Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., University of Texas at Dallas 1997
• 

  Duke Appointment History

  • Assistant Research Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2002 - 2006
  • Instructor, Temporary in the Department of Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2002
• Research
• 

  Selected Grants

  • The role of gastrin in esophageal submucosal gland acinar ductal metaplasia awarded by National Institutes of Health 2018 - 2023
  • Reversible Mitochondrial Protein Acetylation and Metabolic Regulation awarded by Buck Institute for Research on Aging 2017 - 2019
  • Eli Lilly Collaboration awarded by Eli Lilly and Company 2017 - 2018
  • Reversible Mitochondrial Protein Acetylation and Metabolic Regulation awarded by Gladstone 2010 - 2017
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Khan, MW, Priyadarshini, M, Cordoba-Chacon, J, Becker, TC, and Layden, BT. "Hepatic hexokinase domain containing 1 (HKDC1) improves whole body glucose tolerance and insulin sensitivity in pregnant mice." Biochimica Et Biophysica Acta. Molecular Basis of Disease 1865, no. 3 (March 2019): 678-687.  Full Text
    • Haldeman, JM, Conway, AE, Arlotto, ME, Slentz, DH, Muoio, DM, Becker, TC, and Newgard, CB. "Creation of versatile cloning platforms for transgene expression and dCas9-based epigenome editing." Nucleic Acids Research 47, no. 4 (February 2019): e23-null.  Full Text
    • Pusec, CM, De Jesus, A, Khan, MW, Terry, AR, Ludvik, AE, Xu, K, Giancola, N, Pervaiz, H, Daviau Smith, E, Ding, X, Harrison, S, Chandel, NS, Becker, TC, Hay, N, Ardehali, H, Cordoba-Chacon, J, and Layden, BT. "Hepatic HKDC1 Expression Contributes to Liver Metabolism." Endocrinology 160, no. 2 (February 2019): 313-330.  Full Text
    • Oh, E, Ahn, M, Afelik, S, Becker, TC, Roep, BO, and Thurmond, DC. "Syntaxin 4 Expression in Pancreatic β-Cells Promotes Islet Function and Protects Functional β-Cell Mass." Diabetes 67, no. 12 (December 2018): 2626-2639.  Full Text
    • Wang, H, Bender, A, Wang, P, Karakose, E, Inabnet, WB, Libutti, SK, Arnold, A, Lambertini, L, Stang, M, Chen, H, Kasai, Y, Mahajan, M, Kinoshita, Y, Fernandez-Ranvier, G, Becker, TC, Takane, KK, Walker, LA, Saul, S, Chen, R, Scott, DK, Ferrer, J, Antipin, Y, Donovan, M, Uzilov, AV, Reva, B, Schadt, EE, Losic, B, Argmann, C, and Stewart, AF. "Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas." Nature Communications 8, no. 1 (October 3, 2017): 767-null.  Full Text
    • Hayes, HL, Zhang, L, Becker, TC, Haldeman, JM, Stephens, SB, Arlotto, M, Moss, LG, Newgard, CB, and Hohmeier, HE. "A Pdx-1-Regulated Soluble Factor Activates Rat and Human Islet Cell Proliferation." Molecular and Cellular Biology 36, no. 23 (December 2016): 2918-2930.  Full Text
    • Rosario, W, Singh, I, Wautlet, A, Patterson, C, Flak, J, Becker, TC, Ali, A, Tamarina, N, Philipson, LH, Enquist, LW, Myers, MG, and Rhodes, CJ. "The Brain-to-Pancreatic Islet Neuronal Map Reveals Differential Glucose Regulation From Distinct Hypothalamic Regions." Diabetes 65, no. 9 (September 2016): 2711-2723.  Full Text
    • Marzban, L, Tomas, A, Becker, TC, Rosenberg, L, Oberholzer, J, Fraser, PE, Halban, PA, and Verchere, CB. "Erratum. Small Interfering RNA—Mediated Suppression of Proislet Amyloid Polypeptide Expression Inhibits Islet Amyloid Formation and Enhances Survival of Human Islets in Culture. Diabetes 2008;57:3045—3055." Diabetes 65, no. 3 (March 2016): 818-818.  Full Text
    • Guo, C, Ludvik, AE, Arlotto, ME, Hayes, MG, Armstrong, LL, Scholtens, DM, Brown, CD, Newgard, CB, Becker, TC, Layden, BT, Lowe, WL, and Reddy, TE. "Coordinated regulatory variation associated with gestational hyperglycaemia regulates expression of the novel hexokinase HKDC1." Nature communications 6 (February 4, 2015): 6069-.  Full Text
