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Thomas Norton Denny

Professor in Medicine
Medicine, Duke Human Vaccine Institute
Box 103020, Durham, NC 27710
2 Genome Ct, Room 4077 MSRB II, Durham, NC 27710

Overview


Thomas N. Denny, MSc, M.Phil, is the Chief Operating Officer of the Duke Human Vaccine Institute (DHVI), Associate Dean for Duke Research and Discovery @RTP, and a Professor of Medicine in the Department of Medicine at Duke University Medical Center. He is also an Affiliate Member of the Duke Global Health Institute. Previously, he served on the Health Sector Advisory Council of the Duke University Fuquay School of Business. Prior to joining Duke, he was an Associate Professor of Pathology, Laboratory Medicine and Pediatrics, Associate Professor of Preventive Medicine and Community Health and Assistant Dean for Research in Health Policy at the New Jersey Medical School, Newark, New Jersey. He has served on numerous committees for the NIH over the last two decades and currently is the principal investigator of an NIH portfolio in excess of 65 million dollars. Mr. Denny was a 2002-2003 Robert Wood Johnson Foundation Health Policy Fellow at the Institute of Medicine of the National Academies (IOM). As a fellow, he served on the US Senate Health, Education, Labor and Pensions Committee with legislation/policy responsibilities in global AIDS, bioterrorism, clinical trials/human subject protection and vaccine related-issues.

As the Chief Operating Officer of the DHVI, Mr. Denny has senior oversight of the DHVI research portfolio and the units/teams that support the DHVI mission. He has extensive international experience and previously was a consultant to the U.S. Centers for Disease Control and Prevention (CDC) for the President’s Emergency Plan for AIDS Relief (PEPFAR) project to oversee the development of an HIV and Public Health Center of Excellence laboratory network in Guyana. In September 2004, the IOM appointed him as a consultant to their Board on Global Health Committee studying the options for overseas placement of U.S. health professionals and the development of an assessment plan for activities related to the 2003 PEPFAR legislative act. In the 1980s, Mr. Denny helped establish a small laboratory in the Republic of Kalmykia (former Soviet Union) to improve the care of children with HIV/AIDS and served as a Board Member of the Children of Chernobyl Relief Fund Foundation. In 2005, Mr. Denny was named a consulting medical/scientific officer to the WHO Global AIDS Program in Geneva. He has also served as program reviewers for the governments of the Netherlands and South Africa as well as an advisor to several U.S. biotech companies. He currently serves as the Chair of the Scientific Advisory Board for Grid Biosciences.

Mr. Denny has authored and co-authored more than 200 peer-reviewed papers and serves on the editorial board of Communications in Cytometry and Journal of Clinical Virology. He holds an M.Sc in Molecular and Biomedical Immunology from the University of East London and a degree in Medical Law (M.Phil) from the Institute of Law and Ethics in Medicine, School of Law, University of Glasgow. In 1991, he completed a course of study in Strategic Management at The Wharton School, University of Pennsylvania. In 1993, he completed the Program for Advanced Training in Biomedical Research Management at Harvard School of Public Health. In December 2005, he was inducted as a Fellow into the College of Physicians of Philadelphia, the oldest medical society in the US.

While living in New Jersey, Mr. Denny was active in his community, gaining additional experience from two publicly elected positions. In 2000, Mr. Denny was selected by the New Jersey League of Municipalities to Chair the New Jersey Community Mental Health Citizens’ Advisory Board and Mental Health Planning Council as a gubernatorial appointment.

Current Duke Appointments & Affiliations


Professor in Medicine · 2021 - Present Medicine, Duke Human Vaccine Institute, Medicine
Research Professor of Global Health · 2013 - Present Duke Global Health Institute, University Institutes and Centers
Member of the Duke Human Vaccine Institute · 2006 - Present Duke Human Vaccine Institute, Institutes and Centers

Recent News Items


Published September 5, 2024
Experimental Flu Vaccines to Be Made at Duke
Published January 27, 2023
Overseeing Duke’s Vaccine Research Enterprise
Published December 16, 2021
Omicron and the Holidays Add up to 'Perfect Storm' for COVID Cases, Duke Expert Warns

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Recent Scholarly Works


Development and genomic characterization of a diverse HIV-1 variant reference panel for nucleic acid-based testing.

Journal article J Clin Virol · June 2026 BACKGROUND: The high worldwide genetic diversity of HIV poses significant challenges for its detection and diagnosis by nucleic acid testing (NAT). Well-characterized reference panels are important for evaluating the analytical performance of HIV tests. OB ... Full text Link to item Cite

Longitudinal evaluation of HIV-1 LAg incidence assay and proficiency panel stability for external quality assurance.

Journal article Microbiol Spectr · April 10, 2026 Accurate HIV incidence estimates are essential for monitoring epidemic trends and evaluating prevention efforts. The limiting antigen (LAg) avidity enzyme immunoassay is the most widely used method to classify recent versus long-term HIV infections. The Ex ... Full text Link to item Cite

CXCR4-tropic HIV-1 infection in an immunocompetent monkey model.

Journal article Nat Commun · March 9, 2026 Current animal models of HIV-1 infection are either immunocompromised or rely on proxy viruses instead of HIV-1. Here, we establish an immunocompetent animal model for CXCR4-tropic HIV-1 in owl monkeys (Aotus nancymaae). Through analysis of 191 owl monkeys ... Full text Link to item Cite
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Recent Grants


NIAID Virology Quality Assurance (VQA)

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2026 - 2033

Nonhuman Primate Core Virology Laboratory for AIDS Vaccine Research and Development

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2024 - 2031

External Quality Assurance Program Oversight Laboratory (EQAPOL)

ResearchPrincipal Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2024 - 2031

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Education


University of Glasgow (United Kingdom) · 2010 M.Phil.
University of East London (United Kingdom) · 2001 M.S.