Thomas Theis
Assistant Research Professor of Chemistry

Theis' research is at the intersection of Spin Physics and Hyperpolarization Chemistry . It has applications in the study of biochemical dynamics and molecular imaging. The Theis lab drives innovation of magnetic resonance tools and techniques to break the sensitivity limits of NMR   and MRI . The innovations enable i) biochemical structure elucidation with unprecedented limits of detection, and ii) molecular imaging to spy on molecular transformations deep inside tissue. The scientists study and control the spin dynamics of chemical hyperpolarization transfer processes and employ quantum mechanical tricks to protect hyperpolarization from relaxation, which enables molecular tracking on hour-long timescales. The developed technology enhances NMR and MRI signals by 4 to 8 orders of magnitude. The enhanced signals are used to probe biochemical dynamics in vitro , as well as metabolic transformations in vivo . Furthermore, the lab develops unconventional MR detection schemes to probe the hyperpolarized signals. These alternative MR sensors promise ultra sensitive miniaturized and portable NMR and MRI . To propel these efforts, the lab works with a wide range of collaborators at Duke , Vanderbilt , Harvard , MGH , RWTH Aachen , UC Berkeley and UC San Francisco .

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