    • Hobson, A, Draney, C, Stratford, A, Becker, TC, Lu, D, Arlotto, M, and Tessem, JS. "Aurora Kinase A is critical for the Nkx6.1 mediated β-cell proliferation pathway." Islets 7, no. 1 (January 2015): e1027854-null.  Full Text
    • Civitarese, AE, MacLean, PS, Carling, S, Kerr-Bayles, L, McMillan, RP, Pierce, A, Becker, TC, Moro, C, Finlayson, J, Lefort, N, Newgard, CB, Mandarino, L, Cefalu, W, Walder, K, Collier, GR, Hulver, MW, Smith, SR, and Ravussin, E. "Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL." Cell Metab 11, no. 5 (May 5, 2010): 412-426.  Full Text  Link to Item
    • Odegaard, ML, Joseph, JW, Jensen, MV, Lu, D, Ilkayeva, O, Ronnebaum, SM, Becker, TC, and Newgard, CB. "The mitochondrial 2-oxoglutarate carrier is part of a metabolic pathway that mediates glucose- and glutamine-stimulated insulin secretion." The Journal of Biological Chemistry 285, no. 22 (May 2010): 16530-16537.  Full Text
    • Anderson, KR, Torres, CA, Solomon, K, Becker, TC, Newgard, CB, Wright, CV, Hagman, J, and Sussel, L. "Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3." The Journal of Biological Chemistry 284, no. 45 (November 2009): 31236-31248.  Full Text
    • Dunn-Meynell, AA, Sanders, NM, Compton, D, Becker, TC, Eiki, J-I, Zhang, BB, and Levin, BE. "Relationship among brain and blood glucose levels and spontaneous and glucoprivic feeding." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 29, no. 21 (May 2009): 7015-7022.  Full Text
    • Levin, BE, Becker, TC, Eiki, J-I, Zhang, BB, and Dunn-Meynell, AA. "Ventromedial hypothalamic glucokinase is an important mediator of the counterregulatory response to insulin-induced hypoglycemia." Diabetes 57, no. 5 (May 2008): 1371-1379.  Full Text
    • Ronnebaum, SM, Joseph, JW, Ilkayeva, O, Burgess, SC, Lu, D, Becker, TC, Sherry, AD, and Newgard, CB. "Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolism." The Journal of Biological Chemistry 283, no. 21 (May 2008): 14248-14256.  Full Text
    • Schisler, JC, Fueger, PT, Babu, DA, Hohmeier, HE, Tessem, JS, Lu, D, Becker, TC, Naziruddin, B, Levy, M, Mirmira, RG, and Newgard, CB. "Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1." Molecular and Cellular Biology 28, no. 10 (May 2008): 3465-3476.  Full Text
    • Marzban, L, Tomas, A, Becker, TC, Rosenberg, L, Oberholzer, J, Fraser, PE, Halban, PA, and Verchere, BC. "Small interfering RNA-mediated suppression of proislet amyloid polypeptide expression inhibits islet amyloid formation and enhances survival of human islets in culture." Diabetes 57, no. 11 (2008): 3045-3055.  Full Text
    • Schroeder-Gloeckler, JM, Rahman, SM, Janssen, RC, Qiao, L, Shao, J, Roper, M, Fischer, SJ, Lowe, E, Orlicky, DJ, McManaman, JL, Palmer, C, Gitomer, WL, Huang, W, O'Doherty, RM, Becker, TC, Klemm, DJ, Jensen, DR, Pulawa, LK, Eckel, RH, and Friedman, JE. "CCAAT/enhancer-binding protein beta deletion reduces adiposity, hepatic steatosis, and diabetes in Lepr(db/db) mice." The Journal of Biological Chemistry 282, no. 21 (May 2007): 15717-15729.  Full Text
    • Hardy, OT, Hohmeier, HE, Becker, TC, Manduchi, E, Doliba, NM, Gupta, RK, White, P, Stoeckert, CJ, Matschinsky, FM, Newgard, CB, and Kaestner, KH. "Functional genomics of the beta-cell: short-chain 3-hydroxyacyl-coenzyme A dehydrogenase regulates insulin secretion independent of K+ currents." Molecular Endocrinology (Baltimore, Md.) 21, no. 3 (March 2007): 765-773.  Full Text
    • Ronnebaum, SM, Ilkayeva, O, Burgess, SC, Joseph, JW, Lu, D, Stevens, RD, Becker, TC, Sherry, AD, Newgard, CB, and Jensen, MV. "A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion." The Journal of Biological Chemistry 281, no. 41 (October 2006): 30593-30602.  Full Text
