrah, Jacob P. Kelly, Michel G. Khouri, Damian M. Craig, Carol Haynes, G Michael Felker, et al. “High-Density Lipoprotein Particle Subfractions in Heart Failure With Preserved or Reduced Ejection Fraction.” J Am Coll Cardiol 73, no. 2 (January 22, 2019): 177–86. https://doi.org/10.1016/j.jacc.2018.10.059.
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  - Limkakeng, Alexander T., Ricardo Henao, Deepak Voora, Thomas O’Connell, Michelle Griffin, Ephraim L. Tsalik, Svati Shah, Christopher W. Woods, and Geoffrey S. Ginsburg. “Pilot study of myocardial ischemia-induced metabolomic changes in emergency department patients undergoing stress testing.” Plos One 14, no. 2 (2019): e0211762. https://doi.org/10.1371/journal.pone.0211762.
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  - Dhingra, Radhika, Lydia Coulter Kwee, David Diaz-Sanchez, Robert B. Devlin, Wayne Cascio, Elizabeth R. Hauser, Simon Gregory, et al. “Evaluating DNA methylation age on the Illumina MethylationEPIC Bead Chip.” Plos One 14, no. 4 (2019): e0207834. https://doi.org/10.1371/journal.pone.0207834.
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  - Abraham, Dennis M., Teresa E. Lee, Lewis J. Watson, Lan Mao, Gurangad Chandok, Hong-Gang Wang, Stephan Frangakis, et al. “The two-pore domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction.” J Clin Invest 128, no. 11 (November 1, 2018): 4843–55. https://doi.org/10.1172/JCI95945.
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  - Okeke, Nwora Lance, Fawaz Alenezi, Gerald S. Bloomfield, Allison Dunning, Meredith E. Clement, Svati H. Shah, Susanna Naggie, and Eric J. Velazquez. “Determinants of Left Ventricular Hypertrophy and Diastolic Dysfunction in an HIV Clinical Cohort.” J Card Fail 24, no. 8 (August 2018): 496–503. https://doi.org/10.1016/j.cardfail.2018.06.003.
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  - Shantavasinkul, Prapimporn Chattranukulchai, Michael J. Muehlbauer, James R. Bain, Olga R. Ilkayeva, Damian M. Craig, Christopher B. Newgard, Laura P. Svetkey, Svati H. Shah, and Alfonso Torquati. “Improvement in insulin resistance after gastric bypass surgery is correlated with a decline in plasma 2-hydroxybutyric acid.” Surg Obes Relat Dis 14, no. 8 (August 2018): 1126–32. https://doi.org/10.1016/j.soard.2018.03.033.
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  - Volgman, Annabelle Santos, Latha S. Palaniappan, Neelum T. Aggarwal, Milan Gupta, Abha Khandelwal, Aruna V. Krishnan, Judith H. Lichtman, et al. “Atherosclerotic Cardiovascular Disease in South Asians in the United States: Epidemiology, Risk Factors, and Treatments: A Scientific Statement From the American Heart Association.” Circulation 138, no. 1 (July 3, 2018): e1–34. https://doi.org/10.1161/CIR.0000000000000580.
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  - Gusarova, Viktoria, Colm O’Dushlaine, Tanya M. Teslovich, Peter N. Benotti, Tooraj Mirshahi, Omri Gottesman, Cristopher V. Van Hout, et al. “Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes.” Nat Commun 9, no. 1 (June 13, 2018): 2252. https://doi.org/10.1038/s41467-018-04611-z.
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  - Roselli, Carolina, Mark D. Chaffin, Lu-Chen Weng, Stefanie Aeschbacher, Gustav Ahlberg, Christine M. Albert, Peter Almgren, et al. “Multi-ethnic genome-wide association study for atrial fibrillation.” Nat Genet 50, no. 9 (June 11, 2018): 1225–33. https://doi.org/10.1038/s41588-018-0133-9.
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  - Musunuru, Kiran, Pankaj Arora, John P. Cooke, Jane F. Ferguson, Ray E. Hershberger, Kathleen T. Hickey, Jin-Moo Lee, et al. “Interdisciplinary Models for Research and Clinical Endeavors in Genomic Medicine: A Scientific Statement From the American Heart Association.” Circ Genom Precis Med 11, no. 6 (June 2018): e000046. https://doi.org/10.1161/HCG.0000000000000046.
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  - Hayes, Sharonne N., Esther S. H. Kim, Jacqueline Saw, David Adlam, Cynthia Arslanian-Engoren, Katherine E. Economy, Santhi K. Ganesh, et al. “Spontaneous Coronary Artery Dissection: Current State of the Science: A Scientific Statement From the American Heart Association.” Circulation 137, no. 19 (May 8, 2018): e523–57. https://doi.org/10.1161/CIR.0000000000000564.
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  - Turcot, Valérie, Yingchang Lu, Heather M. Highland, Claudia Schurmann, Anne E. Justice, Rebecca S. Fine, Jonathan P. Bradfield, et al. “Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.” Nat Genet 50, no. 5 (May 2018): 765–66. https://doi.org/10.1038/s41588-018-0050-y.
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  - Turcot, Valérie, Yingchang Lu, Heather M. Highland, Claudia Schurmann, Anne E. Justice, Rebecca S. Fine, Jonathan P. Bradfield, et al. “Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.” Nat Genet 50, no. 5 (May 2018): 766–67. https://doi.org/10.1038/s41588-018-0082-3.
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  - McGarrah, Robert W., Scott B. Crown, Guo-Fang Zhang, Svati H. Shah, and Christopher B. Newgard. “Cardiovascular Metabolomics.” Circ Res 122, no. 9 (April 27, 2018): 1238–58. https://doi.org/10.1161/CIRCRESAHA.117.311002.
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  - Butler, Javed, Andreas P. Kalogeropoulos, Kevin J. Anstrom, Priscilla Y. Hsue, Raymond J. Kim, Rebecca Scherzer, Sanjiv J. Shah, et al. “Diastolic Dysfunction in Individuals With Human Immunodeficiency Virus Infection: Literature Review, Rationale and Design of the Characterizing Heart Function on Antiretroviral Therapy (CHART) Study.” J Card Fail 24, no. 4 (April 2018): 255–65. https://doi.org/10.1016/j.cardfail.2018.02.001.
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  - Denus, S. de, J. L. Rouleau, D. L. Mann, G. S. Huggins, N. L. Pereira, S. H. Shah, T. P. Cappola, R. Fouodjio, I. Mongrain, and M. -. P. Dubé. “CYP3A4 genotype is associated with sildenafil concentrations in patients with heart failure with preserved ejection fraction.” Pharmacogenomics J 18, no. 2 (April 2018): 232–37. https://doi.org/10.1038/tpj.2017.8.
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  - McGarrah, Robert W., and Svati H. Shah. “Integrative Omics: Harnessing the Proteome to Maximize the Potential of the Genome.” Circulation 137, no. 11 (March 13, 2018): 1173–75. https://doi.org/10.1161/CIRCULATIONAHA.117.032807.
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  - Okeke, Nwora Lance, Damian M. Craig, Michael J. Muehlbauer, Olga Ilkayeva, Meredith E. Clement, Susanna Naggie, and Svati H. Shah. “Metabolites predict cardiovascular disease events in persons living with HIV: a pilot case-control study.” Metabolomics 14, no. 3 (March 2018). https://doi.org/10.1007/s11306-018-1318-z.
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  - Brummett, Beverly H., Michael A. Babyak, Abanish Singh, Elizabeth R. Hauser, Rong Jiang, Kim M. Huffman, William E. Kraus, Svati H. Shah, Ilene C. Siegler, and Redford B. Williams. “Lack of Association of a Functional Polymorphism in the Serotonin Receptor Gene With Body Mass Index and Depressive Symptoms in a Large Meta-Analysis of Population Based Studies.” Front Genet 9 (2018): 423. https://doi.org/10.3389/fgene.2018.00423.
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  - Wang, Hanghang, Michael J. Muehlbauer, Sara K. O’Neal, Christopher B. Newgard, Elizabeth R. Hauser, James R. Bain, and Svati H. Shah. “Recommendations for Improving Identification and Quantification in Non-Targeted, GC-MS-Based Metabolomic Profiling of Human Plasma.” Metabolites 7, no. 3 (August 25, 2017). https://doi.org/10.3390/metabo7030045.
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  - Jiang, Rong, Michael A. Babyak, Beverly H. Brummett, Elizabeth R. Hauser, Svati H. Shah, Richard C. Becker, Ilene C. Siegler, et al. “Brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism is associated with disease severity and incidence of cardiovascular events in a patient cohort.” Am Heart J 190 (August 2017): 40–45. https://doi.org/10.1016/j.ahj.2017.05.002.
