Scholars@Duke
Terence Z. Wong

Terence Z. Wong

Professor of Radiology
Radiology, Nuclear Medicine
terence.wong@duke.edu
Box 3949 Med Ctr, Durham, NC 27710
Dept of Radiology, Div of Nucl, DMP Room 1W18, Durham, NC 27710

Scholarly Works - Journal articles

The GIANT trial (ECOG-ACRIN EA2186) methods paper: A randomized phase II study of gemcitabine and nab-paclitaxel compared with 5-fluorouracil, leucovorin, and liposomal irinotecan in older patients with treatment-naïve metastatic pancreatic cancer - defining a new treatment option for older vulnerable patients.

Journal article J Geriatr Oncol · April 2023 INTRODUCTION: Pancreatic cancer is the fourth leading cause of cancer-related death in the US with an increasing incidence in older adults (OA) over age 70. There are currently no treatment guidelines for OA with metastatic pancreatic cancer (mPCA) and sel ... Full text Link to item Cite

Increased tryptophan, but not increased glucose metabolism, predict resistance of pembrolizumab in stage III/IV melanoma.

Journal article Oncoimmunology · 2023 Clinical trials of combined IDO/PD1 blockade in metastatic melanoma (MM) failed to show additional clinical benefit compared to PD1-alone inhibition. We reasoned that a tryptophan-metabolizing pathway other than the kynurenine one is essential. We immunohi ... Full text Open Access Link to item Cite

Tumor protein p53 mutation in archived tumor samples from a 12-year survivor of stage 4 pancreatic ductal adenocarcinoma may predict long-term survival with DeltaRex-G: A case report and literature review.

Journal article Mol Clin Oncol · September 2021 DeltaRex-G is a replication-incompetent amphotropic murine leukemia virus-based retroviral vector that displays a collagen-matrix-targeting decapeptide on its surface envelope protein, gp70, and encodes a cytocidal 'dominant negative', i.e. a truncated con ... Full text Open Access Link to item Cite

18F-FDG-PET/CT Imaging for Gastrointestinal Malignancies.

Journal article Radiol Clin North Am · September 2021 Gastrointestinal malignancies encompass a variety of primary tumor sites, each with different staging criteria and treatment approaches. In this review we discuss technical aspects of 18F-FDG-PET/CT scanning to optimize information from both the PET and co ... Full text Open Access Link to item Cite

Neuroendocrine and Adrenal Tumors, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.

Journal article J Natl Compr Canc Netw · July 28, 2021 The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Neuroendocrine and Adrenal Gland Tumors focus on the diagnosis, treatment, and management of patients with neuroendocrine tumors (NETs), adrenal tumors, pheochromocytomas, paragangliom ... Full text Link to item Cite

Evaluating Alzheimer Disease With Flortaucipir and Florbetapir PET: A Clinical Case Series.

Journal article Clin Nucl Med · July 1, 2021 Early, accurate diagnosis of Alzheimer disease (AD) is essential but remains challenging. Neuropathological hallmarks of AD are β-amyloid neuritic plaques and tau protein neurofibrillary tangles. 18F-Florbetapir is one of several available PET tracers for ... Full text Open Access Link to item Cite

Complete Evaluation of Dementia: PET and MRI Correlation and Diagnosis for the Neuroradiologist.

Journal article AJNR Am J Neuroradiol · June 2021 This article will familiarize neuroradiologists with the pathophysiology, clinical findings, and standard MR imaging and PET imaging features of multiple forms of dementia as well as new emerging techniques. Cases were compiled from multiple institutions w ... Full text Open Access Link to item Cite

Implementation of a Hepatic Artery Infusion Program: Initial Patient Selection and Perioperative Outcomes of Concurrent Hepatic Artery Infusion and Systemic Chemotherapy for Colorectal Liver Metastases.

Journal article Ann Surg Oncol · December 2020 BACKGROUND: Hepatic artery infusion (HAI) combined with systemic chemotherapy is a treatment strategy for patients with unresectable liver-only or liver-dominant colorectal liver metastases (CRLM). Although HAI has previously been performed in only a few c ... Full text Link to item Cite

Early 18F-FDG-PET Response During Radiation Therapy for HPV-Related Oropharyngeal Cancer May Predict Disease Recurrence.

Journal article Int J Radiat Oncol Biol Phys · November 15, 2020 PURPOSE: Early indication of treatment outcome may guide therapeutic de-escalation strategies in patients with human papillomavirus (HPV)-related oropharyngeal cancer (OPC). This study investigated the relationships between tumor volume and 18F-fluorodeoxy ... Full text Open Access Link to item Cite

Pilot Study of [18F] Fluorodeoxyglucose Positron Emission Tomography (FDG-PET)/Magnetic Resonance Imaging (MRI) for Staging of Muscle-invasive Bladder Cancer (MIBC).

Journal article Clin Genitourin Cancer · October 2020 INTRODUCTION: Computed tomography (CT) has limited diagnostic accuracy for staging of muscle-invasive bladder cancer (MIBC). [18F] Fluorodeoxyglucose positron emission tomography (FDG-PET)/magnetic resonance imaging (MRI) is a novel imaging modality incorp ... Full text Open Access Link to item Cite

Quality Improvement Initiatives to Assess and Improve PET/CT Injection Infiltration Rates at Multiple Centers.

Journal article J Nucl Med Technol · December 2019 PET/CT radiotracer infiltration is not uncommon and is often outside the imaging field of view. Infiltration can negatively affect image quality, image quantification, and patient management. Until recently, there has not been a simple way to routinely pra ... Full text Link to item Cite

Changes on Midchemoradiation Therapy Fluorodeoxyglucose Positron Emission Tomography for Cervical Cancer Are Associated with Prognosis.

Journal article Int J Radiat Oncol Biol Phys · October 1, 2019 PURPOSE: To assess whether radiographic and metabolic changes on midchemoradiation therapy (CRT) fluorodeoxyglucose positron emission tomography and computed tomography (FDG-PET/CT) for cervical cancer predict outcome. METHODS AND MATERIALS: Women with Int ... Full text Link to item Cite

Molecular Imaging and Therapy for Neuroendocrine Tumors.

Journal article Curr Treat Options Oncol · August 29, 2019 Neuroendocrine tumors (NETs) are relatively rare, with 12,000-15,000 new cases diagnosed annually in the USA. Although NETs are a diverse group of neoplasms, they share common molecular targets that can be exploited using nuclear medicine techniques for bo ... Full text Link to item Cite

Visual and semiquantitative analysis of 82Rb uptake in malignant tumors on PET/CT: first systematic analysis.

Journal article Nucl Med Commun · May 2019 OBJECTIVE: The objective of this study was to analyze the uptake of rubidium in malignant tumors. PARTICIPANTS AND METHODS: Sixteen malignant lesions were included. Two radiologists compared each lesion to four references (subcutaneous fat, lung, mediastin ... Full text Link to item Cite

Financial Management Skills in Aging, MCI and Dementia: Cross Sectional Relationship to 18F-Florbetapir PET Cortical β-amyloid Deposition.

Journal article J Prev Alzheimers Dis · 2019 BACKGROUND: There is a need to more fully characterize financial capacity losses in the preclinical and prodromal stages of Alzheimer's disease (AD) and their pathological substrates. OBJECTIVES: To test the association between financial skills and cortica ... Full text Link to item Cite

Predictors of Survival in 211 Patients with Stage IV Pulmonary and Gastroenteropancreatic MIBG-Positive Neuroendocrine Tumors Treated with 131I-MIBG.

