Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., University of Texas at Dallas 1997
• 

  Duke Appointment History

  • Assistant Research Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2002 - 2006
  • Instructor, Temporary in the Department of Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2002
• Research
• 

  Selected Grants

  • The role of gastrin in esophageal submucosal gland acinar ductal metaplasia awarded by National Institutes of Health 2018 - 2023
  • Reversible Mitochondrial Protein Acetylation and Metabolic Regulation awarded by Buck Institute for Research on Aging 2017 - 2019
  • Eli Lilly Collaboration awarded by Eli Lilly and Company 2017 - 2018
  • Reversible Mitochondrial Protein Acetylation and Metabolic Regulation awarded by Gladstone 2010 - 2017
• Publications & Artistic Works
• 

  Selected Publications

  • Journal Articles

    • Wang, H, Bender, A, Wang, P, Karakose, E, Inabnet, WB, Libutti, SK, Arnold, A, Lambertini, L, Stang, M, Chen, H, Kasai, Y, Mahajan, M, Kinoshita, Y, Fernandez-Ranvier, G, Becker, TC, Takane, KK, Walker, LA, Saul, S, Chen, R, Scott, DK, Ferrer, J, Antipin, Y, Donovan, M, Uzilov, AV, Reva, B, Schadt, EE, Losic, B, Argmann, C, and Stewart, AF. "Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas." Nature Communications 8, no. 1 (October 3, 2017): 767-null.  Full Text
    • Hayes, HL, Zhang, L, Becker, TC, Haldeman, JM, Stephens, SB, Arlotto, M, Moss, LG, Newgard, CB, and Hohmeier, HE. "A Pdx-1-Regulated Soluble Factor Activates Rat and Human Islet Cell Proliferation." Molecular and Cellular Biology 36, no. 23 (December 2016): 2918-2930.  Full Text
    • Rosario, W, Singh, I, Wautlet, A, Patterson, C, Flak, J, Becker, TC, Ali, A, Tamarina, N, Philipson, LH, Enquist, LW, Myers, MG, and Rhodes, CJ. "The Brain-to-Pancreatic Islet Neuronal Map Reveals Differential Glucose Regulation From Distinct Hypothalamic Regions." Diabetes 65, no. 9 (September 2016): 2711-2723.  Full Text
    • Marzban, L, Tomas, A, Becker, TC, Rosenberg, L, Oberholzer, J, Fraser, PE, Halban, PA, and Verchere, CB. "Erratum. Small Interfering RNA—Mediated Suppression of Proislet Amyloid Polypeptide Expression Inhibits Islet Amyloid Formation and Enhances Survival of Human Islets in Culture. Diabetes 2008;57:3045—3055." Diabetes 65, no. 3 (March 2016): 818-818.  Full Text
    • Guo, C, Ludvik, AE, Arlotto, ME, Hayes, MG, Armstrong, LL, Scholtens, DM, Brown, CD, Newgard, CB, Becker, TC, Layden, BT, Lowe, WL, and Reddy, TE. "Coordinated regulatory variation associated with gestational hyperglycaemia regulates expression of the novel hexokinase HKDC1." Nature communications 6 (February 4, 2015): 6069-.  Full Text
    • Hobson, A, Draney, C, Stratford, A, Becker, TC, Lu, D, Arlotto, M, and Tessem, JS. "Aurora Kinase A is critical for the Nkx6.1 mediated β-cell proliferation pathway." Islets 7, no. 1 (January 2015): e1027854-null.  Full Text
    • Civitarese, AE, MacLean, PS, Carling, S, Kerr-Bayles, L, McMillan, RP, Pierce, A, Becker, TC, Moro, C, Finlayson, J, Lefort, N, Newgard, CB, Mandarino, L, Cefalu, W, Walder, K, Collier, GR, Hulver, MW, Smith, SR, and Ravussin, E. "Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL." Cell Metab 11, no. 5 (May 5, 2010): 412-426.  Full Text  Link to Item