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  - Wang, Hanghang, Kevin Anstrom, Olga Ilkayeva, Michael J. Muehlbauer, James R. Bain, Steven McNulty, Christopher B. Newgard, et al. “Sildenafil Treatment in Heart Failure With Preserved Ejection Fraction: Targeted Metabolomic Profiling in the RELAX Trial.” Jama Cardiol 2, no. 8 (August 1, 2017): 896–901. https://doi.org/10.1001/jamacardio.2017.1239.
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  - Lawler, Patrick R., Akintunde O. Akinkuolie, Audrey Y. Chu, Svati H. Shah, William E. Kraus, Damian Craig, Latha Padmanabhan, et al. “Atherogenic Lipoprotein Determinants of Cardiovascular Disease and Residual Risk Among Individuals With Low Low-Density Lipoprotein Cholesterol.” Journal of the American Heart Association 6, no. 7 (July 21, 2017). https://doi.org/10.1161/jaha.117.005549.
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  - Saleheen, Danish, Wei Zhao, Robin Young, Christopher P. Nelson, WeangKee Ho, Jane F. Ferguson, Asif Rasheed, et al. “Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions.” Circulation 135, no. 24 (June 13, 2017): 2336–53. https://doi.org/10.1161/CIRCULATIONAHA.116.022069.
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  - Wang, Alice, Lydia Coulter Kwee, Elizabeth Grass, Megan L. Neely, Simon G. Gregory, Keith A. A. Fox, Paul W. Armstrong, et al. “Whole blood sequencing reveals circulating microRNA associations with high-risk traits in non-ST-segment elevation acute coronary syndrome.” Atherosclerosis 261 (June 2017): 19–25. https://doi.org/10.1016/j.atherosclerosis.2017.03.041.
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  - Guimarães, Patrícia O., Jie-Lena Sun, Kristian Kragholm, Svati H. Shah, Karen S. Pieper, William E. Kraus, Elizabeth R. Hauser, Christopher B. Granger, L. Kristin Newby, and L. MURDOCK Horizon 1 Cardiovascular Study Investigators Durham, NC. “Corrigendum to 'Association of Standard Clinical and Laboratory Variables with Red Blood Cell Distribution Width (RDW)'[Am. Heart J. (2016) 22-28].” Am Heart J 188 (June 2017): 196. https://doi.org/10.1016/j.ahj.2017.05.011.
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  - Stitziel, Nathan O., Amit V. Khera, Xiao Wang, Andrew J. Bierhals, A Christina Vourakis, Alexandra E. Sperry, Pradeep Natarajan, et al. “ANGPTL3 Deficiency and Protection Against Coronary Artery Disease.” J Am Coll Cardiol 69, no. 16 (April 25, 2017): 2054–63. https://doi.org/10.1016/j.jacc.2017.02.030.
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  - Cheng, Susan, Svati H. Shah, Elizabeth J. Corwin, Oliver Fiehn, Robert L. Fitzgerald, Robert E. Gerszten, Thomas Illig, et al. “Potential Impact and Study Considerations of Metabolomics in Cardiovascular Health and Disease: A Scientific Statement From the American Heart Association.” Circ Cardiovasc Genet 10, no. 2 (April 2017). https://doi.org/10.1161/HCG.0000000000000032.
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  - Luo, Nancy, Damian Craig, Olga Ilkayeva, Michael Muehlbauer, William E. Kraus, Christopher B. Newgard, Svati H. Shah, and Sudarshan Rajagopal. “Plasma acylcarnitines are associated with pulmonary hypertension.” Pulm Circ 7, no. 1 (March 2017): 211–18. https://doi.org/10.1086/690554.
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  - Webb, Thomas R., Jeanette Erdmann, Kathleen E. Stirrups, Nathan O. Stitziel, Nicholas G. D. Masca, Henning Jansen, Stavroula Kanoni, et al. “Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease.” J Am Coll Cardiol 69, no. 7 (February 21, 2017): 823–36. https://doi.org/10.1016/j.jacc.2016.11.056.
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  - Wang, Hanghang, Patrick H. Pun, Lydia Kwee, Damian Craig, Carol Haynes, Megan Chryst-Ladd, Laura P. Svetkey, et al. “Apolipoprotein L1 Genetic Variants Are Associated with Chronic Kidney Disease but Not with Cardiovascular Disease in a Population Referred for Cardiac Catheterization.” Cardiorenal Med 7, no. 2 (February 2017): 96–103. https://doi.org/10.1159/000453458.
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  - Brænne, Ingrid, Lingyao Zeng, Christina Willenborg, Vinicius Tragante, Thorsten Kessler, Thorsten CARDIoGRAM Consortium, Thorsten CARDIoGRAMplusC4D Consortium, et al. “Genomic correlates of glatiramer acetate adverse cardiovascular effects lead to a novel locus mediating coronary risk.” Plos One 12, no. 8 (2017): e0182999. https://doi.org/10.1371/journal.pone.0182999.
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  - McGarrah, Robert W., Jacob P. Kelly, Damian M. Craig, Carol Haynes, Ryan C. Jessee, Kim M. Huffman, William E. Kraus, and Svati H. Shah. “A Novel Protein Glycan-Derived Inflammation Biomarker Independently Predicts Cardiovascular Disease and Modifies the Association of HDL Subclasses with Mortality.” Clin Chem 63, no. 1 (January 2017): 288–96. https://doi.org/10.1373/clinchem.2016.261636.
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  - Breitner, Susanne, Alexandra Schneider, Robert B. Devlin, Cavin K. Ward-Caviness, David Diaz-Sanchez, Lucas M. Neas, Wayne E. Cascio, et al. “Associations among plasma metabolite levels and short-term exposure to PM2.5 and ozone in a cardiac catheterization cohort.” Environ Int 97 (December 2016): 76–84. https://doi.org/10.1016/j.envint.2016.10.012.
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  - Hampel, Regina, Susanne Breitner, William E. Kraus, Elizabeth Hauser, Svati Shah, Cavin K. Ward-Caviness, Robert Devlin, et al. “Short-term effects of air temperature on plasma metabolite concentrations in patients undergoing cardiac catheterization.” Environ Res 151 (November 2016): 224–32. https://doi.org/10.1016/j.envres.2016.07.010.
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  - McGarrah, Robert W., and Svati H. Shah. “Exomes, Proteins, and Cardiovascular Disease: Making Sense of the Signals.” Circ Cardiovasc Genet 9, no. 4 (August 2016): 318–19. https://doi.org/10.1161/CIRCGENETICS.116.001549.
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  - Hunter, Wynn G., Jacob P. Kelly, Robert W. McGarrah, Michel G. Khouri, Damian Craig, Carol Haynes, Olga Ilkayeva, et al. “Metabolomic Profiling Identifies Novel Circulating Biomarkers of Mitochondrial Dysfunction Differentially Elevated in Heart Failure With Preserved Versus Reduced Ejection Fraction: Evidence for Shared Metabolic Impairments in Clinical Heart Failure.” J Am Heart Assoc 5, no. 8 (July 29, 2016). https://doi.org/10.1161/JAHA.115.003190.
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  - Samad, Zainab, Amit N. Vora, Allison Dunning, Phillip J. Schulte, Linda K. Shaw, Fawaz Al-Enezi, Mads Ersboll, et al. “Aortic valve surgery and survival in patients with moderate or severe aortic stenosis and left ventricular dysfunction.” Eur Heart J 37, no. 28 (July 21, 2016): 2276–86. https://doi.org/10.1093/eurheartj/ehv701.
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  - Pagidipati, Neha J., Kshipra Hemal, Adrian Coles, Daniel B. Mark, Rowena J. Dolor, Patricia A. Pellikka, Udo Hoffmann, et al. “Sex Differences in Functional and CT Angiography Testing in Patients With Suspected Coronary Artery Disease.” J Am Coll Cardiol 67, no. 22 (June 7, 2016): 2607–16. https://doi.org/10.1016/j.jacc.2016.03.523.
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  - Nioi, Paul, Asgeir Sigurdsson, Gudmar Thorleifsson, Hannes Helgason, Arna B. Agustsdottir, Gudmundur L. Norddahl, Anna Helgadottir, et al. “Variant ASGR1 Associated with a Reduced Risk of Coronary Artery Disease.” N Engl J Med 374, no. 22 (June 2, 2016): 2131–41. https://doi.org/10.1056/NEJMoa1508419.
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  - Hunter, Wynn G., Jacob P. Kelly, Robert W. McGarrah, William E. Kraus, and Svati H. Shah. “Metabolic Dysfunction in Heart Failure: Diagnostic, Prognostic, and Pathophysiologic Insights From Metabolomic Profiling.” Curr Heart Fail Rep 13, no. 3 (June 2016): 119–31. https://doi.org/10.1007/s11897-016-0289-5.
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  - Sun, Haipeng, Kristine C. Olson, Chen Gao, Domenick A. Prosdocimo, Meiyi Zhou, Zhihua Wang, Darwin Jeyaraj, et al. “Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure.” Circulation 133, no. 21 (May 24, 2016): 2038–49. https://doi.org/10.1161/CIRCULATIONAHA.115.020226.
