Scholars@Duke
Timothy Arthur James Haystead

Timothy Arthur James Haystead

Professor of Pharmacology and Cancer Biology
Pharmacology & Cancer Biology
timothy.haystead@dm.duke.edu
Duke Box 3813, Durham, NC 27710
C 118 LSRC, Durham, NC 27708

Scholarly Works - Conferences

Leveraging surface Hsp90 expression for rapid-on-site breast cancer diagnostics

Conference Optics Infobase Conference Papers · January 1, 2020 We developed a portable, low-cost, handheld fluorescent microscope to perform rapid heat shock protein 90 (Hsp90) molecular imaging. The source of non-specific signal and diffusion kinetics of the probe is studied. ... Cite

Optimizing fluorescently-tethered Hsp90 inhibitor dose for maximal specific uptake by breast tumors

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2018 Despite improvements in surgical resection, 20-40% of patients undergoing breast conserving surgery require at least one additional re-excision. Leveraging the unique surface expression of heat shock protein 90 (Hsp90), a chaperone protein involved in seve ... Full text Cite

Abstract C86: Tethered Hsp90 inhibitors carrying optical or radioiodinated probes reveal selective internalization of ectopic Hsp90 in malignant breast tumor cells.

Conference Molecular Cancer Therapeutics · November 1, 2013 AbstractHsp90 inhibitors have demonstrated unusual selectivity for tumor cells despite its ubiquitous expression. This phenomenon has remained unexplained but could be influenced by ectopically expressed Hsp ... Full text Cite