Journal article J Nucl Med · November 2018 This retrospective analysis identifies predictors of survival in a cohort of patients with meta-iodobenzylguanidine (MIBG)-positive stage IV pulmonary and gastroenteropancreatic neuroendocrine tumor (P/GEP-NET) treated with 131I-MIBG therapy, to inform tre ... Full text Open Access Link to item Cite

NCCN Guidelines Insights: Neuroendocrine and Adrenal Tumors, Version 2.2018.

Journal article J Natl Compr Canc Netw · June 2018 The NCCN Guidelines for Neuroendocrine and Adrenal Tumors provide recommendations for the management of adult patients with neuroendocrine tumors (NETs), adrenal gland tumors, pheochromocytomas, and paragangliomas. Management of NETs relies heavily on the ... Full text Link to item Cite

Pitfalls of post-treatment PET after de-intensified chemoradiotherapy for HPV-associated oropharynx cancer: Secondary analysis of a phase 2 trial.

Journal article Oral Oncol · March 2018 OBJECTIVES: We evaluated patterns of nodal response and positive predictive value (PPV) of 3 month post-treatment PET in patients with HPV-associated oropharyngeal cancer treated on a multi-institutional de-intensification trial. MATERIALS AND METHODS: Eli ... Full text Open Access Link to item Cite

Early cardiac perfusion defects after left-sided radiation therapy for breast cancer: is there a volume response?

Journal article Breast Cancer Res Treat · July 2017 PURPOSE: Cardiac single-photon emission computed tomography (SPECT) is often used to identify defects in myocardial perfusion due to atherosclerotic coronary artery disease. It was also used in studies to evaluate radiation therapy (RT)-associated cardiac ... Full text Link to item Cite

Integration of PET/MR Hybrid Imaging into Radiation Therapy Treatment.

Journal article Magn Reson Imaging Clin N Am · May 2017 Hybrid PET/MR imaging is in early development for treatment planning. This article briefly reviews research and clinical applications of PET/MR imaging in radiation oncology. With improvements in workflow, more specific tracers, and fast and robust acquisi ... Full text Link to item Cite

Hybrid PET/MR: State-of-the-Art and Future Challenges.

Journal article Magn Reson Imaging Clin N Am · May 2017 Full text Link to item Cite

Patient and tumor characteristics predictive of an elevated hepatopulmonary shunt fraction before radioembolization of hepatic tumors.

Journal article Nucl Med Commun · September 2016 OBJECTIVE: To determine whether any patient or hepatic tumor characteristics are predictive of hepatopulmonary shunt fraction when performed before radioembolization. MATERIALS AND METHODS: A retrospective review was performed on 190 patients who underwent ... Full text Link to item Cite

ACR-ASNR Practice Parameter for Brain PET/CT Imaging Dementia.

Journal article Clin Nucl Med · February 2016 This practice parameter is for both FDG and amyloid brain PET or PET/computed tomography (CT) for patients with cognitive decline, and has been developed collaboratively by the American College of Radiology (ACR) and the American Society for Neuroradiology ... Full text Link to item Cite

MR-PET evaluation of 1-month post-ablation therapy for hepatocellular carcinoma: preliminary observations.

Journal article Abdom Imaging · August 2015 PURPOSE: The purpose of the study was to evaluate the feasibility and protocol optimization of whole-body hybrid MR-PET system performed 1-month after post-locoregional thermoablative procedures for hepatocellular carcinomas (HCCs). MATERIALS AND METHODS: ... Full text Link to item Cite

MR-PET co-registration in upper abdominal imaging: quantitative comparison of two different T1-weighted gradient echo sequences: initial observations.

Journal article Abdom Imaging · August 2015 PURPOSE: The purpose of this study is to quantitatively compare the accuracy of spatial registration of Cartesian breath-hold 3D-GRE and non-respiratory-triggered free-breathing radial 3D-GRE images with PET data acquisition on whole-body hybrid MR-PET sys ... Full text Link to item Cite

Impact of delayed lymphoscintigraphy for sentinel lymphnode biopsy for breast cancer.

Journal article J Surg Oncol · June 2015 BACKGROUND: Despite universal adoption of sentinel lymph node biopsy (SLNB) for breast cancer, there remains no standardized protocol for preoperative lymphoscintographic assessment of sentinel nodes. Both immediate and delayed lymphoscintigraphy are curre ... Full text Link to item Cite

Florbetapir F 18 amyloid PET and 36-month cognitive decline: a prospective multicenter study.

Journal article Mol Psychiatry · September 2014 This study was designed to evaluate whether subjects with amyloid beta (Aβ) pathology, detected using florbetapir positron emission tomorgraphy (PET), demonstrated greater cognitive decline than subjects without Aβ pathology. Sixty-nine cognitively normal ... Full text Link to item Cite

Impact of ¹⁸F-florbetapir PET imaging of β-amyloid neuritic plaque density on clinical decision-making.

Journal article Neurocase · August 2014 ¹⁸F-florbetapir positron emission tomography (PET) imaging of the brain is now approved by the Food and Drug Administration (FDA) approved for estimation of β -amyloid neuritic plaque density when evaluating patients with cognitive impairment. However, its ... Full text Link to item Cite

A phase 1 study of 131I-CLR1404 in patients with relapsed or refractory advanced solid tumors: dosimetry, biodistribution, pharmacokinetics, and safety.

Journal article PLoS One · 2014 INTRODUCTION: (131)I-CLR1404 is a small molecule that combines a tumor-targeting moiety with a therapeutic radioisotope. The primary aim of this phase 1 study was to determine the administered radioactivity expected to deliver 400 mSv to the bone marrow. T ... Full text Link to item Cite

PET with 62Cu-ATSM and 62Cu-PTSM is a useful imaging tool for hypoxia and perfusion in pulmonary lesions.

Journal article AJR Am J Roentgenol · November 2013 OBJECTIVE: Hypoxia is a characteristic of many tumors and portends a worse prognosis in lung, cervical, prostate, and rectal cancers. Unlike the others, lung cancers present a unique challenge in measuring hypoxia, with invasive biopsies and higher rates o ... Full text Link to item Cite

Cortical β-amyloid levels and neurocognitive performance after cardiac surgery.

Journal article BMJ Open · September 20, 2013 INTRODUCTION: Neurological and neurocognitive dysfunction occurs frequently in the large number of increasingly elderly patients undergoing cardiac surgery every year. Perioperative cognitive deficits have been shown to persist after discharge and up to se ... Full text Open Access Link to item Cite

Mapping the effects of ApoE4, age and cognitive status on 18F-florbetapir PET measured regional cortical patterns of beta-amyloid density and growth.

Journal article Neuroimage · September 2013 BACKGROUND: Although it is well known that many clinical and genetic factors have been associated with beta-amyloid deposition, few studies have examined the interactions of such factors across different stages of Alzheimer's pathogenesis. METHODS: We used ... Full text Link to item Cite

Positron emission tomography in radiation treatment planning: the potential of metabolic imaging.

Journal article Radiol Clin North Am · September 2013 Treatment planning and delivery of radiation therapy has benefited from new technology and techniques. Given the convergence of the improved ability to image active tumor and the delivery of radiation to very specific targets, the implications for a tighte ... Full text Link to item Cite

FDG-PET/CT characterization of adrenal nodules: diagnostic accuracy and interreader agreement using quantitative and qualitative methods.

