Scholars@Duke
Talal I Dahhan

Talal I Dahhan

Adjunct Associate Professor in the Department of Medicine
Medicine, Pulmonary, Allergy, and Critical Care Medicine
talal.dahhan@duke.edu
DUMC 102351 - 330 Trent Dr, Durham, NC 27710
330 Trent Dr, Durham, NC 27710

Selected Publications

Clinical outcomes and safety of sotatercept in pulmonary arterial hypertension: A systematic review and meta-analysis of randomized controlled trials.

Journal Article Vascul Pharmacol · September 2025 INTRODUCTION: Pulmonary arterial hypertension (PAH) remains a life-threatening condition characterized by high morbidity and mortality. However, recent therapeutic advancements have offered a paradigm shift in terms of therapeutic goals. METHODS: We conduc ... Full text Link to item Cite

Evaluation of patients with severe pulmonary hypertension and a range of comorbidities prescribed inhaled treprostinil.

Journal Article JHLT Open · November 2024 BACKGROUND: Patients with pulmonary arterial hypertension (PAH) and additional cardiac or pulmonary comorbidities have a poor prognosis and are frequently excluded from clinical trials. The purpose of this study was to evaluate outcomes of patients with pu ... Full text Open Access Link to item Cite

Variation in Sedative and Analgesic Use During the COVID-19 Pandemic and Associated Outcomes

Journal Article Chest Critical Care · March 1, 2024 Background: Providing analgesia and sedation is an essential component of caring for many mechanically ventilated patients. The selection of analgesic and sedative medications during the COVID-19 pandemic, and the impact of these sedation practices on pati ... Full text Cite

The Association of Post-Lung Transplant Pulmonary Embolism With the Development of Chronic Lung Allograft Dysfunction.

Conference Transplant Direct · February 2024 BACKGROUND: Pulmonary embolism (PE) is a rare yet serious postoperative complication for lung transplant recipients (LTRs). The association between timing and severity of PE and the development of chronic allograft lung dysfunction (CLAD) has not been desc ... Full text Link to item Cite

Chronic Thromboembolic Pulmonary Hypertension

Journal Article Current Respiratory Medicine Reviews · January 1, 2024 While the majority of patients have complete resolution of their acute pulmonary embolism (PE) after an adequate course of anticoagulation, some patients remain symptomatic with evidence of chronic PE. Chronic Thromboembolic Pulmonary Hypertension (CTEPH) ... Full text Cite

The Saudi Critical Care Society practice guidelines on the management of COVID-19 in the ICU: Therapy section.

Journal Article J Infect Public Health · January 2022 BACKGROUND: The rapid increase in coronavirus disease 2019 (COVID-19) cases during the subsequent waves in Saudi Arabia and other countries prompted the Saudi Critical Care Society (SCCS) to put together a panel of experts to issue evidence-based recommend ... Full text Link to item Cite

Clinical characteristics and outcomes of critically ill mechanically ventilated COVID-19 patients receiving interleukin-6 receptor antagonists and corticosteroid therapy: a preliminary report from a multinational registry.

Journal Article Eur J Med Res · October 2, 2021 BACKGROUND: Interleukin-6 receptor antagonists (IL-6RAs) and steroids are emerging immunomodulatory therapies for severe and critical coronavirus disease (COVID-19). In this preliminary report, we aim to describe the epidemiology, clinical characteristics, ... Full text Link to item Cite

Use of hospital resources in the care of patients with intermediate risk pulmonary embolism.

Journal Article Eur Heart J Acute Cardiovasc Care · May 11, 2021 BACKGROUND: Risk stratification and management of hemodynamically stable pulmonary embolism remains challenging. Professional societies have published stratification schemes, but little is known about the management of patients with intermediate risk pulmo ... Full text Link to item Cite

Experience in Transitioning From Parenteral Prostacyclins to Selexipag in Pulmonary Arterial Hypertension.