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  - Pereira, Naveen L., Jeffrey B. Geske, Manuel Mayr, Svati H. Shah, and Charanjit S. Rihal. “Pharmacogenetics of Clopidogrel: An Unresolved Issue.” Circ Cardiovasc Genet 9, no. 2 (April 2016): 185–88. https://doi.org/10.1161/CIRCGENETICS.115.001318.
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  - Guimarães, Patrícia O., Jie-Lena Sun, Kristian Kragholm, Svati H. Shah, Karen S. Pieper, William E. Kraus, Elizabeth R. Hauser, Christopher B. Granger, L Kristin Newby, and L Kristin MURDOCK Horizon 1 Cardiovascular Study Investigators. “Association of standard clinical and laboratory variables with red blood cell distribution width.” Am Heart J 174 (April 2016): 22–28. https://doi.org/10.1016/j.ahj.2016.01.001.
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  - Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators, Heribert, Nathan O. Stitziel, Kathleen E. Stirrups, Nicholas G. D. Masca, Jeanette Erdmann, Paola G. Ferrario, Inke R. König, et al. “Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease.” N Engl J Med 374, no. 12 (March 24, 2016): 1134–44. https://doi.org/10.1056/NEJMoa1507652.
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  - Voora, Deepak, and Svati H. Shah. “Pharmacometabolomics Meets Genetics: A "Natural" Clinical Trial of Statin Effects.” J Am Coll Cardiol 67, no. 10 (March 15, 2016): 1211–13. https://doi.org/10.1016/j.jacc.2016.01.022.
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  - McGarrah, Robert W., Damian M. Craig, Carol Haynes, Z Elaine Dowdy, Svati H. Shah, and William E. Kraus. “High-density lipoprotein subclass measurements improve mortality risk prediction, discrimination and reclassification in a cardiac catheterization cohort.” Atherosclerosis 246 (March 2016): 229–35. https://doi.org/10.1016/j.atherosclerosis.2016.01.012.
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  - Wolf, Matthew J., Dagny Noeth, Chidambaram Rammohan, and Svati H. Shah. “Complexities of Genetic Testing in Familial Dilated Cardiomyopathy.” Circ Cardiovasc Genet 9, no. 1 (February 2016): 95–99. https://doi.org/10.1161/CIRCGENETICS.115.001157.
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  - Ahmad, Tariq, Jacob P. Kelly, Robert W. McGarrah, Anne S. Hellkamp, Mona Fiuzat, Jeffrey M. Testani, Teresa S. Wang, et al. “Prognostic Implications of Long-Chain Acylcarnitines in Heart Failure and Reversibility With Mechanical Circulatory Support.” J Am Coll Cardiol 67, no. 3 (January 26, 2016): 291–99. https://doi.org/10.1016/j.jacc.2015.10.079.
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  - Shah, Svati H., Donna Arnett, Steven R. Houser, Geoffrey S. Ginsburg, Calum MacRae, Seema Mital, Joseph Loscalzo, and Jennifer L. Hall. “Opportunities for the Cardiovascular Community in the Precision Medicine Initiative.” Circulation 133, no. 2 (January 12, 2016): 226–31. https://doi.org/10.1161/CIRCULATIONAHA.115.019475.
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  - Dungan, Jennifer R., Xuejun Qin, Benjamin D. Horne, John F. Carlquist, Abanish Singh, Melissa Hurdle, Elizabeth Grass, et al. “Case-Only Survival Analysis Reveals Unique Effects of Genotype, Sex, and Coronary Disease Severity on Survivorship.” Plos One 11, no. 5 (2016): e0154856. https://doi.org/10.1371/journal.pone.0154856.
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  - Ward-Caviness, Cavin K., Lucas M. Neas, Colette Blach, Carol S. Haynes, Karen LaRocque-Abramson, Elizabeth Grass, Elaine Dowdy, et al. “Genetic Variants in the Bone Morphogenic Protein Gene Family Modify the Association between Residential Exposure to Traffic and Peripheral Arterial Disease.” Plos One 11, no. 4 (2016): e0152670. https://doi.org/10.1371/journal.pone.0152670.
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  - Nikpay, Majid, Anuj Goel, Hong-Hee Won, Leanne M. Hall, Christina Willenborg, Stavroula Kanoni, Danish Saleheen, et al. “A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease.” Nat Genet 47, no. 10 (October 2015): 1121–30. https://doi.org/10.1038/ng.3396.
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  - Stafford-Smith, Mark, Yi-Ju Li, Joseph P. Mathew, Yen-Wei Li, Yunqi Ji, Barbara G. Phillips-Bute, Carmelo A. Milano, et al. “Genome-wide association study of acute kidney injury after coronary bypass graft surgery identifies susceptibility loci.” Kidney Int 88, no. 4 (October 2015): 823–32. https://doi.org/10.1038/ki.2015.161.
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  - Ward-Caviness, Cavin K., William E. Kraus, Colette Blach, Carol S. Haynes, Elaine Dowdy, Marie Lynn Miranda, Robert B. Devlin, et al. “Association of Roadway Proximity with Fasting Plasma Glucose and Metabolic Risk Factors for Cardiovascular Disease in a Cross-Sectional Study of Cardiac Catheterization Patients.” Environ Health Perspect 123, no. 10 (October 2015): 1007–14. https://doi.org/10.1289/ehp.1306980.
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  - Burke, Lora E., Jun Ma, Kristen M. J. Azar, Gary G. Bennett, Eric D. Peterson, Yaguang Zheng, William Riley, et al. “Current Science on Consumer Use of Mobile Health for Cardiovascular Disease Prevention: A Scientific Statement From the American Heart Association.” Circulation 132, no. 12 (September 22, 2015): 1157–1213. https://doi.org/10.1161/CIR.0000000000000232.
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  - Dokun, Ayotunde O., Lingdan Chen, Mitsuharu Okutsu, Charles R. Farber, Surovi Hazarika, W Schuyler Jones, Damian Craig, et al. “ADAM12: a genetic modifier of preclinical peripheral arterial disease.” Am J Physiol Heart Circ Physiol 309, no. 5 (September 2015): H790–803. https://doi.org/10.1152/ajpheart.00803.2014.
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  - Parikh, Kishan S., Sudarshan Rajagopal, Kristine Arges, Tariq Ahmad, Joseph Sivak, Prashant Kaul, Svati H. Shah, et al. “Use of outcome measures in pulmonary hypertension clinical trials.” Am Heart J 170, no. 3 (September 2015): 419-29.e3. https://doi.org/10.1016/j.ahj.2015.06.010.
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  - Kertai, Miklos D., Yi-Ju Li, Yunqi Ji, Wenjing Qi, Frederick W. Lombard, Svati H. Shah, William E. Kraus, et al. “Genome-wide association study of new-onset atrial fibrillation after coronary artery bypass grafting surgery.” Am Heart J 170, no. 3 (September 2015): 580-90.e28. https://doi.org/10.1016/j.ahj.2015.06.009.
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  - Singh, Abanish, Michael A. Babyak, Beverly H. Brummett, Rong Jiang, Lana L. Watkins, John C. Barefoot, William E. Kraus, et al. “Computing a Synthetic Chronic Psychosocial Stress Measurement in Multiple Datasets and its Application in the Replication of G × E Interactions of the EBF1 Gene.” Genet Epidemiol 39, no. 6 (September 2015): 489–97. https://doi.org/10.1002/gepi.21910.
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  - Shah, Asad A., Simon G. Gregory, Deidre Krupp, Sheng Feng, Allison Dorogi, Carol Haynes, Elizabeth Grass, et al. “Epigenetic profiling identifies novel genes for ascending aortic aneurysm formation with bicuspid aortic valves.” Heart Surg Forum 18, no. 4 (August 30, 2015): E134–39. https://doi.org/10.1532/hsf.1247.
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  - Singh, Abanish, Michael A. Babyak, Daniel K. Nolan, Beverly H. Brummett, Rong Jiang, Ilene C. Siegler, William E. Kraus, Svati H. Shah, Redford B. Williams, and Elizabeth R. Hauser. “Gene by stress genome-wide interaction analysis and path analysis identify EBF1 as a cardiovascular and metabolic risk gene.” Eur J Hum Genet 23, no. 6 (June 2015): 854–62. https://doi.org/10.1038/ejhg.2014.189.
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  - Shah, Svati H., and Christopher B. Newgard. “Integrated metabolomics and genomics: systems approaches to biomarkers and mechanisms of cardiovascular disease.” Circ Cardiovasc Genet 8, no. 2 (April 2015): 410–19. https://doi.org/10.1161/CIRCGENETICS.114.000223.
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  - Shah, Asad A., Carol Haynes, Damian M. Craig, Jacqueline Sebek, Elizabeth Grass, Karen Abramson, Elizabeth Hauser, et al. “Genetic variants associated with vein graft stenosis after coronary artery bypass grafting.” Heart Surg Forum 18, no. 1 (February 27, 2015): E1–5. https://doi.org/10.1532/hsf.1214.