    • Jensen, MV, Joseph, JW, Ilkayeva, O, Burgess, S, Lu, D, Ronnebaum, SM, Odegaard, M, Becker, TC, Sherry, AD, and Newgard, CB. "Compensatory responses to pyruvate carboxylase suppression in islet beta-cells. Preservation of glucose-stimulated insulin secretion." The Journal of Biological Chemistry 281, no. 31 (August 2006): 22342-22351.  Full Text
    • Cao, W, Collins, QF, Becker, TC, Robidoux, J, Lupo, EG, Xiong, Y, Daniel, KW, Floering, L, and Collins, S. "p38 Mitogen-activated protein kinase plays a stimulatory role in hepatic gluconeogenesis." The Journal of Biological Chemistry 280, no. 52 (December 2005): 42731-42737.  Full Text
    • Schisler, JC, Jensen, PB, Taylor, DG, Becker, TC, Knop, FK, Takekawa, S, German, M, Weir, GC, Lu, D, Mirmira, RG, and Newgard, CB. "The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells." Proceedings of the National Academy of Sciences of the United States of America 102, no. 20 (May 9, 2005): 7297-7302.  Full Text
    • Iype, T, Francis, J, Garmey, JC, Schisler, JC, Nesher, R, Weir, GC, Becker, TC, Newgard, CB, Griffen, SC, and Mirmira, RG. "Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes." The Journal of Biological Chemistry 280, no. 17 (April 2005): 16798-16807.  Full Text
    • Bain, JR, Schisler, JC, Takeuchi, K, Newgard, CB, and Becker, TC. "An adenovirus vector for efficient RNA interference-mediated suppression of target genes in insulinoma cells and pancreatic islets of langerhans." Diabetes 53, no. 9 (September 2004): 2190-2194.  Link to Item
    • Newgard, CB, Becker, TC, Berman, HK, and O'Doherty, RM. "Regulation of overexpressed hexokinases in liver and islet cells." Biochem Soc Trans 25, no. 1 (February 1997): 118-122. (Review)  Link to Item
    • Becker, TC, Noel, RJ, Johnson, JH, Lynch, RM, Hirose, H, Tokuyama, Y, Bell, GI, and Newgard, CB. "Differential effects of overexpressed glucokinase and hexokinase I in isolated islets. Evidence for functional segregation of the high and low Km enzymes." The Journal of Biological Chemistry 271, no. 1 (January 1996): 390-394.  Full Text
    • Argaud, D, Lange, AJ, Becker, TC, Okar, DA, el-Maghrabi, MR, Newgard, CB, and Pilkis, SJ. "Adenovirus-mediated overexpression of liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in gluconeogenic rat hepatoma cells. Paradoxical effect on Fru-2,6-P2 levels." J Biol Chem 270, no. 41 (October 13, 1995): 24229-24236.  Link to Item
    • Becker, TC, BeltrandelRio, H, Noel, RJ, Johnson, JH, and Newgard, CB. "Overexpression of hexokinase I in isolated islets of Langerhans via recombinant adenovirus. Enhancement of glucose metabolism and insulin secretion at basal but not stimulatory glucose levels." The Journal of Biological Chemistry 269, no. 33 (August 1994): 21234-21238.
    • Ferber, S, BeltrandelRio, H, Johnson, JH, Noel, RJ, Cassidy, LE, Clark, S, Becker, TC, Hughes, SD, and Newgard, CB. "GLUT-2 gene transfer into insulinoma cells confers both low and high affinity glucose-stimulated insulin release. Relationship to glucokinase activity." The Journal of Biological Chemistry 269, no. 15 (April 1994): 11523-11529.
    • Becker, TC, Noel, RJ, Coats, WS, Gómez-Foix, AM, Alam, T, Gerard, RD, and Newgard, CB. "Chapter 8 Use of Recombinant Adenovirus for Metabolic Engineering of Mammalian Cells." Methods in Cell Biology 43, no. C (January 1, 1994): 161-189.  Full Text
    • Thomas, CB, Meade, JC, and Holmes, EW. "Aminoimidazole carboxamide ribonucleoside toxicity: A model for study of pyrimidine starvation." Journal of Cellular Physiology 107, no. 3 (1981): 335-344.

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