    • Odegaard, ML, Joseph, JW, Jensen, MV, Lu, D, Ilkayeva, O, Ronnebaum, SM, Becker, TC, and Newgard, CB. "The mitochondrial 2-oxoglutarate carrier is part of a metabolic pathway that mediates glucose- and glutamine-stimulated insulin secretion." The Journal of Biological Chemistry 285, no. 22 (May 2010): 16530-16537.  Full Text
    • Anderson, KR, Torres, CA, Solomon, K, Becker, TC, Newgard, CB, Wright, CV, Hagman, J, and Sussel, L. "Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3." The Journal of Biological Chemistry 284, no. 45 (November 2009): 31236-31248.  Full Text
    • Dunn-Meynell, AA, Sanders, NM, Compton, D, Becker, TC, Eiki, J-I, Zhang, BB, and Levin, BE. "Relationship among brain and blood glucose levels and spontaneous and glucoprivic feeding." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 29, no. 21 (May 2009): 7015-7022.  Full Text
    • Levin, BE, Becker, TC, Eiki, J-I, Zhang, BB, and Dunn-Meynell, AA. "Ventromedial hypothalamic glucokinase is an important mediator of the counterregulatory response to insulin-induced hypoglycemia." Diabetes 57, no. 5 (May 2008): 1371-1379.  Full Text
    • Ronnebaum, SM, Joseph, JW, Ilkayeva, O, Burgess, SC, Lu, D, Becker, TC, Sherry, AD, and Newgard, CB. "Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolism." The Journal of Biological Chemistry 283, no. 21 (May 2008): 14248-14256.  Full Text
    • Schisler, JC, Fueger, PT, Babu, DA, Hohmeier, HE, Tessem, JS, Lu, D, Becker, TC, Naziruddin, B, Levy, M, Mirmira, RG, and Newgard, CB. "Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1." Molecular and Cellular Biology 28, no. 10 (May 2008): 3465-3476.  Full Text
    • Marzban, L, Tomas, A, Becker, TC, Rosenberg, L, Oberholzer, J, Fraser, PE, Halban, PA, and Verchere, BC. "Small interfering RNA-mediated suppression of proislet amyloid polypeptide expression inhibits islet amyloid formation and enhances survival of human islets in culture." Diabetes 57, no. 11 (2008): 3045-3055.  Full Text
    • Schroeder-Gloeckler, JM, Rahman, SM, Janssen, RC, Qiao, L, Shao, J, Roper, M, Fischer, SJ, Lowe, E, Orlicky, DJ, McManaman, JL, Palmer, C, Gitomer, WL, Huang, W, O'Doherty, RM, Becker, TC, Klemm, DJ, Jensen, DR, Pulawa, LK, Eckel, RH, and Friedman, JE. "CCAAT/enhancer-binding protein beta deletion reduces adiposity, hepatic steatosis, and diabetes in Lepr(db/db) mice." The Journal of Biological Chemistry 282, no. 21 (May 2007): 15717-15729.  Full Text
    • Hardy, OT, Hohmeier, HE, Becker, TC, Manduchi, E, Doliba, NM, Gupta, RK, White, P, Stoeckert, CJ, Matschinsky, FM, Newgard, CB, and Kaestner, KH. "Functional genomics of the beta-cell: short-chain 3-hydroxyacyl-coenzyme A dehydrogenase regulates insulin secretion independent of K+ currents." Molecular Endocrinology (Baltimore, Md.) 21, no. 3 (March 2007): 765-773.  Full Text
    • Ronnebaum, SM, Ilkayeva, O, Burgess, SC, Joseph, JW, Lu, D, Stevens, RD, Becker, TC, Sherry, AD, Newgard, CB, and Jensen, MV. "A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion." The Journal of Biological Chemistry 281, no. 41 (October 2006): 30593-30602.  Full Text
    • Jensen, MV, Joseph, JW, Ilkayeva, O, Burgess, S, Lu, D, Ronnebaum, SM, Odegaard, M, Becker, TC, Sherry, AD, and Newgard, CB. "Compensatory responses to pyruvate carboxylase suppression in islet beta-cells. Preservation of glucose-stimulated insulin secretion." The Journal of Biological Chemistry 281, no. 31 (August 2006): 22342-22351.  Full Text