Journal article Acad Radiol · August 2013 PURPOSE: To determine interreader agreement and diagnostic accuracy across varying levels of reader experience using qualitative and quantitative methods of evaluating adrenal nodules using ((18)F)-fluorodeoxyglucose-positron emission tomography/computed t ... Full text Link to item Cite

Does the preparation and utilization of 99mTc-sulfur colloid affect the outcomes of breast lymphoscintigraphy?

Journal article J Nucl Med Technol · June 2013 UNLABELLED: The purpose of this study was to determine whether certain factors in the preparation and use of (99m)Tc-sulfur colloid affected the number of sentinel lymph nodes (SLNs) detected during SLN mapping and during intraoperative SLN identification. ... Full text Link to item Cite

Radium-223 chloride: a potential new treatment for castration-resistant prostate cancer patients with metastatic bone disease.

Journal article Cancer Manag Res · 2013 BACKGROUND: Radium-223 chloride ((223)Ra; Alpharadin) is an alpha-emitting radioisotope that targets areas of osteoblastic metastasis and is excreted by the small intestine. When compared with beta-emitters (eg, strontium-89, samarium-153), (223)Ra deliver ... Full text Link to item Cite

Assessing the impact of radiation-induced changes in soft tissue density ∕ thickness on the study of radiation-induced perfusion changes in the lung and heart.

Journal article Med Phys · December 2012 PURPOSE: Abnormalities in single photon emission computed tomography (SPECT) perfusion within the lung and heart are often detected following radiation for tumors in∕around the thorax (e.g., lung cancer or left-sided breast cancer). The presence of SPECT p ... Full text Link to item Cite

Quantification of Tc-99m sestamibi distribution in normal breast tissue using dedicated breast SPECT-CT

Journal article Lecture Notes in Computer Science Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics · August 15, 2012 The use of Tc-99m-Sestamibi in molecular breast imaging is common due to its preferential uptake in malignant tissue. However, quantification of the baseline uptake in normal, healthy breast tissue is not possible using planar-imaging devices. Using our de ... Full text Cite

A multicenter prospective evaluation of the clinical utility of F-18 FDG-PET/CT in patients with AJCC stage IIIB or IIIC extremity melanoma.

Journal article Ann Surg · August 2012 OBJECTIVE/BACKGROUND: There is a high risk of relapse in stage IIIB/IIIC melanoma. The utility of 2-[fluorine-18]-fluoro-2-deoxy-D-glucose positron emission tomography integrated with computed tomography (FDG-PET/CT) in these patients to evaluate response ... Full text Link to item Cite

R. Edward Coleman, MD, 1943-2012.

Journal article J Nucl Med · August 2012 Link to item Cite

111-In-capromab pendetide imaging using hybrid-γ camera-computer tomography technology is not reliable in detecting seminal vesicle invasion in patients with prostate cancer.

Journal article Urol Oncol · 2012 OBJECTIVES: In this study, we evaluate the diagnostic utility of a hybrid γ-camera-computer tomography (SPECT-CT) indium-111 (111-In)-capromab pendetide scan in detecting seminal vesicle invasion (SVI) in select patients evaluated for primary surgical trea ... Full text Link to item Cite

Initial In Vivo Quantification of Tc-99m Sestamibi Uptake as a Function of Tissue Type in Healthy Breasts Using Dedicated Breast SPECT-CT.

Journal article J Oncol · 2012 A pilot study is underway to quantify in vivo the uptake and distribution of Tc-99m Sestamibi in subjects without previous history of breast cancer using a dedicated SPECT-CT breast imaging system. Subjects undergoing diagnostic parathyroid imaging studies ... Full text Open Access Link to item Cite

How much is a picture worth? Putting amyloid imaging to the test.

Journal article Dement Geriatr Cogn Dis Extra · January 2012 Full text Link to item Cite

Colocalization of gadolinium-diethylene triamine pentaacetic acid with high-molecular-weight molecules after intracerebral convection-enhanced delivery in humans.

Journal article Neurosurgery · September 2011 BACKGROUND: Convection-enhanced delivery (CED) permits site-specific therapeutic drug delivery within interstitial spaces at increased dosages through circumvention of the blood-brain barrier. CED is currently limited by suboptimal methodologies for monito ... Full text Link to item Cite

Prognostic significance of parameters derived from co-registered 18F-fluorodeoxyglucose PET and contrast-enhanced MRI in patients with high-grade glioma.

Journal article Br J Radiol · April 2011 OBJECTIVE: The aim of this study was to determine the prognostic significance of the volume and intensity of abnormal (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) accumulation within areas of contrast enhancement on post-therapeutic volu ... Full text Link to item Cite

Evaluation of 18F-FDG PET and MRI associations in pediatric diffuse intrinsic brain stem glioma: a report from the Pediatric Brain Tumor Consortium.

Journal article J Nucl Med · February 2011 UNLABELLED: The purpose of this study was to assess (18)F-FDG uptake in children with a newly diagnosed diffuse intrinsic brain stem glioma (BSG) and to investigate associations with progression-free survival (PFS), overall survival (OS), and MRI indices. ... Full text Link to item Cite

Utility of FDG PET/CT in inflammatory cardiovascular disease.

Journal article Radiographics · 2011 Inflammatory disorders of the cardiovascular system can affect the myocardium, pericardium, or vessel walls. Patients with myocardial and pericardial disease may present with chest pain, palpitations, and shortness of breath, symptoms resembling myocardial ... Full text Link to item Cite

The role of adaptive and functional imaging modalities in radiation therapy: approach and application from a radiation oncology perspective.

Journal article Semin Ultrasound CT MR · December 2010 The field of radiation oncology relies heavily on imaging modalities. From initial consultation to treatment completion, images are used to guide nearly every step of the patient encounter. Technological advances in diagnostic radiology continue to be read ... Full text Link to item Cite

A systematic review of the factors affecting accuracy of SUV measurements.

Journal article AJR Am J Roentgenol · August 2010 OBJECTIVE: There is growing interest in using PET/CT for evaluating early response to therapy in cancer treatment. Although widely available and convenient to use, standardized uptake value (SUV) measurements can be influenced by a variety of biologic and ... Full text Link to item Cite

Colonic schwannoma visualized on FDG PET/CT.

Journal article Clin Nucl Med · March 2010 Full text Link to item Cite

Radiation-induced reductions in regional lung perfusion: 0.1-12 year data from a prospective clinical study.

Journal article Int J Radiat Oncol Biol Phys · February 1, 2010 PURPOSE: To assess the time and regional dependence of radiation therapy (RT)-induced reductions in regional lung perfusion 0.1-12 years post-RT, as measured by single photon emission computed tomography (SPECT) lung perfusion. MATERIALS/METHODS: Between 1 ... Full text Link to item Cite

Regional lung density changes after radiation therapy for tumors in and around thorax.

Journal article Int J Radiat Oncol Biol Phys · January 1, 2010 Featured Publication PURPOSE: To study the temporal nature of regional lung density changes and to assess whether the dose-dependent nature of these changes is associated with patient- and treatment-associated factors. METHODS AND MATERIALS: Between 1991 and 2004, 118 patients ... Full text Link to item Cite

Utility of functional imaging in prediction or assessment of treatment response and prognosis following thermotherapy.

Journal article Int J Hyperthermia · 2010 The purpose of this review is to examine the roles that functional imaging may play in prediction of treatment response and determination of overall prognosis in patients who are enrolled in thermotherapy trials, either in combination with radiotherapy, ch ... Full text Link to item Cite

Utilization of (111)In-Capromab pendetide SPECT-CT for detecting seminal vesicle invasion with recurrent prostate cancer after primary in situ therapy.

