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William Todd Cade

Professor of Orthopaedic Surgery
Orthopaedic Surgery, Physical Therapy
311 Trent Drive, Durham, NC 27710
311 Trent Drive, Durham, NC 27710

Scholarly Works - Preprints


Adjunctive nebulization of Idursulfase to intravenous treatment enhances cardiac proteome adaptations in IDS-KO mice.

Preprint · September 10, 2026 UNLABELLED: Mucopolysaccharidosis Type II (MPS-II) is a rare X-linked lysosomal storage disorder, characterized by deficiency of the lysosomal hydrolase iduronate 2-sulphatase (IDS). Cardiac impairments contribute to mortality in patients. Enzyme replaceme ... Full text Link to item Cite

Matrix Produced by Diseased Cardiac Fibroblasts Affects Early Myotube Formation and Function

Preprint · 2022 The extracellular matrix (ECM) provides both physical and chemical cues that dictate cell function and contribute to the muscle maintenance. Muscle cells require efficient mitochondria to satisfy their high energy demand, however, the role the ECM ... Full text Cite