Scholars@Duke
Teresa Kathleen Tarrant

Teresa Kathleen Tarrant

Associate Professor of Medicine
Medicine, Rheumatology and Immunology
teresa.tarrant@duke.edu
200 Trent Dr., DUMC 3874, Durham, NC 27710
235 Sands Resarch Bldg, 303 Research Dr., Durham, NC 27710

Scholarly Works - Journal articles

ADA2 genotype and enzyme activity may predict vasculitic or hematologic DADA2 phenotype.

Journal article J Hum Immun · September 7, 2026 Deficiency of adenosine deaminase 2 (DADA2) is an autoinflammatory disease with diverse phenotypes. We describe the genetics, phenotypes, and treatment of n = 48 DADA2 patients from Germany, Austria, and Switzerland. We report a high incidence of hematolog ... Full text Link to item Cite

A case of progressive multifocal leukoencephalopathy in an adult patient with ADA-SCID.

Journal article J Hum Immun · September 7, 2026 This case report describes progressive multifocal leukoencephalopathy in a patient with ADA-SCID status after gene therapy. Persistent metabolic dysfunction likely contributed to JC virus reactivation, highlighting this rare complication of ADA-SCID and in ... Full text Link to item Cite

Diagnostic Implications and Correlates of Plasma Adenosine Deaminase 2 Activity and ADA2 Variants.

Journal article Arthritis Rheumatol · March 2026 OBJECTIVE: Deficiency of adenosine deaminase 2 (DADA2) is a monogenic autoinflammatory disease manifested as polyarteritis nodosa, stroke, and bone marrow failure. Leveraging an international cohort of 200 DADA2 cases, we aimed to characterize the diagnost ... Full text Link to item Cite

Early identification of delayed-onset ADA deficiency: The case for expanded first-tier newborn screening.

Journal article J Hum Immun · January 5, 2026 Delayed-onset ADA deficiency was identified in two patients who were not detected by standard newborn screening for SCID. These findings support expanding first-tier newborn screening to include purine profiling alongside TREC assays, ensuring early diagno ... Full text Link to item Cite

A Review of Adenosine Deaminase 2 (ADA2) as a Biomarker of Monocyte/Macrophage Activation.

Journal article Curr Allergy Asthma Rep · January 3, 2026 PURPOSE OF REVIEW: Adenosine deaminase 2 (ADA2) is predominantly expressed by and secreted from activated monocytes and macrophages into plasma. This review explores the utility of ADA2 as a biomarker of monocyte/macrophage activation in a range of conditi ... Full text Link to item Cite

Clinicopathologic Features and the Spectrum of Myelokathexis in Warts, Hypogammaglobulinemia, Infections, Myelokathexis Syndrome.

Journal article Lab Invest · August 2025 Warts, hypogammaglobulinemia, infections, myelokathexis (WHIM) syndrome is a rare primary immunodeficiency disorder predominantly caused by germline CXCR4 variants. Bone marrow (BM) evaluation showing myelokathexis helps to establish the diagnosis of WHIM ... Full text Link to item Cite

Multi-Year Registry Study of Elapegademase Treatment in Patients With Adenosine Deaminase Severe Combined Immunodeficiency (ADA-SCID) Requiring Enzyme Replacement Therapy.

Journal article J Clin Immunol · March 27, 2025 PURPOSE: The safety and tolerability of elapegademase (elapegademase-lvlr; Revcovi®) a PEGylated recombinant adenosine deaminase (ADA), were demonstrated in two Phase 3 clinical trials in the U.S. and Japan in patients with ADA-deficient severe combined im ... Full text Link to item Cite

Evolving spectrum of adenosine deaminase (ADA) deficiency: Assessing genotype pathogenicity according to expressed ADA activity of 46 variants.

Journal article J Allergy Clin Immunol · January 2025 BACKGROUND: Deficiency of adenosine deaminase (ADA or ADA1) has broad clinical and genetic heterogeneity. Screening techniques can identify asymptomatic infants whose phenotype and prognosis are indeterminate, and who may carry ADA variants of unknown sign ... Full text Link to item Cite

Early-onset neutropenia and mixed phenotype in ADA2 deficiency: diagnostic and therapeutic challenges.

