Scholars@Duke
Thomas Michael Price

Thomas Michael Price

Professor Emeritus of Obstetrics and Gynecology
Obstetrics and Gynecology, Reproductive Endocrinology & Infertility
thomas.m.price@duke.edu
Box 3143 Med Ctr, Durham, NC 27710
Duke Fertility Clinic, 5601 Arringdon Park Dr., Ste 210, Morrisville, NC 27560
Office hours M-F 8 am - 5 pm  

Featured Works

Actions of steroids in mitochondria.

Journal article Semin Reprod Med · May 2007 Featured Publication Investigations of indirect and direct actions of steroids on the mitochondria are relatively new areas of research. In this review we provide brief background information regarding mitochondrial structure and function and then focus upon interactions of gl ... Full text Link to item Cite

Binding of progesterone to cell surfaces of human granulosa-lutein cells.

Journal article J Steroid Biochem Mol Biol · September 2006 Featured Publication Progesterone is produced by granulosa cells under the influence of luteinizing hormone. Nuclear progesterone receptors have been found in rat granulosa cells. Human granulosa-lutein cells rapidly respond to progesterone with an increase in intracellular ca ... Full text Link to item Cite

Immunofluorescent localization of a novel progesterone receptor(s) in a T47D-Y breast cancer cell line lacking genomic progesterone receptor expression.

Journal article J Soc Gynecol Investig · December 2005 Featured Publication OBJECTIVE: To identify a novel nongenomic progesterone receptor (PR), PR-M, in T47D-Y breast cancer cells lacking genomic PR expression. METHODS: Immunofluorescent staining of T47D and T47D-Y breast cancer cells with selective anti-PR antibodies and ligand ... Full text Link to item Cite

Membrane-bound progesterone receptor expression in human aortic endothelial cells.

Journal article J Histochem Cytochem · August 2003 Featured Publication Observational studies demonstrate that estradiol and progesterone affect vasoreactivity. In animal studies, progesterone treatment causes immediate relaxation of precontracted arteries with inhibition of calcium influx in vascular endothelial and smooth mu ... Full text Link to item Cite

Cloning and expression of a novel, truncated, progesterone receptor.

Journal article Mol Cell Endocrinol · February 28, 2003 Featured Publication Progesterone acts via two specific receptors to affect gene transcription in target tissues. Progesterone receptor (PR) B contains 933 amino acids while PR A is a truncated version lacking the initial 164 amino acids. We have cloned a novel, truncated PR f ... Full text Link to item Cite

Identification of progesterone receptor in human subcutaneous adipose tissue.

Journal article J Clin Endocrinol Metab · February 1998 Featured Publication Sex steroids are postulated to play a role in adipose tissue regulation and distribution, because the amount and location of adipose tissue changes during puberty and menopause. Because of the nature of adipose tissue, receptors for the female sex steroids ... Full text Link to item Cite

Estrogen regulation of adipose tissue lipoprotein lipase--possible mechanism of body fat distribution.

Journal article Am J Obstet Gynecol · January 1998 Featured Publication OBJECTIVE: The purpose of this study was to evaluate the regulation of lipoprotein lipase activity, protein mass, and messenger ribonucleic acid by estradiol. STUDY DESIGN: Premenopausal women not taking exogenous sex steroids had transdermal 17 beta-estra ... Full text Link to item Cite

Differences in the estrogen content of breast adipose tissue in women by menopausal status and hormone use.

Journal article Obstet Gynecol · August 1997 Featured Publication OBJECTIVE: To determine the levels of free estrone (E1) and estradiol (E2) in breast adipocytes of premenopausal women, premenopausal women using oral contraceptives (OCs), postmenopausal women, and postmenopausal women using estrogen replacement therapy ( ... Full text Link to item Cite

Single-dose pharmacokinetics of sublingual versus oral administration of micronized 17 beta-estradiol.

Journal article Obstet Gynecol · March 1997 Featured Publication OBJECTIVE: To investigate the pharmacokinetic profiles of different doses of micronized 17 beta-estradiol administered by oral or sublingual routes. METHODS: Single doses of micronized 17 beta-estradiol were administered orally (1 mg, 0.5 mg) or sublingual ... Full text Link to item Cite

Relationship between adipose stromal-vascular cells and adipocytes in human adipose tissue.

Journal article Anal Quant Cytol Histol · April 1996 Featured Publication OBJECTIVE: To determine the relative amounts of RNA and DNA from adipocytes and adipose stromal-vascular cells to better assess differential gene expression for estrogen receptor and cytochrome P450 aromatase in the two cell fractions of adipose tissue. ST ... Link to item Cite

Determination of estrogen receptor messenger ribonucleic acid (mRNA) and cytochrome P450 aromatase mRNA levels in adipocytes and adipose stromal cells by competitive polymerase chain reaction amplification.

Journal article J Clin Endocrinol Metab · October 1993 Featured Publication Clinical evidence suggests that sex hormones affect adipose tissue metabolism and deposition. To investigate the biosynthesis and possible action of estrogen in adipose tissue, we report the use of competitive, specific polymerase chain reaction amplificat ... Full text Link to item Cite

Single- and multiple-dose pharmacokinetics of a low-dose oral contraceptive in women with chronic renal failure undergoing peritoneal dialysis.

Journal article Am J Obstet Gynecol · May 1993 Featured Publication OBJECTIVE: Our purpose was to compare the pharmacokinetic parameters of oral administration of a 35 micrograms ethinyl estradiol, 1 mg norethindrone pill in peritoneal dialysis patients and normal women. STUDY DESIGN: A single-dose study was performed with ... Full text Link to item Cite