Scholars@Duke
Sweta Patel

Sweta Patel

Associate Professor of Medicine
Medicine, Pulmonary, Allergy, and Critical Care Medicine
sweta.patel@duke.edu
Box 103050, Durham, NC 27710
310 Trent Drive, Room 209, Durham, NC 27710

Scholarly Works - Journal articles

The Reply.

Journal article Am J Med · February 2026 Full text Link to item Cite

Alterations of the Upper Respiratory Microbiome Among Children Living With HIV Infection in Botswana.

Journal article J Infect Dis · October 15, 2025 Children living with HIV (CLWH) are at high risk of colonization and infection by respiratory pathogens, though this risk can be reduced by other microbes in the upper respiratory microbiome. The impact of HIV infection on the pediatric upper respiratory m ... Full text Link to item Cite

Serotype epidemiology and antibiotic resistance of pneumococcal isolates colonizing infants in Botswana (2016-2019).

Journal article PLoS One · 2024 BACKGROUND: In 2012, Botswana introduced 13-valent pneumococcal conjugate vaccine (PCV-13) to its childhood immunization program in a 3+0 schedule, achieving coverage rates of above 90% by 2014. In other settings, PCV introduction has been followed by an i ... Full text Link to item Cite

Non-diphtheriae Corynebacterium species are associated with decreased risk of pneumococcal colonization during infancy.

Journal article ISME J · March 2022 Streptococcus pneumoniae (pneumococcus) is a leading cause of severe infections among children and adults. Interactions between commensal microbes in the upper respiratory tract and S. pneumoniae are poorly described. In this study, we sought to identify i ... Full text Link to item Cite

Evolution of pneumococcal serotype epidemiology in Botswana following introduction of 13-valent pneumococcal conjugate vaccine.

Journal article PLoS One · 2022 Pneumococcal conjugate vaccines reduce the burden of invasive pneumococcal disease, but the sustained effect of these vaccines can be diminished by an increase in disease caused by non-vaccine serotypes. To describe pneumococcal serotype epidemiology in Bo ... Full text Link to item Cite

Effect of Haemophilus influenzae Type b and 13-Valent Pneumococcal Conjugate Vaccines on Childhood Pneumonia Hospitalizations and Deaths in Botswana.

Journal article Clin Infect Dis · July 15, 2021 BACKGROUND: Globally, pneumonia is the leading cause of death among children. Few data exist regarding the effect of Haemophilus influenzae type b (Hib) vaccine and 13-valent pneumococcal conjugate vaccine (PCV-13) on the burden of childhood pneumonia in A ... Full text Link to item Cite

Placental Transfer of Respiratory Syncytial Virus Antibody Among HIV-Exposed, Uninfected Infants.

Journal article J Pediatric Infect Dis Soc · July 13, 2020 BACKGROUND: Maternal human immunodeficiency virus (HIV) infection is associated with lower placental transfer of antibodies specific to several childhood pathogens. Our objective for this study was to evaluate the effect of maternal HIV infection on the pl ... Full text Link to item Cite

Predictors of Poor Outcomes Among Infants With Respiratory Syncytial Virus-associated Acute Lower Respiratory Infection in Botswana.

Journal article Pediatr Infect Dis J · May 2019 Among children 1-23 months of age with respiratory syncytial virus-associated acute lower respiratory infection in Botswana, young age (<6 months), household use of wood as a cooking fuel, moderate or severe malnutrition and oxygen saturation <90% on room ... Full text Link to item Cite

Ethylene Glycol Toxicity in the Setting of Recurrent Ingestion: A Case Report and Literature Review.

Journal article Cureus · April 3, 2019 Ethylene glycol (EG) poisoning is a toxicologic emergency requiring high clinical suspicion and early diagnosis to prevent life-threatening complications. Direct EG quantification methods involve cumbersome and time-consuming laboratory tests of limited ut ... Full text Link to item Cite

Diagnostic accuracy of C-reactive protein for active pulmonary tuberculosis: a meta-analysis.