Journal article Front Immunol · 2025 BACKGROUND: Adenosine deaminase 2 deficiency (DADA-2) is an autoinflammatory syndrome caused by mutations in the ADA2 gene. ADA-2 functions as an enzyme in purine metabolism and is presumed to play roles in immune regulation. The clinical spectrum of DADA2 ... Full text Link to item Cite

Purine Nucleoside Phosphorylase Deficiency Presenting with Neurological Involvement: A Case Report of Two Siblings

Journal article Asthma Allergy Immunology · August 1, 2024 Purine nucleoside phosphorylase (PNP) deficiency is a rare immunodeficiency syndrome generally characterized by profound T cell deficiency and variable B cell function. More than half of PNP-deficient patients present with neurological dysfunction, with ma ... Full text Cite

A phase 3 randomized trial of mavorixafor, a CXCR4 antagonist, for WHIM syndrome.

Journal article Blood · July 4, 2024 We investigated efficacy and safety of mavorixafor, an oral CXCR4 antagonist, in participants with warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome, a rare immunodeficiency caused by CXCR4 gain-of-function variants. This randomiz ... Full text Link to item Cite

CD40 ligand antagonist dazodalibep in Sjögren's disease: a randomized, double-blinded, placebo-controlled, phase 2 trial.

Journal article Nat Med · June 2024 Sjögren's disease (SjD) is a chronic, systemic autoimmune disease with no approved disease-modifying therapies. Dazodalibep (DAZ), a novel nonantibody fusion protein, is a CD40 ligand antagonist that blocks costimulatory signals between T and B cells and a ... Full text Link to item Cite

Treatment with Elapegademase Restores Immunity in Infants with Adenosine Deaminase Deficient Severe Combined Immunodeficiency.

Journal article J Clin Immunol · April 27, 2024 PURPOSE: Patients with adenosine deaminase 1 deficient severe combined immunodeficiency (ADA-SCID) are initially treated with enzyme replacement therapy (ERT) with polyethylene glycol-modified (PEGylated) ADA while awaiting definitive treatment with hemato ... Full text Link to item Cite

Aged G Protein-Coupled Receptor Kinase 3 (Grk3)-Deficient Mice Exhibit Enhanced Osteoclastogenesis and Develop Bone Lesions Analogous to Human Paget's Disease of Bone.

Journal article Cells · March 23, 2023 Paget's Disease of Bone (PDB) is a metabolic bone disease that is characterized by dysregulated osteoclast function leading to focal abnormalities of bone remodeling. It can lead to pain, fracture, and bone deformity. G protein-coupled receptor kinase 3 (G ... Full text Link to item Cite

The Role of T Helper Type 2 (Th2) Cytokines in the Pathogenesis of Eosinophilic Granulomatosis with Polyangiitis (eGPA): an Illustrative Case and Discussion.

Journal article Curr Allergy Asthma Rep · November 2022 PURPOSEOF REVIEW: The pathogenesis of eosinophilic granulomatosis with polyangiitis (eGPA) is driven largely by CD4 + type 2 helper T cells (Th2), B cells, and eosinophils. Interleukin (IL)-4 and IL-13 are critical cytokines in Th2 cell-mediated inflammati ... Full text Link to item Cite

Practical guidance for the diagnosis and management of secondary hypogammaglobulinemia: A Work Group Report of the AAAAI Primary Immunodeficiency and Altered Immune Response Committees.

Journal article J Allergy Clin Immunol · May 2022 Secondary hypogammaglobulinemia (SHG) is characterized by reduced immunoglobulin levels due to acquired causes of decreased antibody production or increased antibody loss. Clarification regarding whether the hypogammaglobulinemia is secondary or primary is ... Full text Link to item Cite

eConsults' Impact on Care Access and Wait Times in Rheumatology.

Journal article J Clin Rheumatol · April 1, 2022 BACKGROUND/OBJECTIVE: A growing number of health systems have implemented eConsults to improve access to specialty advice, but few studies have described their use in rheumatology or impact on visit wait times. We evaluated the uptake of an eConsult progra ... Full text Open Access Link to item Cite

Elucidating the pathogenesis of adenosine deaminase 2 deficiency: current status and unmet needs

Journal article Expert opinion on orphan drugs · March 28, 2022 Introduction Humans have two adenosine deaminase isozymes, ADA1 and ADA2, which differ in affinity for their substrates, adenosine (Ado) and 2ʹdeoxyadenosine (dAdo), and their localization. Inherited deficiencies of ADA1 and ADA2 compromise different aspe ... Full text Open Access Cite

G protein-coupled receptor kinase 3 modulates mesenchymal stem cell proliferation and differentiation through sphingosine-1-phosphate receptor regulation.