    • Cao, W, Collins, QF, Becker, TC, Robidoux, J, Lupo, EG, Xiong, Y, Daniel, KW, Floering, L, and Collins, S. "p38 Mitogen-activated protein kinase plays a stimulatory role in hepatic gluconeogenesis." The Journal of Biological Chemistry 280, no. 52 (December 2005): 42731-42737.  Full Text
    • Schisler, JC, Jensen, PB, Taylor, DG, Becker, TC, Knop, FK, Takekawa, S, German, M, Weir, GC, Lu, D, Mirmira, RG, and Newgard, CB. "The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells." Proceedings of the National Academy of Sciences of the United States of America 102, no. 20 (May 9, 2005): 7297-7302.  Full Text
    • Iype, T, Francis, J, Garmey, JC, Schisler, JC, Nesher, R, Weir, GC, Becker, TC, Newgard, CB, Griffen, SC, and Mirmira, RG. "Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes." The Journal of Biological Chemistry 280, no. 17 (April 2005): 16798-16807.  Full Text
    • Bain, JR, Schisler, JC, Takeuchi, K, Newgard, CB, and Becker, TC. "An adenovirus vector for efficient RNA interference-mediated suppression of target genes in insulinoma cells and pancreatic islets of langerhans." Diabetes 53, no. 9 (September 2004): 2190-2194.  Link to Item
    • Newgard, CB, Becker, TC, Berman, HK, and O'Doherty, RM. "Regulation of overexpressed hexokinases in liver and islet cells." Biochem Soc Trans 25, no. 1 (February 1997): 118-122. (Review)  Link to Item
    • Becker, TC, Noel, RJ, Johnson, JH, Lynch, RM, Hirose, H, Tokuyama, Y, Bell, GI, and Newgard, CB. "Differential effects of overexpressed glucokinase and hexokinase I in isolated islets. Evidence for functional segregation of the high and low Km enzymes." J Biol Chem 271, no. 1 (January 5, 1996): 390-394.  Link to Item
    • Argaud, D, Lange, AJ, Becker, TC, Okar, DA, el-Maghrabi, MR, Newgard, CB, and Pilkis, SJ. "Adenovirus-mediated overexpression of liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in gluconeogenic rat hepatoma cells. Paradoxical effect on Fru-2,6-P2 levels." J Biol Chem 270, no. 41 (October 13, 1995): 24229-24236.  Link to Item
    • Becker, TC, BeltrandelRio, H, Noel, RJ, Johnson, JH, and Newgard, CB. "Overexpression of hexokinase I in isolated islets of Langerhans via recombinant adenovirus. Enhancement of glucose metabolism and insulin secretion at basal but not stimulatory glucose levels." J Biol Chem 269, no. 33 (August 19, 1994): 21234-21238.  Link to Item
    • Ferber, S, BeltrandelRio, H, Johnson, JH, Noel, RJ, Cassidy, LE, Clark, S, Becker, TC, Hughes, SD, and Newgard, CB. "GLUT-2 gene transfer into insulinoma cells confers both low and high affinity glucose-stimulated insulin release. Relationship to glucokinase activity." J Biol Chem 269, no. 15 (April 15, 1994): 11523-11529.  Link to Item
    • Becker, TC, Noel, RJ, Coats, WS, Gómez-Foix, AM, Alam, T, Gerard, RD, and Newgard, CB. "Use of recombinant adenovirus for metabolic engineering of mammalian cells." Methods in cell biology 43 Pt A (1994): 161-189.  Full Text
    • Thomas, CB, Meade, JC, and Holmes, EW. "Aminoimidazole carboxamide ribonucleoside toxicity: A model for study of pyrimidine starvation." Journal of Cellular Physiology 107, no. 3 (1981): 335-344.

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