Journal article Int J Urol · December 2009 Featured Publication The aim of this study was to evaluate the diagnostic value of a hybrid (111)In-capromab pendetide fused computed tomography (CT) scan in detecting seminal vesicle invasion (SVI) in the setting of recurrent prostate cancer following primary in situ therapy. ... Full text Link to item Cite

Accuracy of real time noninvasive temperature measurements using magnetic resonance thermal imaging in patients treated for high grade extremity soft tissue sarcomas.

Journal article Med Phys · November 2009 Featured Publication PURPOSE: To establish accuracy of real time noninvasive temperature measurements using magnetic resonance thermal imaging in patients treated for high grade extremity soft tissue sarcomas. METHODS: Protocol patients with advanced extremity sarcomas were tr ... Full text Link to item Cite

Use of 111in-capromab pendetide immunoscintigraphy to image localized prostate cancer foci within the prostate gland.

Journal article J Urol · September 2009 PURPOSE: We compared the results of a preoperative (111)In-capromab pendetide scan co-registered with computerized tomography with pathological findings in the surgically excised prostate to determine whether the scan can efficiently detect cancer in the p ... Full text Link to item Cite

Dynamic contrast-enhanced magnetic resonance imaging as a predictor of clinical outcome in canine spontaneous soft tissue sarcomas treated with thermoradiotherapy.

Journal article Clin Cancer Res · August 1, 2009 PURPOSE: This study tests whether dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters obtained from canine patients with soft tissue sarcomas, treated with hyperthermia and radiotherapy, are predictive of therapeutic outcome. EXPERIME ... Full text Link to item Cite

Association between RT-induced changes in lung tissue density and global lung function.

Journal article Int J Radiat Oncol Biol Phys · July 1, 2009 Featured Publication PURPOSE: To assess the association between radiotherapy (RT)-induced changes in computed tomography (CT)-defined lung tissue density and pulmonary function tests (PFTs). METHODS AND MATERIALS: Patients undergoing incidental partial lung RT were prospective ... Full text Link to item Cite

Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study.

Journal article J Clin Oncol · June 20, 2009 Featured Publication PURPOSE: To assess the safety and efficacy of neoadjuvant bevacizumab with standard chemoradiotherapy in locally advanced rectal cancer and explore biomarkers for response. PATIENTS AND METHODS: In a phase I/II study, 32 patients received four cycles of th ... Full text Link to item Cite

Dose-dependent effects of radiation therapy on cerebral blood flow, metabolism, and neurocognitive dysfunction.

Journal article Int J Radiat Oncol Biol Phys · March 15, 2009 PURPOSE: A prospective study was performed to formally relate dose-dependent radiologically defined changes in normal brain induced by radiotherapy (RT) to neurocognitive dysfunction in subjects with primary brain tumors. METHODS AND MATERIALS: Adult patie ... Full text Link to item Cite

Clinical Utility of Magnetic Resonance Thermal Imaging (MRTI) For Realtime Guidance of Deep Hyperthermia.

Journal article Proc SPIE Int Soc Opt Eng · February 25, 2009 A critical need has emerged for volumetric thermometry to visualize 3D temperature distributions in real time during deep hyperthermia treatments used as an adjuvant to radiation or chemotherapy for cancer. For the current effort, magnetic resonance therma ... Full text Link to item Cite

Adrenal nodules at FDG PET/CT in patients known to have or suspected of having lung cancer: a proposal for an efficient diagnostic algorithm.

Journal article Radiology · February 2009 Featured Publication PURPOSE: To develop an algorithm to maximize the diagnostic yield of positron emission tomography (PET)/computed tomography (CT) by using defined attenuation and standardized uptake value (SUV) criteria. MATERIALS AND METHODS: An IRB-approved, HIPAA-compli ... Full text Link to item Cite

DCE-MRI parameters have potential to predict response of locally advanced breast cancer patients to neoadjuvant chemotherapy and hyperthermia: a pilot study.

Journal article Int J Hyperthermia · 2009 Featured Publication UNLABELLED: Combined therapies represent a staple of modern medicine. For women treated with neoadjuvant chemotherapy (NA ChT) for locally advanced breast cancer (LABC), early determination of whether the patient will fail to respond can enable the use of ... Full text Link to item Cite

I-131, I-123, and F-18 FDG-PET imaging in a patient with diffuse sclerosing variant of papillary thyroid cancer.

Journal article Clin Nucl Med · December 2008 Featured Publication PURPOSE: To compare the sensitivity of I-123 total body iodine (TBI) scan, I-131 TBI, and PET scanning with 2-deoxy-2[F-18]fluoro-D-glucose (FDG-PET) scans for detection of residual/recurrent disease in patients with diffuse sclerosing variant of papillary ... Full text Link to item Cite

Interpretation and reporting of positron emission tomography-computed tomographic scans.

Journal article Semin Ultrasound CT MR · August 2008 Featured Publication Body oncology positron emission tomography-computed tomographic (PET-CT) exams are particularly complex and time-consuming studies to interpret and report. An integrated approach is required to provide the referring physician with the full clinical value o ... Full text Link to item Cite

Lipid-poor adenomas on unenhanced CT: does histogram analysis increase sensitivity compared with a mean attenuation threshold?

Journal article AJR Am J Roentgenol · July 2008 Featured Publication OBJECTIVE: The purpose of our study was to evaluate the efficacy of CT histogram analysis for further characterization of lipid-poor adenomas on unenhanced CT. MATERIALS AND METHODS: One hundred thirty-two adrenal nodules were identified in 104 patients wi ... Full text Link to item Cite

Use of local (111)in-capromab pendetide scan results to predict outcome after salvage radiotherapy for prostate cancer.

Journal article Int J Radiat Oncol Biol Phys · June 1, 2008 Featured Publication PURPOSE: The (111)In-capromab pendetide scan (ProstaScint; Cytogen Corp., Princeton NJ) is approved by the Food and Drug Administration to evaluate increasing prostate-specific antigen (PSA) levels after radical prostatectomy. This study evaluated the role ... Full text Link to item Cite

Intracerebral infusion of an EGFR-targeted toxin in recurrent malignant brain tumors.

Journal article Neuro Oncol · June 2008 Featured Publication The purpose of this study is to determine the maximum tolerated dose (MTD), dose-limiting toxicity (DLT), and intracerebral distribution of a recombinant toxin (TP-38) targeting the epidermal growth factor receptor in patients with recurrent malignant brai ... Full text Link to item Cite

The association between RT-induced changes in lung density and global lung function.

Journal article J Clin Oncol · May 20, 2008 13543 Background: Radiation (RT)-induced lung injury is a common side effect following thoracic RT. The study of RT-induced lung injury is complicated by the multiple endpoints considered (e.g., radiologic vs. symptomatic vs. functional). The association b ... Link to item Cite

A pilot study: 131I-antitenascin monoclonal antibody 81c6 to deliver a 44-Gy resection cavity boost.

Journal article Neuro Oncol · April 2008 Featured Publication The purpose of this study was to determine the feasibility and assess the efficacy and toxicity, among newly diagnosed malignant glioma patients, of administering (131)I-labeled murine antitenascin monoclonal antibody 81C6 ((131)I-81C6) into a surgically c ... Full text Link to item Cite

PET of hypoxia and perfusion with 62Cu-ATSM and 62Cu-PTSM using a 62Zn/62Cu generator.

