Timothy Joseph McMahon

Journal article Transfusion · October 2015 Featured Publication BACKGROUND: Transfusion of red blood cells (RBCs) is a frequent health care practice. However, unfavorable consequences may occur from transfusions of stored RBCs and are associated with RBC changes during storage. Loss of S-nitrosohemoglobin (SNO-Hb) and ... Full text Link to item Cite

Restoration of intracellular ATP production in banked red blood cells improves inducible ATP export and suppresses RBC-endothelial adhesion.

Journal article Am J Physiol Heart Circ Physiol · December 15, 2014 Featured Publication Transfusion of banked red blood cells (RBCs) has been associated with poor cardiovascular outcomes. Storage-induced alterations in RBC glycolytic flux, attenuated ATP export, and microvascular adhesion of transfused RBCs in vivo could contribute, but the u ... Full text Link to item Cite

Transpulmonary flux of S-nitrosothiols and pulmonary vasodilation during nitric oxide inhalation: role of transport.

Journal article Am J Respir Cell Mol Biol · July 2012 Featured Publication Inhaled nitric oxide (iNO) is used to treat pulmonary hypertension and is being investigated for prevention of bronchopulmonary dysplasia in neonates. Extrapulmonary effects of iNO are widely recognized, but the underlying chemistry and pharmacology are po ... Full text Link to item Cite

Impaired adenosine-5'-triphosphate release from red blood cells promotes their adhesion to endothelial cells: a mechanism of hypoxemia after transfusion.

Journal article Crit Care Med · November 2011 Featured Publication OBJECTIVE: Transfusion of red blood cells has been linked to disappointing clinical outcomes in the critically ill, but specific mechanisms of organ dysfunction after transfusion remain poorly understood. We tested the hypothesis that red blood cell storag ... Full text Link to item Cite

Evolution of adverse changes in stored RBCs.

Journal article Proc Natl Acad Sci U S A · October 23, 2007 Featured Publication Recent studies have underscored questions about the balance of risk and benefit of RBC transfusion. A better understanding of the nature and timing of molecular and functional changes in stored RBCs may provide strategies to improve the balance of benefit ... Full text Link to item Cite

Transport and peripheral bioactivities of nitrogen oxides carried by red blood cell hemoglobin: role in oxygen delivery.

Journal article Physiology (Bethesda) · April 2007 Featured Publication The biology of NO (nitric oxide) is poorly explained by the activity of the free radical NO ((.)NO) itself. Although (.)NO acts in an autocrine and paracrine manner, it is also in chemical equilibrium with other NO species that constitute stable stores of ... Full text Link to item Cite

Excitation-contraction coupling in airway smooth muscle.

Journal article J Biol Chem · October 6, 2006 Featured Publication Excitation-contraction (EC) coupling in striated muscles is mediated by the cardiac or skeletal muscle isoform of voltage-dependent L-type Ca(2+) channel (Ca(v)1.2 and Ca(v)1.1, respectively) that senses a depolarization of the cell membrane, and in respon ... Full text Link to item Cite

Extrapulmonary effects of inhaled nitric oxide: role of reversible S-nitrosylation of erythrocytic hemoglobin.

Journal article Proc Am Thorac Soc · April 2006 Featured Publication Early applications of inhaled nitric oxide (iNO), typically in the treatment of diseases marked by acute pulmonary hypertension, were met by great enthusiasm regarding the purported specificity of iNO: vasodilation by iNO was specific to the lung (without ... Full text Link to item Cite

A nitric oxide processing defect of red blood cells created by hypoxia: deficiency of S-nitrosohemoglobin in pulmonary hypertension.

Journal article Proc Natl Acad Sci U S A · October 11, 2005 Featured Publication The mechanism by which hypoxia [low partial pressure of O(2) (pO(2))] elicits signaling to regulate pulmonary arterial pressure is incompletely understood. We considered the possibility that, in addition to its effects on smooth muscle, hypoxia may influen ... Full text Link to item Cite

Hemoglobin and nitric oxide.

Journal article N Engl J Med · July 24, 2003 Featured Publication Full text Link to item Cite

S-nitrosylation in health and disease.

Journal article Trends Mol Med · April 2003 Featured Publication S-nitrosylation is a ubiquitous redox-related modification of cysteine thiol by nitric oxide (NO), which transduces NO bioactivity. Accumulating evidence suggests that the products of S-nitrosylation, S-nitrosothiols (SNOs), play key roles in human health ... Full text Link to item Cite

Nitric oxide in the human respiratory cycle.

Journal article Nat Med · July 2002 Featured Publication Interactions of nitric oxide (NO) with hemoglobin (Hb) could regulate the uptake and delivery of oxygen (O(2)) by subserving the classical physiological responses of hypoxic vasodilation and hyperoxic vasconstriction in the human respiratory cycle. Here we ... Full text Link to item Cite

Functional coupling of oxygen binding and vasoactivity in S-nitrosohemoglobin.

Journal article J Biol Chem · June 2, 2000 Featured Publication S-Nitrosohemoglobin (SNO-Hb) is a vasodilator whose activity is allosterically modulated by oxygen ("thermodyamic linkage"). Blood vessel contractions are favored in the oxygenated structure, and vasorelaxant activity is "linked" to deoxygenation, as illus ... Full text Link to item Cite

Concerted nitric oxide/oxygen delivery by hemoglobin.

Journal article Methods Enzymol · 1999 Featured Publication Full text Link to item Cite

Influence of Zaprinast on vascular tone and vasodilator responses in the cat pulmonary vascular bed.

Journal article J Appl Physiol (1985) · April 1993 Featured Publication The influence of Zaprinast (M&B 22948), a guanosine 3',5'-cyclic monophosphate (cGMP)-specific phosphodiesterase inhibitor, was investigated in the pulmonary vascular bed of the cat under conditions of controlled blood flow and constant left atrial pressur ... Full text Link to item Cite

Pulmonary vasodilator response to vagal stimulation is blocked by N omega-nitro-L-arginine methyl ester in the cat.

Journal article Circ Res · February 1992 Featured Publication The effect of N omega-nitro-L-arginine methyl ester (L-NAME), an inhibitor of endothelium-derived relaxing factor production, on the vasodilator response to efferent vagal stimulation was investigated in the pulmonary vascular bed of the intact-chest cat u ... Full text Link to item Cite

N omega-nitro-L-arginine methyl ester selectively inhibits pulmonary vasodilator responses to acetylcholine and bradykinin.

Journal article J Appl Physiol (1985) · November 1991 Featured Publication The effects of N omega-nitro-L-arginine methyl ester (L-NAME), an inhibitor of endothelium-derived relaxing factor (EDRF) production, on vascular tone and responses were investigated in the pulmonary vascular bed of the intact-chest cat under conditions of ... Full text Link to item Cite