Scholars@Duke
Timothy Robert Koves

Timothy Robert Koves

Associate Professor in Medicine
Medicine, Geriatrics and Palliative Care
tim.koves@duke.edu
Duke Box 104775, Durham, NC 27704
300 North Duke Street, 50-202 / Carmichael Bldg, Durham, NC 27701

Scholarly Works - Conferences

Abstract Wed007: Postnatal loss of the nuclear receptor PPARĪ± in cardiomyocytes promotes glycolytic remodeling and cardiomyocyte dedifferentiation via Fbp2 downregulation

Conference Circulation Research · August 2025 Cardiomyocytes (CMs) undergo metabolic and contractile reprogramming during cardiac stress and injury. This reprogramming response includes a fuel metabolic shift to a more fetal-like or immature state with downregulation in fatty acid ... Full text Cite

Skeletal muscle mitochondrial inertia is associated with carnitine acetyltransferase activity and physical function in humans.

Conference JCI Insight · January 10, 2023 BACKGROUNDAt the onset of exercise, the speed at which phosphocreatine (PCr) decreases toward a new steady state (PCr on-kinetics) reflects the readiness to activate mitochondrial ATP synthesis, which is secondary to Acetyl-CoA availability in skeletal mus ... Full text Link to item Cite

Abstract P284: The Chemotherapeutic Agent Docetaxel Disrupts Mitochondrial Energetics in 3D Human Bioengineered Myobundles

Conference Circulation · March 5, 2019 Taxanes (i.e. docetaxel, (TAX)) comprise the first line-treatment for breast cancer (BC), mostly in combination with anthracyclines like doxorubicin (DOX). The efficacy of these drugs as antineoplastic agents has helped to boost 10-yea ... Full text Cite