Journal article AJR Am J Roentgenol · February 2008 Featured Publication OBJECTIVE: Copper-diacetyl-bis(N4-methylthiosemicarbazone) (Cu-ATSM) and copper-pyruvaldehyde-bis(N4-methylthiosemicarbazone) (Cu-PTSM) are being studied as potential markers of hypoxia and perfusion, respectively. The use of short-lived radionuclides (e.g ... Full text Link to item Cite

Clinical experience with alpha-particle emitting 211At: treatment of recurrent brain tumor patients with 211At-labeled chimeric antitenascin monoclonal antibody 81C6.

Journal article J Nucl Med · January 2008 Featured Publication UNLABELLED: alpha-Particle-emitting radionuclides, such as (211)At, with a 7.2-h half-life, may be optimally suited for the molecularly targeted radiotherapy of strategically sensitive tumor sites, such as those in the central nervous system. Because of th ... Full text Link to item Cite

Quantitative effects of contrast enhanced CT attenuation correction on PET SUV measurements.

Journal article Mol Imaging Biol · 2008 Featured Publication PURPOSE: The presence of contrast materials on computed tomography (CT) images can cause problems in the attenuation correction of positron emission tomography (PET) images. These are because of errors converting the CT attenuation of contrast to 511-keV a ... Full text Link to item Cite

Initial patient study with dedicated dual-modality SPECT-CT mammotomography

Journal article IEEE Nuclear Science Symposium Conference Record · December 1, 2007 Dual-modality SPECT-CT dedicated breast imaging offers great promise in the detection/staging of cancer and the monitoring of treatment therapies. The sequential acquisition with emission (nuclear) and transmission (x-ray) 3D imaging systems can aid in loc ... Full text Cite

Prospective assessment of radiotherapy-associated cardiac toxicity in breast cancer patients: analysis of data 3 to 6 years after treatment.

Journal article Cancer · October 15, 2007 Featured Publication BACKGROUND: Radiation therapy (RT) to the left breast/chest wall has been linked with cardiac dysfunction. Previously, the authors identified cardiac perfusion defects in approximately 50% to 60% of patients 0.5 to 2 years post-RT. In the current study, th ... Full text Link to item Cite

PET/CT Protocols and Practical Issues for the Evaluation of Patients with Head and Neck Cancer.

Journal article PET Clin · October 2007 This article presents general considerations for optimum PET/CT imaging in patients with head and neck disease. Based on these considerations, the clinical PET/CT imaging protocols currently used at the authors' center are described. ... Full text Link to item Cite

Clinical utility of a patient-specific algorithm for simulating intracerebral drug infusions.

Journal article Neuro Oncol · July 2007 Convection-enhanced delivery (CED) is a novel drug delivery technique that uses positive infusion pressure to deliver therapeutic agents directly into the interstitial spaces of the brain. Despite the promise of CED, clinical trials have demonstrated that ... Full text Link to item Cite

Head and neck cancer: dedicated FDG PET/CT protocol for detection--phantom and initial clinical studies.

Journal article Radiology · July 2007 Featured Publication PURPOSE: To retrospectively compare the sensitivity of a dedicated fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) protocol versus a standard whole-body PET/CT protocol for detection of head and neck cancer, ... Full text Link to item Cite

Complete pathological response to bevacizumab and chemoradiation in advanced rectal cancer.

Journal article Nat Clin Pract Oncol · May 2007 Featured Publication BACKGROUND: Localized rectal cancer responds well to 5-fluorouracil and radiation-based regimens. A phase I-II trial is currently testing the efficacy of adding bevacizumab, a VEGF-specific antibody, to standard chemoradiotherapy. The case presented here i ... Full text Link to item Cite

Updated assessment of the six-minute walk test as predictor of acute radiation-induced pneumonitis.

Journal article Int J Radiat Oncol Biol Phys · March 1, 2007 Featured Publication PURPOSE: To assess the utility of the 6-minute walk test (6MWT) as a predictor of symptomatic radiation-induced pneumonitis (RP). METHODS: As part of a prospective trial to study radiation-induced lung injury, 53 patients receiving thoracic radiotherapy (R ... Full text Link to item Cite

Practical approach to diagnostic CT combined with PET.

Journal article AJR Am J Roentgenol · March 2007 Featured Publication OBJECTIVE: Protocols for PET/CT are not yet standardized. In particular, image quality, utilization, and reporting of the findings of the CT component of PET/CT can vary widely, making it complicated for physicians to request the appropriate information. I ... Full text Link to item Cite

Intracerebral infusate distribution by convection-enhanced delivery in humans with malignant gliomas: descriptive effects of target anatomy and catheter positioning.

Journal article Neurosurgery · February 2007 OBJECTIVE: Convection-enhanced delivery (CED) holds tremendous potential for drug delivery to the brain. However, little is known about the volume of distribution achieved within human brain tissue or how target anatomy and catheter positioning influence d ... Full text Link to item Cite

Prospective assessment of dosimetric/physiologic-based models for predicting radiation pneumonitis.

Journal article Int J Radiat Oncol Biol Phys · January 1, 2007 PURPOSE: Clinical and 3D dosimetric parameters are associated with symptomatic radiation pneumonitis rates in retrospective studies. Such parameters include: mean lung dose (MLD), radiation (RT) dose to perfused lung (via SPECT), and pre-RT lung function. ... Full text Link to item Cite

Impact of patient-specific factors, irradiated left ventricular volume, and treatment set-up errors on the development of myocardial perfusion defects after radiation therapy for left-sided breast cancer.

Journal article Int J Radiat Oncol Biol Phys · November 15, 2006 Featured Publication PURPOSE: The aim of this study was to assess the impact of patient-specific factors, left ventricle (LV) volume, and treatment set-up errors on the rate of perfusion defects 6 to 60 months post-radiation therapy (RT) in patients receiving tangential RT for ... Full text Link to item Cite

A tracer dose of technetium-99m-labeled liposomes can estimate the effect of hyperthermia on intratumoral doxil extravasation.

Journal article Clin Cancer Res · November 15, 2006 Featured Publication PURPOSE: A noninvasive method to monitor intratumoral Doxil delivery in individual patients during targeted tumor therapy is important to predict treatment response. The purpose of this study was to determine if a small tracer dose of technetium-99m (99mTc ... Full text Link to item Cite

Novel human IgG2b/murine chimeric antitenascin monoclonal antibody construct radiolabeled with 131I and administered into the surgically created resection cavity of patients with malignant glioma: phase I trial results.

Journal article J Nucl Med · June 2006 Featured Publication UNLABELLED: Results from animal experiments have shown that human IgG2/mouse chimeric antitenascin 81C6 (ch81C6) monoclonal antibody exhibited higher tumor accumulation and enhanced stability compared with its murine parent. Our objective was to determine ... Link to item Cite

Intertumoral differences in hypoxia selectivity of the PET imaging agent 64Cu(II)-diacetyl-bis(N4-methylthiosemicarbazone).

Journal article J Nucl Med · June 2006 UNLABELLED: Cu-Diacetyl-bis(N(4)-methylthiosemicarbazone) (Cu-ATSM) is a recently developed PET imaging agent for tumor hypoxia. However, its accuracy and reliability for measuring hypoxia have not been fully characterized in vivo. The aim of this study wa ... Link to item Cite

Salvage radioimmunotherapy with murine iodine-131-labeled antitenascin monoclonal antibody 81C6 for patients with recurrent primary and metastatic malignant brain tumors: phase II study results.

