Thomas Myron Coffman

Journal article Am J Physiol Renal Physiol · March 2010 Featured Publication Previous studies have shown that Akita mice bearing the Ins2(+/C96Y) mutation have significant advantages as a type I diabetes platform for developing models of diabetic nephropathy (DN; Gurley SB, Clare SE, Snow KP, Hu A, Meyer TW, Coffman TM. Am J Physio ... Full text Link to item Cite

The impact of microsomal prostaglandin e synthase 1 on blood pressure is determined by genetic background.

Journal article Hypertension · February 2010 Featured Publication Prostaglandin (PG)E(2) has multiple actions that may affect blood pressure. It is synthesized from arachidonic acid by the sequential actions of phospholipases, cyclooxygenases, and PGE synthases. Although microsomal PGE synthase (mPGES)1 is the only genet ... Full text Link to item Cite

Vascular endothelial growth factor receptor 2 controls blood pressure by regulating nitric oxide synthase expression.

Journal article Hypertension · September 2009 Featured Publication Drugs and antibodies that interrupt vascular endothelial growth factor (VEGF) signaling pathways improve outcomes in patients with a variety of cancers by inhibiting tumor angiogenesis. A major adverse effect of these treatments is hypertension, suggesting ... Full text Link to item Cite

Glomerular type 1 angiotensin receptors augment kidney injury and inflammation in murine autoimmune nephritis.

Journal article J Clin Invest · April 2009 Featured Publication Studies in humans and animal models indicate a key contribution of angiotensin II to the pathogenesis of glomerular diseases. To examine the role of type 1 angiotensin (AT1) receptors in glomerular inflammation associated with autoimmune disease, we genera ... Full text Link to item Cite

Disruption of the Ang II type 1 receptor promotes longevity in mice.

Journal article J Clin Invest · March 2009 Featured Publication The renin-angiotensin system plays a role in the etiology of hypertension and the pathophysiology of cardiac and renal diseases in humans. Ang II is the central product of this system and is involved in regulating immune responses, inflammation, cell growt ... Full text Link to item Cite

Kidney in hypertension: guyton redux.

Journal article Hypertension · April 2008 Featured Publication Full text Link to item Cite

The renin-angiotensin system and diabetic nephropathy.

Journal article Semin Nephrol · March 2007 Featured Publication The renin-angiotensin system (RAS) has key regulatory functions for blood pressure and fluid homeostasis. In addition, dysregulation of the system can have maladaptive effects to promote tissue injury in chronic diseases such as hypertension, heart failure ... Full text Link to item Cite

Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney.

Journal article Proc Natl Acad Sci U S A · November 21, 2006 Featured Publication Essential hypertension is a common disease, yet its pathogenesis is not well understood. Altered control of sodium excretion in the kidney may be a key causative feature, but this has been difficult to test experimentally, and recent studies have challenge ... Full text Link to item Cite

A WNK in the kidney controls blood pressure.

Journal article Nat Genet · October 2006 Featured Publication Full text Link to item Cite

Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice.

Journal article J Clin Invest · August 2006 Featured Publication The carboxypeptidase ACE2 is a homologue of angiotensin-converting enzyme (ACE). To clarify the physiological roles of ACE2, we generated mice with targeted disruption of the Ace2 gene. ACE2-deficient mice were viable, fertile, and lacked any gross structu ... Full text Link to item Cite

Prostacyclin protects against elevated blood pressure and cardiac fibrosis.

Journal article Cell Metab · September 2005 Featured Publication Specific inhibitors of COX-2 have been associated with increased risk for cardiovascular complications. These agents reduce prostacyclin (PGI2) without affecting production of thromboxane (Tx) A2. While this abnormal pattern of eicosanoid generation has be ... Full text Link to item Cite

Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system.

Journal article J Clin Invest · April 2005 Featured Publication Angiotensin II, acting through type 1 angiotensin (AT(1)) receptors, has potent effects that alter renal excretory mechanisms. Control of sodium excretion by the kidney has been suggested to be the critical mechanism for blood pressure regulation by the re ... Full text Link to item Cite

E-prostanoid-3 receptors mediate the proinflammatory actions of prostaglandin E2 in acute cutaneous inflammation.

Journal article J Immunol · July 15, 2004 Featured Publication PGs are derived from arachidonic acid by PG-endoperoxide synthase (PTGS)-1 and PTGS2. Although enhanced levels of PGs are present during acute and chronic inflammation, a functional role for prostanoids in inflammation has not been clearly defined. Using a ... Full text Link to item Cite

Proinflammatory actions of thromboxane receptors to enhance cellular immune responses.

Journal article J Immunol · December 15, 2003 Featured Publication Metabolism of arachidonic acid by the cyclo-oxygenase (COX) pathway generates a family of prostanoid mediators. Nonsteroidal anti-inflammatory drugs (NSAIDs) act by inhibiting COX, thereby reducing prostanoid synthesis. The efficacy of these agents in redu ... Full text Link to item Cite

Eicosanoids: lipid mediators of inflammation in transplantation.

Journal article Springer Semin Immunopathol · September 2003 Featured Publication Eicosanoids are a family of lipid mediators derived from the metabolism of arachidonic acid. Eicosanoids, such as prostanoids and leukotrienes, have a wide range of biological actions including potent effects on inflammation and immunity. It has been almos ... Full text Link to item Cite

Rho kinase promotes alloimmune responses by regulating the proliferation and structure of T cells.

Journal article J Immunol · July 1, 2003 Featured Publication Coordinated rearrangements of the actin-myosin cytoskeleton facilitate early and late events in T cell activation and signal transduction. As many important features of cell shape rearrangement involve small GTP-binding proteins, we examined the contributi ... Full text Link to item Cite