Journal article Stem Cell Res Ther · January 29, 2022 BACKGROUND: The bone marrow niche supports hematopoietic cell development through intimate contact with multipotent stromal mesenchymal stem cells; however, the intracellular signaling, function, and regulation of such supportive niche cells are still bein ... Full text Open Access Link to item Cite

Light-Triggered Drug Release from Red Blood Cells Suppresses Arthritic Inflammation.

Journal article Adv Ther (Weinh) · January 2022 Arthritis is a leading cause of disability in adults, which can be intensely incapacitating. The location and intensity of the pain is both subjective and challenging to manage. Consequently, patient-directed delivery of anti-inflammatories is an essential ... Full text Link to item Cite

Combinatorial depletions of G-protein coupled receptor kinases in immune cells identify pleiotropic and cell type-specific functions.

Journal article Front Immunol · 2022 G-protein coupled receptor kinases (GRKs) participate in the regulation of chemokine receptors by mediating receptor desensitization. They can be recruited to agonist-activated G-protein coupled receptors (GPCRs) and phosphorylate their intracellular parts ... Full text Link to item Cite

Taking phototherapeutics from concept to clinical launch.

Journal article Nat Rev Chem · November 2021 More than four decades have passed since the first example of a light-activated (caged) compound was described. In the intervening years, a large number of light-responsive derivatives have been reported, several of which have found utility under a variety ... Full text Link to item Cite

Neutrophils self-limit swarming to contain bacterial growth in vivo.

Journal article Science · June 18, 2021 Neutrophils communicate with each other to form swarms in infected organs. Coordination of this population response is critical for the elimination of bacteria and fungi. Using transgenic mice, we found that neutrophils have evolved an intrinsic mechanism ... Full text Link to item Cite

Paget's Disease of Bone: Osteoimmunology and Osteoclast Pathology.

Journal article Curr Allergy Asthma Rep · March 25, 2021 PURPOSE OF REVIEW: The purpose of this review is to recognize clinical features of Paget's disease of bone and to describe how the osteoclast, a myeloid-derived cell responsible for bone resorption, contributes to the disease. RECENT FINDINGS: Recent studi ... Full text Link to item Cite

A Mimic of Ankylosing Spondylitis, Ochronosis: Case Report and Review of the Literature.

Journal article Curr Allergy Asthma Rep · March 5, 2021 PURPOSE OF REVIEW: Ochronosis and alkaptonuria are manifestations of the same condition-a rare autosomal recessive disorder resulting from a constitutional lack of homogentisate 1,2-dioxygenase (HGD) with the consequent accumulation of homogentisic acid (H ... Full text Open Access Link to item Cite

Hydroxychloroquine and COVID-19: a Rheumatologist's Take on the Lessons Learned.

Journal article Curr Allergy Asthma Rep · January 21, 2021 PURPOSE OF REVIEW: Told from the viewpoint of rheumatologists, this review tells the story of hydroxychloroquine and its swift ascent to become a household name as a therapeutic strategy against the novel SARS-CoV-2 virus. This review describes the history ... Full text Link to item Cite

Mesenchymal stromal cells reprogram monocytes and macrophages with processing bodies.

Journal article Stem Cells · January 2021 Mesenchymal stromal cells (MSCs) are widely used in clinical trials because of their ability to modulate inflammation. The success of MSCs has been variable over 25 years, most likely due to an incomplete understanding of their mechanism. After MSCs are in ... Full text Open Access Link to item Cite

Taking phototherapeutics from concept to clinical launch.

Journal article Nat Rev Chem · 2021 More than four decades have passed since the first example of a light-activated (caged) compound was described. In the intervening years, a large number of light-responsive derivatives have been reported, several of which have found utility under a variety ... Full text Open Access Link to item Cite

Elucidating the pathogenesis of adenosine deaminase 2 deficiency: current status and unmet needs

Journal article Expert Opinion on Orphan Drugs · January 1, 2021 Introduction: Humans have two adenosine deaminase isozymes, ADA1 and ADA2, which differ in affinity for their substrates, adenosine (Ado) and 2ʹdeoxyadenosine (dAdo), and their localization. Inherited deficiencies of ADA1 and ADA2 compromise different aspe ... Full text Open Access Cite

Is the HScore useful in COVID-19?