Journal article Int J Tuberc Lung Dis · September 1, 2017 SETTING: Systematic screening for active pulmonary tuberculosis (PTB) is recommended for high-risk populations, including people living with the human immunodeficiency virus (PLHIV); however, currently recommended TB screening tools are inadequate for most ... Full text Link to item Cite

Cryptococcosis Serotypes Impact Outcome and Provide Evidence of Cryptococcus neoformans Speciation.

Journal article mBio · June 9, 2015 UNLABELLED: Cryptococcus neoformans is a human opportunistic fungal pathogen causing severe disseminated meningoencephalitis, mostly in patients with cellular immune defects. This species is divided into three serotypes: A, D, and the AD hybrid. Our object ... Full text Link to item Cite

Diarrheal Illness and Healthcare Seeking Behavior among a Population at High Risk for Diarrhea in Dhaka, Bangladesh.

Journal article PLoS One · 2015 Diarrhea remains one of the major causes of death in Bangladesh. We studied diarrheal disease risk and healthcare seeking behavior among populations at high risk for diarrhea in Dhaka, Bangladesh. Data were obtained from a cross-sectional survey conducted ... Full text Link to item Cite

Memory B cell responses to Vibrio cholerae O1 lipopolysaccharide are associated with protection against infection from household contacts of patients with cholera in Bangladesh.

Journal article Clin Vaccine Immunol · June 2012 Vibrio cholerae O1 causes cholera, a dehydrating diarrheal disease. We have previously shown that V. cholerae-specific memory B cell responses develop after cholera infection, and we hypothesize that these mediate long-term protective immunity against chol ... Full text Link to item Cite

Memory B cell and other immune responses in children receiving two doses of an oral killed cholera vaccine compared to responses following natural cholera infection in Bangladesh.

Journal article Clin Vaccine Immunol · May 2012 Current oral cholera vaccines induce lower protective efficacy and shorter duration of protection against cholera than wild-type infection provides, and this difference is most pronounced in young children. Despite this, there are limited data comparing im ... Full text Link to item Cite

Comparison of memory B cell, antibody-secreting cell, and plasma antibody responses in young children, older children, and adults with infection caused by Vibrio cholerae O1 El Tor Ogawa in Bangladesh.

Journal article Clin Vaccine Immunol · August 2011 Children bear a large component of the global burden of cholera. Despite this, little is known about immune responses to cholera in children, especially those under 5 years of age. Cholera vaccine studies have demonstrated lower long-term protective effica ... Full text Link to item Cite

Mixed infections and In Vivo evolution in the human fungal pathogen Cryptococcus neoformans.

Journal article mBio · May 18, 2010 Koch's postulates are criteria establishing a causal relationship between a microbe and a disease that lead to the assumption that diseases are caused by a single strain or its evolved forms. Cryptococcus neoformans is a life-threatening human fungal patho ... Full text Link to item Cite

Diploids in the Cryptococcus neoformans serotype A population homozygous for the alpha mating type originate via unisexual mating.

Journal article PLoS Pathog · January 2009 The ubiquitous environmental human pathogen Cryptococcus neoformans is traditionally considered a haploid fungus with a bipolar mating system. In nature, the alpha mating type is overwhelmingly predominant over a. How genetic diversity is generated and mai ... Full text Link to item Cite

Impact of mating type, serotype, and ploidy on the virulence of Cryptococcus neoformans.

Journal article Infect Immun · July 2008 Hybridization with polyploidization is a significant biological force driving evolution. The effect of combining two distinct genomes in one organism on the virulence potential of pathogenic fungi is not clear. Cryptococcus neoformans, the most common caus ... Full text Link to item Cite

alpha AD alpha hybrids of Cryptococcus neoformans: evidence of same-sex mating in nature and hybrid fitness.

Journal article PLoS Genet · October 2007 Cryptococcus neoformans is a ubiquitous human fungal pathogen that causes meningoencephalitis in predominantly immunocompromised hosts. The fungus is typically haploid, and sexual reproduction involves two individuals with opposite mating types/sexes, alph ... Full text Link to item Cite