Journal Article J Cardiovasc Pharmacol · April 2020 Parenteral prostacyclin therapies remain first-line therapy for patients with pulmonary arterial hypertension (PAH) with class IV symptoms. In selected patients who have been clinically stabilized, switching to selexipag, a chemically distinct prostacyclin ... Full text Open Access Link to item Cite

Identification, diagnosis, treatment, and in-hospital outcomes of acute pulmonary embolism: Results from a single integrated health system.

Journal Article Am Heart J · October 2019 BACKGROUND: Although the high-risk acute pulmonary embolism (PE) population has been described, little is known about the contemporary inpatient experience and practice patterns of the PE population as a whole. METHODS: All patients with a diagnosis of acu ... Full text Link to item Cite

Evaluation of Rescue Thrombolysis in Cardiac Arrest Secondary to Suspected or Confirmed Pulmonary Embolism.

Journal Article Ann Pharmacother · July 2019 BACKGROUND: Pulmonary embolism (PE) is the associated cause of unexplained cardiac arrest in 5% to 13% of patients. Although thrombolytic agents have been studied, patient outcomes during cardiac arrest are lacking. OBJECTIVE: The purpose of this study was ... Full text Link to item Cite

Outcomes of lung disease-associated pulmonary hypertension and impact of elevated pulmonary vascular resistance.

Journal Article Respir Med · April 2019 BACKGROUND: The clinical characteristics, hemodynamic changes and outcomes of lung disease-associated pulmonary hypertension (LD-PH) are poorly defined. METHODS: A prospective cohort of PH patients undergoing initial hemodynamic assessment was collected, f ... Full text Link to item Cite

Clinical Features and Outcomes of Patients with Sarcoidosis-associated Pulmonary Hypertension.

Journal Article Sci Rep · March 11, 2019 The presence of pulmonary hypertension (PH) significantly worsens outcomes in patients with advanced sarcoidosis, but its optimal management is unknown. We aimed to characterize a large sarcoidosis-associated pulmonary hypertension (SAPH) cohort to better ... Full text Open Access Link to item Cite

Echocardiography in the Risk Assessment of Acute Pulmonary Embolism.

Journal Article Semin Respir Crit Care Med · February 2017 Acute pulmonary embolism (PE) is a major cause of morbidity and mortality and is classified as massive (high risk), submassive (intermediate risk), or nonmassive (low risk) based on the hemodynamic status and clinical characteristics of the patient. At thi ... Full text Link to item Cite

Clinical and echocardiographic predictors of mortality in acute pulmonary embolism.

Journal Article Cardiovasc Ultrasound · October 28, 2016 PURPOSE: The aim of this study was to evaluate the utility of adding quantitative assessments of cardiac function from echocardiography to clinical factors in predicting the outcome of patients with acute pulmonary embolism (PE). METHODS: Patients with a d ... Full text Open Access Link to item Cite

Clinical and echocardiographic predictors of mortality in acute pulmonary embolism

Journal Article Cardiovascular ultrasound · October 28, 2016 PURPOSE: The aim of this study was to evaluate the utility of adding quantitative assessments of cardiac function from echocardiography to clinical factors in predicting the outcome of patients with acute pulmonary embolism (PE). METHODS: Patients with a d ... Cite

Abnormalities in hyperpolarized (129)Xe magnetic resonance imaging and spectroscopy in two patients with pulmonary vascular disease.

Journal Article Pulm Circ · March 2016 The diagnosis of pulmonary vascular disease (PVD) is usually based on hemodynamic and/or clinical criteria. Noninvasive imaging of the heart and proximal vasculature can also provide useful information. An alternate approach to such criteria in the diagnos ... Full text Link to item Cite

Pulmonary Embolism

Journal Article · January 1, 2013 Full text Cite

Recurrent thyroid storm induced by heretofore unrecognised causes in a patient with thyroid cancer

Journal Article BMJ Case Reports · April 15, 2009 An unusual encounter of a thyroid storm, on two separate occasions, is reported in a patient with metastatic differentiated thyroid cancer following initially direct trauma to, and later tumour embolisation of, a metastatic skeletal lesion. Shortly after a ... Full text Cite