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  - Do, Ron, Nathan O. Stitziel, Hong-Hee Won, Anders Berg Jørgensen, Stefano Duga, Pier Angelica Merlini, Adam Kiezun, et al. “Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction.” Nature 518, no. 7537 (February 5, 2015): 102–6. https://doi.org/10.1038/nature13917.
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  - Halim, Sharif A., Megan L. Neely, Karen S. Pieper, Svati H. Shah, William E. Kraus, Elizabeth R. Hauser, Robert M. Califf, Christopher B. Granger, and L Kristin Newby. “Simultaneous consideration of multiple candidate protein biomarkers for long-term risk for cardiovascular events.” Circ Cardiovasc Genet 8, no. 1 (February 2015): 168–77. https://doi.org/10.1161/CIRCGENETICS.113.000490.
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  - Schick, Ursula M., Paul L. Auer, Joshua C. Bis, Honghuang Lin, Peng Wei, Nathan Pankratz, Leslie A. Lange, et al. “Association of exome sequences with plasma C-reactive protein levels in >9000 participants.” Hum Mol Genet 24, no. 2 (January 15, 2015): 559–71. https://doi.org/10.1093/hmg/ddu450.
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  - Ahmad, Tariq, Teresa Wang, Emily C. O’Brien, Marc D. Samsky, John A. Pura, Yuliya Lokhnygina, Joseph G. Rogers, et al. “Effects of left ventricular assist device support on biomarkers of cardiovascular stress, fibrosis, fluid homeostasis, inflammation, and renal injury.” Jacc Heart Fail 3, no. 1 (January 2015): 30–39. https://doi.org/10.1016/j.jchf.2014.06.013.
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  - Li, Josephine H., Sunil Suchindran, Svati H. Shah, William E. Kraus, Geoffrey S. Ginsburg, and Deepak Voora. “SLCO1B1 genetic variants, long-term low-density lipoprotein cholesterol levels and clinical events in patients following cardiac catheterization.” Pharmacogenomics 16, no. 5 (2015): 449–58. https://doi.org/10.2217/pgs.15.2.
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  - Lim, Elaine T., Peter Würtz, Aki S. Havulinna, Priit Palta, Taru Tukiainen, Karola Rehnström, Tõnu Esko, et al. “Distribution and medical impact of loss-of-function variants in the Finnish founder population.” Plos Genet 10, no. 7 (July 2014): e1004494. https://doi.org/10.1371/journal.pgen.1004494.
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  - Mäkinen, Ville-Petteri, Mete Civelek, Qingying Meng, Bin Zhang, Jun Zhu, Candace Levian, Tianxiao Huan, et al. “Integrative genomics reveals novel molecular pathways and gene networks for coronary artery disease.” Plos Genet 10, no. 7 (July 2014): e1004502. https://doi.org/10.1371/journal.pgen.1004502.
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  - Peloso, Gina M., Paul L. Auer, Joshua C. Bis, Arend Voorman, Alanna C. Morrison, Nathan O. Stitziel, Jennifer A. Brody, et al. “Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks.” Am J Hum Genet 94, no. 2 (February 6, 2014): 223–32. https://doi.org/10.1016/j.ajhg.2014.01.009.
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  - Bhattacharya, Sayanti, Christopher B. Granger, Damian Craig, Carol Haynes, James Bain, Robert D. Stevens, Elizabeth R. Hauser, et al. “Validation of the association between a branched chain amino acid metabolite profile and extremes of coronary artery disease in patients referred for cardiac catheterization.” Atherosclerosis 232, no. 1 (January 2014): 191–96. https://doi.org/10.1016/j.atherosclerosis.2013.10.036.
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  - Connelly, Jessica J., Olga A. Cherepanova, Jennifer F. Doss, Themistoclis Karaoli, Travis S. Lillard, Christina A. Markunas, Sarah Nelson, et al. “Epigenetic regulation of COL15A1 in smooth muscle cell replicative aging and atherosclerosis.” Hum Mol Genet 22, no. 25 (December 20, 2013): 5107–20. https://doi.org/10.1093/hmg/ddt365.
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  - Patel, Mahesh J., Bryan C. Batch, Laura P. Svetkey, James R. Bain, Christy Boling Turer, Carol Haynes, Michael J. Muehlbauer, Robert D. Stevens, Christopher B. Newgard, and Svati H. Shah. “Race and sex differences in small-molecule metabolites and metabolic hormones in overweight and obese adults.” Omics : A Journal of Integrative Biology 17, no. 12 (December 2013): 627–35. https://doi.org/10.1089/omi.2013.0031.
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  - Ward-Caviness, Cavin, Carol Haynes, Colette Blach, Elaine Dowdy, Simon G. Gregory, Svati H. Shah, Benjamin D. Horne, William E. Kraus, and Elizabeth R. Hauser. “Gene-smoking interactions in multiple Rho-GTPase pathway genes in an early-onset coronary artery disease cohort.” Hum Genet 132, no. 12 (December 2013): 1371–82. https://doi.org/10.1007/s00439-013-1339-7.
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  - Becker, R. C., D. Voora, and S. H. Shah. “Hemostasis and Thrombosis” 2 (August 29, 2013): 602–11. https://doi.org/10.1016/B978-0-12-382227-7.00052-5.
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  - Batch, Bryan C., Svati H. Shah, Christopher B. Newgard, Christy B. Turer, Carol Haynes, James R. Bain, Michael Muehlbauer, et al. “Branched chain amino acids are novel biomarkers for discrimination of metabolic wellness.” Metabolism: Clinical and Experimental 62, no. 7 (July 2013): 961–69. https://doi.org/10.1016/j.metabol.2013.01.007.
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  - Shah, Asad A., Damian M. Craig, Nicholas D. Andersen, Judson B. Williams, Syamal D. Bhattacharya, Svati H. Shah, Richard L. McCann, and G Chad Hughes. “Risk factors for 1-year mortality after thoracic endovascular aortic repair.” J Thorac Cardiovasc Surg 145, no. 5 (May 2013): 1242–47. https://doi.org/10.1016/j.jtcvs.2012.05.005.
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  - Chan, Kenneth, Riyaz S. Patel, Paul Newcombe, Christopher P. Nelson, Atif Qasim, Stephen E. Epstein, Susan Burnett, et al. “Association between the chromosome 9p21 locus and angiographic coronary artery disease burden: a collaborative meta-analysis.” J Am Coll Cardiol 61, no. 9 (March 5, 2013): 957–70. https://doi.org/10.1016/j.jacc.2012.10.051.
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  - Brummett, Beverly H., Michael A. Babyak, Rong Jiang, Svati H. Shah, Richard C. Becker, Carol Haynes, Megan Chryst-Ladd, et al. “A functional polymorphism in the 5HTR2C gene associated with stress responses also predicts incident cardiovascular events.” Plos One 8, no. 12 (2013): e82781. https://doi.org/10.1371/journal.pone.0082781.
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  - CARDIoGRAMplusC4D Consortium, Nilesh J., Panos Deloukas, Stavroula Kanoni, Christina Willenborg, Martin Farrall, Themistocles L. Assimes, John R. Thompson, et al. “Large-scale association analysis identifies new risk loci for coronary artery disease.” Nat Genet 45, no. 1 (January 2013): 25–33. https://doi.org/10.1038/ng.2480.
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  - Nolan, Daniel, William E. Kraus, Elizabeth Hauser, Yi-Ju Li, Dana K. Thompson, Jessica Johnson, Hsiang-Cheng Chen, et al. “Genome-wide linkage analysis of cardiovascular disease biomarkers in a large, multigenerational family.” Plos One 8, no. 8 (2013): e71779. https://doi.org/10.1371/journal.pone.0071779.
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  - EVOLVE Trial Investigators, Patrick S., Glenn M. Chertow, Geoffrey A. Block, Ricardo Correa-Rotter, Tilman B. Drüeke, Jürgen Floege, William G. Goodman, et al. “Effect of cinacalcet on cardiovascular disease in patients undergoing dialysis.” N Engl J Med 367, no. 26 (December 27, 2012): 2482–94. https://doi.org/10.1056/NEJMoa1205624.
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  - Shah, Svati H., Happy Thakkar, Asad A. Shah, Nicholas D. Andersen, James Bain, Carol Haynes, Michael Muehlbauer, et al. “Metabolites Reporting on Mitochondrial Function Predict Response to Biventricular Pacing.” Circulation 126, no. 21 (November 20, 2012).
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  - Thakkar, Happy, Jonathan P. Piccini, Albert Y. Sun, Carol Haynes, Elizabeth Grass, Kent Nilsson, Jason I. Koontz, Patrick Hranitzky, and Svati H. Shah. “Connexin-43 Gene Variants are Associated with Risk of Ventricular Arrhythmias in Patients with a Depressed Ejection Fraction.” Circulation 126, no. 21 (November 20, 2012).