Journal article Lancet · May 16, 2020 Full text Link to item Cite

Diagnostic interpretation of genetic studies in patients with primary immunodeficiency diseases: A working group report of the Primary Immunodeficiency Diseases Committee of the American Academy of Allergy, Asthma & Immunology.

Journal article J Allergy Clin Immunol · January 2020 Genetic testing has become an integral component of the diagnostic evaluation of patients with suspected primary immunodeficiency diseases. Results of genetic testing can have a profound effect on clinical management decisions. Therefore clinical providers ... Full text Link to item Cite

On Command Drug Delivery via Cell-Conveyed Phototherapeutics.

Journal article Small · September 2019 Herein, the use of red blood cells (RBCs) as carriers of cytoplasmically interned phototherapeutic agents is described. Photolysis promotes drug release from the RBC carrier thereby providing the means to target specific diseased sites. This strategy is re ... Full text Link to item Cite

Laser Light Therapy in Inflammatory, Musculoskeletal, and Autoimmune Disease.

Journal article Curr Allergy Asthma Rep · July 2, 2019 PURPOSE OF REVIEW: The goal of this review is to summarize the field to date and to discuss strengths and limitations of low-level laser (light) therapy (LLLT) for the future investigation as a treatment of inflammatory disease. RECENT FINDINGS: LLLT is a ... Full text Link to item Cite

Chemerin-activated functions of CMKLR1 are regulated by G protein-coupled receptor kinase 6 (GRK6) and β-arrestin 2 in inflammatory macrophages.

Journal article Mol Immunol · February 2019 Chemerin receptor (CMKLR1) is a G protein-coupled receptor (GPCR) implicated in macrophage-mediated inflammation and in several forms of human arthritis. Analogous to other GPCR, CMKLR1 is likely regulated by G protein-coupled receptor kinase (GRK) phospho ... Full text Link to item Cite

Chronic norovirus infection in primary immune deficiency disorders: an international case series.

Journal article Diagn Microbiol Infect Dis · January 2019 OBJECTIVE: Predictive factors associated with clinical outcomes of chronic norovirus infection (CNI) in primary immunodeficiency diseases (PIDD) are lacking. METHOD: We sought to characterize CNI using a multi-institutional cohort of patients with PIDD and ... Full text Link to item Cite

A functional genomics predictive network model identifies regulators of inflammatory bowel disease.

Journal article Nat Genet · October 2017 A major challenge in inflammatory bowel disease (IBD) is the integration of diverse IBD data sets to construct predictive models of IBD. We present a predictive model of the immune component of IBD that informs causal relationships among loci previously li ... Full text Link to item Cite

Dendritic Cells Interpret Haptotactic Chemokine Gradients in a Manner Governed by Signal-to-Noise Ratio and Dependent on GRK6.

Journal article Curr Biol · May 8, 2017 Navigation of cells along gradients of guidance cues is a determining step in many developmental and immunological processes. Gradients can either be soluble or immobilized to tissues as demonstrated for the haptotactic migration of dendritic cells (DCs) t ... Full text Link to item Cite

Single Cell Chemical Cytometry of Akt Activity in Rheumatoid Arthritis and Normal Fibroblast-like Synoviocytes in Response to Tumor Necrosis Factor α.

Journal article Anal Chem · August 2, 2016 The etiology of rheumatoid arthritis (RA) is poorly understood, and 30% of patients are unresponsive to established treatments targeting tumor necrosis factor α (TNFα). Akt kinase is implicated in TNFα signaling and may act as a barometer of patient respon ... Full text Link to item Cite

Immune Gamma Globulin Therapeutic Indications in Immune Deficiency and Autoimmunity.

Journal article Curr Allergy Asthma Rep · July 2016 Immune gamma globulin (IgG) has a long history in the treatment of both primary immune deficiency and autoimmune disorders. Disease indications continue to expand and new-generation products increase the versatility of delivery. This review encompasses a h ... Full text Link to item Cite

Apoptotic Debris Accumulates on Hematopoietic Cells and Promotes Disease in Murine and Human Systemic Lupus Erythematosus.

