Scholars@Duke
Sven Eric Jordt

Sven Eric Jordt

Distinguished Professor of Anesthesiology
Anesthesiology
3094, MS27, Durham, NC 27710-3094
3 Genome Ct., MSRB3, Room 6122, Durham, NC 27710-3094

Scholarly Works - Preprints

Chili Pepper Flavourants in "Heat" and "Unflavoured" Oral Nicotine Pouches Marketed in the United States.

Preprint · August 27, 2026 BACKGROUND: In the United States, several states have restricted sales of flavoured tobacco products, including popular menthol- and mint-flavoured Oral Nicotine Pouches (ONP). In response, tobacco companies introduced "unflavoured" ONP containing odorless ... Full text Link to item Cite

Combustible Tobacco-Free Cigarettes Containing a Nicotine Analogue - a Dangerous Design to Counter Smoking Regulations?

Preprint · 2026 Combustible herbal, or “non-tobacco”, cigarettes are often advertised as healthier than tobacco cigarettes and as non-addictive, due to their lack of nicotine. In May 2026, we discovered a US-based website promoting a “non-tobacco” combustible ciga ... Full text Cite

Health Risk Assessment for an Unregulated Neurotoxic Nicotine Analogue in Oral Pouch Products.

Preprint · December 23, 2025 BACKGROUND: Oral pouch products containing nicotine analogues such as 6-methyl nicotine (6MN) were recently introduced to evade federal and state regulations. Preclinical studies demonstrated that 6MN is more toxic than nicotine and binds to nicotinic rece ... Full text Link to item Cite

Absence of Sensory Cooling Activity and Cooling Agents from California's New "Non-Menthol" Cigarettes Marketed in 2025.

Preprint · December 2, 2025 BACKGROUND: Since late 2022, the sale of most flavoured tobacco products has been prohibited in California, including menthol cigarettes. Tobacco companies responded by introducing "non-menthol" cigarettes in which menthol was replaced with WS-3, an odorle ... Full text Link to item Cite

Artificial Sweeteners in US-Marketed Oral Nicotine Pouch Products: Correlation with Nicotine Contents and Effects on Product Preference.

Preprint · January 27, 2024 INTRODUCTION: Artificial sweeteners are listed as ingredients of oral nicotine pouches (ONPs), a new product category with rapidly growing market share. The exact sweetener contents of ONPs remain unknown. Artificial sweeteners in ONPs may facilitate initi ... Full text Link to item Cite

Vagus nerve stimulation rescues persistent pain following orthopedic surgery in adult mice.

Preprint · May 17, 2023 Postoperative pain is a major clinical problem imposing a significant burden on our patients and society. Up to 57% of patients experience persistent postoperative pain 2 years after orthopedic surgery [49]. Although many studies have contributed to the ne ... Full text Link to item Cite