Journal article J Clin Oncol · January 1, 2006 Featured Publication PURPOSE: To assess the efficacy and toxicity of intraresection cavity iodine-131-labeled murine antitenascin monoclonal antibody 81C6 (131I-m81C6) among recurrent malignant brain tumor patients. PATIENTS AND METHODS: In this phase II trial, 100 mCi of 131I ... Full text Link to item Cite

3'-Deoxy-3'-[F-18]fluorothymidine positron emission tomography in patients with recurrent glioblastoma multiforme: comparison with Gd-DTPA enhanced magnetic resonance imaging.

Journal article Mol Imaging Biol · 2006 Featured Publication INTRODUCTION: The accumulation of 3'-deoxy-3'-[F-18]fluorothymidine (FLT) on positron emission tomography (PET) images in patients with glioblastoma multiforme was evaluated and correlated with gadopentetate dimeglumine (Gd-DTPA) enhancement in magnetic re ... Full text Link to item Cite

Diagnosis of a solitary cardiac metastasis from ocular melanoma.

Journal article J Thorac Cardiovasc Surg · December 2005 Full text Link to item Cite

The incidence and functional consequences of RT-associated cardiac perfusion defects.

Journal article Int J Radiat Oncol Biol Phys · September 1, 2005 PURPOSE: Radiation therapy (RT) for left-sided breast cancer has been associated with cardiac dysfunction. We herein assess the temporal nature and volume dependence of RT-induced left ventricular perfusion defects and whether these perfusion defects are r ... Full text Link to item Cite

Dosimetry and radiographic analysis of 131I-labeled anti-tenascin 81C6 murine monoclonal antibody in newly diagnosed patients with malignant gliomas: a phase II study.

Journal article J Nucl Med · June 2005 UNLABELLED: The objective was to perform dosimetry and evaluate dose-response relationships in newly diagnosed patients with malignant brain tumors treated with direct injections of (131)I-labeled anti-tenascin murine 81C6 monoclonal antibody (mAb) into su ... Link to item Cite

Characterizing tumor changes during neoadjuvant treatment of locally advanced breast cancer patients (LABC) using dynamic-enhanced magnetic resonance imaging (DE-MRI)

Journal article Proc. SPIE - Int. Soc. Opt. Eng. (USA) · 2005 At Duke University Medical Center, selective LABC patients were treated on a protocol using neoadjuvant Myocet/Paclitaxel (ChT) and HT. With the purpose of generating perfusion/permeability parametric maps and to use gadolinium (Gd) enhancement curves to s ... Full text Link to item Cite

Predicting radiotherapy-induced cardiac perfusion defects.

Journal article Med Phys · January 2005 The purpose of this work is to compare the efficacy of mathematical models in predicting the occurrence of radiotherapy-induced left ventricular perfusion defects assessed using single-photon emission computed tomography (SPECT). The basis of this study is ... Full text Link to item Cite

Using FDG-PET activity as a surrogate for tumor cell density and its effect on equivalent uniform dose calculation.

Journal article Med Phys · September 2004 The concept of equivalent uniform dose (EUD) has been suggested as a means to quantitatively consider heterogeneous dose distributions within targets. Tumor cell density/function is typically assumed to be uniform. We herein propose to use 18F-labeled 2-de ... Full text Link to item Cite

Feasibility of optimizing the dose distribution in lung tumors using fluorine-18-fluorodeoxyglucose positron emission tomography and single photon emission computed tomography guided dose prescriptions.

Journal article Med Phys · June 2004 The information provided by functional images may be used to guide radiotherapy planning by identifying regions that require higher radiation dose. In this work we investigate the dosimetric feasibility of delivering dose to lung tumors in proportion to th ... Full text Link to item Cite

Positron emission tomography with 2-deoxy-2-[(18)F]fluoro-D-glucose for evaluating local and distant disease in patients with cervical cancer.

Journal article Mol Imaging Biol · 2004 PURPOSE: To assess the accuracy of positron emission tomography (PET) with 2-deoxy-2-[(18)F]fluoro-D-glucose (FDG) for evaluating local and distant disease in patients with cervical cancer. METHODS: The PET imaging database maintained at our institution wa ... Full text Link to item Cite

PET and brain tumor image fusion.

Journal article Cancer J · 2004 PET imaging with (18)F-2-deoxy-2-fluoro-D-glucose (FDG-PET) is useful both for the initial evaluation of brain tumors and for follow up after therapy. Over 400 FDG-PET studies are performed at Duke University Medical Center annually for brain tumors. Image ... Full text Link to item Cite

Progress report of a Phase I study of the intracerebral microinfusion of a recombinant chimeric protein composed of transforming growth factor (TGF)-alpha and a mutated form of the Pseudomonas exotoxin termed PE-38 (TP-38) for the treatment of malignant brain tumors.

Journal article J Neurooncol · October 2003 TP-38 is a recombinant chimeric targeted toxin composed of the EGFR binding ligand TGF-alpha and a genetically engineered form of the Pseudomonas exotoxin, PE-38. After in vitro and in vivo animal studies that showed specific activity and defined the maxim ... Full text Link to item Cite

Symptomatic cardiac events following radiation therapy for left-sided breast cancer: possible association with radiation therapy-induced changes in regional perfusion.

Journal article Clin Breast Cancer · August 2003 Our group has demonstrated that tangential radiation therapy (RT) to the left breast or chest wall can cause perfusion changes in the anterior myocardium. We assess if RT-induced perfusion changes are associated with the development of symptoms consistent ... Link to item Cite

The role of PET scanning in the detection of recurrent cervical cancer.

Journal article Gynecol Oncol · July 2003 OBJECTIVES: [(18)F] Fluoro-2-deoxyglucose positron emission tomography (FDG PET) has recently been established as a sensitive and specific method of detecting lymph node metastases in newly diagnosed cervical cancer. Little is known about the efficacy of P ... Full text Link to item Cite

Positron emission tomography imaging of brain tumors.

Journal article Neuroimaging Clin N Am · November 2002 A wide variety of metabolic features of brain tumors can be imaged using PET, including glucose metabolism, blood flow, oxygen consumption, amino acid metabolism, and lipid synthesis. Currently, FDG is the most widely available PET tracer for body imaging ... Full text Link to item Cite

The role of F-18 FDG positron emission tomography in preoperative assessment of the liver in patients being considered for curative resection of hepatic metastases from colorectal cancer.

Journal article Clin Nucl Med · August 2002 PURPOSE: The authors' goal was to determine the sensitivity and specificity of F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) for identifying patients with hepatic metastases from colorectal cancer and the accuracy of PET for determining ... Full text Link to item Cite

Impact of computed tomography-positron emission tomography fusion in staging patients with thoracic malignancies.

Journal article Ann Thorac Surg · July 2002 BACKGROUND: Positron emission tomography (PET) has been demonstrated to improve staging in patients with thoracic malignancies. This study evaluates the ability of a new imaging technique to improve the spatial resolution and accuracy of PET. METHODS: Pati ... Full text Link to item Cite

Efficiency comparison between 99m Tc-tetrofosmin and 99m Tc-sestamibi myocardial perfusion studies.

Journal article Nucl Med Commun · March 2002 The purpose of this investigation was to compare the efficiency of two different imaging protocols using two different clinically available 99mTc labelled myocardial perfusion tracers. One thousand one hundred and thirty-four imaging studies were performed ... Full text Link to item Cite

Phase II trial of murine (131)I-labeled antitenascin monoclonal antibody 81C6 administered into surgically created resection cavities of patients with newly diagnosed malignant gliomas.