Journal article J Immunol · May 15, 2016 Apoptotic debris, autoantibody, and IgG-immune complexes (ICs) have long been implicated in the inflammation associated with systemic lupus erythematosus (SLE); however, it remains unclear whether they initiate immune-mediated events that promote disease. ... Full text Link to item Cite

G Protein Coupled Receptor Kinase 3 Regulates Breast Cancer Migration, Invasion, and Metastasis.

Journal article PLoS One · 2016 Triple negative breast cancer (TNBC) is a heterogeneous disease that has a poor prognosis and limited treatment options. Chemokine receptor interactions are important modulators of breast cancer metastasis; however, it is now recognized that quantitative s ... Full text Link to item Cite

Roles of chemokines CCL2 and CCL5 in the pharmacokinetics of PEGylated liposomal doxorubicin in vivo and in patients with recurrent epithelial ovarian cancer.

Journal article Nanomedicine · October 2015 UNLABELLED: Nanoparticles (NPs) are cleared by monocytes and macrophages. Chemokines CCL2 and CCL5 are key mediators for recruitment of these immune cells into tumors and tissues. The purpose of this study was to investigate effects of CCL2 and CCL5 on the ... Full text Link to item Cite

Effects of tumor microenvironment heterogeneity on nanoparticle disposition and efficacy in breast cancer tumor models.

Journal article Clin Cancer Res · December 1, 2014 PURPOSE: Tumor cells are surrounded by a complex microenvironment. The purpose of our study was to evaluate the role of heterogeneity of the tumor microenvironment in the variability of nanoparticle (NP) delivery and efficacy. EXPERIMENTAL DESIGNS: C3(1)-T ... Full text Link to item Cite

Autoimmune lymphoproliferative syndrome: an update and review of the literature.

Journal article Curr Allergy Asthma Rep · September 2014 Autoimmune lymphoproliferative syndrome (ALPS) is characterized by immune dysregulation due to a defect in lymphocyte apoptosis. The clinical manifestations may be noted in multiple family members and include lymphadenopathy, splenomegaly, increased risk o ... Full text Link to item Cite

Targeting the molecular and cellular interactions of the bone marrow niche in immunologic disease.

Journal article Curr Allergy Asthma Rep · February 2014 Recent investigations have expanded our knowledge of the regulatory bone marrow (BM) niche, which is critical in maintaining and directing hematopoietic stem cell (HSC) self-renewal and differentiation. Osteoblasts, mesenchymal stem cells (MSCs), and CXCL1 ... Full text Link to item Cite

Nanoparticle-based diagnostic imaging of inflammation in rheumatic disease.

Journal article Curr Rheumatol Rev · 2014 A variety of imaging modalities assists in the diagnosis and assessment of rheumatoid arthritis and of other rheumatic disorders; however, the definitive diagnosis of inflammatory arthritides can be challenging, especially in the early stages of disease. C ... Full text Link to item Cite

G protein-coupled receptor kinase-3-deficient mice exhibit WHIM syndrome features and attenuated inflammatory responses.

Journal article J Leukoc Biol · December 2013 Chemokine receptor interactions coordinate leukocyte migration in inflammation. Chemokine receptors are GPCRs that when activated, are phosphorylated by GRKs to turn off G protein-mediated signaling yet recruit additional signaling machinery. Recently, GRK ... Full text Link to item Cite

Autoimmunity in immunodeficiency.

Journal article Curr Allergy Asthma Rep · August 2013 Primary immunodeficiencies (PID) comprise a diverse group of clinical disorders with varied genetic defects. Paradoxically, a substantial proportion of PID patients develop autoimmune phenomena in addition to having increased susceptibility to infections f ... Full text Link to item Cite

G-protein signaling modulator-3, a gene linked to autoimmune diseases, regulates monocyte function and its deficiency protects from inflammatory arthritis.

Journal article Mol Immunol · June 2013 Polymorphism at the GPSM3 gene locus is inversely associated with four systemic autoimmune diseases, including rheumatoid arthritis and ankylosing spondylitis. G-protein signaling modulator-3 (GPSM3) expression is most pronounced in myeloid cells, in which ... Full text Link to item Cite

Cellular targeting in autoimmunity.