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  - Shah, Svati H., Sheng Feng, Elizabeth Grass, Carol Haynes, Megan Chryst-Ladd, Damian Craig, Elizabeth R. Hauser, Christopher B. Newgard, William E. Kraus, and Simon G. Gregory. “Integration of Whole Genome Methylation with Metabolomics Identifies Novel Cardiovascular Disease Genes.” Circulation 126, no. 21 (November 20, 2012).
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  - Ward-Caviness, Cavin, Lucas Neas, Carol Haynes, Colette Blach, Elizabeth Burns, Karen LaRocque-Abramson, Elaine Dowdy, et al. “Genetic Variants in the Bone Morphogenic Protein (BMP) Family of Genes Interact with Mobile Source Air Pollution to Increase Risk of Peripheral Arterial Disease.” Circulation 126, no. 21 (November 20, 2012).
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  - Levin, Pamela J., Anthony G. Visco, Svati H. Shah, Rebekah G. Fulton, and Jennifer M. Wu. “Characterizing the phenotype of advanced pelvic organ prolapse.” Female Pelvic Med Reconstr Surg 18, no. 5 (September 2012): 299–302. https://doi.org/10.1097/SPV.0b013e31826a53de.
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  - Wu, Jennifer M., Anthony G. Visco, Elizabeth A. Grass, Damian M. Craig, Rebekah G. Fulton, Carol Haynes, Alison C. Weidner, and Svati H. Shah. “Matrix metalloproteinase-9 genetic polymorphisms and the risk for advanced pelvic organ prolapse.” Obstet Gynecol 120, no. 3 (September 2012): 587–93. https://doi.org/10.1097/AOG.0b013e318262234b.
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  - Shah, Svati H., William E. Kraus, and Christopher B. Newgard. “Metabolomic profiling for the identification of novel biomarkers and mechanisms related to common cardiovascular diseases: form and function.” Circulation 126, no. 9 (August 28, 2012): 1110–20. https://doi.org/10.1161/CIRCULATIONAHA.111.060368.
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  - Gurbel, Paul A., Matthew T. Roe, Joseph A. Jakubowski, Svathi Shah, David Erlinge, Shaun G. Goodman, Kurt Huber, et al. “Translational platelet research in patients with coronary artery disease: what are the major knowledge gaps?” Thromb Haemost 108, no. 1 (July 2012): 12–20. https://doi.org/10.1160/TH12-01-0039.
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  - Shah, Svati H., Jie-Lena Sun, Robert D. Stevens, James R. Bain, Michael J. Muehlbauer, Karen S. Pieper, Carol Haynes, et al. “Baseline metabolomic profiles predict cardiovascular events in patients at risk for coronary artery disease.” Am Heart J 163, no. 5 (May 2012): 844-850.e1. https://doi.org/10.1016/j.ahj.2012.02.005.
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  - Wu, Jennifer M., Anthony G. Visco, Elizabeth A. Grass, Damian M. Craig, Rebekah G. Fulton, Carol Haynes, Cindy L. Amundsen, and Svati H. Shah. “Comprehensive analysis of LAMC1 genetic variants in advanced pelvic organ prolapse.” Am J Obstet Gynecol 206, no. 5 (May 2012): 447.e1-447.e6. https://doi.org/10.1016/j.ajog.2012.01.033.
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  - Davies, Robert W., George A. Wells, Alexandre F. R. Stewart, Jeanette Erdmann, Svati H. Shah, Jane F. Ferguson, Alistair S. Hall, et al. “A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex.” Circ Cardiovasc Genet 5, no. 2 (April 1, 2012): 217–25. https://doi.org/10.1161/CIRCGENETICS.111.961243.
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  - Shah, Asad A., Damian M. Craig, Jacqueline K. Sebek, Carol Haynes, Robert C. Stevens, Michael J. Muehlbauer, Christopher B. Granger, et al. “Metabolic profiles predict adverse events after coronary artery bypass grafting.” J Thorac Cardiovasc Surg 143, no. 4 (April 2012): 873–78. https://doi.org/10.1016/j.jtcvs.2011.09.070.
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  - Nolan, Daniel K., Beth Sutton, Carol Haynes, Jessica Johnson, Jacqueline Sebek, Elaine Dowdy, David Crosslin, et al. “Fine mapping of a linkage peak with integration of lipid traits identifies novel coronary artery disease genes on chromosome 5.” Bmc Genet 13 (February 27, 2012): 12. https://doi.org/10.1186/1471-2156-13-12.
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  - Shah, S. H., D. R. Crosslin, C. S. Haynes, S. Nelson, C. B. Turer, R. D. Stevens, M. J. Muehlbauer, et al. “Branched-chain amino acid levels are associated with improvement in insulin resistance with weight loss.” Diabetologia 55, no. 2 (February 2012): 321–30. https://doi.org/10.1007/s00125-011-2356-5.
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  - Williams, Eric S., Svati H. Shah, Jonathan P. Piccini, Albert Y. Sun, Jason I. Koontz, Sana M. Al-Khatib, and Patrick M. Hranitzky. “Predictors of mortality in patients with chronic kidney disease and an implantable defibrillator: an EPGEN substudy.” Europace 13, no. 12 (December 2011): 1717–22. https://doi.org/10.1093/europace/eur253.
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  - Brunner, Michael P., Svati H. Shah, Damian M. Craig, Robert D. Stevens, Michael J. Muehlbauer, James R. Bain, Christopher B. Newgard, et al. “Effect of heparin administration on metabolomic profiles in samples obtained during cardiac catheterization.” Circ Cardiovasc Genet 4, no. 6 (December 2011): 695–700. https://doi.org/10.1161/CIRCGENETICS.111.960575.
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  - Bhattacharya, Sayanti, Damian Craig, Carol Haynes, Christopher B. Granger, Robert D. Stevens, Elizabeth R. Hauser, William E. Kraus, Christopher B. Newgard, L. K. Newby, and Svati H. Shah. “Peripheral Metabolite Profiles Discriminate Coronary Artery Disease in a Sequential Cohort of Cardiac Catheterization Patients.” Circulation 124, no. 21 (November 22, 2011).
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  - Lappé, Jason M., Benjamin D. Horne, Svati H. Shah, Heidi T. May, Joseph B. Muhlestein, Donald L. Lappé, Abdallah G. Kfoury, et al. “Red cell distribution width, C-reactive protein, the complete blood count, and mortality in patients with coronary disease and a normal comparison population.” Clin Chim Acta 412, no. 23–24 (November 20, 2011): 2094–99. https://doi.org/10.1016/j.cca.2011.07.018.
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  - IBC 50K CAD Consortium, Ehsan. “Large-scale gene-centric analysis identifies novel variants for coronary artery disease.” Plos Genet 7, no. 9 (September 2011): e1002260. https://doi.org/10.1371/journal.pgen.1002260.
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  - Voora, Deepak, John Horton, Svati H. Shah, Linda K. Shaw, and L Kristin Newby. “Polymorphisms associated with in vitro aspirin resistance are not associated with clinical outcomes in patients with coronary artery disease who report regular aspirin use.” Am Heart J 162, no. 1 (July 2011): 166-72.e1. https://doi.org/10.1016/j.ahj.2011.03.026.
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  - Minear, Mollie A., David R. Crosslin, Beth S. Sutton, Jessica J. Connelly, Sarah C. Nelson, Shera Gadson-Watson, Tianyuan Wang, et al. “Polymorphic variants in tenascin-C (TNC) are associated with atherosclerosis and coronary artery disease.” Hum Genet 129, no. 6 (June 2011): 641–54. https://doi.org/10.1007/s00439-011-0959-z.
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  - Shah, Svati H., Laura P. Svetkey, and Christopher B. Newgard. “Branching out for detection of type 2 diabetes.” Cell Metab 13, no. 5 (May 4, 2011): 491–92. https://doi.org/10.1016/j.cmet.2011.04.003.
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  - Laferrère, Blandine, David Reilly, Sara Arias, Nicholas Swerdlow, Prakash Gorroochurn, Baani Bawa, Mousumi Bose, et al. “Differential metabolic impact of gastric bypass surgery versus dietary intervention in obese diabetic subjects despite identical weight loss.” Sci Transl Med 3, no. 80 (April 27, 2011): 80re2. https://doi.org/10.1126/scitranslmed.3002043.
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  - Sun, Albert Y., Jason I. Koontz, Svati H. Shah, Jonathan P. Piccini, Kent R. Nilsson, Damian Craig, Carol Haynes, Simon G. Gregory, Patrick M. Hranitzky, and Geoffrey S. Pitt. “The S1103Y cardiac sodium channel variant is associated with implantable cardioverter-defibrillator events in blacks with heart failure and reduced ejection fraction.” Circ Cardiovasc Genet 4, no. 2 (April 2011): 163–68. https://doi.org/10.1161/CIRCGENETICS.110.958652.