Journal article J Clin Oncol · March 1, 2002 PURPOSE: To assess the efficacy and toxicity of intraresection cavity (131)I-labeled murine antitenascin monoclonal antibody 81C6 and determine its true response rate among patients with newly diagnosed malignant glioma. PATIENTS AND METHODS: In this phase ... Full text Link to item Cite

Fractal reconstruction of breast perfusion before and after hyperthermia treatments

Journal article ASME International Mechanical Engineering Congress and Exposition Proceedings · January 1, 2002 Thermal modeling for hyperthermia breast patients can provide relevant information to better understand the temperatures achieved during treatment. However, human breast is much perfiased, making knowledge of the perfusion crucial to the accuracy of the te ... Full text Cite

Fractal reconstruction of breast perfusion before and after hyperthermia treatments

Journal article American Society of Mechanical Engineers, Bioengineering Division (Publication) BED · 2002 Cite

Positron emission tomography: brain tumors and lung cancer.

Journal article Radiol Clin North Am · September 2001 F-18 fluorodeoxyglucose positron emission tomography is a uniquely powerful diagnostic tool that noninvasively provides information that is critical to appropriate clinical management of patients with non-small cell lung cancer. Not only does the functiona ... Full text Link to item Cite

Intra-operative MR guidance during trans-sphenoidal pituitary resection: preliminary results.

Journal article J Magn Reson Imaging · January 2001 The use of intra-operative MR image guidance has the potential to improve the precision, extent, and safety of trans-sphenoidal pituitary resections. The trans-sphenoidal approach to pituitary surgery has been performed for some time (1--3). Until now thes ... Full text Link to item Cite

27. PET Image Interpretation. Attenuation-Corrected (ATN) Vs Non-Attenuation Corrected (NATN) Images.

Journal article Clin Positron Imaging · July 2000 Purpose: The purpose of this study was to evaluate the difference, if any, in lesion detection in ATN and NATN images.Methods: Sixty-one consecutive patients having clinical whole body FDG PET scans for oncologic indications were included. The patients wer ... Full text Link to item Cite

Dosimetry and dose-response relationships in newly diagnosed patients with malignant gliomas treated with iodine-131-labeled anti-tenascin monoclonal antibody 81C6 therapy.

Journal article Int J Radiat Oncol Biol Phys · March 1, 2000 PURPOSE: The objective of this study was to perform the dosimetry and evaluate the dose-response relationships in newly diagnosed patients with malignant brain tumors treated by direct injections of (131)I-labeled 81C6 monoclonal antibody (MAb) into surgic ... Full text Link to item Cite

Registration of three-dimensional magnetic resonance and radionuclide skeletal images.

Journal article Clin Nucl Med · November 1999 PURPOSE: To apply postprocessing techniques to register three-dimensional TI-201 bone SPECT datasets with MRI. This may provide more accurate anatomic-functional correlation when localizing active tumors. MATERIALS AND METHODS: Three-dimensional datasets w ... Full text Link to item Cite

Craniotomy for tumor treatment in an intraoperative magnetic resonance imaging unit.

Journal article Neurosurgery · September 1999 OBJECTIVE: The complex three-dimensional anatomic features of the brain and its vulnerability to surgical intervention make the surgical treatment of intracranial tumors challenging. We evaluated the surgical treatment of supratentorial tumors using intrao ... Full text Link to item Cite

Intraoperative MR imaging guidance for intracranial neurosurgery: experience with the first 200 cases.

Journal article Radiology · May 1999 PURPOSE: To review preliminary experience with an open-bore magnetic resonance (MR) imaging system for guidance in intracranial surgical procedures. MATERIALS AND METHODS: A vertically oriented, open-configuration 0.5-T MR imager was housed in a sterile pr ... Full text Link to item Cite

Computer-based imaging and interventional MRI: applications for neurosurgery.

Journal article Comput Med Imaging Graph · 1999 Advances in computer technology and the development of open MRI systems definitely enhanced intraoperative image-guidance in neurosurgery. Based upon the integration of previously acquired and processed 3D information and the corresponding anatomy of the p ... Full text Link to item Cite

Intraoperative magnetic resonance imaging guidance for intracranial neurosurgical procedures

Journal article Seminars in Interventional Radiology · January 1, 1999 A 0.5 Tesla open configuration magnetic resonance imaging (MRI) system (Signa SP [GE Medical Systems; Milwaukee, WI]) is sited in an operating room environment at Brigham and Women's Hospital for MRI-guided surgical and interventional procedures. The verti ... Full text Cite

Interactive MR image guidance for neurosurgical and minimally-invasive procedures

Journal article Proceedings of SPIE the International Society for Optical Engineering · January 1, 1999 Advantages of MR imaging for guidance of minimally invasive procedures include exceptional soft tissue contrast, intrinsic multiplanar imaging capability, and absence of exposure to ionizing radiation. Specialized imaging sequences are available and under ... Cite

Transsphenoidal pituitary resection with intraoperative MR guidance: Preliminary results

Journal article Proceedings of SPIE the International Society for Optical Engineering · January 1, 1999 The use of intraoperative MR image guidance has the potential to improve the precision, extent and safety of transsphenoidal pituitary resections. At Brigham and Women's Hospital, an open-bore configuration 0.5 T MR system (SIGNA SP, GE Medical Systems, Mi ... Cite

MR imaging guidance for minimally invasive procedures

Journal article Proceedings of SPIE the International Society for Optical Engineering · December 1, 1998 Image guidance is one of the major challenges common to all minimally invasive procedures including biopsy, thermal ablation, endoscopy, and laparoscopy. This is essential for 1) identifying the target lesion, 2) planning the minimally invasive approach, a ... Full text Cite

Open-configuration MR imaging, intervention, and surgery of the urinary tract.

Journal article Urol Clin North Am · February 1998 The open-configuration MR imaging system provides new applications both in diagnosis and in therapy of conditions in the urinary tract. In addition to conventional imaging, the open configuration permits MR imaging of patients in many positions. This has a ... Full text Link to item Cite

Evaluation of intracranial cysts by intraoperative MR.

Journal article J Magn Reson Imaging · 1998 Eleven patients with intracranial cystic collections were evaluated in the open-bore intraoperative MR system. In each case, the cystic collection or the surrounding cerebrospinal fluid (CSF) space was injected with .02 to .5 cc of .5 mol/l gadopentetate d ... Full text Link to item Cite

Intraoperative dynamic MRI: localization of sites of brain tumor recurrence after high-dose radiotherapy.

Journal article J Magn Reson Imaging · 1998 In patients with malignant astrocytomas or metastatic brain disease treated with high-dose radiotherapy, conventional imaging methods may not adequately distinguish recurrent tumor from radiation change. We used a fast spoiled gradient refocusing technique ... Full text Link to item Cite

Real-time monitoring and analysis of MR-guided laser ablation in an open-configuration MR-system

Journal article Proceedings of SPIE the International Society for Optical Engineering · January 1, 1997 Our goal was to investigate whether an open 0.5T MR-system with integrated frameless stereotactic guidance tools can provide sufficient intraoperative monitoring of interstitial laser therapy (ILT). Temperature-sensitive T1-weighted Fast-Spin-Echo (FSE)- o ... Full text Cite

Automatic motion correction for breast MR imaging.

Journal article Radiology · March 1996 In 29 gadolinium-enhanced breast magnetic resonance (MR) examinations, breast motion prevented accurate and efficient image processing. To compensate for global rotations and translations, an automatic motion correction method with a ratio-variance minimiz ... Full text Link to item Cite

Cat-scratch disease simulating lymphoma.