Journal article Curr Allergy Asthma Rep · December 2012 Many biologic agents that were first approved for the treatment of malignancies are now being actively investigated and used in a variety of autoimmune diseases such as rheumatoid arthritis (RA), antineutrophil cytoplasmic antibody (ANCA)-associated vascul ... Full text Link to item Cite

Decreased Th17 and antigen-specific humoral responses in CX₃ CR1-deficient mice in the collagen-induced arthritis model.

Journal article Arthritis Rheum · May 2012 OBJECTIVE: CX(3) CR1 is a chemokine receptor that uniquely binds to its ligand fractalkine (CX(3) CL1) and has been shown to be important in inflammatory arthritis responses, largely due to its effects on cellular migration. This study was undertaken to te ... Full text Link to item Cite

Second generation automated anti-CCP test better predicts the clinical diagnosis of rheumatoid arthritis.

Journal article J Clin Immunol · February 2012 Rheumatoid arthritis (RA) is one of the most common systemic autoimmune diseases. The presence of antibodies to cyclic citrullinated peptide (CCP) is better at discriminating RA patients and is also associated with significantly more disease activity compa ... Full text Link to item Cite

Enhanced Th17-cell responses render CCR2-deficient mice more susceptible for autoimmune arthritis.

Journal article PLoS One · 2011 CCR2 is considered a proinflammatory mediator in many inflammatory diseases such as rheumatoid arthritis. However, mice lacking CCR2 develop exacerbated collagen-induced arthritis. To explore the underlying mechanism, we investigated whether autoimmune-ass ... Full text Link to item Cite

Sclerosing mesenteritis successfully treated with a TNF antagonist.

Journal article BMJ Case Rep · December 20, 2010 A 29-year-old female presented with intermittent nausea, vomiting, fevers, abdominal pain and fatigue. CT scans of the abdomen revealed inflammatory changes within the mesentery and small bowel. Histopathology of the mesentery and omentum showed chronic in ... Full text Link to item Cite

Multimodal optical and Gd-based nanoparticles for imaging in inflammatory arthritis.

Journal article Clin Exp Rheumatol · 2009 OBJECTIVES: This report documents a multimodal nanoparticle (MNP) contrast agent, containing embedded luminophores and surface-immobilized gadolinium chelates, as a contrast agent of inflamed synovium in a collagen induced arthritis (CIA) model. METHODS: D ... Link to item Cite

S100A9 is not essential for disease expression in an acute (K/BxN) or chronic (CIA) model of inflammatory arthritis.

Journal article Scand J Rheumatol · 2009 OBJECTIVE: S100A8 (calgranulin A, MRP8) and S100A9 (calgranulin B, MRP14) are calcium-binding proteins highly expressed by activated myeloid cells and thought to be involved in the pathogenesis of inflammatory diseases. Circulating levels of S100A8/S100A9 ... Full text Link to item Cite

A desensitization protocol for the mAb cetuximab.

Journal article J Allergy Clin Immunol · January 2009 Full text Link to item Cite

Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN).

Journal article Clin Immunol · October 2008 OBJECTIVE: Chemokine receptors are G-protein coupled receptors (GPCRs) phosphorylated by G-protein receptor kinases (GRKs) after ligand-mediated activation. We hypothesized that GRK subtypes differentially regulate granulocyte chemotaxis and clinical disea ... Full text Link to item Cite

An endogenous TNF-alpha antagonist induced by splice-switching oligonucleotides reduces inflammation in hepatitis and arthritis mouse models.

Journal article Mol Ther · July 2008 Tumor necrosis factor-alpha (TNF-alpha) is a key mediator of inflammatory diseases, including rheumatoid arthritis (RA), and anti-TNF-alpha drugs such as etanercept are effective treatments. Splice-switching oligonucleotides (SSOs) are a new class of drugs ... Full text Link to item Cite

An Endogenous TNF-α Antagonist Induced by Splice-switching Oligonucleotides Reduces Inflammation in Hepatitis and Arthritis Mouse Models.

Journal article Mol Ther · July 2008 Tumor necrosis factor-α (TNF-α) is a key mediator of inflammatory diseases, including rheumatoid arthritis (RA), and anti-TNF-α drugs such as etanercept are effective treatments. Splice-switching oligonucleotides (SSOs) are a new class of drugs designed to ... Full text Link to item Cite

Chemokines and leukocyte trafficking in rheumatoid arthritis.