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  - Plant, Sheila R., Greg P. Samsa, Svati H. Shah, and Larry B. Goldstein. “Exploration of a hypothesized independent association of a common 9p21.3 gene variant and ischemic stroke in patients with and without angiographic coronary artery disease.” Cerebrovasc Dis 31, no. 2 (2011): 117–22. https://doi.org/10.1159/000321510.
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  - Assimes, Themistocles L., Hilma Hólm, Sekar Kathiresan, Muredach P. Reilly, Gudmar Thorleifsson, Benjamin F. Voight, Jeanette Erdmann, et al. “Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies.” J Am Coll Cardiol 56, no. 19 (November 2, 2010): 1552–63. https://doi.org/10.1016/j.jacc.2010.06.022.
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  - Wallentin, Lars, Stefan James, Robert F. Storey, Martin Armstrong, Bryan J. Barratt, Jay Horrow, Steen Husted, et al. “Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: a genetic substudy of the PLATO trial.” Lancet 376, no. 9749 (October 16, 2010): 1320–28. https://doi.org/10.1016/S0140-6736(10)61274-3.
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  - Shah, Svati H., Christopher B. Granger, Elizabeth R. Hauser, William E. Kraus, Jie-Lena Sun, Karen Pieper, Charlotte L. Nelson, et al. “Reclassification of cardiovascular risk using integrated clinical and molecular biosignatures: Design of and rationale for the Measurement to Understand the Reclassification of Disease of Cabarrus and Kannapolis (MURDOCK) Horizon 1 Cardiovascular Disease Study.” Am Heart J 160, no. 3 (September 2010): 371-379.e2. https://doi.org/10.1016/j.ahj.2010.06.051.
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  - Gretarsdottir, Solveig, Annette F. Baas, Gudmar Thorleifsson, Hilma Holm, Martin den Heijer, Jean-Paul P. M. de Vries, Steef E. Kranendonk, et al. “Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm.” Nat Genet 42, no. 8 (August 2010): 692–97. https://doi.org/10.1038/ng.622.
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  - Zhang, Lisheng, Jessica J. Connelly, Karsten Peppel, Leigh Brian, Svati H. Shah, Sarah Nelson, David R. Crosslin, et al. “Aging-related atherosclerosis is exacerbated by arterial expression of tumor necrosis factor receptor-1: evidence from mouse models and human association studies.” Hum Mol Genet 19, no. 14 (July 15, 2010): 2754–66. https://doi.org/10.1093/hmg/ddq172.
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  - Shah, Svati H., James R. Bain, Michael J. Muehlbauer, Robert D. Stevens, David R. Crosslin, Carol Haynes, Jennifer Dungan, et al. “Association of a peripheral blood metabolic profile with coronary artery disease and risk of subsequent cardiovascular events.” Circ Cardiovasc Genet 3, no. 2 (April 2010): 207–14. https://doi.org/10.1161/CIRCGENETICS.109.852814.
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  - Tai, E. S., M. L. S. Tan, R. D. Stevens, Y. L. Low, M. J. Muehlbauer, D. L. M. Goh, O. R. Ilkayeva, et al. “Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men.” Diabetologia 53, no. 4 (April 2010): 757–67. https://doi.org/10.1007/s00125-009-1637-8.
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  - Califf, Robert M., Svati H. Shah, and L Kristin Newby. “Biomarker bonanza?” J Am Coll Cardiol 55, no. 12 (March 23, 2010): 1197–99. https://doi.org/10.1016/j.jacc.2009.10.051.
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  - Chen, Hsiang-Cheng, Virginia Byers Kraus, Yi-Ju Li, Sarah Nelson, Carol Haynes, Jessica Johnson, Thomas Stabler, et al. “Genome-wide linkage analysis of quantitative biomarker traits of osteoarthritis in a large, multigenerational extended family.” Arthritis Rheum 62, no. 3 (March 2010): 781–90. https://doi.org/10.1002/art.27288.
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  - Horne, Benjamin D., Elizabeth R. Hauser, Liyong Wang, Joseph B. Muhlestein, Jeffrey L. Anderson, John F. Carlquist, Svati H. Shah, and William E. Kraus. “Validation study of genetic associations with coronary artery disease on chromosome 3q13-21 and potential effect modification by smoking.” Ann Hum Genet 73, no. Pt 6 (November 2009): 551–58. https://doi.org/10.1111/j.1469-1809.2009.00540.x.
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  - Koontz, Jason I., Daniel Haithcock, Valerie Cumbea, Anthony Waldron, Kristie Stricker, Amy Hughes, Kent Nilsson, et al. “Rationale and design of the Duke Electrophysiology Genetic and Genomic Studies (EPGEN) biorepository.” Am Heart J 158, no. 5 (November 2009): 719–25. https://doi.org/10.1016/j.ahj.2009.08.011.
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  - Voora, Deepak, Svati H. Shah, Ivan Spasojevic, Shazia Ali, Carol R. Reed, Benjamin A. Salisbury, and Geoffrey S. Ginsburg. “The SLCO1B1*5 genetic variant is associated with statin-induced side effects.” J Am Coll Cardiol 54, no. 17 (October 20, 2009): 1609–16. https://doi.org/10.1016/j.jacc.2009.04.053.
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  - Rodgers, George P., Jamie B. Conti, Jeffrey A. Feinstein, Brian P. Griffin, Jerry D. Kennett, Svati Shah, Mary Norine Walsh, Eric S. Williams, and Jeffrey L. Williams. “ACC 2009 survey results and recommendations: Addressing the cardiology workforce crisis A report of the ACC board of trustees workforce task force.” J Am Coll Cardiol 54, no. 13 (September 22, 2009): 1195–1208. https://doi.org/10.1016/j.jacc.2009.08.001.
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  - Huffman, Kim M., Svati H. Shah, Robert D. Stevens, James R. Bain, Michael Muehlbauer, Cris A. Slentz, Charles J. Tanner, et al. “Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women.” Diabetes Care 32, no. 9 (September 2009): 1678–83. https://doi.org/10.2337/dc08-2075.
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  - Shah, Svati H., and James A. de Lemos. “Biomarkers and cardiovascular disease: determining causality and quantifying contribution to risk assessment.” Jama 302, no. 1 (July 1, 2009): 92–93. https://doi.org/10.1001/jama.2009.949.
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  - Newgard, C. B., J. An, J. R. Bain, M. J. Muehlbauer, R. D. Stevens, L. F. Lien, A. M. Haqq, et al. “A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance (DOI:10.1016/j.cmet.2009.02.002).” Cell Metabolism 9, no. 6 (May 14, 2009): 565–66. https://doi.org/10.1016/j.cmet.2009.05.001.
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  - Chan, M., R. C. Becker, S. H. Shah, and S. R. Levine. “Coagulopathy and Stroke,” April 8, 2009, 152–69. https://doi.org/10.1002/9781444308198.ch12.
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  - Newgard, Christopher B., Jie An, James R. Bain, Michael J. Muehlbauer, Robert D. Stevens, Lillian F. Lien, Andrea M. Haqq, et al. “A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance.” Cell Metab 9, no. 4 (April 2009): 311–26. https://doi.org/10.1016/j.cmet.2009.02.002.
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  - Shah, Svati H., and Geoffrey S. Pitt. “Genetics of cardiac repolarization.” Nat Genet 41, no. 4 (April 2009): 388–89. https://doi.org/10.1038/ng0409-388.
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  - Gudbjartsson, Daniel F., Unnur S. Bjornsdottir, Eva Halapi, Anna Helgadottir, Patrick Sulem, Gudrun M. Jonsdottir, Gudmar Thorleifsson, et al. “Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction.” Nat Genet 41, no. 3 (March 2009): 342–47. https://doi.org/10.1038/ng.323.
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  - Crosslin, David R., Svati H. Shah, Sarah C. Nelson, Carol S. Haynes, Jessica J. Connelly, Shera Gadson, Pascal J. Goldschmidt-Clermont, et al. “Genetic effects in the leukotriene biosynthesis pathway and association with atherosclerosis.” Hum Genet 125, no. 2 (March 2009): 217–29. https://doi.org/10.1007/s00439-008-0619-0.
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  - Shah, Svati H., Elizabeth R. Hauser, James R. Bain, Michael J. Muehlbauer, Carol Haynes, Robert D. Stevens, Brett R. Wenner, et al. “High heritability of metabolomic profiles in families burdened with premature cardiovascular disease.” Mol Syst Biol 5 (2009): 258. https://doi.org/10.1038/msb.2009.11.
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  - Shah, Svati H., Neil J. Freedman, Lisheng Zhang, David R. Crosslin, David H. Stone, Carol Haynes, Jessica Johnson, et al. “Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis.” Plos Genet 5, no. 1 (January 2009): e1000318. https://doi.org/10.1371/journal.pgen.1000318.