Journal article J Comput Assist Tomogr · 1996 Full text Link to item Cite

Stereoscopically guided characterization of three-dimensional dynamic MR images of the breast.

Journal article Radiology · January 1996 A workstation was used to postprocess volume-rendered three-dimensional (3D) dynamic contrast material-enhanced magnetic resonance (MR) images of a breast carcinoma and a breast adenoma. Use of a 3D cursor allowed stereoscopic interactive probing of specif ... Full text Link to item Cite

A theoretical model for input impedance of interstitial microwave antennas with choke.

Journal article Int J Radiat Oncol Biol Phys · February 1, 1994 PURPOSE: Two important characteristics for interstitial microwave antennas used in clinical hyperthermia are: (1) a good impedance match to minimize reflected power; and (2) a good power deposition pattern which is independent of insertion depth. A major p ... Full text Link to item Cite

A coaxial microwave applicator for transurethral hyperthermia of the prostate.

Journal article Prostate · 1993 Benign prostatic hyperplasia (BPH) is a common disease of elderly men. The current definitive treatment for urinary obstruction caused by this disease is surgery (transurethral resection of the prostate, or TURP). Recent evidence suggests that hyperthermia ... Full text Link to item Cite

Interstitial microwave-induced hyperthermia and iridium brachytherapy for the treatment of obstructing biliary carcinomas.

Journal article Int J Hyperthermia · 1992 In a phase I clinical study, 10 patients with obstructive biliary carcinomas were treated with single-antenna interstitial microwave hyperthermia and iridium-192 brachytherapy. For each patient a standard biliary drainage catheter was implanted percutaneou ... Full text Link to item Cite

Thermal clearance for CBF determination.

Journal article J Neurosurg · February 1990 Full text Link to item Cite

Intraoperative disseminated intravascular coagulation in a patient with ulcerative colitis.

Journal article Conn Med · October 1989 A patient with acute ulcerative colitis who developed acute disseminated intravascular coagulation during the course of a proctocolectomy is presented. Ulcerative colitis may represent a rare cause of acute disseminated intravascular coagulation. ... Link to item Cite

Transient finite element analysis of thermal methods used to estimate SAR and blood flow in homogeneously and nonhomogeneously perfused tumour models.

Journal article Int J Hyperthermia · 1988 A two-dimensional time-dependent finite element model was developed to evaluate thermal techniques for estimating blood flow and specific absorption rate (SAR). In these computer simulations, homogeneously and nonhomogeneously perfused tumour models were h ... Full text Link to item Cite

Interstitial hyperthermia and iridium brachytherapy in treatment of malignant glioma. A phase I clinical trial.

Journal article J Neurosurg · April 1986 An oncolytic effect of hyperthermia in the 42 degrees to 43 degrees C range has been previously demonstrated in cell culture and animal models. To apply this modality clinically, an interstitial microwave antenna array system has been developed for the del ... Full text Link to item Cite

Control of the SAR Pattern with in an Interstitial Microwave Array through Variation of Antenna Driving Phase

Journal article IEEE Transactions on Microwave Theory and Techniques · January 1, 1986 The interstitial microwave antenna-array hyperthermia (IMAAH) system produces a pattern of specific absorption rate (SAR) that is nonuniform within a 2-cm square array driven in phase at 915 MHz. Theory and experiment show that the point of phase coherence ... Full text Cite

SAR Patterns from an Interstitial Microwave Antenna-Array Hyperthermia System

Journal article IEEE Transactions on Microwave Theory and Techniques · January 1, 1986 In recent years, a number of groups have been investigating the use of interstitial microwave antenna-array hyperthermia (IMAAH) systems for the treatment of superficial and deep-seated tumors. A critical parameter in any hyperthermia system is the SAR (sp ... Full text Cite

CONTROL OF THE SAR PATTERN WITHIN AN INTERSTITIAL MICROWAVE ARRAY THROUGH VARIATION OF ANTENNA DRIVING PHASE.

Journal article IEEE Transactions on Microwave Theory and Techniques · 1986 The interstitial microwave antenna-array hyperthermia (IMAAH) system described produces a pattern of specific absorption rate (SAR) that is nonuniform within a 2-cm square array driven in phase at 915 MHz. Theory and experiment show that the point of phase ... Cite

SAR PATTERNS FROM AN INTERSTITIAL MICROWAVE ANTENNA-ARRAY HYPERTHERMIA SYSTEM.

Journal article IEEE Transactions on Microwave Theory and Techniques · 1986 Theoretical and measured values of the SAR (specific absorption rate) distribution are compared for an array of four 915-MHz antennas implanted on the corners of a 2-cm square array. The overall length of the antennas was assumed to be 7 cm in the theoreti ... Cite

SAR PATTERNS FROM AN INTERSTITIAL MICROWAVE ANTENNA ARRAY HYPERTHERMIA SYSTEM.

Journal article undefined · January 1, 1986 Effective treatment of cancer using interstitial hyperthermia demands that the entire tumor volume be heated to temperatures in the 43 degree -55 degree C range while surrounding normal tissue is held near 43 degree C. A number of factors which affect the ... Cite

INVESTIGATION OF A SLOTTED COAXIAL ANTENNA FOR USE IN HYPERTHERMIA TREATMENT OF CANCER.

Journal article Bioengineering Proceedings of the Northeast Conference · December 1, 1985 The goal of the interstitial microwave antenna array hyperthermia (IMAAH) system is to heat the entire tumor volume to a therapeutic temperature without overheating the surrounding normal tissue. This requires the ability to control the energy deposition p ... Cite

AUTOMATED MEASUREMENT OF POWER DEPOSITION PATTERNS FROM INTERSTITIAL MICROWAVE ANTENNAS USED IN HYPERTHERMIA.

Journal article Bioengineering Proceedings of the Northeast Conference · December 1, 1985 An interstitial microwave antenna array hyperthermia (IMAAH) system has been developed to provide localized hyperthermia. In this system, an array of modified brachytherapy catheters is inserted directly into the tumor. These nylon catheters (2. 2 mm OD) a ... Cite

Intraoperative interstitial microwave-induced hyperthermia and brachytherapy.

Journal article Int J Radiat Oncol Biol Phys · September 1985 Intra-operative placement of 11-gauge nylon catheters into deep-seated unresectable tumors for interstitial brachytherapy permits localized heating of tumors (hyperthermia) using microwave (915 MHz) antennas which are inserted into these catheters. Four pr ... Full text Link to item Cite

Rheological properties of living cytoplasm: a preliminary investigation of squid axoplasm (Loligo pealei).

Journal article Cell Motil · 1984 A magnetic sphere viscoelastometer has been developed to perform rheological experiments in living axoplasm of Loligo pealei. The technique includes the use of a calibrated magnetic sphere viscoelastometer on surgically implanted ferro-magnetic spheres in ... Full text Link to item Cite

Rheological properties of living cytoplasm: endoplasm of Physarum plasmodium.

Journal article J Cell Biol · October 1983 Magnetic sphere viscoelastometry, video microscopy, and the Kamiya double chamber method (Kamiya, N., 1940, Science [Wash. DC], 92:462-463.) have been combined in an optical and rheological investigation of the living endoplasm of Physarum polycephalum. Th ... Full text Link to item Cite

Interstitial hyperthermia in combination with brachytherapy.

Journal article Radiology · July 1983 Flexible coaxial cables were modified to serve as microwave antennas operating at a frequency of 915 MHz. These antennas were inserted into nylon afterloading tubes that had been implanted in tumors using conventional interstitial implantation techniques f ... Full text Link to item Cite