Journal article Pathophysiology · February 21, 2006 Leukocyte infiltration into the joint space and tissues is an essential component of the pathogenesis of rheumatoid arthritis (RA). In this review, we will summarize the current understanding of the mechanisms of leukocyte trafficking into the synovium, fo ... Full text Link to item Cite

Tgf-beta inhibits activation and uveitogenicity of primary but not of fully polarized retinal antigen-specific memory-effector T cells.

Journal article Invest Ophthalmol Vis Sci · November 2003 PURPOSE: TGF-beta exerts suppressive effects on immunity, but its potential applications in therapy of ocular autoimmunity have not been widely explored. In the present study, the effects of TGF-beta on uveitogenic T cells were examined. METHODS: The effec ... Full text Link to item Cite

B cell loss leading to remission in severe systemic lupus erythematosus.

Journal article J Rheumatol · February 2003 Systemic lupus erythematosus (SLE) pathogenesis is mediated in part by autoantibodies. We describe a patient with central nervous system lupus who developed a loss of B cells with associated hypogammaglobulinemia and sinopulmonary infections requiring intr ... Link to item Cite

Mice deficient in inducible nitric oxide synthase are susceptible to experimental autoimmune uveoretinitis.

Journal article Invest Ophthalmol Vis Sci · May 1999 PURPOSE: Nitric oxide (NO) is an important mediator of inflammatory tissue damage. The present study addresses the question whether inducible nitric oxide synthase (iNOS), and consequently the ability to upregulate NO, is required to effect the pathogenesi ... Link to item Cite

Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon gamma, nitric oxide, and apoptosis.

Journal article J Exp Med · January 18, 1999 Pathogenic effector T cells in experimental autoimmune uveitis (EAU) are T helper type 1-like, and interleukin (IL)-12 is required for their generation and function. Therefore, we expected that IL-12 administration would have disease-enhancing effects. Mic ... Full text Link to item Cite

Endogenous IL-12 is required for induction and expression of experimental autoimmune uveitis.

Journal article J Immunol · July 1, 1998 Experimental autoimmune uveitis (EAU) has been associated with a Th1 response. However, in IFN-gamma-deficient mice, EAU develops in the context of an effector response having Th2-like elements, and administration of IL-12 to mice immunized for EAU inducti ... Link to item Cite

T cell traffic and the inflammatory response in experimental autoimmune uveoretinitis.

Journal article Invest Ophthalmol Vis Sci · April 1998 PURPOSE: To quantify S-antigen-specific (S-Ag) T cells in the retina after adoptive transfer, and to evaluate their role in the initiation and progress of destructive ocular inflammation in experimental autoimmune uveoretinitis (EAU). METHODS: Lewis rats w ... Link to item Cite

Endogenous IL-12 is required for induction and expression of experimental autoimmune uveitis

Journal article FASEB Journal · March 20, 1998 Pathogenic T cells involved in experimental autoimmune uveitis (EAU) are thought to be Th1-like. However, IFN-γ deficient (GKO) mice develop EAU in the context of an effector response having many elements of a Th2-like cytokine profile. IL-12 promotes Th1 ... Cite

IFN-gamma-deficient mice develop experimental autoimmune uveitis in the context of a deviant effector response.

Journal article J Immunol · June 15, 1997 Experimental autoimmune uveitis (EAU) is a T cell-mediated disease that targets the neural retina and serves as a model of human uveitis. Uveitogenic effector T cells have a Th1-like phenotype (high IFN-gamma, low IL-4), and genetic susceptibility to EAU i ... Link to item Cite

TGF-β suppresses antigen stimulation of a uveitogenic t cell line through an effect on antigen-presenting cells

Journal article FASEB Journal · December 1, 1996 TGF-β is thought to have a central role in the control of cell-mediated autoimmunity. We wished to examine the effect of TGF- β on stimulation of the uveitogenic rat T cell line SP35, specific to peptide 35 of the retinal S-Antigen. SP35 cells were stimula ... Cite

TGF-β suppresses antigen stimulation of a uveitogenic T cell line through an effect on antigen-presenting cells

Journal article Investigative Ophthalmology and Visual Science · February 15, 1996 Purpose: Numerous studies have implicated the suppressive cytokine TGF-β1 as having a central role in the control of cell-mediated autoimmunity. We therefore wished to examine the effect of TGF-β1 on stimulation of the highly uveitogenic rat T cell line SP ... Cite