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  - Chen, Hsiang-Cheng, Svati H. Shah, Yi-Ju Li, Thomas V. Stabler, Joanne M. Jordan, and Virginia Byers Kraus. “Inverse association of general joint hypermobility with hand and knee osteoarthritis and serum cartilage oligomeric matrix protein levels.” Arthritis Rheum 58, no. 12 (December 2008): 3854–64. https://doi.org/10.1002/art.24319.
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  - Voora, Deepak, Svati H. Shah, Carol R. Reed, Jun Zhai, David R. Crosslin, Chad Messer, Benjamin A. Salisbury, and Geoffrey S. Ginsburg. “Pharmacogenetic predictors of statin-mediated low-density lipoprotein cholesterol reduction and dose response.” Circ Cardiovasc Genet 1, no. 2 (December 2008): 100–106. https://doi.org/10.1161/CIRCGENETICS.108.795013.
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  - Samad, Zainab, Tracy Y. Wang, Camille G. Frazier, Svati H. Shah, Rowena J. Dolor, and L Kristin Newby. “Closing the gap: treating hypertension in women.” Cardiol Rev 16, no. 6 (November 2008): 305–13. https://doi.org/10.1097/CRD.0b013e31817f9350.
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  - Shah, Svati H., Elizabeth R. Hauser, David Crosslin, Liyong Wang, Carol Haynes, Jessica Connelly, Sarah Nelson, et al. “ALOX5AP variants are associated with in-stent restenosis after percutaneous coronary intervention.” Atherosclerosis 201, no. 1 (November 2008): 148–54. https://doi.org/10.1016/j.atherosclerosis.2008.01.011.
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  - Chen, H. -. C., S. Shah, T. V. Stabler, Y. -. J. Li, and V. B. Kraus. “Biomarkers associated with clinical phenotypes of hand osteoarthritis in a large multigenerational family: the CARRIAGE family study.” Osteoarthritis Cartilage 16, no. 9 (September 2008): 1054–59. https://doi.org/10.1016/j.joca.2007.12.010.
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  - Wang, L., E. R. Hauser, S. H. Shah, D. Seo, P. Sivashanmugam, S. T. Exum, S. G. Gregory, et al. “Polymorphisms of the tumor suppressor gene LSAMP are associated with left main coronary artery disease.” Ann Hum Genet 72, no. Pt 4 (July 2008): 443–53. https://doi.org/10.1111/j.1469-1809.2008.00433.x.
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  - Sutton, Beth S., David R. Crosslin, Svati H. Shah, Sarah C. Nelson, Anthony Bassil, A Brent Hale, Carol Haynes, et al. “Comprehensive genetic analysis of the platelet activating factor acetylhydrolase (PLA2G7) gene and cardiovascular disease in case-control and family datasets.” Hum Mol Genet 17, no. 9 (May 1, 2008): 1318–28. https://doi.org/10.1093/hmg/ddn020.
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  - Connelly, Jessica J., Svati H. Shah, Jennifer F. Doss, Shera Gadson, Sarah Nelson, David R. Crosslin, A Brent Hale, et al. “Genetic and functional association of FAM5C with myocardial infarction.” Bmc Med Genet 9 (April 22, 2008): 33. https://doi.org/10.1186/1471-2350-9-33.
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  - Helgadottir, Anna, Gudmar Thorleifsson, Kristinn P. Magnusson, Solveig Grétarsdottir, Valgerdur Steinthorsdottir, Andrei Manolescu, Gregory T. Jones, et al. “The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm.” Nat Genet 40, no. 2 (February 2008): 217–24. https://doi.org/10.1038/ng.72.
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  - Crowley, Anna Lisa, Manesh R. Patel, Thomas Bashore, Salvador Borges-Neto, James G. Jollis, Robert M. Judd, Raymond J. Kim, Thomas Ryan, Svati H. Shah, and Pamela S. Douglas. “Training cardiovascular specialists in imaging: a curriculum based on fundamental concepts required for multimodal imaging.” Am Heart J 154, no. 5 (November 2007): 838–45. https://doi.org/10.1016/j.ahj.2007.07.007.
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  - Ginsburg, Geoffrey S., Svati H. Shah, and Jeanette J. McCarthy. “Taking cardiovascular genetic association studies to the next level.” J Am Coll Cardiol 50, no. 10 (September 4, 2007): 930–32. https://doi.org/10.1016/j.jacc.2007.05.025.
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  - Helgadottir, A., G. Thorleifsson, A. Manolescu, S. Gretarsdottir, T. Blondal, A. Jonasdottir, A. Sigurdsson, et al. “A common variant on chromosome 9p21 affects the risk of myocardial infarction.” Obstetrical and Gynecological Survey 62, no. 9 (September 1, 2007): 585–87. https://doi.org/10.1097/01.ogx.0000279313.65556.85.
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  - Shah, Svati H. “Gene polymorphisms and susceptibility to coronary artery disease.” Pediatr Blood Cancer 48, no. 7 (June 15, 2007): 738–41. https://doi.org/10.1002/pbc.21110.
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  - Helgadottir, Anna, Gudmar Thorleifsson, Andrei Manolescu, Solveig Gretarsdottir, Thorarinn Blondal, Aslaug Jonasdottir, Adalbjorg Jonasdottir, et al. “A common variant on chromosome 9p21 affects the risk of myocardial infarction.” Science 316, no. 5830 (June 8, 2007): 1491–93. https://doi.org/10.1126/science.1142842.
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  - Wang, Liyong, Elizabeth R. Hauser, Svati H. Shah, Margaret A. Pericak-Vance, Carol Haynes, David Crosslin, Marco Harris, et al. “Peakwide mapping on chromosome 3q13 identifies the kalirin gene as a novel candidate gene for coronary artery disease.” Am J Hum Genet 80, no. 4 (April 2007): 650–63. https://doi.org/10.1086/512981.
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  - Shah, S. H., W. E. Kraus, D. C. Crossman, C. B. Granger, J. L. Haines, C. J. H. Jones, V. Mooser, et al. “Serum lipids in the GENECARD study of coronary artery disease identify quantitative trait loci and phenotypic subsets on chromosomes 3q and 5q.” Ann Hum Genet 70, no. Pt 6 (November 2006): 738–48. https://doi.org/10.1111/j.1469-1809.2006.00288.x.
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  - Connelly, J. J., T. Wang, J. E. Cox, C. Haynes, L. Wang, S. H. Shah, D. R. Crosslin, et al. “GATA2 is associated with familial early-onset coronary artery disease.” Plos Genetics 2, no. 8 (August 25, 2006). https://doi.org/10.1371/journal.pgen.0020139.
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  - Connelly, Jessica J., Tianyuan Wang, Julie E. Cox, Carol Haynes, Liyong Wang, Svati H. Shah, David R. Crosslin, et al. “GATA2 is associated with familial early-onset coronary artery disease.” Plos Genet 2, no. 8 (August 25, 2006): e139. https://doi.org/10.1371/journal.pgen.0020139.
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  - Shah, S. H., D. S. Liebeskind, J. L. Saver, S. Starkman, F. Vinuela, G. Duckwiler, R. Jahan, et al. “Influence of gender on outcomes after intra-arterial thrombolysis for acute ischemic stroke.” Neurology 66, no. 11 (2006): 1745–46. https://doi.org/10.1212/01.wnl.0000218208.31305.84.
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  - Shah, Svati H., Michael A. Schmidt, Hao Mei, William K. Scott, Elizabeth R. Hauser, and Silke Schmidt. “Searching for epistatic interactions in nuclear families using conditional linkage analysis.” Bmc Genet 6 Suppl 1 (December 30, 2005): S148. https://doi.org/10.1186/1471-2156-6-S1-S148.
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  - Frazier, Camille G., Svati H. Shah, Paul W. Armstrong, Manjushri V. Bhapkar, Darren K. McGuire, Zygmunt Sadowski, Arni Kristinsson, et al. “Prevalence and management of hypertension in acute coronary syndrome patients varies by sex: observations from the Sibrafiban versus aspirin to Yield Maximum Protection from ischemic Heart events postacute cOroNary sYndromes (SYMPHONY) randomized clinical trials.” Am Heart J 150, no. 6 (December 2005): 1260–67. https://doi.org/10.1016/j.ahj.2005.08.004.
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  - Shah, S., M. Patel, A. Goyal, A. Amos, R. Baeza, A. Halabi, G. Lam, R. G. Mitchell, G. Oliveira, and A. M. Valente. “Highlights from the American Heart Association Annual Scientific Sessions 2004: November 7-10, 2004.” American Heart Journal 149, no. 2 (January 1, 2005): 240–53. https://doi.org/10.1016/j.ahj.2004.12.001.
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  - Parsons, Elizabeth, L Kristin Newby, Manjushri V. Bhapkar, Karen P. Alexander, Harvey D. White, Svati H. Shah, Cheryl D. Bushnell, Robert M. Califf, and Robert M. Symphony and 2nd Symphony Investigators. “Postmenopausal hormone use in women with acute coronary syndromes.” J Womens Health (Larchmt) 13, no. 8 (October 2004): 863–71. https://doi.org/10.1089/jwh.2004.13.863.
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  - Hauser, Elizabeth R., David C. Crossman, Christopher B. Granger, Jonathan L. Haines, Christopher J. H. Jones, Vincent Mooser, Brendan McAdam, et al. “A genomewide scan for early-onset coronary artery disease in 438 families: the GENECARD Study.” Am J Hum Genet 75, no. 3 (September 2004): 436–47. https://doi.org/10.1086/423900.
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  - Shah, Svati H., Jean-Pierre Dery, Michael C. Fischi, John F. Heitner, Geoffrey A. Kunz, Trip J. Meine, Manesh R. Patel, Anne Marie Valente, Richard E. Waters, and Jonathan Yager. “Highlights from the American College of Cardiology Annual Scientific Sessions 2004: March 9-12, 2004.” Am Heart J 148, no. 2 (August 2004): 254. https://doi.org/10.1016/j.ahj.2004.05.028.
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  - Shah, Svati H., and L Kristin Newby. “C-reactive protein: a novel marker of cardiovascular risk.” Cardiol Rev 11, no. 4 (July 2003): 169–79. https://doi.org/10.1097/01.CRD.0000077906.74217.6E.
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  - Shah, S. H., K. P. Alexander, and E. D. Peterson. “PCI in women.” Cardiology Review 20, no. 3 (March 1, 2003): 24–29.
  - Shah, Svati H., Michael H. Sketch, and James E. Tcheng. “Acute myocardial infarction in a young male while playing paintball.” J Invasive Cardiol 14, no. 11 (November 2002): 713–15.
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- Other Articles
  - Kertai, Miklos D., Yen-Wei Li, Yi-Ju Li, Svati H. Shah, William E. Kraus, Manuel L. Fontes, Mark Stafford-Smith, et al. “G protein-coupled receptor kinase 5 gene polymorphisms are associated with postoperative atrial fibrillation after coronary artery bypass grafting in patients receiving β-blockers.” Circ Cardiovasc Genet, October 2014. https://doi.org/10.1161/CIRCGENETICS.113.000451.
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- Conference Papers
  - Karhausen, Jörn A., Wenjing Qi, Alan M. Smeltz, Yi-Ju Li, Svati H. Shah, William E. Kraus, Joseph P. Mathew, Mihai V. Podgoreanu, Miklos D. Kertai, and Miklos D. Duke Perioperative Genetics Safety Outcomes (PEGASUS) Investigative Team. “Genome-Wide Association Study Links Receptor Tyrosine Kinase Inhibitor Sprouty 2 to Thrombocytopenia after Coronary Artery Bypass Surgery.” In Thromb Haemost, 118:1572–85, 2018. https://doi.org/10.1055/s-0038-1667199.
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  - Denus, S. de, J. L. Rouleau, D. L. Mann, G. S. Huggins, T. P. Cappola, S. H. Shah, J. Keleti, et al. “A pharmacogenetic investigation of intravenous furosemide in decompensated heart failure: a meta-analysis of three clinical trials.” In Pharmacogenomics J, 17:192–200, 2017. https://doi.org/10.1038/tpj.2016.4.
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  - Kelly, J. P., W. Hunter, R. W. McGarrah, D. Craig, C. Haynes, E. J. Velazquez, G. M. Felker, et al. “Novel Protein Glycan Inflammatory Biomarkers Predict Adverse Events in Heart Failure with Preserved Ejection Fraction.” In Journal of Cardiac Failure, 21:S89–S89, 2015. https://doi.org/10.1016/j.cardfail.2015.06.266.
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  - Dokun, Ayotunde O., Mitsuharu Okutsu, Damian Craig, Svati H. Shah, W Schuyler Jones, Douglas A. Marchuk, R John Lye, and Brian H. Annex. “ADAM12 Modifies Severity of Peripheral Arterial Disease; Evidence From Preclinical and Human Studies.” In Circulation, Vol. 128. LIPPINCOTT WILLIAMS & WILKINS, 2013.
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  - Aras, Mandar A., Damian M. Craig, Carol Haynes, James R. Bain, Michael J. Muehlbauer, Robert D. Stevens, Olga Ilkayeva, et al. “Peripheral Metabolite Profiles Predict Cardiomyopathy in a Cohort of Cardiac Catheterization Patients.” In Circulation, Vol. 128. LIPPINCOTT WILLIAMS & WILKINS, 2013.
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  - Li, Josephine H., Sunil Suchindran, Svati H. Shah, William E. Kraus, Geoffrey S. Ginsburg, and Deepak Voora. “Effect of SLCO1B1*5 on Low-Density Lipoprotein Cholesterol Levels and Long-Term Clinical Events in Patients During Statin Therapy Following Cardiac Catheterization.” In Circulation, Vol. 128. LIPPINCOTT WILLIAMS & WILKINS, 2013.
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  - McGarrah, Robert W., Damian M. Craig, Carol Haynes, Z Elaine Dowdy, Svati H. Shah, and William E. Kraus. “High-density Lipoprotein Particle Concentration Has a Stronger Inverse Association With Cardiovascular Events Than High-density Lipoprotein Cholesterol in a Coronary Catheterization Population.” In Circulation, Vol. 128. LIPPINCOTT WILLIAMS & WILKINS, 2013.
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  - Shah, Svati H., Lydia Kwee, Nathan Stitziel, Elizabeth R. Hauser, Carol Haynes, Sekar Kathiresan, Simon G. Gregory, and William E. Kraus. “Rare Variants Identified With Whole Exome Chip Genotyping Are Associated With Insulin Resistance and Glycemic Control.” In Circulation, Vol. 128. LIPPINCOTT WILLIAMS & WILKINS, 2013.
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  - Shah, Svati H., William E. Kraus, Olga Ilkaveva, Robert Stevens, Carol Haynes, Gregory D. Lewis, Christopher B. Newgard, and Robert E. Gerszten. “Metabolomic Profiling in a Human Model of Myocardial Infarction Identifies Novel Early Biomarkers of Cellular Damage.” In Circulation, Vol. 128. LIPPINCOTT WILLIAMS & WILKINS, 2013.
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  - Chan, K., R. S. Patel, P. Newcombe, C. P. Nelson, A. Qasim, S. E. Epstein, S. Burnett, et al. “126 CHROMOSOME 9P21 LOCUS AND ANGIOGRAPHIC CORONARY ARTERY DISEASE BURDEN: A COLLABORATIVE META-ANALYSIS.” In Heart, 99:A75.1-A75. BMJ, 2013. https://doi.org/10.1136/heartjnl-2013-304019.126.
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  - Kraus, William E., Mark P. Donahue, Svati H. Shah, David J. Whellan, Anne Hellkamp, Christopher M. O’Connor, and G. M. Felker. “Association of Small Molecule Metabolic Intermediates that Predict Cardiovascular Mortality with Peak VO2 in a Heart Failure Population.” In Circulation, Vol. 127. LIPPINCOTT WILLIAMS & WILKINS, 2013.
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  - Kraus, William E., Sheng Feng, Elizabeth R. Hauser, Simon G. Gregory, Carol Haynes, Z. E. Dowdy, Damian M. Craig, and Svati H. Shah. “Association of Gene Expression Signatures with Small Molecule Metabolic Intermediates that Predict Cardiovascular Mortality in CATHGEN.” In Circulation, Vol. 127. LIPPINCOTT WILLIAMS & WILKINS, 2013.
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  - Ward-Caviness, Cavin, Lucas Neas, Carol Haynes, Colette Blachi, Wayne Cascio, Robert Devlin, David Diaz-Sanchez, et al. “Mobile Source Air Pollution is Associated with the Plasma Concentration of Multiple Acylcarnitines in a Large Cardiovascular Cohort.” In Circulation, Vol. 127. LIPPINCOTT WILLIAMS & WILKINS, 2013.
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  - Shah, Asad A., Damian M. Craig, Carol Haynes, Jacqueline K. Sebek, Elizabeth Grass, Karen Abramson, Peter K. Smith, et al. “Genome-Wide Association Identifies Genetic Variants Associated With Vein Graft Stenosis After Coronary Artery Bypass Grafting.” In Circulation, Vol. 124. LIPPINCOTT WILLIAMS & WILKINS, 2011.
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  - Shah, Asad A., Damian M. Craig, Judson B. Williams, Syamal D. Bhattacharya, Nicholas D. Andersen, Svati H. Shah, Richard L. McCann, and G Chad Hughes. “PS24. Risk Factors for Non-Procedure Related Mortality One Year after Thoracic Endovascular Aortic Repair.” In Journal of Vascular Surgery, 53:36S-36S. Elsevier BV, 2011. https://doi.org/10.1016/j.jvs.2011.03.077.
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